Search

Your search keyword '"E. Yoshii"' showing total 38 results
Start Over Author "E. Yoshii" Publisher wiley
38 results on '"E. Yoshii"'

1. ChemInform Abstract: Cyclobutane Structures Fused to a 13-Membered Ring

Author

K. Takeda, Kentaro Yamaguchi, E. Yoshii, and A. Shimotani

Subjects
chemistry.chemical_compound, Methyl carbon, chemistry, Stereochemistry, Diastereomer, Moiety, General Medicine, Ring (chemistry), Cyclobutane
Abstract

The structures of two diastereomers, (1R * ,6aS * , 14aS * ,14bR * ,13E)- and (1R * ,6aR * ,14aR * ,14bS * ,13E)-1,14a-dimethyl-1,2,6,6a,7,8,9,10,11,12-decahydro-4H,5H,14aH-6a,14c-epoxy-3-cyclobuta[1',2':1,2]cyclopentadeca[2,3,4-b,c]furan-4,5-dione, in which a cyclobutane moiety is fused to a 13-membered ring are reported for the first time. The two diastereomers exhibit similar conformations except for the configuration about the methyl carbon (C15)

Published
2010
Full Text
View/download PDF

38. Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity.

Author

Yoshii E

Subjects
Acrylates chemistry, Biocompatible Materials chemistry, Dental Materials chemistry, Dental Materials toxicity, HeLa Cells, Humans, Materials Testing, Methacrylates chemistry, Resins, Synthetic chemistry, Resins, Synthetic toxicity, Structure-Activity Relationship, Acrylates toxicity, Biocompatible Materials toxicity, Methacrylates toxicity
Abstract

Thirty-nine acrylates and methacrylates that had been used in dental resin materials were evaluated by a cytotoxicity test, and the relationships between their structures and cytotoxicity were studied to predict cytotoxic levels of dental resin materials in order to develop new low-toxic resin materials. All the acrylates evaluated were more toxic than corresponding methacrylates. In both the acrylates and methacrylates, a hydroxyl group seemed to enhance cytotoxicity. Dimethacrylates with 14 or fewer oxyethylene chains showed similar cytotoxicity while dimethacrylates with 23 oxyethylene chains showed lower cytotoxicity. The cytotoxicity ranking of monomers widely used in dental resin materials was bisphenol A bis 2-hydroxypropyl methacrylate (bisGMA) > urethane dimethacrylate (UDMA) > triethyleneglycol dimethacrylate (3G) > 2-hydroxyethyl methacrylate (HEMA) > methyl methacrylate (MMA). In acrylates, methacrylates, and ethylmethacrylates with either substituents, the lipophilicity of substituents affected their cytotoxicity, and an inverse correlation between IC50 and logP was observed. These results will be useful in developing new resin materials with low toxic monomer compositions.

Published
1997
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results