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3. A pilot trial of neoadjuvant pyrotinib plus trastuzumab, dalpiciclib, and letrozole for triple‐positive breast cancer

Author

Shiwen Huo, Jinqi Xue, Shuo Wang, Huilian Shan, Guanglei Chen, Nan Niu, Yimin Wang, Fang Qiu, Yi Zhao, Fei Xing, Xinyu Zheng, Wei Tu, Ke Li, Hai Zhao, Meiyue Tang, Qianshi Xu, Chao Liu, Yafei Zhao, Xiaofan Jiang, Zheng Pang, Keliang Zhang, Dianlong Zhang, Zhe‐Sheng Chen, and Caigang Liu

Subjects
dalpiciclib, letrozole, neoadjuvant therapy, pyrotinib, trastuzumab, triple‐positive breast cancer, Medicine
Abstract

Abstract Triple‐positive breast cancer (TPBC) poorly responds to current standard neoadjuvant therapy (trastuzumab plus pertuzumab and chemotherapy). Our previous MUKDEN 01 study showed a promising total pathological complete response (tpCR) rate of 30.4% with neoadjuvant pyrotinib (pan‐human epidermal growth factor receptor tyrosine kinase inhibitor) plus dalpiciclib (cyclin‐dependent kinase 4/6 inhibitor) and letrozole, but the efficacy remains suboptimal. This pilot study (NCT05228951) explored adding trastuzumab to this triplet neoadjuvant regimen in patients with stage II–III TPBC. The primary endpoint was tpCR (ypT0/is, ypN0) rate. Between February 2022 and June 2022, 12 patients were enrolled, and seven (58%; 95% confidence interval [CI], 27.7%–84.8%) patients achieved tpCR. The rate of residual cancer burden (RCB) 0–I was 75% (95% CI, 46.8%–91.1%). The objective response rate (ORR) was 92% (95% CI, 64.6%–98.5%). Mean Ki‐67 level was significantly reduced from 45.0% (95% CI, 19.5%–70.5%) at baseline to 17.2% (95% CI, 0.7%–33.7%) after neoadjuvant therapy (p = 0.03). The most common grade 3 adverse events were diarrhea (four [33%]) and decreased neutrophil count (three [25%]). No grade 4 adverse events or treatment‐related deaths occurred. This four‐drug neoadjuvant regimen shows promising pathological response with an acceptable safety profile in patients with TPBC. A randomized controlled trial (NCT05638594) of this regimen is being conducted.

Published
2024
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7. The Effects of Biofeedback-based Stimulated Recall on Self-Regulated Online Learning: A Gender and Cognitive Taxonomy Perspective

Author

Zhai, X., Fang, Q., Dong, Y., Wei, Z., Yuan, J., Cacciolatti, L., and Yang, Y.

Subjects
Biofeedback, Stimulated Recall, Self-Regulated, Taxonomy, education
Abstract

Previous studies posited the effectiveness of Stimulated Recall (SR) by exposing learners to recorded videos enhancing their personal perceptions and authentic understanding of knowledge in an interactive classroom. However, few studies explored how SR is implemented in a relatively static context, e.g., online self-directed learning, or took human factors, e.g., cognitive style and gender, into consideration in such a context. To fill this gap, the current study, based on previous psychological research findings, aims to introduce biofeedback as a stimulus for learners to engage in retrospection regarding their learning behavior. A quasi-experimental design study was carried out over a 12-week set of EFL (English as a Foreign Language) self-regulated online reading activities. The participants consisted of an experimental group (54 undergraduate students) and a control group (52 undergraduate students) at one Chinese university. Pre-post tests on reading performance and their association with a specific cognitive taxonomy were assessed through a developed scale instrument, whereas physiological signals (e.g., gazing duration, verbal fixation and brain wave) were captured via eye-tracking and electroencephalograph (EEG) technology. The results emphasized that (a) students’ reading ability and cognitive hierarchy significantly improved through biofeedback. Moreover, (b) learners in single level-one cognitive hierarchic groups had significant improvements in both cognitive abilities and reading comprehension, whereas learners in multi-level hierarchic groups had no significant enhancements. Finally, (c) the optical data results and EEG reports showed that males favor procedural feedback and females have a preference for a conclusive assessment.

Published
2018

9. Method to describe the distribution of wind velocity and its application in wind resource evaluation

Author

Hai Zhou, Siyu Hu, Ji Wu, Fang Qin, Dengxuan Li, and Haikun Wei

Subjects
concentration degree, concentration period, renewable resource evaluation, wind power, Technology, Science
Abstract

Abstract A convenient and effective method based on vector analysis was proposed in this paper to quantitatively describe the pattern of the wind speed distribution curve. This method can accurately describe the steepness of the single‐peak curve by using two parameters of concentration degree (CD) and concentration period (CP). Through the analysis of wind speed data in China over the past 40 years, this paper found that regional wind resources with larger CD were poorer, while regional wind resources with larger CP were richer. In addition, there were obvious cubic relationships between the CP and the average wind power density. These two parameters could reflect the richness of wind energy and realize the comparisons of wind resources across time and scales. In comparison with conventional approaches, this method is simpler and avoids fitting process, which has broad promotion prospects in the field of power grids.

