184 results on '"Dorronsoro A"'
Search Results
2. Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
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Palomar‐Cros, Anna, primary, Straif, Kurt, additional, Romaguera, Dora, additional, Aragonés, Nuria, additional, Castaño‐Vinyals, Gemma, additional, Martin, Vicente, additional, Moreno, Victor, additional, Gómez‐Acebo, Inés, additional, Guevara, Marcela, additional, Aizpurua, Amaia, additional, Molina‐Barceló, Ana, additional, Jiménez‐Moleón, José‐Juan, additional, Tardón, Adonina, additional, Contreras‐Llanes, Manuel, additional, Marcos‐Gragera, Rafael, additional, Huerta, José Mª, additional, Pérez‐Gómez, Beatriz, additional, Espinosa, Ana, additional, Hernández‐Segura, Natalia, additional, Obón‐Santacana, Mireia, additional, Alonso‐Molero, Jessica, additional, Burgui, Rosana, additional, Amiano, Pilar, additional, Pinto‐Carbó, Marina, additional, Olmedo‐Requena, Rocio, additional, Fernández‐Tardón, Guillermo, additional, Santos‐Sánchez, Vanessa, additional, Fernández de Larrea‐Baz, Nerea, additional, Fernández‐Villa, Tania, additional, Casabonne, Delphine, additional, Dierssen‐Sotos, Trinidad, additional, Ardanaz, Eva, additional, Dorronsoro, Ane, additional, Pollán, Marina, additional, Kogevinas, Manolis, additional, and Lassale, Camille, additional
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- 2023
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3. Building a European Partnership for next generation, systems‐based Environmental Risk Assessment (PERA)
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Sousa, José Paulo, primary, Aldrich, Annette, additional, Axelman, Johan, additional, Backhaus, Thomas, additional, Brendel, Stephan, additional, Dorronsoro, Begoña, additional, Duquesne, Sabine, additional, Focks, Andreas, additional, Holz, Sheila, additional, Knillmann, Saskia, additional, Pieper, Silvia, additional, Schmied‐Tobies, Maria, additional, Silva, Emília, additional, Topping, Chris, additional, Wipfler, Louise, additional, and Williams, James, additional
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- 2022
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4. The occurrence of non‐anatomical therapeutic chemical‐international nonproprietary name molecules in suspected illegal or illegally traded health products in Europe: A retrospective and prospective study
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M Mendoza Barrios, Magdalena Poplawska, Eric Deconinck, Per Vidar Syversen, Roman Leist, Karl-Henrik Jönsson, Andreas Hackl, I Dorronsoro Diaz, Marina Zemser, Nico Beerbaum, Albena Mihailova, Alla Kozokin, Peter Keizers, Marie Bertrand, Maria Afxentiou, Oliver el-Atma, Celine Vanhee, Agata Blazewicz, Graziella Li-Ship, Josephine Loasby Al-Sayed, Lone Stengelshøj Olsen, Pauline Guinot, Steven Young, and Maria-Jao Portela
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Market surveillance ,International Nonproprietary Name ,Pharmaceutical Science ,Prospective data ,Context (language use) ,Performance-Enhancing Substances ,01 natural sciences ,Analytical Chemistry ,03 medical and health sciences ,0302 clinical medicine ,Anatomical therapeutic chemical ,Terminology as Topic ,Environmental health ,Health care ,Humans ,Environmental Chemistry ,Medicine ,Prospective Studies ,030216 legal & forensic medicine ,Prospective cohort study ,GEON/OMCL network ,Spectroscopy ,Retrospective Studies ,Illicit Drugs ,business.industry ,010401 analytical chemistry ,Commerce ,illegal medicinal products ,non-ATC-INN drugs ,0104 chemical sciences ,Europe ,Physical performance ,Drug and Narcotic Control ,business - Abstract
The General European Official Medicines Control Laboratory (OMCL) Network (GEON), co-ordinated by the European Directorate for the Quality of Medicines & HealthCare (EDQM), regularly organises market surveillance studies on specific categories of suspected illegal or illegally traded products. These studies are generally based on a combination of retrospective and prospective data collection over a defined period of time. This paper reports the results of the most recent study in this context with the focus on health products containing non-Anatomical Therapeutic Chemical-International Nonproprietary Name (ATC-INN) molecules. In total 1104 cases were reported by 16 countries for the period between January 2017 and the end of September 2019. The vast majority of these samples (83%) were collected from the illegal market, while only 3% originated from a legal source. For the rest of the samples, categorisation was not possible. Moreover, 69% of all the reported samples were presented as medicines, including sexual performance enhancers, sports performance enhancers, physical performance enhancers and cognitive enhancers or nootropic molecules that act on the central nervous system (CNS). Although the popularity of anabolics, PDE-5 inhibitors and CNS drugs in illegal products has already been reported, the study showed some new trends and challenges. Indeed, 11% of the samples contained molecules of biological origin, that is, research peptides, representing the second most reported category in this study. Furthermore, the study also clearly shows the increasing popularity of Selective Androgen Receptor Modulators and nootropics, two categories that need attention and should be further monitored.
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- 2021
5. Evolutionary Algorithms for Mobile Ad Hoc Networks
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Bernabé Dorronsoro, Patricia Ruiz, Grégoire Danoy, Yoann Pigné, Pascal Bouvry and Bernabé Dorronsoro, Patricia Ruiz, Grégoire Danoy, Yoann Pigné, Pascal Bouvry
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- 2014
6. Computational Intelligence in Wireless Sensor and Ad Hoc Networks
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Sergio Toral, Ciprian Dobre, Bernabé Dorronsoro, Mesut Günes, and Daniel G. Reina
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Electronic computers. Computer science ,QA75.5-76.95 - Published
- 2016
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7. A Survey on the Application of Evolutionary Algorithms for Mobile Multihop Ad Hoc Network Optimization Problems
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D. G. Reina, P. Ruiz, R. Ciobanu, S. L. Toral, B. Dorronsoro, and C. Dobre
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Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Evolutionary algorithms are metaheuristic algorithms that provide quasioptimal solutions in a reasonable time. They have been applied to many optimization problems in a high number of scientific areas. In this survey paper, we focus on the application of evolutionary algorithms to solve optimization problems related to a type of complex network like mobile multihop ad hoc networks. Since its origin, mobile multihop ad hoc network has evolved causing new types of multihop networks to appear such as vehicular ad hoc networks and delay tolerant networks, leading to the solution of new issues and optimization problems. In this survey, we review the main work presented for each type of mobile multihop ad hoc network and we also present some innovative ideas and open challenges to guide further research in this topic.
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- 2016
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8. Kosaki overgrowth syndrome due to a novel de novo PDGFRB variant
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Hernández Dorronsoro, Unai, primary, Gawlinski, Pawel, additional, Lasa‐Aranzasti, Amaia, additional, Martínez‐Soroa, Itziar, additional, Artola Aizalde, Elena, additional, Saez Villaverde, Raquel, additional, Aguirre Rodríguez, Cristina, additional, and Satrustegi Aritziturri, Miren, additional
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- 2021
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9. Author response for 'Kosaki overgrowth syndrome due to a novel de novo PDGFRB variant'
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Miren Satrustegi Aritziturri, Itziar Martínez-Soroa, Amaia Lasa-Aranzasti, Elena Artola Aizalde, Unai Hernández Dorronsoro, Raquel Saez Villaverde, Cristina Aguirre Rodríguez, and Pawel Gawlinski
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business.industry ,KOSAKI OVERGROWTH SYNDROME ,Cancer research ,Medicine ,PDGFRB ,business - Published
- 2021
10. Phenolics and carotenoids recovery from agroindustrial mango waste using microwave‐assisted extraction: Extraction and modeling
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José Luis Pasquel-Reátegui, Hugo A. Martinez-Correa, Eliana Marcela Vélez-Erazo, and Oscar Humberto Dorronsoro-Guerrero
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chemistry.chemical_classification ,Chromatography ,chemistry ,General Chemical Engineering ,Extraction (chemistry) ,Carotenoid ,Microwave assisted ,Food Science - Published
- 2021
11. Kosaki overgrowth syndrome due to a novel de novo <scp> PDGFRB </scp> variant
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Cristina Aguirre Rodríguez, Elena Artola Aizalde, Amaia Lasa-Aranzasti, Itziar Martínez-Soroa, Miren Satrustegi Aritziturri, Raquel Saez Villaverde, Pawel Gawlinski, and Unai Hernández Dorronsoro
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KOSAKI OVERGROWTH SYNDROME ,Genetics ,Cancer research ,PDGFRB ,Biology ,Genetics (clinical) - Published
- 2021
12. Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging
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Marta Garcia-Contreras, Antonio L. Amelio, Paul D. Robbins, Akaitz Dorronsoro, Ruenn Chai Lai, Adrian Reich, Lana Corbo, Donna B. Stolz, Camillo Ricordi, Donald G. Phinney, Laura J. Niedernhofer, Tianpeng Zhang, Siddaraju V. Boregowda, Sai Kiang Lim, Robert W. Brooks, Mohammad Fallahi, Johnny Huard, Sara J. McGowan, Luise Angelini, Aiping Lu, Diego Grassi, Fernando E. Santiago, and Mitra Lavasani
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0301 basic medicine ,Senescence ,Aging ,senescence ,Human Embryonic Stem Cells ,Longevity ,Biology ,Extracellular vesicles ,Extracellular Vesicles ,Mice ,03 medical and health sciences ,0302 clinical medicine ,stem cells ,Senotherapeutics ,In vivo ,Animals ,Humans ,Cellular Senescence ,Mice, Knockout ,Original Paper ,mesenchymal stem cells ,Mesenchymal stem cell ,Cell Biology ,Fibroblasts ,Endonucleases ,Original Papers ,Embryonic stem cell ,Cell biology ,DNA-Binding Proteins ,Mice, Inbred C57BL ,030104 developmental biology ,Culture Media, Conditioned ,Models, Animal ,Stem cell ,030217 neurology & neurosurgery ,Function (biology) ,Signal Transduction ,Adult stem cell - Abstract
Aging drives progressive loss of the ability of tissues to recover from stress, partly through loss of somatic stem cell function and increased senescent burden. We demonstrate that bone marrow‐derived mesenchymal stem cells (BM‐MSCs) rapidly senescence and become dysfunctional in culture. Injection of BM‐MSCs from young mice prolonged life span and health span, and conditioned media (CM) from young BM‐MSCs rescued the function of aged stem cells and senescent fibroblasts. Extracellular vesicles (EVs) from young BM‐MSC CM extended life span of Ercc1 −/− mice similarly to injection of young BM‐MSCs. Finally, treatment with EVs from MSCs generated from human ES cells reduced senescence in culture and in vivo, and improved health span. Thus, MSC EVs represent an effective and safe approach for conferring the therapeutic effects of adult stem cells, avoiding the risks of tumor development and donor cell rejection. These results demonstrate that MSC‐derived EVs are highly effective senotherapeutics, slowing the progression of aging, and diseases driven by cellular senescence., Extracellular vesicles from young bone marrow‐derived mesenchymal stem cells (MSC) reduce markers of senescence in vitro. EVs derived from MSCs generated from human embryonic stem cells reduced expression of senescence markers in culture and in vivo in accelerated and naturally aged mice and improved measures of healthspan. This work demonstrates the senotherapeutic potential of extracellular vesicles in suppressing senescence‐driven age related disease.
