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19 results on '"FLORIO, SALVATORE"'

5. Effect of rMnSOD on Sodium Reabsorption in Renal Proximal Tubule in Ochratoxin A—Treated Rats

Author

Damiano, Sara, primary, Puzio, Maria V., additional, Squillacioti, Caterina, additional, Mirabella, Nicola, additional, Zona, Enrica, additional, Mancini, Aldo, additional, Borrelli, Antonella, additional, Astarita, Carlo, additional, Boffo, Silvia, additional, Giordano, Antonio, additional, Avallone, Luigi, additional, Florio, Salvatore, additional, and Ciarcia, Roberto, additional

Published
2017
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6. Recombinant Mitochondrial Manganese Containing Superoxide Dismutase Protects Against Ochratoxin A‐Induced Nephrotoxicity

Author

Ciarcia, Roberto, primary, Damiano, Sara, additional, Squillacioti, Caterina, additional, Mirabella, Nicola, additional, Pagnini, Ugo, additional, Florio, Alessia, additional, Severino, Lorella, additional, Capasso, Giovambattista, additional, Borrelli, Antonella, additional, Mancini, Aldo, additional, Boffo, Silvia, additional, Romano, Gaetano, additional, Giordano, Antonio, additional, and Florio, Salvatore, additional

Published
2015
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7. Comparison of Dasatinib, Nilotinib, and Imatinib in the Treatment of Chronic Myeloid Leukemia

Author

Ciarcia, Roberto, primary, Damiano, Sara, additional, Puzio, Maria Valeria, additional, Montagnaro, Serena, additional, Pagnini, Francesco, additional, Pacilio, Carmen, additional, Caparrotti, Giuseppe, additional, Bellan, Cristiana, additional, Garofano, Tiziana, additional, Polito, Maria Sole, additional, Giordano, Antonio, additional, and Florio, Salvatore, additional

Published
2015
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11. Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients

Author

Ciarcia, Roberto, primary, Vitiello, Maria Teresa, additional, Galdiero, Massimiliano, additional, Pacilio, Carmen, additional, Iovane, Valentina, additional, d'Angelo, Danila, additional, Pagnini, David, additional, Caparrotti, Giuseppe, additional, Conti, Daniele, additional, Tomei, Valentina, additional, Florio, Salvatore, additional, and Giordano, Antonio, additional

Published
2012
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12. Hydrocortisone attenuates cyclosporin A-induced nephrotoxicity in rats

Author

Ciarcia, Roberto, primary, Damiano, Sara, additional, Fiorito, Filomena, additional, Granato, Giovanna, additional, Pagnini, Francesco, additional, Mastellone, Vincenzo, additional, Iovane, Valentina, additional, Alfano, Luigi, additional, Valenti, Fabio, additional, Florio, Salvatore, additional, and Giordano, Antonio, additional

Published
2012
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13. 2,3,7,8-Tetrachlorodibenzo-p-dioxin modifies expression and nuclear/cytosolic localization of bovine herpesvirus 1 immediate-early protein (bICP0) during infection

Author

Fiorito, Filomena, primary, Marfè, Gabriella, additional, Granato, Giovanna E., additional, Ciarcia, Roberto, additional, De Blasio, Emma, additional, Tafani, Marco, additional, Florio, Salvatore, additional, De Martino, Luisa, additional, Muzi, Gianmarco, additional, Pagnini, Ugo, additional, and Giordano, Antonio, additional

Published
2010
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18. Effect of rMnSOD on Sodium Reabsorption in Renal Proximal Tubule in Ochratoxin A—Treated Rats

Author

Enrica Zona, Sara Damiano, Luigi Avallone, Aldo Mancini, Silvia Boffo, Antonio Giordano, Carlo Astarita, Antonella Borrelli, Caterina Squillacioti, Maria Valeria Puzio, Salvatore Florio, Roberto Ciarcia, Nicola Mirabella, Damiano, Sara, Puzio, MARIA VALERIA, Squillacioti, Caterina, Mirabella, Nicola, Zona, Enrica, Mancini, Aldo, Borrelli, Antonella, Avallone, Luigi, Florio, Salvatore, and Ciarcia, Roberto