Published
2022
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13. The basic physics of the binary black hole merger GW150914

Author

Abbott, B., Abbott, R., Abbott, T., Abernathy, M., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R., Adya, V., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O., Aiello, L., Ain, A., Ajith, P., Allen, B., Allocca, A., Altin, P., Anderson, S., Anderson, W., Arai, K., Araya, M., Arceneaux, C., Areeda, J., Arnaud, N., Arun, K., Ascenzi, S., Ashton, G., Ast, S., Aston, S., Astone, P., Aufmuth, P., Aulbert, C., Babak, S., Bacon, P., Bader, M., Baker, P., Baldaccini, F., Ballardin, G., Ballmer, S., Barayoga, J., Barclay, S., Barish, B., Barker, D., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J., Baune, C., Bavigadda, V., Bazzan, M., Bejger, M., Bell, A., Berger, B., Bergmann, G., Berry, C., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I., Billingsley, G., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M., Blackburn, J., Blair, C., Blair, D., Blair, R., Bloemen, S., Bock, O., Boer, M., Bogaert, G., Bogan, C., Bohe, A., Bond, C., Bondu, F., Bonnand, R., Boom, B., Bork, R., Boschi, V., Bose, S., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P., Braginsky, V., Branchesi, M., Brau, J., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Broida, J., Brooks, A., Brown, D., Brown, N., Brunett, S., Buchanan, C., Buikema, A., Bulik, T., Bulten, H., Buonanno, A., Buskulic, D., Buy, C., Byer, R., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Calderón Bustillo, J., Callister, T., Calloni, E., Camp, J., Cannon, K., Cao, J., Capano, C., Capocasa, E., Carbognani, F., Caride, S., Casanueva Diaz, J., Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C., Cerboni Baiardi, L., Cerretani, G., Cesarini, E., Chamberlin, S., Chan, M., Chao, S., Charlton, P., Chassande-Mottin, E., Cheeseboro, B., Chen, H., Chen, Y., Cheng, C., Chincarini, A., Chiummo, A., Cho, H., Cho, M., Chow, J., Christensen, N., Chu, Q., Chua, S., Chung, S., Ciani, G., Clara, F., Clark, J., Cleva, F., Coccia, E., Cohadon, P., Colla, A., Collette, C., Cominsky, L., Constancio, M., Conte , A., Conti, L., Cook, D., Corbitt, T., Cornish, N., Corsi, A., Cortese, S., Costa, C., Coughlin, M., Coughlin, S., Coulon, J., Countryman, S., Couvares, P., Cowan, E., Coward, D., Cowart, M., Coyne, D., Coyne, R., Craig, K., Creighton, J., Cripe, J., Crowder, S., Cumming, A., Cunningham, L., Cuoco, E., Dal Canton, T., Danilishin, S., D’Antonio, S., Danzmann, K., Darman, N., Dasgupta, A., Da Silva Costa, C., Dattilo, V., Dave, I., Davier, M., Davies, G., Daw, E., Day, R., De, S., DeBra, D., Debreczeni, G., Degallaix, J., De Laurentis, M., Deléglise, S., Del Pozzo, W., Denker, T., Dent, T., Dergachev, V., DeRosa, R., DeSalvo, R., Devine, R., Dhurandhar, S., Díaz, M., Fiore, L., Giovanni, M., Girolamo, T., Lieto, A., Pace, S., Palma, I., Virgilio, A., Dolique, V., Donovan, F., Dooley, K., Doravari, S., Douglas, R., Downes, T., Drago, M., Drever, R., Driggers, J., Ducrot, M., Dwyer, S., Edo, T., Edwards, M., Effler, A., Eggenstein, H., Ehrens, P., Eichholz, J., Eikenberry, S., Engels, W., Essick, R., Etzel, T., Evans, M., Evans, T., Everett, R., Factourovich, M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Fang, Q., Farinon, S., Farr, B., Farr, W., Favata, M., Fays, M., Fehrmann, H., Fejer, M., Fenyvesi, E., Ferrante, I., Ferreira, E., Ferrini, F., Fidecaro, F., Fiori, I., Fiorucci, D., Fisher, R., Flaminio, R., Fletcher, M., Fong, H., Fournier, J., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fritschel, P., Frolov, V., Fulda, P., Fyffe, M., Gabbard, H., Gair, J., Gammaitoni, L., Gaonkar, S., Garufi, F., Gaur, G., Gehrels, N., Gemme, G., Geng, P., Genin, E., Gennai, A., George, J., Gergely, L., Germain, V., Ghosh, A., Ghosh, S., Giaime, J., Giardina, K., Giazotto, A., Gill, K., Glaefke, A., Goetz, E., Goetz, R., Gondan, L., González, G., Castro, J., Gopakumar, A., Gordon, N., Gorodetsky, M., Gossan, S., Gosselin, M., Gouaty, R., Grado, A., Graef, C., Graff, P., Granata, M., Grant, A., Gras, S., Gray, C., Greco, G., Green, A., Groot, P., Grote, H., Grunewald, S., Guidi, G., Guo, X., Gupta, A., Gupta, M., Gushwa, K., Gustafson, E., Gustafson, R., Hacker, J., Hall, B., Hall, E., Hamilton, H., Hammond, G., Haney, M., Hanke, M., Hanks, J., Hanna, C., Hannam, M., Hanson, J., Hardwick, T., Harms, J., Harry, G., Harry, I., Hart, M., Hartman, M., Haster, C., Haughian, K., Healy, J., Heidmann, A., Heintze, M., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I., Hennig, J., Henry, J., Heptonstall, A., Heurs, M., Hild, S., Hoak, D., Hofman, D., Holt, K., Holz, D., Hopkins, P., Hough, J., Houston, E., Howell, E., Hu, Y., Huang, S., Huerta, E., Huet, D., Hughey, B., Husa, S., Huttner, S., Huynh-Dinh, T., Indik, N., Ingram, D., Inta, R., Isa, H., Isac, J., Isi, M., Isogai, T., Iyer, B., Izumi, K., Jacqmin, T., Jang, H., Jani, K., Jaranowski, P., Jawahar, S., Jian, L., Jiménez-Forteza, F., Johnson, W., Johnson-McDaniel, N., Jones, D., Jones, R., Jonker, R., Ju, L., K, H., Kalaghatgi, C., Kalogera, V., Kandhasamy, S., Kang, G., Kanner, J., Kapadia, S., Karki, S., Karvinen, K., Kasprzack