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- 2021
13. Phenolics and carotenoids recovery from agroindustrial mango waste using microwave‐assisted extraction: Extraction and modeling
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Vélez‐Erazo, Eliana Marcela, primary, Pasquel‐Reátegui, José Luis, additional, Dorronsoro‐Guerrero, Oscar Humberto, additional, and Martínez‐Correa, Hugo Alexander, additional
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- 2021
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14. Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging
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Dorronsoro, Akaitz, primary, Santiago, Fernando E., additional, Grassi, Diego, additional, Zhang, Tianpeng, additional, Lai, Ruenn Chai, additional, McGowan, Sara J., additional, Angelini, Luise, additional, Lavasani, Mitra, additional, Corbo, Lana, additional, Lu, Aiping, additional, Brooks, Robert W., additional, Garcia‐Contreras, Marta, additional, Stolz, Donna B., additional, Amelio, Antonio, additional, Boregowda, Siddaraju V., additional, Fallahi, Mohammad, additional, Reich, Adrian, additional, Ricordi, Camillo, additional, Phinney, Donald G., additional, Huard, Johnny, additional, Lim, Sai Kiang, additional, Niedernhofer, Laura J., additional, and Robbins, Paul D., additional
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- 2021
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15. The occurrence of non‐anatomical therapeutic chemical‐international nonproprietary name molecules in suspected illegal or illegally traded health products in Europe: A retrospective and prospective study
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Deconinck, Eric, primary, Vanhee, Celine, additional, Keizers, Peter, additional, Guinot, Pauline, additional, Mihailova, Albena, additional, Syversen, Per Vidar, additional, Li‐Ship, Graziella, additional, Young, Steven, additional, Blazewicz, Agata, additional, Poplawska, Magdalena, additional, Al‐Sayed, Josephine Loasby, additional, Stengelshøj Olsen, Lone, additional, el‐Atma, Oliver, additional, Leist, Roman, additional, Jönsson, Karl‐Henrik, additional, Afxentiou, Maria, additional, Barrios, M. Mendoza, additional, Diaz, I. Dorronsoro, additional, Zemser, Marina, additional, Kozokin, Alla, additional, Hackl, Andreas, additional, Portela, Maria‐Jao, additional, Beerbaum, Nico, additional, and Bertrand, Marie, additional
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- 2021
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16. Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study
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Androniki Naska, Kim Overvad, Kuanrong Li, Eric J. Duell, Domenico Palli, Giovanna Tagliabue, Christina Bamia, Ingegerd Johansson, Petra H.M. Peeters, Nicholas J. Wareham, Anne Tjønneland, Paul Brennan, Bas Bueno-de-Mesquita, Kathryn E. Bradbury, Antonia Trichopoulou, Miguel Rodríguez-Barranco, Guri Skeie, Marie-Christine Boutron-Ruault, Salvatore Panico, Franco Berrino, Rosario Tumino, Verena Katzke, Marc J. Gunter, Sabine Naudin, Elisabete Weiderpass Vainio, Pietro Ferrari, Inger T. Gram, Anne Laure Védié, Elio Riboli, Aurelio Barricarte, Miren Dorronsoro, Nada Assi, Tristan Jaouen, José Ramón Quirós, Rudolf Kaaks, Heiner Boeing, Maria Dolores Chirlaque, Malin Sund, Hanna Sternby, Carlotta Sacerdote, Vinciane Rebours, and Cecilie Kyrø
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0301 basic medicine ,Cancer Research ,business.industry ,Hazard ratio ,Alcohol ,medicine.disease ,Confidence interval ,European Prospective Investigation into Cancer and Nutrition ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Pancreatic cancer ,Medicine ,Smoking status ,business ,Prospective cohort study ,Wine intake ,Demography - Abstract
Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake.
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- 2018
17. Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study
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Kim Overvad, Paolo Vineis, Ruth C. Travis, Renée T. Fortner, Raul Zamora-Ros, Miren Dorronsoro, Petra H.M. Peeters, Eva Ardanaz, Marie-Christine Boutron-Ruault, Julie A. Schmidt, María José Sánchez, Rosario Tumino, Anja Olsen, Isabelle Romieu, Silvia Franceschi, Carine Biessy, Fabrice Bonnet, Krasimira Aleksandrova, Konstantinos K. Tsilidis, Anne Tjønneland, Laure Dossus, Claudia Agnoli, Sabina Rinaldi, Antonia Trichopoulou, Carlo La Vecchia, Salvatore Panico, Maria Sandström, Agnès Fournier, Guri Skeie, Domenico Palli, Kay-Tee Khaw, Elisabete Weiderpass, Elio Riboli, Rudolf Kaaks, Lena Maria Nilsson, Anne-Sophie Navionis, H B As Bueno-de-Mesquita, Augustin Scalbert, Dagfinn Aune, Eleni Peppa, Maria-Dolores Chirlaque, and José Ramón Quirós
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0301 basic medicine ,Oncology ,endocrine system ,Cancer Research ,medicine.medical_specialty ,endocrine system diseases ,business.industry ,Thyroid disease ,Case-control study ,Cancer ,Adipokine ,medicine.disease ,Thyroid carcinoma ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Breast cancer ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Prospective cohort study ,business ,Thyroid cancer - Abstract
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwi ...
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- 2017
18. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
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Rosario Tumino, Jody van den Ouweland, Kathryn E. Bradbury, Petra H.M. Peeters, Martin Almquist, Fränzel J.B. Van Duijnhoven, Anja Olsen, Giuseppe Matullo, Miren Dorronsoro, Heinz Freisling, Mazda Jenab, Weimin Ye, Eivind Ness-Jensen, Elio Riboli, Maria Dolores Chirlaque, Jonas Manjer, Marina Kvaskoff, Veronika Fedirko, Verena Katzke, H. Bas Bueno-de-Mesquita, Dagfinn Aune, Marie-Christine Boutron-Ruault, Claudia Agnoli, Mireia Obón-Santacana, Frida Renström, Elisabete Weiderpass, Claire Cadeau, Teresa Norat, Cristina Lasheras, Kay-Tee Khaw, Maria Kritikou, Salvatore Panico, Henk J. van Kranen, Karina Standahl Olsen, Nicholas J. Wareham, Anouk Halfweeg, Arnulf Langhammer, María José Sánchez, Heiner Boeing, Kim Overvad, Anne Tjønneland, Domenico Palli, Antonia Trichopoulou, Ellen Kampman, Neil Murphy, Magritt Brustad, Aurelio Barricarte, Kristian Hveem, Eric J. Duell, Peter D. Siersema, Anastasia Kotanidou, and Tilman Kühn
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,25-Hydroxyvitamin D 2 ,Vitamin D and neurology ,Prospective cohort study ,2. Zero hunger ,business.industry ,Case-control study ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,030104 developmental biology ,Endocrinology ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Nested case-control study ,Calcifediol ,business ,Body mass index - Abstract
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trondelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
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- 2017
19. Toxicity Assessment of Sediments with Natural Anomalous Concentrations in Heavy Metals by the Use of Bioassay
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Francisco Martín, Marlon Escoto, Juan Fernández, Emilia Fernández, Elena Arco, Manuel Sierra, and Carlos Dorronsoro
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Chemical engineering ,TP155-156 - Abstract
The potential toxicity in riverbed sediments was assessed with a bioassay using the bioluminescent bacteria Vibrio fischeri. The selected area was characterized by the presence of ultramafic rocks (peridotites), and the sediments had high values in Ni, Cr, and Co. For the toxicity bioassay with Vibrio fischeri, water-soluble forms were used. The results indicated that most of the samples had a very low degree of toxicity, with 10% of reduction in luminescence in relation to the control; meanwhile 25% of the samples had a moderate degree of toxicity with a reduction in luminescence between 13 and 21% in relation to the control. The toxicity index correlated significantly with the concentrations of Ni and Cr in the water extracts. This toxicity bioassay was proved to be a sensitive and useful tool to detect potential toxicity in solutions, even with anomalous concentrations in heavy metals of natural origin.
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- 2010
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20. Hepcidin levels and gastric cancer risk in the EPIC-EurGast study
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Núria Aranda, Bodil Ohlsson, Francesca Fasanelli, Heiner Boeing, Antonio Agudo, Ana Fonseca-Nunes, Fulvio Ricceri, Rosario Tumino, Domenico Palli, Aurora Perez-Cornago, Mazda Jenab, Petra H.M. Peeters, Elisabete Weiderpass, Emilio Sánchez-Cantalejo, José María Huerta, Leila Lujan-Barroso, Rudolf Kaaks, Miren Dorronsoro, H. Bas Bueno-de-Mesquita, Monica Tous, Tilman Kühn, Anja Olsen, Kim Overvad, Kay-Tee Khaw, José Maria Quirós, Klas Sjöberg, Amanda J. Cross, Marc J. Gunter, Antonia Trichopoulou, Vittorio Krogh, Anne Tjønneland, Aurelio Barricarte, Effie Vasilopoulou, Eleni Peppa, Amalia Mattiello, Victoria Arija, and Paula Jakszyn
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Hepcidin ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Stomach cancer ,biology ,business.industry ,Stomach ,Confounding ,nutritional and metabolic diseases ,Cancer ,Odds ratio ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Ferritin ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,biology.protein ,business - Abstract
Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l = 0.96, 95% CI = 0.93–0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: −69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.
