1. The Rome Transplant Network model compared to the Italian Bone Marrow Donor Registry activity for unrelated donor search process and transplant efficiency for hematologic malignancy
- Author
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William Arcese, Andrea Mengarelli, Alessandra Picardi, Nicoletta Sacchi, Gottardo De Angelis, Marco Andreani, Anna Chierichini, Laura Cudillo, Fabio Di Piazza, Francesca Bonifazi, Raffaella Cerretti, Simona Pollichieni, Maria Cristina Tirindelli, Ilaria Mangione, Antonella Ferrari, Teresa Dentamaro, Renato Marciano, and Anna Maria Gallina
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Immunology ,Hematology ,Histocompatibility Testing ,Human leukocyte antigen ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Unrelated Donor ,030220 oncology & carcinogenesis ,Cord blood ,Internal medicine ,medicine ,Hematologic malignancy ,Immunology and Allergy ,Bone Marrow Donors Worldwide ,Bone marrow ,Young adult ,business ,030215 immunology - Abstract
BACKGROUND From 2011 to 2014, a total of 71% of the 3834 patients with hematologic malignancies successfully identified a matched unrelated donor (MUD) through the Italian Bone Marrow Donor Registry (IBMDR), corresponding to a transplant efficiency of 62%. STUDY DESIGN AND METHODS From 2006, the Rome Transplant Network (RTN) followed a hierarchical selection strategy for the alternative donor search: first MUD, second cord blood, and third haploidentical donor. Using a low-resolution HLA, a preliminary query (PQ) was performed in all cases with assignment of good or poor score if more or less than 10 MUDs were identified in Bone Marrow Donors Worldwide. Herein we assessed the utility of PQ and of high-resolution (HR) HLA from the start of the search. Moreover, we compared the donor identification and the transplant efficiency between IBMDR and RTN. RESULTS At RTN 79% of 417 patients met a good PQ with a 50% MUD identification versus 12.5% with poor PQ. Our policy led to 78 and 74% of alternative donor identification and transplant efficiency, respectively, higher than IBMDR data equal to 71% (p = 0.007) and 62% (p
- Published
- 2017