, M., Katsavounidis, E., Katzman, W., Kaufer, S., Kaur, T., Kawabe, K., Kéfélian, F., Kehl, M., Keitel, D., Kelley, D., Kells, W., Kennedy, R., Key, J., Khalili, F., Khan, I., Khan, S., Khan, Z., Khazanov, E., Kijbunchoo, N., Kim, C., Kim, J., Kim, K., Kim, N., Kim, W., Kim, Y., Kimbrell, S., King, E., King, P., Kissel, J., Klein, B., Kleybolte, L., Klimenko, S., Koehlenbeck, S., Koley, S., Kondrashov, V., Kontos, A., Korobko, M., Korth, W., Kowalska, I., Kozak, D., Kringel, V., Krishnan, B., Królak, A., Krueger, C., Kuehn, G., Kumar, P., Kumar, R., Kuo, L., Kutynia, A., Lackey, B., Landry, M., Lange, J., Lantz, B., Lasky, P., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E., Lee, C., Lee, H., Lee, K., Lenon, A., Leonardi, M., Leong, J., Leroy, N., Letendre, N., Levin, Y., Lewis, J., Li, T., Libson, A., Littenberg, T., Lockerbie, N., Lombardi, A., London, L., Lord, J., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J., Lousto, C., Lück, H., Lundgren, A., Lynch, R., Ma, Y., Machenschalk, B., MacInnis, M., Macleod, D., Magaña-Sandoval, F., Magaña Zertuche, L., Magee, R., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Mandel, I., Mandic, V., Mangano, V., Mansell, G., Manske, M., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A., Maros, E., Martelli, F., Martellini, L., Martin, I., Martynov, D., Marx, J., Mason, K., Masserot, A., Massinger, T., Masso-Reid, M., Mastrogiovanni, S., Matichard, F., Matone, L., Mavalvala, N., Mazumder, N., McCarthy, R., McClelland, D., McCormick, S., McGuire, S., McIntyre, G., McIver, J., McManus, D., McRae, T., McWilliams, S., Meacher, D., Meadors, G., Meidam, J., Melatos, A., Mendell, G., Mercer, R., Merilh, E., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P., Mezzani, F., Miao, H., Michel, C., Middleton, H., Mikhailov, E., Milano, L., Miller, A., Miller, B., Miller, J., Millhouse, M., Minenkov, Y., Ming, J., Mirshekari, S., Mishra, C., Mitra, S., Mitrofanov, V., Mitselmakher, G., Mittleman, R., Moggi, A., Mohan, M., Mohapatra, S., Montani, M., Moore, B., Moore, C., Moraru, D., Moreno, G., Morriss, S., Mossavi, K., Mours, B., Mow-Lowry, C., Mueller, G., Muir, A., Mukherjee, A., Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Murphy, D., Murray, P., Mytidis, A., Nardecchia, I., Naticchioni, L., Nayak, R., Nedkova, K., Nelemans, G., Nelson, T., Neri, M., Neunzert, A., Newton, G., Nguyen, T., Nielsen, A., Nissanke, S., Nitz, A., Nocera, F., Nolting, D., Normandin, M., Nuttall, L., Oberling, J., Ochsner, E., O’Dell, J., Oelker, E., Ogin, G., Oh, J., Oh, S., Ohme, F., Oliver, M., Oppermann, P., Oram, R., O’Reilly, B., O’Shaughnessy, R., Ottaway, D., Overmier, H., Owen, B., Pai, A., Pai, S., Palamos, J., Palashov, O., Palomba, C., Pal-Singh, A., Pan, H., Pankow, C., Pannarale, F., Pant, B., Paoletti, F., Paoli, A., Papa, M., Paris, H., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Patrick, Z., Pearlstone, B., Pedraza, M., Pedurand, R., Pekowsky, L., Pele, A., Penn, S., Perreca, A., Perri, L., Pfeiffer, H., Phelps, M., Piccinni, O., Pichot, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I., Pitkin, M., Poe, M., Poggiani, R., Popolizio, P., Post, A., Powell, J., Prasad, J., Predoi, V., Prestegard, T., Price, L., Prijatelj, M., Principe, M., Privitera, S., Prix, R., Prodi, G., Prokhorov, L., Puncken, O., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Qin, J., Qiu, S., Quetschke, V., Quintero, E., Quitzow-James, R., Raab, F., Rabeling, D., Radkins, H., Raffai, P., Raja, S., Rajan, C., Rakhmanov, M., Rapagnani, P., Raymond, V., Razzano, M., Re, V., Read, J., Reed, C., Regimbau, T., Rei, L., Reid, S., Reitze, D., Rew, H., Reyes, S., Ricci, F., Riles, K., Rizzo, M., Robertson, N., Robie, R., Robinet, F., Rocchi, A., Rolland, L., Rollins, J., Roma, V., Romano, J., Romano, R., Romanov, G., Romie, J., Rosińska, D., Rowan, S., Rudiger, A., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadeghian, L., Sakellariadou, M., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sammut, L., Sanchez, E., Sandberg, V., Sandeen, B., Sanders, J., Sassolas, B., Sathyaprakash, B., Saulson, P., Sauter, O., Savage, R., Sawadsky, A., Schale, P., Schilling, R., Schmidt, J., Schmidt, P., Schnabel, R., Schofield, R., Schönbeck, A., Schreiber, E., Schuette, D., Schutz, B., Scott, J., Scott, S., Sellers, D., Sengupta, A., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D., Shaffer, T., Shahriar, M., Shaltev, M., Shapiro, B., Shawhan, P., Sheperd, A., Shoemaker, D., Siellez, K., Siemens, X., Sieniawska, M., Sigg, D., Silva, A., Singer, A., Singer, L., Singh, A., Singh, R., Singhal, A., Sintes, A., Slagmolen, B., Smith, J., Smith, N., Smith, R., Son, E., Sorazu, B., Sorrentino, F., Souradeep, T., Srivastava, A., Staley, A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stephens, B., Stevenson, S., Stone, R., Strain, K., Straniero, N., Stratta, G., Strauss, N., Strigin, S., Sturani, R., Stuver, A., Summerscales, T., Sun, L., Sunil, S., Sutton, P., Swinkels, B., Szczepańczyk, M., Tacca, M., Talukder, D., Tanner, D., Tápai, M., Tarabrin, S., Taracchini, A., Taylor, R., Theeg, T., Thirugnanasambandam, M., Thomas, E., Thomas, M., Thomas, P., Thorne, K., Thrane, E., Tiwari, S., Tiwari, V., Tokmakov, K., Toland, K., Tomlinson, C., Tonelli, M., Tornasi, Z., Torres, C., Torrie, C., Töyrä, D., Travasso, F., Traylor, G., Trifirò, D., Tringali, M., Trozzo, L., Tse, M., Turconi, M., Tuyenbayev, D., Ugolini, D., Unnikrishnan, C., Urban, A., Usman, S., Vahlbruch, H., Vajente, G., Valdes, G., Vallisneri, M., van