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, MICROPUNTURE, Biochemistry, rMnSOD, Natriuresis, Nitric oxide, Nephrotoxicity, Kidney Tubules, Proximal, Rats, Sprague-Dawley, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, ANTIOXIDANTS, Internal medicine, medicine, Animals, Humans, OCHRATOXIN A, Molecular Biology, Kidney, NITRIC OXIDE, Cell Biology, Renal sodium reabsorption, biology, Superoxide Dismutase, Reabsorption, Ochratoxins, Renal Reabsorption, Recombinant Proteins, Rats, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, biology.protein, Corn oil
Abstract

Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium that represent toxic real threat for human beings and animal health. In this study we evaluated the effect of a new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) on oxidative stress and on the alterations of fluid reabsorption in renal proximal tubule (PT) as possible causes of OTA nephrotoxicity. Finally, we have measured the concentration of O2- in the kidney through dihydroethidium assay (DHE) and nitric oxide (NO) concentration through nitrites and nitrates assay. Male Sprague Dawley rats weighing 120-150 g were treated for 14 days by gavage, as follows: Control group, 12 rats received a corresponding amount of saline solution (including 10% DMSO); rMnSOD group, 12 rats treated with rMnSOD (10 µg/kg bw); OTA group, 12 rats treated with OTA (0,5 mg/Kg bw) dissolved in 10% DMSO and then scaled to required volume with corn oil; rMnSOD + OTA, 12 rats treated with rMnSOD (10 µg /kg bw) plus OTA (0,5 mg/Kg bw). Our results have shown that rMnSOD restores the alteration of reabsorption in PT in rats treated with OTA plus rMnSOD, probably through the response to pressure natriuresis, where nitric oxide plays a key role. Moreover, rMnSOD prevents the nephrotoxicity induced by OTA probably restoring the balance between superoxide and NO that is most probably the cause of hypertension and renal functional alterations through the inhibition of NO synthase. In conclusion these data provide important information for understanding of mechanism of toxic action of OTA. This article is protected by copyright. All rights reserved

Published
2017

19. Hydrocortisone has a protective effect on CyclosporinA-induced cardiotoxicity

Author

F. Russo, Luca Crispino, Salvatore Florio, Christine Kumar, Ugo Pagnini, Antonio Ruocco, Giuseppina D'Andrilli, Roberto Ciarcia, Florio, Salvatore, Ciarcia, Roberto, Crispino, L., Pagnini, Ugo, Ruocco, A., Kumar, C., D'Andrilli, G., and Russo, Ferdinando

Subjects
Male, Hydrocortisone, Physiology, Clinical Biochemistry, chemistry.chemical_element, Pharmacology, Calcium, Nitric Oxide, Calcium in biology, Lipid peroxidation, chemistry.chemical_compound, Malondialdehyde, Calcium flux, Animals, Myocytes, Cardiac, Cells, Cultured, Calcium metabolism, Cardiotoxicity, Dose-Response Relationship, Drug, Cell Biology, Rats, Oxidative Stress, chemistry, Cytoprotection, Toxicity, Cyclosporine, Lipid Peroxidation, Immunosuppressive Agents, Intracellular
Abstract

CyclosporinA (CsA) is an immunosuppressive drug which induces severe adverse effects such as cardiotoxicity and nephrotoxicity. In several therapeutic protocols CsA is used in association with corticosteroids to obtain better therapeutic results. Recently, our studies showed that CsA increases blood pressure while inhibit Nitric Oxide (NO) production in vivo. In this study we evaluated in rat cardiomyocytes the effects of CsA, used alone or in association with Hydrocortisone (HY), on intracellular calcium concentration, NO production and lipid peroxidation (MDA level). Our results demonstrated that CsA increased intracellular calcium and such effect was dose-dependent. HY used alone, slightly decreased intracellular calcium, while dramatically reduced CsA-induced calcium fluxes. CsA (3.2 microM) increased lipid peroxidation and this effect was blunted by HY. Both CsA and HY inhibited NO production in rat cardiomyocytes acting on this pathway synergically. Our results demonstrated that in rat cardiomyocytes, CsA toxicity is due to a calcium overload, which in turn induce lipid peroxidation and determines oxidative stress-induced cell injury. Treatment with HY effectively inhibits CsA-induced toxicity, decreasing lipid peroxidation as well as calcium intracellular concentration. Our findings seem to suggest that glucocorticoids may be effective in reducing CsA-induced cardiotoxicity at concentrations which are consistent with current therapeutic doses.

Published
2003

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