1. Evaluation of children and adolescent with cystic fibrosis by pancreatic elastography
- Author
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Engin Deniz Yilmaz, Müsemma Karabel, Salih Hattapoğlu, Velat Şen, Kamil Yılmaz, Ahmet Kan, Süreyya Yilmaz, and Hadice Selimoglu Sen
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Cystic Fibrosis ,Disease ,Gastroenterology ,Cystic fibrosis ,Cftr gene ,Internal medicine ,medicine ,Humans ,Child ,Exocrine pancreatic insufficiency ,Pancreas ,medicine.diagnostic_test ,business.industry ,Significant difference ,medicine.disease ,medicine.anatomical_structure ,Chronic Disease ,Pediatrics, Perinatology and Child Health ,Elasticity Imaging Techniques ,Exocrine Pancreatic Insufficiency ,Female ,Elastography ,Inherited disease ,business - Abstract
BACKGROUND Cystic fibrosis (CF) is an autosomal recessively inherited disease. Clinical findings vary by age of the patient, the organ systems involved, and the severity of the CFTR gene mutation. Pancreatic and liver involvement is prominent and exocrine pancreatic insufficiency is observed in the majority of patients. Point shear wave elastography (pSWE) is a non-invasive method that can quantitatively determine tissue elasticity and stiffness. In this study, the morphological evaluation of the pancreas was performed using the pSWE technique in pediatric patients diagnosed with CF. The effectiveness of this method for early detection of pancreatic insufficiency was investigated. METHODS Fifty-five patients with CF (24 girls, 31 boys) and 60 healthy children (29 girls, 31 boys) without any chronic diseases and who were suitable for the pSWE examination were included in the study. RESULTS The mean value of pSWE was 1.12±0.16 in the healthy group and 0.97±0.16 in the patients with cystic fibrosis. There was a statistically significant difference between the two groups (p
- Published
- 2022
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