Bakel, N., van Beuzekom, M., van den Brand, J., Broeck, C., Vander-Hyde, D., van der Schaaf, L., van Heijningen, J., van Veggel, A., Vardaro, M., Vass, S., Vasúth, M., Vaulin, R., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P., Venkateswara, K., Verkindt, D., Vetrano, F., Viceré, A., Vinciguerra, S., Vine, D., Vinet, J., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Voss, D., Vousden, W., Vyatchanin, S., Wade, A., Wade, L., Wade, M., Walker, M., Wallace, L., Walsh, S., Wang, G., Wang, H., Wang, M., Wang, X., Wang, Y., Ward, R., Warner, J., Was, M., Weaver, B., Wei, L., Weinert, M., Weinstein, A., Weiss, R., Wen, L., Weßels, P., Westphal, T., Wette, K., Whelan, J., Whiting, B., Williams, R., Williamson, A., Willis, J., Willke, B., Wimmer, M., Winkler, W., Wipf, C., Wittel, H., Woan, G., Woehler, J., Worden, J., Wright, J., Wu, D., Wu, G., Yablon, J., Yam, W., Yamamoto, H., Yancey, C., Yu, H., Yvert, M., Zadrożny, A., Zangrando, L., Zanolin, M., Zevin, J., Zevin, L., Zhang, L., Zhang, Y., Zhao, Y., Zhao, M., Zhou, M., Zhou, X., (Astro)-Particles Physics, Abbott, B. P., Abbott, R., Abbott, T. D., Abernathy, M. R., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, B., Allocca, A., Altin, P. A., Anderson, S. B., Anderson, W. G., Arai, K., Araya, M. C., Arceneaux, C. C., Areeda, J. S., Arnaud, N., Arun, K. G., Ascenzi, S., Ashton, G., Ast, M., Aston, S. M., Astone, P., Aufmuth, P., Aulbert, C., Babak, S., Bacon, P., Bader, M. K. M., Baldaccini, F., Ballardin, G., Ballmer, S. W., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Baune, C., Bavigadda, V., Bazzan, M., Bejger, M., Bell, A. S., Bergmann, G., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. A., Billingsley, G., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bloemen, S., Bock, O., Boer, M., Bogaert, G., Bogan, C., Bohe, A., Bond, C., Bondu, F., Bonnand, R., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bouffanais, Y., Bozzi, A., Bradaschia, C., Braginsky, V. B., BRANCHESI, MARICA, Brau, J. E., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Broida, J. E., Brooks, A. F., Brown, D. A., Brown, D. D., Brown, N. M., Brunett, S., Buchanan, C. C., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Buy, C., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callister, T., Calloni, E., Camp, J. B., Cannon, K. C., Cao, J., Capano, C. D., Capocasa, E., Carbognani, F., Caride, S., Casanueva Diaz, J., Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. B., CERBONI BAIARDI, LORENZO, Cerretani, G., Cesarini, E., Chamberlin, S. J., Chan, M., Chao, S., Charlton, P., Chassande Mottin, E., Chen, H. Y., Chen, Y., Cheng, C., Chincarini, A., Chiummo, A., Cho, H. S., Cho, M., Chow, J. H., Christensen, N., Chu, Q., Chua, S., Chung, S., Ciani, G., Clara, F., Clark, J. A., Cleva, F., Coccia, E., Cohadon, P. F., Colla, A., Collette, C. G., Cominsky, L., Constancio, M., Conte, A., Conti, L., Cook, D., Corbitt, T. R., Corsi, A., Cortese, S., Costa, C. A., Coughlin, M. W., Coughlin, S. B., Coulon, J. P., Countryman, S. T., Couvares, P., Cowan, E. E., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Cripe, J., Crowder, S. G., Cumming, A., Cunningham, L., Cuoco, E., Dal Canton, T., Danilishin, S. L., D'Antonio, S., Danzmann, K., Darman, N. S., Dasgupta, A., Da Silva Costa, C. F., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Daw, E. J., Day, R., De, S., Debra, D., Debreczeni, G., Degallaix, J., De Laurentis, M., Deléglise, S., Del Pozzo, W., Denker, T., Dent, T., Dergachev, V., De Rosa, R., Derosa, R. T., Desalvo, R., Devine, R. C., Dhurandhar, S., Díaz, M. C., Fiore, L. Di, Giovanni, M. Di, Girolamo, T. Di, Lieto, A. Di, Pace, S. Di, Palma, I. Di, Virgilio, A. Di, Dolique, V., Donovan, F., Dooley, K. L., Doravari, S., Douglas, R., Downes, T. P., Drago, M., Drever, R. W. P., Driggers, J. C., Ducrot, M., Dwyer, S. E., Edo, T. B., Edwards, M. C., Effler, A., Eggenstein, H. B., Ehrens, P., Eichholz, J., Eikenberry, S. S., Engels, W., Essick, R. C., Etzel, T., Evans, M., Evans, T. M., Everett, R., Factourovich, M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Fang, Q., Farinon, S., Farr, B., Farr, W. M., Favata, M., Fays, M., Fehrmann, H., Fejer, M. M., Fenyvesi, E., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Fiori, I., Fiorucci, D., Fisher, R. P., Flaminio, R., Fletcher, M., Fournier, J. D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fritschel, P., Frolov, V. V., Fulda, P., Fyffe, M., Gabbard, H. A. G., Gair, J. R., Gammaitoni, L., Gaonkar, S. G., Garufi, F., Gaur, G., Gehrels, N., Gemme, G., Geng, P., Genin, E., Gennai, A., George, J., Gergely, L., Germain, V., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giaime, J. A., Giardina, K. D., Giazotto, A., Gill, K., Glaefke, A., Goetz, E., Goetz, R., Gondan, L., González, G., Gonzalez