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Your search keyword '"De-Giorgio, Fabio"' showing total 22 results
Start Over Author "De-Giorgio, Fabio" Publisher wiley
22 results on '"De-Giorgio, Fabio"'

1. Sex‐specific behavioural, metabolic and immunohistochemical changes after repeated administration of the synthetic cannabinoid AKB48 in mice

Author

Corli, Giorgia, primary, Roda, Elisa, additional, Tirri, Micaela, additional, Bilel, Sabrine, additional, De Luca, Fabrizio, additional, Strano‐Rossi, Sabina, additional, Gaudio, Rosa Maria, additional, De‐Giorgio, Fabio, additional, Fattore, Liana, additional, Locatelli, Carlo Alessandro, additional, and Marti, Matteo, additional

Published
2023
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21. Sex-specific behavioural, metabolic, and immunohistochemical changes after repeated administration of the synthetic cannabinoid AKB48 in mice.

Author

Corli G, Roda E, Tirri M, Bilel S, De Luca F, Strano-Rossi S, Gaudio RM, De-Giorgio F, Fattore L, Locatelli CA, and Marti M

Subjects
Mice, Male, Female, Animals, Cannabinoid Receptor Agonists pharmacology, Receptors, Cannabinoid, Down-Regulation, Receptor, Cannabinoid, CB1, Cannabinoids pharmacology, Cannabis
Abstract

Background and Purpose: AKB48 is a synthetic cannabinoid illegally sold for its psychoactive cannabis-like effects that have been associated with acute intoxication and whose effects are poorly known., Experimental Approach: Using a behavioural, neurochemical, and immunohistochemical approach, we investigated the pharmaco-toxicological effects, pharmacokinetics, and neuroplasticity at cannabinoid CB 1 receptors in the cerebellum and cortex induced by repeated AKB48 administration in male and female mice., Key Results: The effects of AKB48 varied significantly depending on sex and treatment duration. The first injection impaired sensorimotor responses and reduced body temperature, analgesia, and breath rate to a greater extent in females than in males; the second injection induced stronger effects in males while the third injection of AKB48 induced weaker responses in both sexes, suggesting emergence of tolerance. The CB 1 receptor antagonist NESS-0327 prevented the effects induced by repeated AKB48, confirming a CB 1 receptor-mediated action. Blood AKB48 levels were higher in females than in males and repeated administration caused a progressive rise of AKB48 levels in both sexes, suggesting an inhibitory effect on cytochrome activity. Finally, immunohistochemical analysis revealed higher expression of CB 1 receptors in the cerebellum and cortex of females, and a rapid CB 1 receptor down-regulation in cerebellar and cortical areas following repeated AKB48 injections, with neuroadaptation occurring generally more rapidly in females than in males., Conclusion and Implications: We have shown for the first time that AKB48 effects significantly vary with prolonged use and that sex affects the pharmacodynamic/pharmacokinetic responses to repeated administration, suggesting a sex-tailored approach in managing AKB48-induced intoxication., (© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)

Published
2024
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22. Prevalence of Otolaryngology Diseases in an Urban Homeless Population.

Author

Ralli M, Marinelli A, De-Giorgio F, Crescenzi D, Vincentiis M, Greco A, Arcangeli A, and Ercoli L

Subjects
Humans, Prevalence, Retrospective Studies, Ill-Housed Persons, Otolaryngology, Otorhinolaryngologic Diseases epidemiology
Abstract

Objective: Otolaryngology diseases are common among people experiencing homelessness; however, they are seldom evaluated in a specialist setting, and investigations on their prevalence have rarely been conducted. The aim of this retrospective study was to evaluate the prevalence of otolaryngology conditions in an urban homeless population., Study Design: Retrospective study., Setting: Primary health care facility., Methods: The clinical records of patients referred to the medical facilities of the Primary Care Services of the Eleemosynaria Apostolica, Vatican City, between October 1, 2019, and July 31, 2021, were retrospectively reviewed; those reporting at least 1 otolaryngology disease were included in the study., Results: A total of 2516 records were retrospectively reviewed, and 484 (19.24%) were included in the study. The most common otolaryngology disease was pharyngotonsillitis (n = 118, 24.13%), followed by rhinitis with nasal obstruction (n = 107, 21.88%), hearing loss (n = 93, 19.01%), otitis (n = 81, 16.56%), abscess (n = 46, 9.40%), and sinusitis (n = 33, 6.74%). Head and neck cancer or precancerous lesions were reported in 34 subjects (7.02%). More than 1 simultaneous otolaryngology disorder was found in nearly 50% of our sample. A wide range of comorbidities was also reported., Conclusions: Our results confirm an elevated otolaryngology demand in the homeless population and encourage the development of more efficient and effective strategies for a population-tailored diagnosis and treatment of these conditions.

Published
2022
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