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- 2017
21. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
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Nicholas J. Wareham, Giovanna Tagliabue, Paul Brennan, Salvatore Panico, Miguel Rodríguez-Barranco, Giuseppe Matullo, Alessio Naccarati, Stuart Sherman, Line Moi, Paolo Vineis, María Dolores Chirlaque, Marc J. Gunter, Pagona Lagiou, Rudolf Kaaks, Antonia Trichopoulou, David C. Muller, Verena Katzke, Gianluca Severi, Eva Ardanaz, Ghislaine Scelo, Vinciane Rebours, Murray Korc, H. Bas Bueno-de-Mesquita, Lill-Tove Busund, Elisabete Weiderpass, Samantha Deitz McElyea, Eric J. Duell, Rosario Tumino, Petra H.M. Peeters, Greg Cote, Marie-Christine Boutron-Ruault, Anne Tjønneland, José Ramón Quirós, Anastasia Kotanidou, Núria Sala, Dagfinn Aune, Anja Olsen, Ruth C. Travis, Kim Overvad, Domenico Palli, Leila Lujan-Barroso, Kay-Tee Khaw, Miren Dorronsoro, and Heiner Boeing
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Receiver operating characteristic ,business.industry ,Case-control study ,Cancer ,medicine.disease ,Logistic regression ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Pancreatic cancer ,Internal medicine ,Cohort ,medicine ,business ,Prospective cohort study ,Cohort study - Abstract
Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, -155 and -212) based on previous evidence from our group was evaluated in 225 microscopically confirmed PDAC cases and 225 controls matched on center, sex, fasting status and age/date/time of blood collection. MiR levels in prediagnostic plasma samples were determined by quantitative RT-PCR. Logistic regression was used to model levels and PDAC risk, adjusting for covariates and to estimate area under the receiver operating characteristic curves (AUC). Plasma miR-10b, -21-5p, -30c and -106b levels were significantly higher in cases diagnosed within 2 years of blood collection compared to matched controls (all p-values
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- 2017
22. Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts
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Johan Nilsson Sommar, Anne Tjønneland, Petra H.M. Peeters, Paolo Vineis, Nancy L. Pedersen, Ingeborg M. Kooter, Marloes Eeftens, Carlotta Sacerdote, Alessandro Marcon, Marie Pedersen, Claudia Galassi, Massimo Stafoggia, Andrea Jaensch, Enrica Migliore, Kirsten Thorup Eriksen, Andrei Pyko, Rob Beelen, Laura Fratiglioni, Ranjeet S. Sokhi, Bertil Forsberg, Gerard Hoek, Ming-Yi Tsai, Fulvio Ricceri, Miren Dorronsoro, Gunn Marit Aasvang, H. Bas Bueno-de-Mesquita, Meng Wang, Bernhard Föger, Zorana Jovanovic Andersen, Ulf de Faire, Kees de Hoogh, Gudrun Weinmayr, Sara Grioni, Mette Sørensen, Claes-Göran Östenson, Roel Vermeulen, Pilar Amiano, Ibon Tamayo, Michelle Plusquin, Norun Hjertager Krog, Göran Pershagen, Timothy J. Key, David Olsson, Gabriele Nagel, Bert Brunekreef, Ole Raaschou-Nielsen, Michal Korek, Vittorio Krogh, and Bente Oftedal
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Pollutant ,Cancer Research ,business.industry ,Air pollution ,Cancer ,Environmental exposure ,010501 environmental sciences ,Particulates ,medicine.disease ,medicine.disease_cause ,complex mixtures ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Environmental health ,Parenchyma ,medicine ,business ,Risk assessment ,Kidney cancer ,0105 earth and related environmental sciences - Abstract
Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutant ...
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- 2017
23. Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study
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Dossus, Laure, Franceschi, Silvia, Biessy, Carine, Navionis, Anne-Sophie, Travis, Ruth C, Weiderpass, Elisabete, Scalbert, Augustin, Romieu, Isabelle, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Bonnet, Fabrice, Fournier, Agnès, Fortner, Renee T, Kaaks, Rudolf, Aleksandrova, Krasimira, Trichopoulou, Antonia, La Vecchia, Carlo, Peppa, Eleni, Tumino, Rosario, Panico, Salvatore, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Bueno-de-Mesquita, Bas, Peeters, Petra H, Skeie, Guri, Zamora-Ros, Raul, Chirlaque, María-Dolores, Ardanaz, Eva, Sánchez, Maria-Jose, Quirós, Jose Ramón, Dorronsoro, Miren, Sandström, Maria, Nilsson, Lena Maria, Schmidt, Julie A, Khaw, Kay-Tee, Tsilidis, Konstantinos K, Aune, Dagfinn, Riboli, Elio, Rinaldi, Sabina, Institut National du Cancer, Dossus, Laure, Franceschi, Silvia, Biessy, Carine, Navionis, Anne-Sophie, Travis, Ruth C., Weiderpass, Elisabete, Scalbert, Augustin, Romieu, Isabelle, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Bonnet, Fabrice, Fournier, Agnè, Fortner, Renee T., Kaaks, Rudolf, Aleksandrova, Krasimira, Trichopoulou, Antonia, La Vecchia, Carlo, Peppa, Eleni, Tumino, Rosario, Panico, Salvatore, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Bueno-de-Mesquita, H. Ba, Peeters, Petra H., Skeie, Guri, Zamora-Ros, Raul, Chirlaque, María-Dolore, Ardanaz, Eva, Sánchez, Maria-Jose, Ramón Quirós, Jose, Dorronsoro, Miren, Sandström, Maria, Nilsson, Lena Maria, Schmidt, Julie A., Khaw, Kay-Tee, Tsilidis, Konstantinos K., Aune, Dagfinn, Riboli, Elio, and Rinaldi, Sabina
- Subjects
Adult ,Male ,Cancer Research ,GENE POLYMORPHISM ,BIOMARKERS ,prospective cohort ,Body Mass Index ,POOLED ANALYSIS ,Adipokines ,Risk Factors ,Journal Article ,Biomarkers, Tumor ,Càncer de tiroide ,thyroid cancer ,cytokine ,Humans ,BREAST-CANCER ,Prospective Studies ,Thyroid Neoplasms ,Oncology & Carcinogenesis ,Obesity ,Aged ,ENDOMETRIAL CANCER-RISK ,Science & Technology ,adipokine ,Interleukin-6 ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 ,Incidence ,Public Health, Global Health, Social Medicine and Epidemiology ,Middle Aged ,INTERLEUKIN-10 ,C-REACTIVE PROTEIN ,VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,ADIPOSE-TISSUE ,Oncology ,inflammation ,Case-Control Studies ,Thyroid gland cancer ,PLASMA ADIPONECTIN CONCENTRATIONS ,Obesitat ,Female ,CIRCULATING ADIPONECTIN ,Adiponectin ,Life Sciences & Biomedicine ,1112 Oncology And Carcinogenesis - Abstract
Source at https://doi.org/10.1002/ijc.31172. Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C‐reactive protein, interleukin (IL)‐6, IL‐10 and tumor necrosis factor (TNF)‐α and the risk of TC. A case‐control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer‐free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49–0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67–2.76, Ptrend = 0.37). Increasing levels of IL‐10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13–2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80–3.98, Ptrend = 0.17). Leptin, CRP, IL‐6 and TNF‐α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL‐10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
- Published
- 2017
24. Progressive osseous heteroplasia caused by a mosaic GNAS mutation
- Author
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Arrate Pereda, Jose Maria Martos-Tello, Guiomar Perez de Nanclares, Javier Errea-Dorronsoro, and Intza Garin
- Subjects
0301 basic medicine ,medicine.medical_specialty ,biology ,Ossification ,Sequence analysis ,business.industry ,Endocrinology, Diabetes and Metabolism ,GTP-Binding Protein alpha Subunits ,RNA ,030105 genetics & heredity ,Progressive osseous heteroplasia ,medicine.disease ,Molecular biology ,03 medical and health sciences ,030104 developmental biology ,Endocrinology ,Internal medicine ,Mutation (genetic algorithm) ,medicine ,GNAS complex locus ,biology.protein ,medicine.symptom ,business - Published
- 2018
25. Multiobjective evolutionary algorithms for energy and service level scheduling in a federation of distributed datacenters
- Author
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Sergio Nesmachnow, Santiago Iturriaga, and Bernabé Dorronsoro
- Subjects
Rate-monotonic scheduling ,020203 distributed computing ,Computer science ,Strategy and Management ,Distributed computing ,Evolutionary algorithm ,02 engineering and technology ,Dynamic priority scheduling ,Management Science and Operations Research ,Energy sector ,Fair-share scheduling ,Computer Science Applications ,Scheduling (computing) ,Management of Technology and Innovation ,Service level ,Two-level scheduling ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Business and International Management - Published
- 2016
26. Gallstones and incident colorectal cancer in a large pan‐European cohort study
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Ward, Heather A, primary, Murphy, Neil, additional, Weiderpass, Elisabete, additional, Leitzmann, Michael F, additional, Aglago, Elom, additional, Gunter, Marc J, additional, Freisling, Heinz, additional, Jenab, Mazda, additional, Boutron‐Ruault, Marie‐Christine, additional, Severi, Gianluca, additional, Carbonnel, Franck, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Merino, Susana, additional, Zamora‐Ros, Raul, additional, Rodríguez‐Barranco, Miguel, additional, Dorronsoro, Miren, additional, Chirlaque, Maria‐Dolores, additional, Barricarte, Aurelio, additional, Perez‐Cornago, Aurora, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Masala, Giovanna, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Bueno‐de‐Mesquita, Bas, additional, Vermeulen, Roel, additional, Van Gils, Carla, additional, Nyström, Hanna, additional, Rutegård, Martin, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, and Cross, Amanda J, additional
- Published
- 2019
- Full Text
- View/download PDF
27. Quantitative assessment of left ventricular size and function in cardiac transplant recipients: Side‐by‐side comparison of real time two‐dimensional echocardiography, contrast‐enhanced two‐dimensional echocardiography, three‐dimensional echocardiography, and contrast‐enhanced three‐dimensional echocardiography as compared to magnetic resonance imaging
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Rodriguez‐Mañero, Moises, primary, Azcárate‐Agüero, Pedro, additional, Kreidieh, Bahij, additional, Alvez, María Teresa, additional, Martínez‐Monzonís, Amparo, additional, Diaz‐Dorronsoro, Agnes, additional, Cid‐Menéndez, Adrian, additional, González‐Juanatey, José Ramón, additional, Barba‐Cosials, Joaquin, additional, Rábago, Gregorio, additional, and Bastarrika, Gorka, additional
- Published
- 2019
- Full Text
- View/download PDF
28. Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition
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Park, Jin Young, primary, Bueno‐de‐Mesquita, H. Bas, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Batlle, Jordi, additional, Tjønneland, Anne, additional, Kyro, Cecilie, additional, Rebours, Vinciane, additional, Boutron‐Ruault, Marie‐Christine, additional, Mancini, Francesca Romana, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, La Vecchia, Carlo, additional, Kritikou, Maria, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Peeters, Petra H., additional, Skeie, Guri, additional, Merino, Susana, additional, Duell, Eric J., additional, Rodríguez‐Barranco, Miguel, additional, Dorronsoro, Miren, additional, Chirlaque, Maria‐Dolores, additional, Ardanaz, Eva, additional, Gylling, Björn, additional, Schneede, Jörn, additional, Ericson, Ulrika, additional, Sternby, Hanna, additional, Khaw, Kay‐Tee, additional, Bradbury, Kathryn E., additional, Huybrechts, Inge, additional, Aune, Dagfinn, additional, Vineis, Paolo, additional, and Slimani, Nadia, additional
- Published
- 2018
- Full Text
- View/download PDF
29. Fetal limb soft tissue assessment for prediction of birth weight and umbilical cord blood analytes in gestational diabetes
- Author
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Ainhoa Garicano, Ines Tamarit, Ricardo Sainz de la Cuesta, Marina Cañamares, Jose Garcia-Flores, Izaskun Dorronsoro, O. Nieto, Mireia Cruceyra, and Ana Lopez
- Subjects
medicine.medical_specialty ,Pregnancy ,Cord ,business.industry ,Obstetrics ,Leptin ,Birth weight ,Obstetrics and Gynecology ,medicine.disease ,Umbilical cord ,Surgery ,Gestational diabetes ,medicine.anatomical_structure ,Erythropoietin ,Diabetes mellitus ,medicine ,business ,Genetics (clinical) ,medicine.drug - Abstract
Objective To evaluate the value of third trimester ultrasound (estimated fetal weight, cheek-to-cheek diameter, sectional Wharton's jelly area, sectional areas and fractional volumes in extremities) to predict birth weight and cord biochemical markers at birth (leptin, insulin, c-peptide, IGF1, erythropoietin and ferritin) in diabetic pregnancies. Method Prospective study in 49 patients with gestational diabetes. An ultrasound was performed between 32 and 34 weeks. Clinical data were collected, and a blood sample was obtained from cord after birth. ROC curve models were evaluated for 75th and 90th birth weight percentile. Univariate and multivariate models were used to assess the association between ultrasound and neonatal outcomes. Results Sectional areas and fractional volumes showed significant differences and highest AUC values for predicting birth weight. A significant association was found for extremities measurements with total birth weight and its percentile. The only marker which showed a significant association to estimated fetal weight was erythropoietin. Sectional areas and fractional volumes related to cord leptin, erythropoietin, insulin and c-peptide. Conclusion Sectional areas and fractional volumes improve the predictive value of estimated fetal weight in diabetic pregnancies. They also show a predictive association to biochemical changes in cord (leptin, insulin and erythropoietin) related to increased adiposity and risk of fetal hypoxia. © 2015 John Wiley & Sons, Ltd.