Castro, J. M., Gopakumar, A., Gordon, N. A., Gorodetsky, M. L., Gossan, S. E., Gosselin, M., Gouaty, R., Grado, A., Graef, C., Graff, P. B., Granata, M., Grant, A., Gras, S., Gray, C., GRECO, GIUSEPPE, Green, A. C., Groot, P., Grote, H., Grunewald, S., GUIDI, GIANLUCA MARIA, Guo, X., Gupta, A., Gupta, M. K., Gushwa, K. E., Gustafson, E. K., Gustafson, R., Hacker, J. J., Hall, B. R., Hall, E. D., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hanson, J., Hardwick, T., HARMS, JAN, Harry, G. M., Harry, I. W., Hart, M. J., Hartman, M. T., Haster, C. J., Haughian, K., Heidmann, A., Heintze, M. C., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennig, J., Henry, J., Heptonstall, A. W., Heurs, M., Hild, S., Hoak, D., Hofman, D., Holt, K., Holz, D. E., Hopkins, P., Hough, J., Houston, E. A., Howell, E. J., Hu, Y. M., Huang, S., Huerta, E. A., Huet, D., Hughey, B., Husa, S., Huttner, S. H., Huynh Dinh, T., Indik, N., Ingram, D. R., Inta, R., Isa, H. N., Isac, J. M., Isi, M., Isogai, T., Iyer, B. R., Izumi, K., Jacqmin, T., Jang, H., Jani, K., Jaranowski, P., Jawahar, S., Jian, L., Jiménez Forteza, F., Johnson, W. W., Jones, D. I., Jones, R., Jonker, R. J. G., Ju, L., K, Hari, Kalaghatgi, C. V., Kalogera, V., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Karki, S., Karvinen, K. S., Kasprzack, M., Katsavounidis, E., Katzman, W., Kaufer, S., Kaur, T., Kawabe, K., Kéfélian, F., Kehl, M. S., Keitel, D., Kelley, D. B., Kells, W., Kennedy, R., Key, J. S., Khalili, F. Y., Khan, I., Khan, S., Khan, Z., Khazanov, E. A., Kijbunchoo, N., Kim, Chi Woong, Kim, Chunglee, Kim, J., Kim, K., Kim, N., Kim, W., Kim, Y. M., Kimbrell, S. J., King, E. J., King, P. J., Kissel, J. S., Klein, B., Kleybolte, L., Klimenko, S., Koehlenbeck, S. M., Koley, S., Kondrashov, V., Kontos, A., Korobko, M., Korth, W. Z., Kowalska, I., Kozak, D. B., Kringel, V., Krishnan, B., Królak, A., Krueger, C., Kuehn, G., Kumar, P., Kumar, R., Kuo, L., Kutynia, A., Lackey, B. D., Landry, M., Lange, J., Lantz, B., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E. O., Lee, C. H., Lee, H. K., Lee, H. M., Lee, K., Lenon, A., Leonardi, M., Leong, J. R., Leroy, N., Letendre, N., Levin, Y., Lewis, J. B., Li, T. G. F., Libson, A., Littenberg, T. B., Lockerbie, N. A., Lombardi, A. L., London, L. T., Lord, J. E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lück, H., Lundgren, A. P., Lynch, R., Ma, Y., Machenschalk, B., Macinnis, M., Macleod, D. M., Magaña Sandoval, F., Zertuche, L. Magaña, Magee, R. M., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A. S., Maros, E., MARTELLI, FILIPPO, Martellini, L., Martin, I. W., Martynov, D. V., Marx, J. N., Mason, K., Masserot, A., Massinger, T. J., Masso Reid, M., Mastrogiovanni, S., Matichard, F., Matone, L., Mavalvala, N., Mazumder, N., Mccarthy, R., Mcclelland, D. E., Mccormick, S., Mcguire, S. C., Mcintyre, G., Mciver, J., Mcmanus, D. J., Mcrae, T., Meacher, D., Meadors, G. D., Meidam, J., Melatos, A., Mendell, G., Mercer, R. A., Merilh, E. L., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Mezzani, F., Miao, H., Michel, C., Middleton, H., Mikhailov, E. E., Milano, L., Miller, A. L., Miller, A., Miller, B. B., Miller, J., Millhouse, M., Minenkov, Y., Ming, J., Mirshekari, S., Mishra, C., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Moggi, A., Mohan, M., Mohapatra, S. R. P., MONTANI, MATTEO, Moore, B. C., Moore, C. J., Moraru, D., Moreno, G., Morriss, S. R., Mossavi, K., Mours, B., Mow Lowry, C. M., Mueller, G., Muir, A. W., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Murphy, D. J., Murray, P. G., Mytidis, A., Nardecchia, I., Naticchioni, L., Nayak, R. K., Nedkova, K., Nelemans, G., Nelson, T. J. N., Neri, M., Neunzert, A., Newton, G., Nguyen, T. T., Nielsen, A. B., Nissanke, S., Nitz, A., Nocera, F., Nolting, D., Normandin, M. E. N., Nuttall, L. K., Oberling, J., Ochsner, E., O'Dell, J., Oelker, E., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Oliver, M., Oppermann, P., Oram, Richard J., O'Reilly, B., O'Shaughnessy, R., Ottaway, D. J., Overmier, H., Owen, B. J., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pal Singh, A., Pan, H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Papa, M. A., Paris, H. R., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Patrick, Z., Pearlstone, B. L., Pedraza, M., Pedurand, R., Pekowsky, L., Pele, A., Penn, S., Perreca, A., Perri, L. M., Phelps, M., Piccinni, O. J., Pichot, M., PIERGIOVANNI, FRANCESCO, Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Pitkin, M., Poe, M., Poggiani, R., Popolizio, P., Post, A., Powell, J., Prasad, J., Pratt, J., Predoi, V., Prestegard, T., Price, L. R., Prijatelj, M., Principe, M., Privitera, S., Prix, R., Prodi, G. A., Prokhorov, L., Puncken, O., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Qin, J., Qiu, S., Quetschke, V., Quintero, E. A., Quitzow