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136 results on '"Deng, Yuan"'

2. Rational Design and Precise Synthesis of Single‐Atom Alloy Catalysts for the Selective Hydrogenation of Nitroarenes

Author

Feng, Haisong, primary, Liu, Wei, additional, Wang, Lei, additional, Xu, Enze, additional, Pang, Donghui, additional, Ren, Zhen, additional, Wang, Si, additional, Zhao, Shiquan, additional, Deng, Yuan, additional, Liu, Tianyong, additional, Yang, Yusen, additional, Zhang, Xin, additional, Li, Feng, additional, and Wei, Min, additional

Published
2024
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16. Single‐Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

Author

Ou, Zhihua, primary, Lin, Shitong, additional, Qiu, Jiaying, additional, Ding, Wencheng, additional, Ren, Peidi, additional, Chen, Dongsheng, additional, Wang, Jiaxuan, additional, Tong, Yihan, additional, Wu, Di, additional, Chen, Ao, additional, Deng, Yuan, additional, Cheng, Mengnan, additional, Peng, Ting, additional, Lu, Haorong, additional, Yang, Huanming, additional, Wang, Jian, additional, Jin, Xin, additional, Ma, Ding, additional, Xu, Xun, additional, Wang, Yanzhou, additional, Li, Junhua, additional, and Wu, Peng, additional

Published
2022
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17. Post‐Functionalization of Supramolecular Polymers on Surface and the Chiral Assembly‐Induced Enantioselective Reaction

Author

Ya-Cheng Zhu, Deng Yuan Li, Chen-Hui Shu, Shi-Wen Li, and Pei Nian Liu

Subjects
Biphenyl, chemistry.chemical_classification, Steric effects, 010405 organic chemistry, Enantioselective synthesis, General Chemistry, General Medicine, 010402 general chemistry, 01 natural sciences, Porphyrin, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Supramolecular polymers, chemistry.chemical_compound, chemistry, Heck reaction, Enantiomer, Chirality (chemistry)
Abstract

Although post-functionalization is extensively used to introduce diverse functional groups into supramolecular polymers (SPs) in solution, post-functionalization of SPs on surfaces still remains unexplored. Here we achieved the on-surface post-functionalization of two SPs derived from 5,10,15-tri-(4-pyridyl)-20-bromophenyl porphyrin (Br-TPyP) via cross-coupling reactions on Au(111). The ladder-shaped, Cu-coordinated SPs preformed from Br-TPyP were functionalized through Heck reaction with 4-vinyl-1,1'-biphenyl. In the absence of Cu, Br-TPyP formed chiral SPs as two enantiomers via self-assembly, which were functionalized via divergent cross-coupling reaction with 4-isocyano-1,1'-biphenyl (ICBP). Surprisingly, this reaction was discovered as an enantioselective on-surface reaction induced by the chirality of SPs. Mechanistic analysis and DFT calculations indicated that after debromination of Br-TPyP and the first addition of ICBP, only one attack direction of ICBP to the chiral SP intermediate is permissive in the second addition step due to the steric hindrance, which guaranteed the high enantioselectivity of the reaction.

Published
2021

18. On‐Surface Synthesis of [3]Radialenes via [1+1+1] Cycloaddition

Author

Deng‐Yuan Li, Ying Wang, Xiao‐Yu Hou, Yin‐Ti Ren, Li‐Xia Kang, Fu‐Hua Xue, Ya‐Cheng Zhu, Jian‐Wei Liu, Mengxi Liu, Xing‐Qiang Shi, Xiaohui Qiu, and Pei‐Nian Liu

Subjects
General Chemistry, General Medicine, Catalysis
Abstract

[3]Radialenes are the smallest carbocyclic structures with unusual topologies and cross-conjugated π-electronic structures. Here, we report a novel [1+1+1] cycloaddition reaction for the synthesis of aza[3]radialenes on the Ag(111) surface, where the steric hindrance of the chlorine substituents guides the selective and orientational assembling of the isocyanide precursors. By combining scanning tunneling microscopy, non-contact atomic force microscopy, and time-of-flight secondary ion mass spectrometry, we determined the atomic structure of the produced aza[3]radialenes. Furthermore, two reaction pathways including synergistic and stepwise are proposed based on density functional theory calculations, which reveal the role of the chlorine substituents in the activation of the isocyano groups via electrostatic interaction.

Published
2022

19. On‐Surface Synthesis of [3]Radialenes via [1+1+1] Cycloaddition

Author

Li, Deng‐Yuan, primary, Wang, Ying, additional, Hou, Xiao‐Yu, additional, Ren, Yin‐Ti, additional, Kang, Li‐Xia, additional, Xue, Fu‐Hua, additional, Zhu, Ya‐Cheng, additional, Liu, Jian‐Wei, additional, Liu, Mengxi, additional, Shi, Xing‐Qiang, additional, Qiu, Xiaohui, additional, and Liu, Pei‐Nian, additional

Published
2022
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31. Synthesis and Characterization of a New Organic-Inorganic Hybrid Hydrogel by Using SiO2 Nanoparticles as an Initiator

Author

B. Wang, Ying Zhu, Li Ye, Xiwei Qi, Haiwang Wang, Wu Jiajie, Ma Zhiyu, Bian Jiali, Wenge Liu, Xu Hongyu, Deng Yuan, Xin Xu, and Xinfang Wei

Subjects
Chemistry, Surface initiated, Nanoparticle, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Characterization (materials science), Chemical engineering, Polymerization, Sio2 nanoparticles, Organic inorganic, 0210 nano-technology
Published
2018

