4 results on '"Douglas C. Dover"'
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2. Impact of Socioeconomic Status and Residence Distance on Infant Heart Disease Outcomes in Canada
- Author
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Oluwayomi Olugbuyi, Christopher Smith, Padma Kaul, Douglas C. Dover, Andrew S. Mackie, Sunjidatul Islam, Luke Eckersley, and Lisa K. Hornberger
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clinical outcomes ,congenital heart disease ,population ,remoteness of residence ,socioeconomic status ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Socioeconomic status (SES) impacts clinical outcomes associated with severe congenital heart disease (sCHD). We examined the impact of SES and remoteness of residence (RoR) on congenital heart disease (CHD) outcomes in Canada, a jurisdiction with universal health insurance. Methods and Results All infants born in Canada (excluding Quebec) from 2008 to 2018 and hospitalized with CHD requiring intervention in the first year were identified. Neighborhood level SES income quintiles were calculated, and RoR was categorized as residing 300 km from the closest of 7 cardiac surgical programs. In‐hospital mortality at 300 km, respectively. Although SES and RoR had no impact on sCHD mortality, infants with mCHD living >300 km had a higher risk of mortality relative to those living
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- 2022
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3. Trends in Uptake and Adherence to Oral Anticoagulation for Patients With Incident Atrial Fibrillation at High Stroke Risk Across Health Care Settings
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Haran Yogasundaram, Douglas C. Dover, Nathaniel M. Hawkins, Finlay A. McAlister, Shaun G. Goodman, Justin Ezekowitz, Padma Kaul, and Roopinder K. Sandhu
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adherence ,anticoagulation ,atrial fibrillation ,health care settings ,uptake ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Oral anticoagulation (OAC) therapy prevents morbidity and mortality in nonvalvular atrial fibrillation; whether location of diagnosis influences OAC uptake or adherence is unknown. Methods and Results Retrospective cohort study (2008–2019), identifying adults with incident nonvalvular atrial fibrillation across health care settings (emergency department, hospital, outpatient) at high risk of stroke. OAC uptake and adherence via proportion of days covered for direct OACs and time in therapeutic range for warfarin were measured. Proportion of days covered was categorized as low (0–39%), intermediate (40–79%), and high (80–100%). Warfarin control was defined as time in therapeutic range ≥65%. All‐cause mortality was examined at a 3‐year landmark. Among 75 389 patients with nonvalvular atrial fibrillation (47.0% women, mean 77.4 years), 19.7% were diagnosed in the emergency department, 59.1% in the hospital, and 21.2% in the outpatient setting. Ninety‐day OAC uptake was 51.6% in the emergency department, 50.9% in the hospital, and 67.9% in the outpatient setting (P
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- 2022
- Full Text
- View/download PDF
4. Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia
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Marilyn Stovall, Charles A. Sklar, Stella M. Davies, Barry D. Anderson, Jerry Finklestein, Stephen Qualman, Daniel C. Bowers, Gerald S. Gilchrist, Maura O'Leary, Julie Blatt, Gail E. Tomlinson, Lillian R. Meacham, Sue Hammond, Robert J. Hayashi, Jane Sande, Paul C. Nathan, Lorrie F. Odom, Robert E. Goldsby, Suwen Li, W. Anthony Smithson, George R. Buchanan, Kimberly Whelan, Lisa Diller, Greg Armstrong, Thomas W. Pendergrass, Peter D. Inskip, John Mulvihill, Frederick P. Li, Debra L. Friedman, Vilmarie Rodriguez, Melissa M. Hudson, Robert M. Weetman, Kirsten K. Ness, Lonnie K. Zeltzer, Neyssa Marina, Amanda Termuhlen, Douglas C. Dover, A. T. Meadows, Gregory H. Reaman, Smita Bhatia, Norman E. Breslow, S.M. Davies, Kevin C. Oeffinger, Roger J. Packer, John D. Potter, Ann C. Mertens, Jackie Casallis, Jill Ginsberg, Brian Greffe, John D. Boice, Kathy Ruccione, Joseph P. Neglia, Sarah S. Donaldson, Yutaka Yasui, Joanna L. Perkins, A. Kim Ritchey, Roger L. Berkow, Holcombe E. Grier, Joseph Philip Neglia, Mark T. Greenberg, Dennis Deapen, Raymond J. Hutchinson, Terry A. Vik, Wendy M. Leisenring, ZoAnn E. Dreyer, Frederick B. Ruymann, Louise C. Strong, Teresa J. Vietti, Leslie L. Robison, Arthur R. Ablin, Daniel A. Mulrooney, Michael P. Link, Daniel M. Green, and Jean M. Tersak
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Adult ,Employment ,Male ,Cancer Research ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Population ,Childhood Cancer Survivor Study ,Survivorship curve ,Humans ,Medicine ,Cumulative incidence ,Survivors ,Marriage ,Young adult ,Child ,education ,Aged ,education.field_of_study ,Insurance, Health ,business.industry ,Infant, Newborn ,Infant ,Middle Aged ,Confidence interval ,Survival Rate ,Transplantation ,Leukemia, Myeloid, Acute ,Oncology ,El Niño ,Child, Preschool ,Educational Status ,Female ,business ,Follow-Up Studies - Abstract
BACKGROUND Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML). METHODS This analysis included 272 5-year AML survivors who participated in the Childhood Cancer Survivor Study (CCSS). All patients were diagnosed at age ≤21 years between the years 1970 and 1986, and none underwent stem cell transplantation. Rates of survival, relapse, and late outcomes were analyzed. RESULTS The average follow-up was 20.5 years (range, 5–33 years). The overall survival rate was 97% at 10 years (95% confidence interval [95%CI], 94%–98%) and 94% at 20 years (95% CI, 90%–96%). Six survivors reported 8 recurrences. The cumulative incidence of recurrent AML was 6.6% at 10 years (95% CI, 3.7%–9.6%) and 8.6% at 20 years (95% CI, 5.1%–12.1%). Ten subsequent malignant neoplasms (SMN) were reported, including 4 with a history of radiation therapy, for a 20-year cumulative incidence of 1.7% (95% CI, 0.02%–3.4%). Six cardiac events were reported, for a 20-year cumulative incidence 4.7% (95% CI, 2.1%–7.3%). Half of the survivors reported a chronic medical condition and, compared with siblings, were at increased risk for severe or life-threatening chronic medical conditions (16% vs 5.8%; P < .001). Among those aged ≥25 years, the age-adjusted marriage rates were similar among survivors and the general United States population (57% for both) and lower compared with siblings (67%; P < .01). Survivors' college graduation rates were lower compared with siblings but higher than the general population (40% vs 52% vs 34%, respectively; P < .01). Employment rates were similar between survivors, siblings, and the general population (93%, 97.6%, and 95.8%, respectively). CONCLUSIONS Long-term survival from childhood AML ≥5-years after diagnosis was favorable. Late-occurring medical events remained a concern with socioeconomic achievement lower than expected within the individual family unit, although it was not different from the general United States population. Cancer 2008. © 2008 American Cancer Society.
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- 2008
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