James, R., Raab, F. J., Rabeling, D. S., Radkins, H., Raffai, P., Raja, S., Rajan, C., Rakhmanov, M., Rapagnani, P., Raymond, V., Razzano, M., Re, V., Read, J., Reed, C. M., Regimbau, T., Rei, L., Reid, S., Rew, H., Reyes, S. D., Ricci, F., Riles, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rolland, L., Rollins, J. G., Roma, V. J., Romano, J. D., Romano, R., Romanov, G., Romie, J. H., Rosińska, D., Rowan, S., Rüdiger, A., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadeghian, L., Sakellariadou, M., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sammut, L., Sanchez, E. J., Sandberg, V., Sandeen, B., Sanders, J. R., Sassolas, B., Saulson, P. R., Sauter, O. E. S., Savage, R. L., Sawadsky, A., Schale, P., Schilling, R., Schmidt, J., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schuette, D., Schutz, B. F., Scott, J., Scott, S. M., Sellers, D., Sengupta, A. S., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D. A., Shaffer, T., Shahriar, M. S., Shaltev, M., Shapiro, B., Shawhan, P., Sheperd, A., Shoemaker, D. H., Shoemaker, D. M., Siellez, K., Siemens, X., Sieniawska, M., Sigg, D., Silva, A. D., Singer, A., Singer, L. P., Singh, A., Singh, R., Singhal, A., Sintes, A. M., Slagmolen, B. J. J., Smith, J. R., Smith, N. D., Smith, R. J. E., Son, E. J., Sorazu, B., Sorrentino, F., Souradeep, T., Srivastava, A. K., Staley, A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stephens, B. C., Stone, R., Strain, K. A., Straniero, N., STRATTA, MARIA GIULIANA, Strauss, N. A., Strigin, S., Sturani, R., Stuver, A. L., Summerscales, T. Z., Sun, L., Sunil, S., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Talukder, D., Tanner, D. B., Tápai, M., Tarabrin, S. P., Taracchini, A., Taylor, R., Theeg, T., Thirugnanasambandam, M. P., Thomas, E. G., Thomas, M., Thomas, P., Thorne, K. A., Thorne, K. S., Thrane, E., Tiwari, S., Tiwari, V., Tokmakov, K. V., Toland, K., Tomlinson, C., Tonelli, M., Tornasi, Z., Torres, C. V., Torrie, C. I., Töyrä, D., Travasso, F., Traylor, G., Trifirò, D., Tringali, M. C., Trozzo, L., Tse, M., Turconi, M., Tuyenbayev, D., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Vahlbruch, H., Vajente, G., Valdes, G., van Bakel, N., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., Vander Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., van Veggel, A. A., Vardaro, M., Vass, S., Vasúth, M., Vaulin, R., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Verkindt, D., VETRANO, FLAVIO, VICERE', ANDREA, Vinciguerra, S., Vine, D. J., Vinet, J. Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Voss, D. V., Vousden, W. D., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walker, M., Wallace, L., Walsh, S., Wang, G., Wang, H., Wang, M., Wang, X., Wang, Y., Ward, R. L., Warner, J., Was, M., Weaver, B., Wei, L. W., Weinert, M., Weinstein, A. J., Weiss, R., Wen, L., Weßels, P., Westphal, T., Wette, K., Whelan, J. T., Whiting, B. F., Williams, R. D., Williamson, A. R., Willis, J. L., Willke, B., Wimmer, M. H., Winkler, W., Wipf, C. C., Wiseman, A. G., Wittel, H., Woan, G., Woehler, J., Worden, J., Wright, J. L., Wu, D. S., Wu, G., Yablon, J., Yam, W., Yamamoto, H., Yancey, C. C., Yu, H., Yvert, M., Zadrożny, A., Zangrando, L., Zanolin, M., Zendri, J. P., Zevin, M., Zhang, L., Zhang, M., Zhang, Y., Zhao, C., Zhou, M., Zhou, Z., Zhu, X. J., Zucker, M. E., Zuraw, S. E., Zweizig, J., Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique de Rennes ( IPR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), VIRGO, Ligo, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Országos Tudományos Kutatási Alapprogramok, Scottish Universities Physics Alliance, Natural Sciences and Engineering Research Council of Canada, Science and Technology Facilities Council, European Commission, Council of Scientific and Industrial Research, Fundação de Amparo à Pesquisa do Estado de São Paulo, Australian Research Council, Narodowe Centrum Nauki, National Science Foundation, National Research Foundation of Korea, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Russian Foundation for Basic Research, Department of Science and Technology, Government of Kerala, Branchesi, M., Calloni, Enrico, Cerboni Baiardi, L., DE LAURENTIS, Martina, DE ROSA, Rosario, Fiore, L., Di Giovanni, M., DI GIROLAMO, Tristano, Di Lieto, A., Di Pace, S. Di, Garufi, Fabio, Greco, G., Guidi, G. M., Harms, J., Martelli, F., Milano, Leopoldo, Montani, M., Piergiovanni, F., Stratta, G., Vetrano, F., Viceré, A., The LIGO Scientific Collaboration, The Virgo Collaboration, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Black holes, Gravitational waves, GW150914, General Relativity and Quantum Cosmology, Physics and Astronomy (all), Gravitational-wave observatory, Black hole, General relativity, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, WAVES, GRAVITATIONAL-RADIATION, Gravitational Wave, FOS: Physical sciences, General Physics and Astronomy, General Relativity and Quantum Cosmology (gr-qc), Astrophysics, 01 natural sciences, [ PHYS.GRQC ] Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], MAXIMUM MASS, Binary black hole, 0103 physical sciences, Waveform, First Detection, 010306 general physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), QC, QB, Gravitational Waves, Physics, 010308 nuclear & particles physics, Gravitational wave, Detector, PULSAR, Interferometry, Physics and Astronomy, GW150914, Gravitational Waves, First Detection, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc]
Abstract