42. Palladium-Catalyzed Tandem Reaction of Alkyne-Based Aryl Iodides and SalicylN-Tosylhydrazones to Construct the Spiro[benzofuran-3,2′-chromene] Skeleton

Author

Nian Tai Li, Deng Yuan Li, Xue Song Shang, and Pei Nian Liu

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Stereochemistry, Aryl, Migratory insertion, Alkyne, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, chemistry, Cascade reaction, Benzofuran, Carbene, Palladium
Abstract

A convenient palladium-catalyzed tandem reaction of aryl iodides and salicyl N-tosylhydrazones has been achieved to afford a series of compounds containing the novel spiro[benzofuran-3,2′-chromene] scaffold in moderate to good yields. This efficient catalytic reaction, which tolerates various functional groups, combines alkyne-based 5-exo-dig cyclization, palladium(II) carbene migratory insertion and intramolecular cyclization, generating three new bonds in one reaction.

Published
2016

43. Chronic endothelin-1 infusion causes adipocyte hyperplasia in rats

Author

Deng Yuan Jian, Ching Fai Kwok, Chih Chan Lien, Chi Chang Juan, Jia Ling Jiang, and Low-Tone Ho

Subjects
0301 basic medicine, medicine.medical_specialty, Nutrition and Dietetics, Chemistry, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Adipose tissue, 030209 endocrinology & metabolism, White adipose tissue, Hyperplasia, medicine.disease, Endothelin 1, Fat pad, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Adipogenesis, Internal medicine, Adipocyte, medicine, Receptor
Abstract

Objective The aim of this study was to investigate the regulatory mechanism of endothelin-1 (ET-1), an endothelium-derived vasoconstrictor, on adipogenesis in vitro and in vivo. Methods 3T3-L1 preadipocytes were used to explore the mechanisms mediating ET-1 actions on preadipocyte proliferation and adipocyte differentiation. To investigate the in vivo effect of ET-1, male Sprague-Dawley rats were infused with ET-1 or saline for 4 weeks via intraperitoneally implanted osmotic pumps, and the fat pad weight and adipocyte size of adipose tissues were measured. Results ET-1 stimulated preadipocyte proliferation and increased the cell number at the mitotic clonal expansion stage of adipocyte differentiation via the endothelin A receptor (ETAR) and activation of the protein kinase C (PKC) pathway. ET-1, via ETAR, inhibited adipocyte differentiation partially through an ERK-dependent pathway. Furthermore, no significant difference in the body weight and fat pad weight was observed in either ET-1- or saline-infused rats. Compared with saline-infused rats, the adipocyte cell number was significantly increased but the adipocyte size was significantly decreased in ET-1-infused rats. Conclusions Chronic ET-1 infusion increased the number of small adipocytes without the change of white adipose tissue mass in rats, which were associated with ET-1-stimulated preadipocyte proliferation, but not ET-1-suppressed adipocyte differentiation.

Published
2016

44. Tunable Cascade Reactions of Alkynols with Alkynes under Combined Sc(OTf)3 and Rhodium Catalysis

Author

Hao Jie Chen, Deng Yuan Li, and Pei Nian Liu

Subjects
chemistry.chemical_classification, Reaction conditions, 010405 organic chemistry, Stereochemistry, Alkyne, chemistry.chemical_element, Homogeneous catalysis, General Medicine, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Rhodium, chemistry, Cascade reaction, Cascade, Bond cleavage
Abstract

Two tunable cascade reactions of alkynols and alkynes have been developed by combining Sc(OTf)3 and rhodium catalysis. In the absence of H2O, an endo-cycloisomerization/C-H activation cascade reaction provided 2,3-dihydronaphtho[1,2-b]furans in good to high yields. In the presence of H2O, the product of alkynol hydration underwent an addition/C-H activation cascade reaction with an alkyne, which led to the formation of 4,5-dihydro-3H-spiro[furan-2,1'-isochromene] derivatives in good yields under mild reaction conditions. Mechanistic studies of the cascade reactions indicated that the rate-determining step involves C-H bond cleavage and that the hydration of the alkynol plays a key role in switching between the two reaction pathways.

Published
2015

49. Cross-Coupling of Aryl-Bromide and Porphyrin-Bromide on an Au(111) Surface

Author

Guowen Kuang, Nian Lin, Deng Yuan Li, Tao Lin, Pei Nian Liu, Qiushi Zhang, and Xue Song Shang

Subjects
Aryl, Organic Chemistry, General Chemistry, Porphyrin, Catalysis, law.invention, Coupling (electronics), chemistry.chemical_compound, chemistry, Computational chemistry, law, Bromide, Polymer chemistry, polycyclic compounds, Organic synthesis, Kinetic Monte Carlo, Scanning tunneling microscope
Abstract

Cross-coupling is of great importance in organic synthesis. Here it is demonstrated that cross-coupling of aryl-bromide and porphyrin-bromide takes place on aA u(111 )s urface in vacuo. The products are oligomers consisting of porphyrin moieties linked by p-phenylene at porphyrin's meso-positions. The ratio of the cross-coupled versus homocoupled bonds can be regulated by the reac- tant concentrations. Kinetic Monte Carlo simulations were applied to determine the activatio nb arrier .I ti se xpected that this reaction can be employed in other aryl-bromide precursors for designing alternating co-polymers incorpo- rating porphyrin and other functional moieties.

Published
2015

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