- Published
- 2015
30. Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study
- Author
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Amanda J. Cross, H. B. Bueno-De-Mesquita, Petra H.M. Peeters, Diana Gavrila, Marc J. Gunter, Krasimira Aleksandrova, Veronika Fedirko, Paolo Vineis, Nicholas J. Wareham, Mårten Werner, Talita Duarte-Salles, Mazda Jenab, Christina Bamia, Salvatore Panico, Tilman Kühn, Rudolf Kaaks, Nadia Bastide, Dinesh Kumar Barupal, María José Sánchez, Antonia Trichopoulou, J. Ramón Quirós, Gianluca Severi, Bodil Ohlsson, Heiner Boeing, Sabina Rinaldi, Augustin Scalbert, Anne Tjønneland, Malin Sund, Pagona Lagiou, Klas Sjöberg, Antonio Agudo, Elisabete Weiderpass, Claudia Agnoli, Aurelio Barricarte, Julie A. Schmidt, Alessio Naccarati, Isabelle Romieu, David Achaintre, Marie-Christine Boutron-Ruault, Rosario Tumino, Magdalena Stepien, Nada Assi, Miren Dorronsoro, Ruth C. Travis, Kim Overvad, Calogero Saieva, Anne Floegel, and Kay-Tee Khaw
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0301 basic medicine ,Hepatitis ,Cancer Research ,medicine.medical_specialty ,business.industry ,Metabolite ,Odds ratio ,medicine.disease ,Gastroenterology ,Glutamine ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Internal medicine ,medicine ,Liver function ,Prospective cohort study ,business ,Kynurenine - Abstract
Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer's ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development.
- Published
- 2015
31. Body iron status and gastric cancer risk in the EURGAST study
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Elisabete Weiderpass, Amalia Mattiello, José Ramón Quirós, Esther Molina, Anne Tjønneland, Calogero Saieva, Tilman Kühn, H. B. Bueno-De-Mesquita, Claire Cadeau, Petra H.M. Peeters, Aurelio Barricarte, Pagona Lagiou, Yunxia Lu, Anja Olsen, Antonio Agudo, Christina Bamia, Alessio Naccarati, Guy Fagherazzi, Elio Riboli, Raul Zamora-Ros, Timothy J. Key, Heinz Freisling, Miren Dorronsoro, Mazda Jenab, Nicholas J. Wareham, Núria Aranda, Annika Steffen, Bodil Ohlsson, Heiner Boeing, María José Sánchez, Antonia Trichopoulou, Victoria Arija, Diana Gavrila, Klas Sjöberg, Vittorio Krogh, Paula Jakszyn, Marie-Christine Boutron-Ruault, Verena Katzke, Ana Fonseca-Nunes, Peter D. Siersema, Kay-Tee Khaw, Rosario Tumino, and Amanda J. Cross
- Subjects
chemistry.chemical_classification ,Cancer Research ,medicine.medical_specialty ,medicine.diagnostic_test ,biology ,business.industry ,Transferrin saturation ,Cancer ,medicine.disease ,Gastroenterology ,European Prospective Investigation into Cancer and Nutrition ,Ferritin ,Oncology ,chemistry ,Transferrin ,Internal medicine ,Nested case-control study ,Serum iron ,biology.protein ,Medicine ,business ,Stomach cancer - Abstract
Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 = 0.80, 95% CI = 0.72-0.88; OR10%increment = 0.87, 95% CI = 0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity = 0.04 and TS had a p for heterogeneity = 0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl = 1.13, 95% CI = 1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity = 0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis.
- Published
- 2015
32. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition
- Author
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Anne Tjønneland, Bethany Van Guelpen, Krasimira Aleksandrova, María José Sánchez, J. Ramón Quirós, Miren Dorronsoro, Eva Ardanaz, Amanda J. Cross, Eiliv Lund, Guri Skeie, Maria Santucci de Magistris, Guy Fagherazzi, Kim Overvad, Nadia Bastide, Maria Wennberg, Pagona Lagiou, Petra H.M. Peeters, Peter D. Siersema, Karin Jirström, Eleni Klinaki, Rosario Tumino, Anja Olsen, Verena Katzke, Nicholas J. Wareham, Elisabete Weiderpass, Max Leenders, Neil Murphy, Timothy J. Key, Giovanna Masala, Tilman Kühn, Kay-Tee Khaw, H. Bas Bueno-de-Mesquita, Antonia Trichopoulou, Antonio Agudo, Isabelle Romieu, Fulvio Ricceri, Inge Huybrechts, Sara Grioni, Elio Riboli, Carmen Navarro, Marie-Christine Boutron-Ruault, Bodil Ohlsson, and Heiner Boeing
- Subjects
Consumption (economics) ,Cancer Research ,Cruciferous vegetables ,Colorectal cancer ,business.industry ,Lower risk ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Oncology ,Environmental health ,Cohort ,medicine ,Food science ,business ,Prospective cohort study ,Biomedical sciences - Abstract
Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of 9 years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and a variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of 13 years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95% CI 0.75-1.01, p for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than 10 years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but appears unlikely.
- Published
- 2015
33. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort
- Author
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Petra H.M. Peeters, Elisabete Weiderpass, H. B. Bueno-De-Mesquita, J. Ramón Quirós, Elissavet Valanou, Anne Sofie D Laursen, Eva Ardanaz, Bodil Ohlsson, Heiner Boeing, Veronika Fedirko, Miren Dorronsoro, Mathilde His, Krasimira Aleksandrova, Isabelle Romieu, Kim Overvad, Heinz Freisling, Ruth C. Travis, Klas Sjöberg, Giovanna Masala, Louise Hansen, Maria Wennberg, Guri Skeie, María Dolores Chirlaque, Nicholas J. Wareham, Antonia Trichopoulou, Mazda Jenab, Magdalena Stepien, Fulvio Ricceri, Ingegerd Johansson, Guy Fagherazzi, Verena Katzke, Sabina Sieri, Anne Tjønneland, Tilman Kühn, Catalina Bonet, Amanda J. Cross, Kay-Tee Khaw, Yunxia Lu, Marie-Christine Boutron-Ruault, Maria Kritikou, Salvatore Panico, Christina Bamia, Pietro Ferrari, Marc J. Gunter, Talita Duarte-Salles, Rosario Tumino, and Pagona Lagiou
- Subjects
Cancer Research ,medicine.medical_specialty ,business.industry ,Hazard ratio ,Case-control study ,medicine.disease ,Gastroenterology ,digestive system diseases ,European Prospective Investigation into Cancer and Nutrition ,Endocrinology ,Oncology ,Internal medicine ,Hepatocellular carcinoma ,Cohort ,medicine ,Liver function ,Prospective cohort study ,business ,Cohort study - Abstract
The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
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- 2015
34. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study
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Christina Bamia, Elisabete Weiderpass, P. H. Peeters, Peter D. Siersema, Ulrika Ericson, Heinz Freisling, Salvatore Panico, José María Huerta, Alessio Naccarati, Laureen Dartois, Guri Skeie, Kay-Tee Khaw, Margareta Johansson, Elio Riboli, Domenico Palli, Antonia Trichopoulou, Timothy J. Key, Bengt Wallner, Sandra Colorado-Yohar, Pamela Ferrari, M. C. Boutron-Ruault, Rudolf Kaaks, H. B. Bueno-de-Mesquita, A. Agudo, Dagrun Engeset, Amanda J. Cross, Noémie Travier, Genevieve Buckland, Isabelle Romieu, María José Sánchez, Anne Tjønneland, Bodil Ohlsson, C. A. Gonzalez, M. Dorronsoro, Kan Li, Heiner Boeing, Rosario Tumino, A. M. May, Eva Ardanaz, Pagona Lagiou, Kim Overvad, Valeria Pala, Guy Fagherazzi, and J. R. Quirós
- Subjects
Gerontology ,Cancer Research ,education.field_of_study ,medicine.medical_specialty ,Mediterranean diet ,business.industry ,Population ,Lower risk ,European Prospective Investigation into Cancer and Nutrition ,Oncology ,Internal medicine ,Attributable risk ,Medicine ,business ,Prospective cohort study ,education ,Body mass index ,Cohort study - Abstract
Several modifiable lifestyle factors, including smoking, alcohol, certain dietary factors and weight are independently associated with gastric cancer (GC); however, their combined impact on GC risk is unknown. We constructed a healthy lifestyle index to investigate the joint influence of these behaviors on GC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The analysis included 461,550 participants (662 first incident GC cases) with a mean follow-up of 11.4 years. A healthy lifestyle index was constructed, assigning 1 point for each healthy behavior related to smoking status, alcohol consumption and diet quality (represented by the Mediterranean diet) for assessing overall GC and also body mass index for cardia GC and 0 points otherwise. Risk of GC was calculated using Cox proportional hazards regression models while adjusting for relevant confounders. The highest versus lowest score in the healthy lifestyle index was associated with a significant lower risk of GC, by 51% overall (HR 0.49 95% CI 0.35, 0.70), by 77% for cardia GC (HR 0.23 95% CI 0.08, 0.68) and by 47% for noncardia GC (HR 0.53 (95% CI 0.32, 0.87), p-trends
- Published
- 2015
35. General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition
- Author
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Pietro Ferrari, Calogero Saieva, Elio Riboli, J. Ramón Quirós, Antonia Trichopoulou, Françoise Clavel-Chapelon, Carlos González, Mattias Johansson, Timothy J. Key, Eva Ardanaz, Kay-Tee Khaw, Christina Bamia, Peter D. Siersema, Heinz Freisling, Emilio Sánchez-Cantalejo, Pagona Lagiou, Anne M. May, Jasmine Neamat-Allah, José María Huerta, Rosario Tumino, Salvatore Panico, Amanda J. Cross, Anne Tjønneland, Bengt Wallner, Guy Fagherazzi, Elisabete Weiderpass, Nicholas J. Wareham, Annika Steffen, Alessio Naccarati, Miren Dorronsoro, H B As Bueno-de-Mesquita, Bodil Ohlsson, Rudolf Kaaks, Jytte Halkjær, Yunxia Lu, Heiner Boeing, Valeria Pala, Kim Overvad, and Antoine Racine
- Subjects
Cancer Research ,medicine.medical_specialty ,Waist ,business.industry ,Gastric Cardia Adenocarcinoma ,medicine.disease ,Gastroenterology ,European Prospective Investigation into Cancer and Nutrition ,Surgery ,Oncology ,Internal medicine ,Medicine ,Adenocarcinoma ,Risk factor ,medicine.symptom ,business ,Prospective cohort study ,Body mass index ,Abdominal obesity - Abstract
General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data from 391,456 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and 11 years of follow-up, we comprehensively assessed the association of anthropometric measures with risk of EAC, GCC and GNCC using multivariable proportional hazards regression. One hundred twenty-four incident EAC, 193 GCC and 224 GNCC were accrued. After mutual adjustment, BMI was unrelated to EAC, while WC showed a strong positive association (highest vs. lowest quintile HR = 1.19; 95% CI, 0.63-2.22 and HR = 3.76; 1.72-8.22, respectively). Hip circumference (HC) was inversely related to EAC after controlling for WC, while WC remained positively associated (HR = 0.35; 0.18-0.68, and HR=4.10; 1.94-8.63, respectively). BMI was not associated with GCC or GNCC. WC was related to higher risks of GCC after adjustment for BMI and more strongly after adjustment for HC (highest vs. lowest quintile HR = 1.91; 1.09-3.37, and HR = 2.23; 1.28-3.90, respectively). Our study demonstrates that abdominal, rather than general, obesity is an indisputable risk factor for EAC and also provides evidence for a protective effect of gluteofemoral (subcutaneous) adipose tissue in EAC. Our study further shows that general obesity is not a risk factor for GCC and GNCC, while the role of abdominal obesity in GCC needs further investigation.
