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1. Oncogenic GNAQ and GNA11 Drive Tumorigenesis and Hyper‐Pigmentation in a Zebrafish Model of Human Uveal Melanoma

Author

Emily Hoelzli, Dahlia E. Perez, Andrea M. Henle, Jacqueline A. Lees, and Adam Amsterdam

Subjects
GNA11, biology, business.industry, Melanoma, Cancer, biology.organism_classification, medicine.disease, Biochemistry, eye diseases, medicine.anatomical_structure, Ciliary body, Genetics, Cancer research, Medicine, sense organs, Choroid, Iris (anatomy), business, Molecular Biology, Zebrafish, GNAQ, Biotechnology
Abstract

Uveal melanoma is the most common intraocular cancer, with an estimated 2000 cases diagnosed yearly in the U.S. Tumors arise from melanocytes in the choroid, iris, and ciliary body. Treatment typic...

Published
2015
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