1. Complement Dependence of Localisation of Aggregated IgG in Germinal Centres
- Author
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P. Embling, C. Gutierrez, M Papamichail, M. B. Pepys, P M Johnson, and E.J. Holborow
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Hot Temperature ,Lymphocyte ,Immunology ,Spleen ,Biology ,Immunoglobulin G ,Mice ,In vivo ,medicine ,Animals ,Receptor ,Mice, Inbred BALB C ,Binding Sites ,Germinal center ,Complement C3 ,Complement System Proteins ,General Medicine ,Molecular biology ,Germ Cells ,medicine.anatomical_structure ,biology.protein ,Female ,Early phase ,Injections, Intraperitoneal ,Snake Venoms - Abstract
In vivo decomplementation of mice with cobra factor completely prevented trapping of aggregated human IgG within splenic germinal centres. Observations of the intrasplenic position of the aggregated material within 8 hr of its injection into normal and decomplemented mice suggest that the early phase of localisation in germinal centres depends on binding to lymphocyte C3 receptors.
- Published
- 1975
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