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10 results on '"Fan, Zhiwei"'

5. Polymer Topology Reinforced Synergistic Interactions among Nanoscale Molecular Clusters for Impact Resistance with Facile Processability and Recoverability

Author

Yin, Jia‐Fu, primary, Xiao, Haiyan, additional, Xu, Peidong, additional, Yang, Junsheng, additional, Fan, Zhiwei, additional, Ke, Yubin, additional, Ouyang, Xikai, additional, Liu, Geng Xin, additional, Sun, Tao Lin, additional, Tang, Liqun, additional, Cheng, Stephen Z. D., additional, and Yin, Panchao, additional

Published
2021
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10. UHPLC-MS/MS determination and pharmacokinetic study of plantamajoside in rat plasma after oral administration of single plantamajoside and Plantago asiatica extract.

Author

Bai L, Han L, Lu X, Kang X, Fan Z, Xing R, and Zhou D

Subjects
Administration, Oral, Animals, Catechols administration & dosage, Chromatography, High Pressure Liquid methods, Drug Stability, Glucosides administration & dosage, Limit of Detection, Male, Plant Extracts administration & dosage, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Solid Phase Extraction, Tandem Mass Spectrometry methods, Catechols blood, Catechols pharmacokinetics, Glucosides blood, Glucosides pharmacokinetics, Plant Extracts pharmacokinetics, Plantago chemistry
Abstract

A sensitive and reliable ultra-high performance liquid chromatography coupled with tandem quadrupole mass spectrometry (UHPLC-MS/MS) method was developed for quantitation of plantamajoside in rat plasma. First, this study compared the pharmacokinetic properties of plantamajoside after oral administration of Plantago asiatica extract and pure plantamajoside in rat plasma with approximately the same dosage of 8.98 mg/kg. Second, chromatographic separation was performed on an Acquity HSS C 18 column (50 × 2.1 mm, p.d.1.7 μm) with isocratic elution using methanol-water (80:20, v/v) as mobile phase at a flow rate of 0.25 mL/min. The calibration curves were linear over the range of 0.1-100 ng/mL for plantamajoside. At different time points (0, 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, 6 and 8 h) after administration, the concentrations of plantamajoside in plasma were measured and the main pharmacokinetic parameters were estimated. The study indicates that the pharmacokinetics of plantamajoside in rat plasma have significant differences between two groups., (Copyright © 2016 John Wiley & Sons, Ltd.)

Published
2017
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