- Published
- 2015
36. Plasma fetuin-A concentration, genetic variation in theAHSGgene and risk of colorectal cancer
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Katharina Nimptsch, Gianluca Severi, Young-Ae Lee, Ruth C. Travis, Antonia Trichopoulou, Konstantinos K. Tsilidis, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Kay-Tee Khaw, Heiner Boeing, Verena Katzke, Dimitrios Trichopoulos, Marie-Christine Boutron-Ruault, Miren Dorronsoro, Juergen Janke, Elisabete Weiderpass, Rosario Tumino, Nicholas J. Wareham, Amalia Mattiello, Hanna Nyström, José Ramón Quirós, Kim Overvad, Pagona Lagiou, Aurelio Barricarte Gurrea, Antoine Racine, María Dolores Chirlaque, Sara Grioni, Anne Tjønneland, Jenny Brändstedt, Tobias Pischon, María José Sánchez, Ingrid Ljuslinder, Heinz Freisling, Mazda Jenab, Eugene Jansen, Elio Riboli, Chunsen Wu, Catalina Bonet, Krasimira Aleksandrova, Petra H.M. Peeters, Anja Olsen, So Yeon Kong, Marc J. Gunter, Rudolf Kaaks, Alessio Naccarati, and Peter D. Siersema
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Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Colorectal cancer ,Case-control study ,Single-nucleotide polymorphism ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Endocrinology ,Internal medicine ,Relative risk ,Mendelian randomization ,Medicine ,Risk factor ,business ,alpha-2-HS-glycoprotein - Abstract
Fetuin-A, also referred to as alpha 2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. Hyperinsulinemia is a possible risk factor for colorectal cancer; however, the role of fetuin-A in the development of colorectal cancer is unclear. We investigated the association between circulating fetuin-A and colorectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Fetuin-A concentrations were measured in prediagnostic plasma samples from 1,367 colorectal cancer cases and 1,367 matched controls. In conditional logistic regression models adjusted for potential confounders, the estimated relative risk (95% confidence interval) of colorectal cancer per 40 mg/mL higher fetuin-A concentrations (approximately one standard deviation) was 1.13 (1.02-1.24) overall, 1.21 (1.05-1.39) in men, 1.06 (0.93-1.22) in women, 1.13 (1.00-1.27) for colon cancer and 1.12 (0.94-1.32) for rectal cancer. To improve causal inference in a Mendelian Randomization approach, five tagging single nucleotide polymorphisms of the AHSG gene were genotyped in a subset of 456 case-control pairs. The AHSG allele-score explained 21% of the interindividual variation in plasma fetuin-A concentrations. In instrumental variable analysis, genetically raised fetuin-A was not associated with colorectal cancer risk (relative risk per 40 mg/mL genetically determined higher fetuin-A was 0.98, 95% confidence interval: 0.73-1.33). The findings of our study indicate a modest linear association between fetuin-A concentrations and risk of colorectal cancer but suggest that fetuin-A may not be causally related to colorectal cancer development.
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- 2015
37. Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition
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Paula Jakszyn, Marie-Christine Boutron-Ruault, Börje Ljungberg, Guri Skeie, Esther Molina-Montes, Steffen Weikert, Mattias Johansson, Kim Overvad, Claudia Agnoli, Tilman Kühn, Nadia Bastide, Rosario Tumino, Ulrika Ericson, Amanda J. Cross, Petra H.M. Peeters, Nicholas J. Wareham, Antonia Trichopoulou, Jakob Linseisen, Anne Tjønneland, Kuanrong Li, Domenico Palli, Emily Sonestedt, Nina Roswall, Elisabete Weiderpass, Anette Hjartåker, H. Bas Bueno-de-Mesquita, Ramón Alonso De La Torre, Kathryn E. Bradbury, Kay-Tee Khaw, Carlotta Sacerdote, Salvatore Panico, Annika Steffen, Dimitrios Trichopoulos, Anne-Claire Vergnaud, Antoine Racine, Isabelle Romieu, Sabine Rohrmann, Heinz Freisling, Elio Riboli, Anne Mette Lund Würtz, Aurelio Barricarte, Eleni Peppa, Heiner Boeing, Miren Dorronsoro, and Carmen Santiuste De Pablos
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Cancer Research ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Surgery ,Oncology ,Renal cell carcinoma ,Internal medicine ,Epidemiology ,Red meat ,Medicine ,business ,Kidney cancer ,Cohort study - Abstract
Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR=1.36, 95% CI 1.14-1.62; calibrated, per 50 g/day) and processed meat (HR=1.78, 95% CI 1.05-3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction=0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear. What's new? Kidney cancer strikes different populations with different frequency, with developed nations seeing more cases. In this paper, the authors investigate whether certain elements of diet might correlate with increased incidence of renal cell carcinoma. Using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assessed the amount of meat and fish consumed in populations representing a wide range of dietary habits. They then correlated this data with renal cell carcinoma incidence. They found no effect from eating fish; consuming red and processed meats did increase risk in women, but not in men.
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- 2014
38. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk
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Nimptsch, K, Aleksandrova, K, Boeing, H, Janke, J, Lee, YA, Jenab, M, Bueno-de-Mesquita, HB, Jansen, EH, Tsilidis, KK, Trichopoulou, A, Weiderpass, E, Wu, C, Overvad, K, Tjønneland, A, Boutron-Ruault, MC, Dossus, L, Racine, A, Kaaks, R, Canzian, F, Lagiou, P, Trichopoulos, D, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Johansson, A, Van Guelpen, B, Khaw, KT, Wareham, N, Peeters, PH, Quirós, JR, Venceslá García, A, Molina-Montes, E, Dorronsoro, M, Chirlaque, MD, Barricarte Gurrea, A, Key, TJ, Duarte-Salles, T, Stepien, M, Gunter, MJ, Riboli, E, Pischon, T, Nimptsch, K, Aleksandrova, K, Boeing, H, Janke, J, Lee, Ya, Jenab, M, Bueno De Mesquita, Bh, Jansen, Eh, Tsilidis, Kk, Trichopoulou, A, Weiderpass, E, Wu, C, Overvad, K, Tj?nneland, A, Boutron Ruault, Mc, Dossus, L, Racine, A, Kaaks, R, Canzian, F, Lagiou, P, Trichopoulos, D, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, Salvatore, Johansson, A, Van Guelpen, B, Khaw, Kt, Wareham, N, Peeters, Ph, Quir?s, Jr, Vencesl? Garc?a, A, Molina Montes, E, Dorronsoro, M, Chirlaque, Md, Barricarte Gurrea, A, Key, Tj, Duarte Salles, T, Stepien, M, Gunter, Mj, Riboli, E, and Pischon, T.
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Adult ,Male ,Genotype ,colorectal cancer ,INFLAMMATORY MARKERS ,Polymorphism, Single Nucleotide ,Article ,C-reactive protein ,Risk Factors ,COLON ,Biomarkers, Tumor ,Journal Article ,Humans ,COHORT ,Comparative Study ,Prospective Studies ,Aged ,CRP genetic variants ,Research Support, Non-U.S. Gov't ,WOMEN ,Middle Aged ,Prognosis ,Cardiovascular and Metabolic Diseases ,Case-Control Studies ,Randomized Controlled Trial ,MENDELIAN RANDOMIZATION ,POPULATIONS ,Female ,NUTRITION ,HEALTH ,Colorectal Neoplasms ,Follow-Up Studies - Abstract
High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested case-control study within EPIC including 727 cases diagnosed between 1992 and 2003 and 727 matched controls selected according to an incidence-density sampling protocol. Baseline CRP concentrations were measured in plasma samples by a high sensitivity assay. Tagging single nucleotide polymorphisms (SNPs) in the CRP gene (rs1205, rs1800947, rs1130864, rs2808630, rs3093077) were identified via HapMap. The causal effect of CRP on colorectal cancer risk was examined in a Mendelian Randomization approach utilizing multiple CRP genetic variants as instrumental variables. The SNPs rs1205, rs1800947, rs1130864 and rs3093077 were significantly associated with CRP concentrations and were incorporated in a CRP allele score which was associated with 13% higher CRP concentrations per allele count (95% confidence interval 8%, 19%). Using the CRP-score as instrumental variable, genetically 2-fold higher CRP concentrations were associated with higher risk of colorectal cancer (odds ratio 1.74, 95% confidence interval 1.06, 2.85). Similar observations were made using alternative definitions of instrumental variables. Our findings give support to the hypothesis that elevated circulating CRP may play a direct role in the etiology of colorectal cancer.