The first direct gravitational-wave detection was made by the Advanced Laser Interferometer Gravitational Wave Observatory on September 14, 2015. The GW150914 signal was strong enough to be apparent, without using any waveform model, in the filtered detector strain data. Here, features of the signal visible in the data are analyzed using concepts from Newtonian physics and general relativity, accessible to anyone with a general physics background. The simple analysis presented here is consistent with the fully general-relativistic analyses published elsewhere,in showing that the signal was produced by the inspiral and subsequent merger of two black holes. The black holes were each of approximately 35 Msun, still orbited each other as close as ~350 km apart, and subsequently merged to form a single black hole. Similar reasoning, directly from the data, is used to roughly estimate how far these black holes were from the Earth, and the energy that they radiated in gravitational waves., Comment: updated to match published version

Published
2016

14. PML absorbing boundary conditions for the linearized and nonlinear Euler equations in the case of oblique mean flow

Author

Sarah Anne Parrish and Fang Q. Hu

Subjects
business.industry, Applied Mathematics, Mechanical Engineering, Mathematical analysis, Computational Mechanics, Oblique case, Computational fluid dynamics, Vorticity, Computer Science Applications, Euler equations, Nonlinear system, symbols.namesake, Perfectly matched layer, Mechanics of Materials, symbols, Mean flow, Boundary value problem, business, Mathematics
Abstract

For the case of uniform mean flow in an arbitrary direction, perfectly matched layer (PML) absorbing boundary conditions are presented for both the linearized and nonlinear Euler equations. Although linear perfectly matched side layers with an oblique mean flow have been studied in previous works, we propose in the present paper a construction of corner layer equations that are dynamically stable. Stability issues are investigated by examining the dispersion relations of linear waves supported by the corner layer equations. For increased efficiency, a pseudo mean flow is included in the derivation of the PML equations for the nonlinear case. Numerical examples are given to support the validity of the proposed equations. Specifically, the linear PML formulation is tested for the case of acoustic, vorticity, and entropy waves traveling with an oblique mean flow. The nonlinear formulation is tested with an isentropic vortex moving diagonally with a constant velocity. Copyright © 2008 John Wiley & Sons, Ltd.

Published
2009

15. Describing the quality of life of boys with haemophilia in China: Results of a multicentre study using the CHO-KLAT

Author

Tang, L., primary, Xu, W., additional, Li, C. G., additional, Hou, F., additional, Feng, X. Q., additional, Wang, H., additional, Li, X. J., additional, Li, W. L., additional, Liu, J. P., additional, Sun, L. R., additional, Wang, S. H., additional, Jin, J., additional, Fang, Q., additional, Luke, K. H., additional, Poon, M. C., additional, Blanchette, V. S., additional, Usuba, K., additional, Young, N. L., additional, and Wu, R., additional

Published
2017
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20. A novel gate driver for Si/SiC hybrid switch for multi‐objective optimization

Author

Zongjian Li, Xiaoping Dai, Xi Jiang, Fang Qi, Yang Liu, Pan Ke, Yongzhi Wang, and Jun Wang

Subjects
Power electronics, supply and supervisory circuits, Power semiconductor devices, Optimisation techniques, Control of electric power systems, Relays and switches, Electronics, TK7800-8360
Abstract

Abstract A novel gate driver with simple functional and structural integration is proposed here, which splits the input gate signal and outputs two separate signals with a dedicated delay time to drive the two constitutional switches, aiming at the cost‐effectiveness and power loss reduction of the Si/SiC hybrid switch. The dependency of the hybrid switch's thermal and efficiency performance on the parameters of the gate driver are theoretically and experimentally investigated in a 9 kW 20 kHz Si/SiC hybrid switch based boost converter. A novel load current dependent gate control strategy is proposed to be implemented in the proposed gate driver to achieve the high conversion efficiency under light to medium load condition and balanced junction temperature between the two internal devices under heavy load conditions. The experimental results based on a 20 kHz boost converter show that the Si/SiC hybrid switch with the novel gate driver and optimal current dependent control strategy offers a 163% and 10% rise in power handling capability, respectively, compared to that using the all‐IGBT device and all‐SiC MOSFET device, and yet a considerably lower device cost.

Published
2021
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21. Effects of different food ingredients on the color and absorption spectrum of carminic acid and carminic aluminum lake

Author

Qian Liu, Zhiyong He, Maomao Zeng, Fang Qin, Zhaojun Wang, Guoping Liu, and Jie Chen

Subjects
carminic acid, carminic aluminum lake, color, food additives, metal ions, protein, Nutrition. Foods and food supply, TX341-641
Abstract

Abstract In this study, three foodstuffs (surimi, minced meat, and milk) were dyed with carminic acid and carminic aluminum lake. The effects of protein, metal ions, and food additives on the color of carminic acid and carminic aluminum lake were investigated. After being dyed by carminic acid, the colors of surimi, minced meat, and milk were light purple, red, and gray‐green, respectively. When using carminic aluminum lake, surimi and milk were magenta, and minced meat was red. Regarding the carminic acid solution, the presence of myofibrillar protein (MFP), whey protein isolate (WPI), and soy protein isolate (SPI) turned it red by changing the pH, while the presence of casein made it orange. The carminic aluminum lake solution turned magenta in all four cases, which were not affected by protein. The color of carminic acid and carminic aluminum lake was significantly affected by 0.001–0.1 mol/L Fe3+, 0.001–0.1 mol/L Fe2+, 0.001–0.1 mol/L Cu2+, and 0.1 mol/L Ca2+, limiting their application in iron‐, copper‐, and high‐calcium foods. The color of carminic acid was changed to yellow by 0.01%‐1% sodium nitrite, but 0.01%–1% ascorbic acid and 0.01%–0.1% monascus color did not significantly affect the color of either carminic acid or carminic aluminum lake. This paper provides a reference for the application of carminic acid and carminic aluminum lake in food science.

