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Your search keyword '"De Falco, Maria"' showing total 14 results
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14 results on '"De Falco, Maria"'

5. Helicobacter pylori heat shock protein B (HspB) localizes in vivo in the gastric mucosa and MALT lymphoma

Author

De Luca, Antonio, primary, De Falco, Maria, additional, Manente, Lucrezia, additional, Dattilo, Doriana, additional, Lucariello, Angela, additional, Esposito, Vincenzo, additional, Gnarini, Mariarosaria, additional, Citro, Gennaro, additional, Baldi, Alfonso, additional, Tufano, Maria Antonietta, additional, and Iaquinto, Gaetano, additional

Published
2008
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14. Cyclin T: Three forms for different roles in physiological and pathological functions

Author

Antonio De Luca, Alfonso Baldi, Marco G. Paggi, Maria De Falco, DE LUCA, A., DE FALCO, Maria, Baldi, A., Paggi, M. G., DE LUCA, Antonio, DE FALCO, M, Baldi, Alfonso, and Paggi, Mg

Subjects
Cyclin E, Cyclin T1, biology, Physiology, Cyclin T, Cyclin D, Cell Cycle, Clinical Biochemistry, Cyclin A, HIV, Cell Differentiation, Cell Biology, Molecular biology, Cell biology, Cyclin D1, Cyclin-dependent kinase, Cyclins, biology.protein, Cyclin-dependent kinase complex, Humans, Protein Isoforms, Cyclin A2
Abstract

Cyclins are members of family of proteins involved in the cell cycle regulation. They are regulatory subunits of complexes with proteins called cyclin-dependent kinases (CDKs). There are three forms of cyclin T: cyclin T1, cyclin T2a, and T2b. All cyclin T contain an N-terminal "cyclin homology box," the most conserved region among different members of the cyclin family that serves to bind CDK9. In addition to the N-terminal cyclin domain, cyclin T contains a putative coiled-coil motif, a His-rich motif, and a C-terminal PEST sequence. The CDK9/cyclin T complex is able to activate gene expression in a catalytic-dependent manner, phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. In addition, only cyclin T1 supports interactions between Tat and TAR. The interaction of Tat with cyclin T1 alters the conformation of Tat to enhance the affinity and specificity of the Tat:TAR interaction. On the other hand, CDK9/cyclin T2 complexes are involved in the regulation of terminal differentiation in muscle cells. © 2002 Wiley-Liss, Inc.

Published
2003

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