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- 2016
39. Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study
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Miguel Rodríguez-Barranco, Noémie Travier, Eva Ardanaz, Genevieve Buckland, José Ramón Quirós, Carlos A. González, Aurelio Barricarte, Miren Dorronsoro, Rafael de la Torre, Carmen Navarro, Antoni Pastor, María José Sánchez, Maria Dolores Chirlaque, Pilar Amiano, Amaia Molinuevo, Antonio Agudo, José María Huerta, Leila Lujan-Barroso, [Buckland, Genevieve] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain, [Lujan-Barroso, Leila] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain, [Alberto Gonzalez, Carlos] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain, [Travier, Noemie] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain, [Agudo, Antonio] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain, [Pastor, Antoni] Hosp del Mar, IMIM, Neurosci Res Program, Integrat Pharmacol & Syst Neurosci Res Grp,Med Re, Barcelona, Spain, [de la Torre, Rafael] Hosp del Mar, IMIM, Neurosci Res Program, Integrat Pharmacol & Syst Neurosci Res Grp,Med Re, Barcelona, Spain, [Pastor, Antoni] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela, Spain, [de la Torre, Rafael] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela, Spain, [Lujan-Barroso, Leila] Univ Barcelona, Sch Nursing, Dept Nursing Publ Hlth Mental Hlth & Matern & Chi, Barcelona, Spain, [Amiano, Pilar] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Maria Huerta, Jose] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Navarro, Carmen] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Dolores Chirlaque, Maria] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Sanchez, Maria-Jose] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Barricarte, Aurelio] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Ardanaz, Eva] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Dorronsoro, Miren] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Molinuevo, Amaia] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Amiano, Pilar] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain, [Dorronsoro, Miren] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain, [Maria Huerta, Jose] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain, [Navarro, Carmen] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain, [Dolores Chirlaque, Maria] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain, [Navarro, Carmen] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain, [Dolores Chirlaque, Maria] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain, [Sanchez, Maria-Jose] Inst Invest Biosanitaria Ibs, Andaluzian Sch Publ Hlth, Granada, Spain, [Rodriguez-Barranco, Miguel] Inst Invest Biosanitaria Ibs, Andaluzian Sch Publ Hlth, Granada, Spain, [Barricarte, Aurelio] Navarra Publ Hlth Inst, Dept Epidemiol, Pamplona, Spain, [Ardanaz, Eva] Navarra Publ Hlth Inst, Dept Epidemiol, Pamplona, Spain, [Barricarte, Aurelio] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain, [Ardanaz, Eva] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain, [Ramon Quiros, Jose] Publ Hlth & Hlth Planning Directorate, Asturias, Spain, [de la Torre, Rafael] Pompeu Fabra Univ UPF, Dept Expt & Hlth Sci DCEXS, Barcelona, Spain, AGAUR, Generalitat de Catalunya, Health Research Funds, FEDER funds /European Regional Development Fund (ERDF) 'A way to buid Europe', Spanish Regional Government of Andalusia, Spanish Regional Government of Asturias, Spanish Regional Government of Basque Country, Spanish Regional Government of Murcia, Spanish Regional Government of Navarra, Catalan Institute of Oncology (ICO-IDIBELL), and CIBER Epidemiologia y Salud Publica (CIBERESP)
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Adult ,Male ,Risk ,0301 basic medicine ,Population ,Apoptosis ,Oli d'oliva -- Aspectes nutricionals ,Project ,Disposition ,EPIC ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Animal science ,Humans ,EPIC cohort study ,Medicine ,Hydroxytyrosol ,030212 general & internal medicine ,education ,Oleanolic acid ,Aged ,Cancer ,education.field_of_study ,030109 nutrition & dietetics ,business.industry ,Biomarker ,Middle Aged ,Nutrition Surveys ,Triterpenes ,European Prospective Investigation into Cancer and Nutrition ,Biotechnology ,chemistry ,Spain ,Human plasma ,Cohort ,Female ,business ,Olive oil ,Food Science ,Cohort study - Abstract
cope Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population and compare them with estimates of dietary olive oil intake. Methods and results The final study sample included 141 individuals randomly selected from the European Prospective Investigation into Cancer and Nutrition Spanish cohort. Dietary olive oil intake was estimated using validated dietary history questionnaires. OA concentrations were determined in plasma (from the participants’ stored blood samples) using a HPLC-MS method. Correlation coefficients between OA and olive oil intake were calculated, adjusting for center; sex; age; consumption of olives, apples, grapes, and red wine; and fasting state. The mean OA concentration in olive oil nonconsumers was 0.72 ng/mL (SD 0.82), while in the high olive oil intake group it was 1.32 ng/mL (SD 1.14). The fully adjusted partial Spearman correlations coefficients reached 0.36 (p-value < 0.001) overall, varying minimally by sex and fasting state. Conclusion This is the first study providing steady-state concentrations of triterpenes in humans. The results show that there was low-to-moderate correlation between OA concentrations and olive oil intake in this population.
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- 2017
40. Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
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Christine L. Parr, Lambertus A. Kiemeney, Kim Overvad, Göran Hallmans, Martine M. Ros, José Ramón Quirós, Guy Fagherrazzi, Tina Karapetyan, Isabelle Romieu, Ulrika Ericson, Marc J. Gunter, Inger T. Gram, Roy Ehrnström, Paul N. Appleby, Nina Roswall, H. B. Bueno-de-Mesquita, Domenico Palli, Birgit Teucher, Börje Ljungberg, Jenny Chang-Claude, Carlotta Sacerdote, Petra H.M. Peeters, Nicholas J. Wareham, Heiner Boeing, Kay-Tee Khaw, Eva Ardanaz, Elio Riboli, Françoise Clavel-Chapelon, María Dolores Chirlaque, Miren Dorronsoro, Rosario Tumino, Naomi E. Allen, Vardis Dilis, Antonia Trichopoulou, Timothy J. Key, Sabina Sieri, Esther Molina-Montes, Anne Tjønneland, Steffen Weikert, Paula Jakszyn, Marie-Christine Boutron-Ruault, Salvatore Panico, Allen, Ne, Appleby, Pn, Key, Tj, Bueno de Mesquita, Hb, Ros, Mm, Kiemeney, La, Tj?nneland, A, Roswall, N, Overvad, K, Weikert, S, Boeing, H, Chang Claude, J, Teucher, B, Panico, Salvatore, Sacerdote, C, Tumino, R, Palli, D, Sieri, S, Peeters, P, Quir?s, Jr, Jakszyn, P, Molina Montes, E, Chirlaque, Md, Ardanaz, E, Dorronsoro, M, Khaw, Kt, Wareham, N, Ljungberg, B, Hallmans, G, Ehrnstr?m, R, Ericson, U, Gram, It, Parr, Cl, Trichopoulou, A, Karapetyan, T, Dilis, V, Clavel Chapelon, F, Boutron Ruault, Mc, Fagherrazzi, G, Romieu, I, Gunter, Mj, and Riboli, E.
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Adult ,Dietary Fiber ,Male ,Cancer Research ,medicine.medical_specialty ,Meat ,Urinary Bladder ,Nutritional Status ,Physiology ,Aetiology, screening and detection [ONCOL 5] ,Lower risk ,Plant Proteins, Dietary ,Risk Assessment ,Body Mass Index ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Dietary Carbohydrates ,medicine ,Carcinoma ,Humans ,Prospective Studies ,Prospective cohort study ,Aged ,Molecular epidemiology Aetiology, screening and detection [NCEBP 1] ,Aged, 80 and over ,Bladder cancer ,business.industry ,Smoking ,Feeding Behavior ,Middle Aged ,medicine.disease ,Dietary Fats ,Diet ,European Prospective Investigation into Cancer and Nutrition ,Calcium, Dietary ,Europe ,Endocrinology ,Urinary Bladder Neoplasms ,Oncology ,Plant protein ,Female ,Dietary Proteins ,Risk assessment ,business ,Body mass index - Abstract
Item does not contain fulltext Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 3-30%; p(trend) = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 36-7%, p(trend) = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.
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- 2012
41. Olive oil intake and breast cancer risk in the Mediterranean countries of the European Prospective Investigation into Cancer and Nutrition study
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Antonio Agudo, J. Ramón Quirós, Eva Ardanaz, Christiana A. Demetriou, Miren Dorronsoro, Amalia Mattiello, Antonia Trichopoulou, Noémie Travier, Carmen Navarro, José María Huerta, Carlotta Sacerdote, Pagona Lagiou, Sara Grioni, Giovanna Masala, Silvia Polidoro, Claudia Agnoli, María José Pérez, Androniki Naska, Ana Fonseca-Nunes, Esther Molina, Dimitrios Trichopoulos, Genevieve Buckland, Salvatore Panico, María Dolores Chirlaque, Pilar Amiano, Rosario Tumino, Conchi Moreno-Iribas, Domenico Palli, Maria Concetta Giurdanella, Carlos González, Buckland, G, Travier, N, Agudo, A, Fonseca Nunes, A, Navarro, C, Lagiou, P, Demetriou, C, Amiano, P, Dorronsoro, M, Chirlaque, Md, Huerta, Jm, Molina, E, P?rez, Mj, Ardanaz, E, Moreno Iribas, C, Quir?s, Jr, Naska, A, Trichopoulos, D, Giurdanella, Mc, Tumino, R, Agnoli, C, Grioni, S, Panico, Salvatore, Mattiello, A, Masala, G, Sacerdote, C, Polidoro, S, Palli, D, Trichopoulou, A, and Gonz?lez, Ca
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Risk ,Cancer Research ,medicine.medical_specialty ,medicine.drug_class ,Breast Neoplasms ,Cohort Studies ,Breast cancer ,Epidemiology ,Humans ,Plant Oils ,Medicine ,Prospective cohort study ,Olive Oil ,Gynecology ,Mediterranean Region ,business.industry ,medicine.disease ,Diet ,European Prospective Investigation into Cancer and Nutrition ,Postmenopause ,Receptors, Estrogen ,Oncology ,Hormone receptor ,Estrogen ,Female ,Receptors, Progesterone ,business ,Demography ,Olive oil ,Cohort study - Abstract
Although there is some evidence suggesting that olive oil could reduce breast cancer (BC) risk, the epidemiological data are still relatively limited, not entirely consistent and mainly based on case-control studies. Therefore, we prospectively assessed the association between olive oil and BC risk in postmenopausal women from the Mediterranean cohorts within the European Prospective Investigation into Cancer and Nutrition. The analysis included 62,284 postmenopausal women recruited from Spain, Italy and Greece who had complete dietary data (collected from validated country-specific dietary questionnaires). The risk of BC (overall and by hormone receptor subtypes) was assessed using hazards ratios (HRs) obtained from Cox proportional hazards regression, while adjusting for known BC risk factors. After a mean follow-up of 9 years, 1,256 women were diagnosed with a primary incident invasive BC. The multivariate HRs for BC risk by olive oil intake (highest vs. lowest tertile of g/day/2,000 kcal) were 1.07 (95% CI = 0.91-1.25) in the adjusted model, 1.06 (95% CI = 0.91-1.24) in the model additionally adjusted for reproductive-related factors and 1.10 (95% CI = 0.92-1.31) for the model additionally adjusted for dietary factors. There was no association between olive oil and risk of estrogen or progesterone receptor-positive tumors, but a suggestion of a negative association with estrogens and progesterone receptor-negative tumors. The results from our prospective study showed that olive oil consumption during adult life was not associated with the risk of BC. However, larger prospective studies are still needed to explore possible differences related to hormone receptor status.
