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Your search keyword '"David G. Washburn"' showing total 2 results
Start Over Author "David G. Washburn" Publisher wiley
2 results on '"David G. Washburn"'

1. Modulation of transient receptor potential canonical channel 3 (TRPC3) activity by a novel pharmacological agonist and antagonist in normotensive and hypertensive rats

Author

Joseph P. Marino, Christine G. Schnackenberg, Melissa H. Costell, Sharada Manns, Xiaoping Xu, David G. Washburn, and Roberta E. Bernard

Subjects
medicine.medical_specialty, Chemistry, Pharmacology, Biochemistry, Transient receptor potential channel, TRPC3, Endocrinology, Modulation, Internal medicine, Genetics, medicine, Inverse agonist, Channel (broadcasting), Molecular Biology, Biotechnology
Published
2012
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2. ChemInform Abstract: Addition of Metalated Pyrones to β-Alkoxy Aldehydes: Synthesis of Hydroxylated Spiroketals

Author

Jason D. Katz, David G. Washburn, Michael T. Crimmins, and Frank J. Zawacki

Subjects
Chemistry, Acid catalyzed, Alkoxy group, General Medicine, Ring (chemistry), Medicinal chemistry
Abstract

Addition of lithiated γ-pyrones to β-alkoxy aldehydes followed by acid catalyzed spiroketalization provides a rapid efficient entry to functionalized hydroxylated spiroketals. The efficiency of the spiroketalization step is dependent on the substituents, particularly unprotected hydroxyls, on the chain which becomes the second ring of the spiroketal.

Published
2010
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