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279 results on '"FAN, HONG"'

1. Optical coherence tomography in patients with Wilson's disease

Author

Wei‐Qin Ning, Chun‐Xiao Lyu, Sheng‐Peng Diao, Ye‐Qing Huang, Ai‐Qun Liu, Qing‐Yun Yu, Zhong‐Xing Peng, Ming‐Fan Hong, and Zhi‐Hua Zhou

Subjects
duration, magnetic resonance imaging, optical coherence tomography, Wilson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background Morphological changes of retina in patients with Wilson's disease (WD) can be found by optical coherence tomography (OCT), and such changes had significant differences between neurological forms (NWD) and hepatic forms (HWD) of WD. The aim of this study was to evaluate the relationship between morphological parameters of retina and brain magnetic resonance imaging (MRI) lesions, course of disease, type of disease, and sexuality in WD. Methods A total of 46 WD patients and 40 health controls (HC) were recruited in this study. A total of 42 WD patients were divided into different groups according to clinical manifestations, course of disease, sexuality, and brain MRI lesions. We employed the Global Assessment Scale to assess neurological severity of WD patients. All WD patients and HC underwent retinal OCT to assess the thickness of inner limiting membrane (ILM) layer to retinal pigment epithelium layer and inner retina layer (ILM to inner plexiform layer, ILM–IPL). Results Compared to HWD, NWD had thinner superior parafovea zone (108.07 ± 6.89 vs. 114.40 ± 5.54 μm, p

Published
2023
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9. Persistence with medical treatment for Wilson disease in China based on a single center’s survey research

Author

Zhi‐Hua Zhou, Yun‐Fan Wu, Yan Yan, Ai‐Qun Liu, Qing‐Yun Yu, Zhong‐Xing Peng, Gong‐Qiang Wang, and Ming‐Fan Hong

Subjects
medicine adherence, nonpersistence with drug treatment, persistence with drug treatment, Wilson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background Wilson's disease (WD) is one of the few hereditary diseases that can be successfully treated with medicines. We conduct this survey research to assess treatment persistence among patients with WD and try to identify what factors affect the treatment persistence. Methods We employed WeChat which is the most popular social software in China to carry out this anonymous questionnaire research. The questionnaire included medication adherence scale. We also collected available medical records related to demographic and clinical characteristics. All the patients were divided into group of persistence with drug treatment (PDT) and nonpersistence with drug treatment (n‐PDT). Results We collected 242 qualified questionnaires. Only 66.5% of patients were PDT during the mean 12.6 years of follow‐up. In PDT group, better outcomes were observed: improvement (78.3%) and no change (16.1%) versus those in n‐PDT (55.6%; and 28.4%, respectively). In PDT group, only nine patients deteriorated (6.8%) in comparison with 13 patients in n‐PDT (16.0%). The adverse events (AEs) in PDT group were significantly less than those in n‐PDT group. There were no significant differences in clinical type, gender, age, education level, and family knowledge about WD between the two groups. There were significant differences in AEs and family position toward treatment. Conclusion Medication Adherence of Chinese WD patients was low. One third of the patients (33.5%) were unable to PDT, and it had an important negative effect on clinical outcome. AEs and family support had an important impact on treatment persistence.

Published
2021
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22. Free‐Electron‐Driven Frequency Comb

Author

Zhang, Zi‐Wen, primary, Du, Chao‐Hai, additional, Zhu, Juan‐Feng, additional, Li, Fan‐Hong, additional, Shen, Bitao, additional, Wang, Xingjun, additional, and Liu, Pu‐Kun, additional

Published
2023
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26. Free‐Electron‐Driven Frequency Comb

Author

Zi‐Wen Zhang, Chao‐Hai Du, Juan‐Feng Zhu, Fan‐Hong Li, Bitao Shen, Xingjun Wang, and Pu‐Kun Liu

Subjects
Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published
2023
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29. Formation and evolution of multistage hydrothermal fluids in the Baishitouwa quartz–wolframite vein‐type deposit in the southern Great Xing'an Range tungsten belt, NE China: Constraints from individual fluid inclusion LA‐ICP‐MS analysis

Author

Xie, Wei, primary, Zeng, Qing‐Dong, additional, Huang, Liang‐Liang, additional, Zhou, Ling‐Li, additional, Fan, Hong‐Rui, additional, Wu, Jin‐Jian, additional, Wang, Rui‐Liang, additional, and Zhu, He‐Ping, additional