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- 2012
42. Hepcidin levels and gastric cancer risk in the EPIC-EurGast study
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Jakszyn, Paula, Fonseca-Nunes, Ana, Lujan-Barroso, Leila, Aranda, Núria, Tous, Monica, Arija, Victoria, Cross, Amanda, Bueno-De-Mesquita, Hendrik Bastiaan, Weiderpass, Elisabete, Kühn, Tilman, Kaaks, Rudolf, Sjöberg, Klas, Tumino, Rosario, Palli, Domenico, Ricceri, Fulvio, Fasanelli, Francesca, Krogh, Vittorio, Mattiello, Amalia, Jenab, Mazda, Gunter, Marc, Perez-Cornago, Aurora, Khaw, Kay-Tee, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Trichopoulou, Antonia, Peppa, Eleni, Vasilopoulou, Effie, Boeing, Heiner, Sánchez-Cantalejo, Emilio, Dorronsoro, Miren, Barricarte, Aurelio, Quiros, Jose Maria, Peeters, Petra H, and Agudo, Antonio
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VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 ,VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773 ,hemic and lymphatic diseases ,nutritional and metabolic diseases ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773 - Abstract
Submitted manuscript version. Published version available in International Journal of Cancer 2017, 141(5), 945-951. Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l = 0.96, 95% CI = 0.93–0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: −69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.
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- 2017
43. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
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Duell, Eric J., Lujan-Barroso, Leila, Sala, Núria, Deitz McElyea, Samantha, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Weiderpass, Elisabete, Busund, Lill-Tove, Moi, Line, Muller, David, Aune, Dagfinn, Naccarati, Alessio, Panico, Salavatore, Tagliabue, Giovanna, Tumino, Rosario, Palli, Domenico, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Bueno-De-Mesquita, Hendrik Bastiaan, Peeters, Petra H., Trichopoulou, Antonia, Lagiou, Pagona, Kotanidou, Anastasia, Travis, Ruth C., Wareham, Nick, Khaw, Kay-Tee, Quirõs, Jose Ramõn, Rodríguez-Barranco, Miguel, Dorronsoro, Miren, Chirlaque, María Dolores, Ardanaz, Eva, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Brennan, Paul, Gunter, Marc, Scelo, Ghislaine, Cote, Greg, Sherman, Stuart, and Korc, Murray
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VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 ,cohort studies ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 ,pancreatic cancer ,biomarkers ,microRNAs - Abstract
Accepted manuscript version. Published version available in International Journal of Cancer 2017, 141 (5):905–915 . Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, -155 and -212) based on previous evidence from our group was evaluated in 225 microscopically confirmed PDAC cases and 225 controls matched on center, sex, fasting status and age/date/time of blood collection. MiR levels in prediagnostic plasma samples were determined by quantitative RT-PCR. Logistic regression was used to model levels and PDAC risk, adjusting for covariates and to estimate area under the receiver operating characteristic curves (AUC). Plasma miR-10b, -21-5p, -30c and -106b levels were significantly higher in cases diagnosed within 2 years of blood collection compared to matched controls (all p-values
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- 2017
44. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study
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Kim Overvad, J. Ramón Quirós, Eva Ardanaz, Salvatore Panico, Rosario Tumino, Marc J. Gunter, Antoine Racine, María Dolores Chirlaque, Peter Wallström, Anne Tjønneland, Anna Floegel, Heiner Boeing, Vasiliki Benetou, Cuno S.P.M. Uiterwaal, Kay-Tee Khaw, Malin Sund, Ruth C. Travis, Christina Bamia, Esther Molina-Montes, Marie-Christine Boutron-Ruault, Pagona Lagiou, Sara Grioni, Dimitrios Trichopoulos, Tobias Pischon, Nicholas J. Wareham, Magdalena Stepien, Björn Lindkvist, Nirmala Bhoo-Pathy, Guy Fagherazzi, Miren Dorronsoro, Pietro Ferrari, Elisabete Weiderpass, Veronika Fedirko, Eiliv Lund, Paolo Vineis, Tilman Kühn, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Kathryn E. Bradbury, Talita Duarte-Salles, Neil Murphy, Antonia Trichopoulou, Krasimira Aleksandrova, Anja Olsen, Mazda Jenab, Elio Riboli, Raul Zamora-Ros, Vincent K. Dik, and Lena Maria Nilsson
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Cancer Research ,medicine.medical_specialty ,Pathology ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,medicine.disease ,digestive system diseases ,Confidence interval ,European Prospective Investigation into Cancer and Nutrition ,Oncology ,Hepatocellular carcinoma ,Epidemiology ,medicine ,Prospective cohort study ,business ,Cohort study ,Demography - Abstract
Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend < 0.001]. The corresponding association of tea with HCC risk was 0.41 (95% CI: 0.22-0.78, p-trend = 0.003). There was no compelling evidence of heterogeneity of these associations across strata of important HCC risk factors, including hepatitis B or hepatitis C status (available in a nested case-control study). The inverse, monotonic associations of coffee intake with HCC were apparent for caffeinated (p-trend = 0.009), but not decaffeinated (p-trend = 0.45) coffee for which, however, data were available for a fraction of subjects. Results from this multicentre, European cohort study strengthen the existing evidence regarding the inverse association between coffee/tea and HCC risk. Given the apparent lack of heterogeneity of these associations by HCC risk factors and that coffee/tea are universal exposures, our results could have important implications for high HCC risk subjects.
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- 2014
45. Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case-control study
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Kim Overvad, Rudolf Kaaks, Aurelio Barricarte, Guri Skeie, Dorthe Johansen, Antoine Racine, Björn Lindkvist, Antonia Trichopoulou, Elisavet Valanou, Max Leenders, Elisabete Weiderpass, Veronika Fedirko, Marcial Argueelles, Carla H. van Gils, Fränzel J.B. Van Duijnhoven, Mazda Jenab, Amalia Mattiello, Francesca L. Crowe, Claire Cadeau, Verena A. Grote, Elio Riboli, José María Huerta Castaño, Esther Molina-Montes, Mire Dorronsoro, Krasimira Aleksandrova, Paolo Vineis, Anne Tjønneland, Suzanne M. Jeurnink, Kay-Tee Khaw, Eric J. Duell, Nina Roswall, Peter D. Siersema, Vasiliki Benetou, Heiner Boeing, Malin Sund, Eugene Jansen, Marie-Christine Boutron-Ruault, Martine M. Ros, Rosario Tumino, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Marije F. Bakker, and Vittorio Krogh
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Male ,Cancer Research ,Nutrition and Disease ,medicine.medical_treatment ,pancreatic cancer ,population ,Tocopherols ,vitamin C ,Physiology ,Ascorbic Acid ,SERUM ,chemistry.chemical_compound ,ANTIOXIDANTS ,Voeding en Ziekte ,Micronutrients ,Prospective Studies ,Vitamin A ,POPULATION ,CALIBRATION ,Medicine(all) ,ALPHA-TOCOPHEROL ,Carotene ,Retinol ,food and beverages ,Middle Aged ,tocopherol ,carotenoid ,European Prospective Investigation into Cancer and Nutrition ,antioxidants ,beta-carotene ,Oncology ,Exocrine pancreatic cancer ,Female ,SMOKING ,retinol ,Adult ,Risk ,medicine.medical_specialty ,cohorts ,Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0] ,METABOLISM ,smoking ,alpha-tocopherol ,beta-Carotene ,Pancreatic cancer ,Internal medicine ,medicine ,Humans ,consumption ,Aged ,VLAG ,business.industry ,BETA-CAROTENE ,CONSUMPTION ,COHORTS ,calibration ,medicine.disease ,Carotenoids ,Pancreatic Neoplasms ,Endocrinology ,chemistry ,Case-Control Studies ,Nested case-control study ,business ,alpha-Tocopherol ,metabolism ,serum - Abstract
Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (- and -carotene, lycopene, -cryptoxanthin, canthaxanthin, zeaxanthin and lutein), - and -tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma -carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend=0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend=0.06) and -tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend=0.08. For - and -carotene, lutein, sum of carotenoids and -tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of -carotene, zeaxanthin and -tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted. What's new? Fruits and vegetables may play a role in the prevention of pancreatic cancer, but associations between the antioxidants those foods contain and disease risk remain unclear. In this study, pancreatic cancer risk was inversely associated with increased prediagnostic plasma concentrations of the antioxidants -carotene, zeaxanthin, and -tocopherol. Geographic variations were also detected. In Northern European countries, inverse associations with risk were found for blood levels of several carotenoids, whereas the association was strongest for -tocopherol in Southern European countries. The role of carotenoids and vitamins should be considered in subsequent investigations of the etiology of pancreatic cancer.
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- 2014
46. Association ofCRPgenetic variants with blood concentrations of C-reactive protein and colorectal cancer risk
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Elisabete Weiderpass, J. Ramón Quirós, Antoine Racine, María Dolores Chirlaque, Petra H.M. Peeters, Anders Johansson, Marc J. Gunter, Adoración Venceslá García, Elio Riboli, Esther Molina-Montes, Kim Overvad, Claudia Agnoli, Heiner Boeing, Pagona Lagiou, Young-Ae Lee, Magdalena Stepien, Federico Canzian, Eugene Jansen, Antonia Trichopoulou, Bethany Van Guelpen, Konstantinos K. Tsilidis, Miren Dorronsoro, Krasimira Aleksandrova, Rudolf Kaaks, Jürgen Janke, Dimitrios Trichopoulos, Mazda Jenab, Anne Tjønneland, Laure Dossus, H. B. Bueno-De-Mesquita, Timothy J. Key, Aurelio Barricarte Gurrea, Chunsen Wu, Katharina Nimptsch, Tobias Pischon, Domenico Palli, Kay-Tee Khaw, Nicholas J. Wareham, Rosario Tumino, Marie-Christine Boutron-Ruault, Paolo Vineis, Talita Duarte-Salles, and Salvatore Panico
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,biology ,business.industry ,Colorectal cancer ,C-reactive protein ,Case-control study ,Single-nucleotide polymorphism ,Odds ratio ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Internal medicine ,Mendelian randomization ,medicine ,biology.protein ,business ,Prospective cohort study - Abstract
High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested case-control study within EPIC including 727 cases diagnosed between 1992 and 2003 and 727 matched controls selected according to an incidence-density sampling protocol. Baseline CRP concentrations were measured in plasma samples by a high sensitivity assay. Tagging single nucleotide polymorphisms (SNPs) in the CRP gene (rs1205, rs1800947, rs1130864, rs2808630, rs3093077) were identified via HapMap. The causal effect of CRP on colorectal cancer risk was examined in a Mendelian Randomization approach utilizing multiple CRP genetic variants as instrumental variables. The SNPs rs1205, rs1800947, rs1130864 and rs3093077 were significantly associated with CRP concentrations and were incorporated in a CRP allele score which was associated with 13% higher CRP concentrations per allele count (95% confidence interval 8-19%). Using the CRP-score as instrumental variable, genetically twofold higher CRP concentrations were associated with higher risk of colorectal cancer (odds ratio 1.74, 95% confidence interval 1.06-2.85). Similar observations were made using alternative definitions of instrumental variables. Our findings give support to the hypothesis that elevated circulating CRP may play a direct role in the etiology of colorectal cancer.
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- 2014
47. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
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Elisabete Weiderpass, Paolo Vineis, Niels-Peter Becker, Paula Jakszyn, Salvatore Panico, Antoine Racine, María Dolores Chirlaque, Marie-Christine Boutron-Ruault, Tilman Kühn, Petra H.M. Peeters, Maria Wennberg, Miren Dorronsoro, Kim Overvad, David J. Hughes, Magdalena Stepien, Dimitrios Trichopoulos, Veronika Fedirko, Pagona Lagiou, Alessio Naccarati, Amanda J. Cross, María José Sánchez, Kathryn E. Bradbury, John E. Hesketh, Magdalena Czuban, José Ramón Quirós, Sandra Hybsier, Heinz Freisling, Rudolf Kaaks, Anne Tjønneland, Nadia Bastide, Malene Outzen, So Yeon Kong, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Lutz Schomburg, Engeset Dagrun, Elio Riboli, Heiner Boeing, Mazda Jenab, Ingrid Ljuslinder, Antonia Trichopoulou, Talita Duarte-Salles, Catherine Méplan, Eva Ardanaz, and Guri Skeie
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Oncology ,Gynecology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Colorectal cancer ,chemistry.chemical_element ,Cancer ,Micronutrient ,medicine.disease ,Prostate cancer ,chemistry ,Multicenter study ,Internal medicine ,Cohort ,Medicine ,business ,Prospective cohort study ,Selenium - Abstract
Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring seru ...
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- 2014
48. Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study
- Author
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Giovanna Tagliabue, Paul Brennan, J. Ramón Quirós, Alessia Russo, Roel Vermeulen, Eva Ardanaz, María José Sánchez, Karina Standahl Olsen, Per Guldberg, Fatemeh Saberi Hosnijeh, Giuseppe Matullo, Antonia Trichopoulou, Heiner Boeing, Beatrice Melin, Salvatore Panico, Rosario Tumino, Ruth C. Travis, Marc J. Gunter, Federica Modica, María Dolores Chirlaque, Adoraciõn Venceslá, Miren Dorronsoro, Simonetta Guarrera, Elisabete Weiderpass, N. Charlotte Onland-Moret, Federico Canzian, Anne Tjønneland, Kay-Tee Khaw, Kim Overvad, Paolo Vineis, Nicholas J. Wareham, Ann-Sofie Johansson, Pagona Lagiou, Dimitrios Trichopoulos, Peter M. Nilsson, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Petra H.M. Peeters, Alexandra Nieters, Signe Borgquist, Krasimira Aleksandrova, and Pietro Ferrari
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Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,business.industry ,Follicular lymphoma ,Odds ratio ,medicine.disease ,Peripheral blood mononuclear cell ,Lymphoma ,Real-time polymerase chain reaction ,Internal medicine ,Medicine ,business ,Prospective cohort study ,B-cell lymphoma ,Cohort study - Abstract
Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p 5 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.
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- 2014
49. Genetic association of gastric cancer with miRNA clusters including the cancer-related genesMIR29, MIR25, MIR93andMIR106: Results from the EPIC-EURGAST study
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Mattias Johansson, Sabina Sieri, Françoise Clavel-Chapelon, Emilio Sánchez-Cantalejo, Salvatore Panico, Alessio Naccarati, Kim Overvad, Mattijs E. Numans, Talita Duarte-Salles, Aurelio Barricarte, Núria Sala, Elisabete Weiderpass, Ruth C. Travis, Elio Riboli, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Eiliv Lund, Anne Tjønneland, Rosario Tumino, Virginia Menéndez, Paul Brennan, Yolanda Espinosa-Parrilla, Federico Canzian, Björn Lindkvist, Gabriella Nesi, Catalina Bonet, José María Huerta, Kay-Tee Khaw, Bodil Ohlsson, Heiner Boeing, Malin Sund, Nikos Yiannakouris, Miren Dorronsoro, Antoine Racine, Nicholas J. Wareham, Adoraciõn Venceslá, Xavier Muñoz, Daniele Campa, Marie-Christine Boutron-Ruault, Nadia García, and Carlos A. González
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Genetics ,Cancer Research ,Cancer ,Single-nucleotide polymorphism ,Biology ,medicine.disease_cause ,medicine.disease ,Oncology ,Genetic variation ,microRNA ,Genetic predisposition ,medicine ,Genetic variability ,Carcinogenesis ,Genetic association - Abstract
MicroRNAs (miRNAs) are post-transcriptional gene regulators involved in a wide range of biological processes including tumorigenesis. Deregulation of miRNA pathways has been associated with cancer but the contribution of their genetic variability to this disorder is poorly known. We analyzed the genetic association of gastric cancer (GC) and its anatomical and histological subtypes, with 133 single-nucleotide polymorphisms (SNPs) tagging 15 isolated miRNAs and 24 miRNA clusters potentially involved in cancer, in 365 GC cases and 1,284 matched controls within the European Prospective Investigation into Cancer and Nutrition cohort. Various SNPs were associated with GC under the log-additive model. Furthermore, several of these miRNAs passed the gene-based permutation test when analyzed according to GC subtypes: three tagSNPs of the miR-29a/miR-29b-1 cluster were associated with diffuse subtype (minimum p-value=1.7 x 10(-4); odds ratio, OR=1.72; 95% confidence interval, CI=1.30-2.28), two tagSNPs of the miR-25/miR-93/miR-106b cluster were associated with cardia GC (minimum p-value=5.38 x 10(-3); OR=0.56, 95% CI=0.37-0.86) and one tagSNP of the miR-363/miR-92a-2/miR-19b-2/miR-20b/miR-18b/miR-106a cluster was associated with noncardia GC (minimum p-value=5.40 x 10(-3); OR=1.41, 95% CI=1.12-1.78). Some functionally validated target genes of these miRNAs are implicated in cancer-related processes such as methylation (DNMT3A, DNMT3B), cell cycle (E2F1, CDKN1A, CDKN1C), apoptosis (BCL2L11, MCL1), angiogenesis (VEGFA) and progression (PIK3R1, MYCN). Furthermore, we identified genetic interactions between variants tagging these miRNAs and variants in their validated target genes. Deregulation of the expression of these miRNAs in GC also supports our findings, altogether suggesting for the fist time that genetic variation in MIR29, MIR25, MIR93 and MIR106b may have a critical role in genetic susceptibility to GC and could contribute to the molecular mechanisms of gastric carcinogenesis.
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- 2014
50. Dairy products and risk of hepatocellular carcinoma: The European Prospective Investigation into Cancer and Nutrition
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Krasimira Aleksandrova, Valeria Pala, Elio Riboli, Emily Sonestedt, Aurelio Barricarte, Kim Overvad, Antonia Trichopoulou, Maria Wennberg, Petra H.M. Peeters, Nicholas J. Wareham, Mazda Jenab, Dimitrios Trichopoulos, Magdalena Stepien, Björn Lindkvist, Ana Fonseca-Nunes, Claire Cadeau, Ingegerd Johansson, Esther Molina-Montes, Inger T. Gram, Ruth C. Travis, Anne Tjønneland, Elisabete Weiderpass, Hendrik B. Bueno-de-Mesquita, Domenico Palli, José Ramón Quirós, Christina Bamia, Carlotta Sacerdote, Pagona Lagiou, Salvatore Panico, Talita Duarte-Salles, Paolo Boffetta, Marie-Christine Boutron-Ruault, Veronika Fedirko, Vincent K. Dik, Rosario Tumino, Tilman Kühn, Konstantinos Tsiotas, Carmen Navarro Sánchez, Jytte Halkjær, Kay-Tee Khaw, Miren Dorronsoro, Antoine Racine, Isabelle Romieu, Elisabeth Trepo, Annekatrin Lukanova, and Anette Hjartåker
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Hazard ratio ,Odds ratio ,medicine.disease ,Gastroenterology ,European Prospective Investigation into Cancer and Nutrition ,Hepatocellular carcinoma ,Internal medicine ,Cohort ,medicine ,Vitamin D and neurology ,business ,Prospective cohort study ,Cohort study - Abstract
Intake of dairy products has been associated with risk of some cancers, but findings are often inconsistent and information on hepatocellular carcinoma (HCC) risk is limited, particularly from prospective settings. The aim of our study was to investigate the association between consumption of total and specific dairy products (milk/cheese/yogurt) and their components (calcium/vitamin D/fats/protein), with first incident HCC (N(cases) = 191) in the European Prospective Investigation into Cancer and Nutrition cohort, including a nested case-control subset (N(cases) = 122) with the assessment of hepatitis B virus/hepatitis C virus infections status, liver damage and circulating insulin-like growth factor (IGF)-I levels. For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. A total of 477,206 participants were followed-up for an average of 11 years (person-years follow-up = 5,415,385). In the cohort study, a significant positive HCC risk association was observed for total dairy products (highest vs. lowest tertile, HR = 1.66, 95% CI: 1.13-2.43; p(trend) = 0.012), milk (HR = 1.51, 95% CI: 1.02-2.24; p(trend) = 0.049), and cheese (HR = 1.56, 95% CI: 1.02-2.38; p(trend) = 0.101), but not yogurt (HR = 0.94, 95% CI: 0.65-1.35). Dietary calcium, vitamin D, fat and protein from dairy sources were associated with increased HCC risk, whereas the same nutrients from nondairy sources showed inverse or null associations. In the nested case-control study, similar results were observed among hepatitis-free individuals. Results from this large prospective cohort study suggest that higher consumption of dairy products, particularly milk and cheese, may be associated with increased HCC risk. Validation of these findings in other populations is necessary. Potential biologic mechanisms require further exploration.
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- 2014
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