Published
2023
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38. DBZ (Danshensu Bingpian Zhi), a Novel Natural Compound Derivative, Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice

Author

Jing Wang, Pengfei Xu, Xinni Xie, Jiao Li, Jun Zhang, Jialin Wang, Fan Hong, Jian Li, Youyi Zhang, Yao Song, Xiaohui Zheng, and Yonggong Zhai

Subjects
atherosclerosis, foam cell, inflammation, LXR, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundDBZ (Danshensu Bingpian Zhi), a synthetic derivative of a natural compound found in traditional Chinese medicine, has been reported to suppress lipopolysaccharide‐induced macrophage activation and lipid accumulation in vitro. The aim of this study was to assess whether DBZ could attenuate atherosclerosis at early and advanced stages. Methods and ResultsThe effects of DBZ on the development of atherosclerosis were studied using apolipoprotein E–deficient (apoE−/−) mice. For early treatment, 5‐week‐old apoE−/− mice were fed a Western diet and treated daily by oral gavage with or without DBZ or atorvastatin for 10 weeks. For advanced treatment, 5‐week‐old apoE−/− mice were fed a Western diet for 10 weeks to induce atherosclerosis, and then they were randomly divided into 4 groups and subjected to the treatment of vehicle, 20 mg/kg per day DBZ, 40 mg/kg per day DBZ, or 10 mg/kg per day atorvastatin for the subsequent 10 weeks. We showed that early treatment of apoE−/− mice with DBZ markedly reduced atherosclerotic lesion formation by inhibiting inflammation and decreasing macrophage infiltration into the vessel wall. Treatment with DBZ also attenuated the progression of preestablished diet‐induced atherosclerotic plaques in apoE−/− mice. In addition, we showed that DBZ may affect LXR (liver X receptor) function and that treatment of macrophages with DBZ suppressed lipopolysaccharide‐stimulated cell migration and oxidized low‐density lipoprotein–induced foam cell formation. ConclusionsDBZ potentially has antiatherosclerotic effects that involve the inhibition of inflammation, macrophage migration, leukocyte adhesion, and foam cell formation. These results suggest that DBZ may be used as a therapeutic agent for the prevention and treatment of atherosclerosis.

Published
2017
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40. Hydration Enables Air‐Stable and High‐Performance Layered Cathode Materials for both Organic and Aqueous Potassium‐Ion Batteries

Author

Zhang, Xinyuan, primary, Yang, Xin, additional, Sun, Ge, additional, Yao, Shiyu, additional, Xie, Yu, additional, Zhang, Wei, additional, Liu, Chunbao, additional, Wang, Xiaoqi, additional, Yang, Rui, additional, Jin, Xu, additional, Shen, Ze Xiang, additional, Fan, Hong Jin, additional, and Du, Fei, additional

Published
2022
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49. A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO 3 for Synergistic Tumor Therapy

Author

Le-Le Zhou, Yu-Bin Dong, Qun Guan, Yan-An Li, Wen-Yan Li, and Fan-Hong Lv

Subjects
Cell physiology, biology, 010405 organic chemistry, Chemistry, medicine.medical_treatment, CD44, Cell, Photodynamic therapy, General Medicine, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, medicine.anatomical_structure, biology.protein, Biophysics, medicine, Photosensitizer, BODIPY, Receptor, Intracellular
Abstract

Ca2+ , a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular Ca2+ regulation, such as mitochondrial Ca2+ buffering capacity, can be disrupted by 1 O2 . Thus, the intracellular Ca2+ overload, which is recognized as one of the important cell pro-death factors, can be logically achieved by the synergism of 1 O2 with exogenous Ca2+ delivery. Reported herein is a nanoscale covalent organic framework (NCOF)-based nanoagent, namely CaCO3 @COF-BODIPY-2I@GAG (4), which is embedded with CaCO3 nanoparticle (NP) and surface-decorated with BODIPY-2I as photosensitizer (PS) and glycosaminoglycan (GAG) targeting agent for CD44 receptors on digestive tract tumor cells. Under illumination, the light-triggered 1 O2 not only kills the tumor cells directly, but also leads to their mitochondrial dysfunction and Ca2+ overload. An enhanced antitumor efficiency is achieved via photodynamic therapy (PDT) and Ca2+ overload synergistic therapy.

Published
2020
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