Published
2021
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22. The Adaptive Characteristics of Cholesterol and Bile Acid Metabolism in Nile Tilapia Fed a High-Fat Diet

Author

Rui-Xin Li, Yi-Fan Qian, Wen-Hao Zhou, Jun-Xian Wang, Yan-Yu Zhang, Yuan Luo, Fang Qiao, Li-Qiao Chen, Mei-Ling Zhang, and Zhen-Yu Du

Subjects
Aquaculture. Fisheries. Angling, SH1-691
Abstract

Since high-fat diet (HFD) intake elevates liver cholesterol and enhanced cholesterol-bile acid flux alleviates its lipid deposition, we assumed that the promoted cholesterol-bile acid flux is an adaptive metabolism in fish when fed an HFD. The present study investigated the characteristic of cholesterol and fatty acid metabolism in Nile tilapia (Oreochromis niloticus) after feeding an HFD (13% lipid level) for four and eight weeks. Visually healthy Nile tilapia fingerlings (average weight 3.50±0.05 g) were randomly distributed into four treatments (4-week control diet or HFD and 8-week control diet or HFD). The liver lipid deposition and health statue, cholesterol/bile acid, and fatty acid metabolism were analyzed in fish after short-term and long-term HFD intake. The results showed that 4-week HFD feeding did not change serum alanine transaminase (ALT) and aspartate transferase (AST) enzyme activities, along with comparable liver malondialdehyde (MDA) content. But higher serum ALT and AST enzyme activities and liver MDA content were observed in fish fed 8-week HFD. Intriguingly, remarkably accumulated total cholesterol (mainly cholesterol ester, CE) was observed in the liver of fish fed 4-week HFD, along with slightly elevated free fatty acids (FFAs) and comparable TG contents. Further molecular analysis in the liver showed that obvious accumulation of CE and total bile acids (TBAs) in fish fed 4-week HFD was mainly attributed to the enhancement of cholesterol synthesis, esterification, and bile acid synthesis. Furthermore, the increased protein expressions of acyl-CoA oxidase 1/2 (Acox1 and Acox2), which serve as peroxisomal fatty acid β-oxidation (FAO) rate-limiting enzymes and play key roles in the transformation of cholesterol into bile acids, were found in fish after 4-week HFD intake. Notably, 8-week HFD intake remarkably elevated FFA content (about 1.7-fold increase), and unaltered TBAs were found in fish liver, accompanied by suppressed Acox2 protein level and cholesterol/bile acid synthesis. Therefore, the robust cholesterol-bile acid flux serves as an adaptive metabolism in Nile tilapia when fed a short-term HFD and is possibly via stimulating peroxisomal FAO. This finding enlightens our understanding on the adaptive characteristics of cholesterol metabolism in fish fed an HFD and provides a new possible treatment strategy against metabolic disease induced by HFD in aquatic animals.

Published
2022
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23. Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification

Author

Zheng Zha, Yi-Jiang Liu, Si-Si Liu, Nan Zhang, Jun-Ling Li, Fang Qi, Liang-Yun Jin, Bing Xue, Tao Yang, Yong-Ping Fan, Hui Zhao, and Lei Wang

Subjects
Pathology, RB1-214
Abstract

Background/Aims. Multiple sclerosis (MS) and neuromyelitis optica (NMO) are the most common autoimmune demyelinating diseases of the central nervous system (CNS), with some similar pathological and clinical features. Bu-Shen-Yi-Sui (BSYS) Capsule, a Chinese herbal prescription, has been shown to be a potential therapeutic agent for MS and NMO. However, its antidemyelination mechanism in inflammatory demyelinating diseases of the CNS has not been fully clarified. This study is aimed at exploring the key components and potential mechanism of BSYS in the treatment of CNS demyelinating disease (CNSD) based on network pharmacology. Methods. The potential active ingredients and corresponding potential targets of BSYS Capsule were obtained from the TCMSP, BATMAN-TCM, Swiss Target Prediction platform, and literature research. Disease targets of CNSD were explored through the GeneCards and the DisGeNET databases. The matching targets of BSYS in CNSD were identified from a Venn diagram. The protein-protein interaction (PPI) network was constructed using bioinformatics methods. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the mechanisms of BSYS. Furthermore, the neuroprotective effects of BSYS were evaluated using a cell model of hydrogen peroxide- (H2O2-) induced cell death in OLN-93 cells. Results. A total of 59 potential bioactive components of BSYS Capsule and 227 intersection targets were obtained. Topological analysis showed that AKT had the highest connectivity degrees in the PPI network. Enrichment analysis revealed that the targets of BSYS in the treatment of CNSD were the PI3K-Akt and MAPK signaling pathway, among other pathways. GO analysis results showed that the targets were associated with various biological processes, including apoptosis, reactive oxygen species metabolic process, and response to oxidative stress, among others. The experimental results demonstrated that BSYS drug-containing serum alleviated the H2O2-induced increase in LDH, MDA, and ROS levels and reversed the decrease in SOD and mitochondrial membrane potential induced by H2O2. BSYS treatment also decreased the number of TUNEL (+) cells, downregulated Bcl-2 expression, and upregulated Bax and c-caspase-3 expression by promoting Akt phosphorylation. Conclusion. BSYS Capsule alleviated H2O2-induced OLN-93 cell injury by increasing Akt phosphorylation to suppress oxidative stress and cell apoptosis. Therefore, BSYS can be potentially used for CNSD treatment. However, the results of this study are only derived from in vitro experiments, lacking the validation of in vivo animal models, which is a limitation of our study. We will further verify the underlying mechanisms of BSYS in animal experiments in the future.

Published
2022
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24. Numerical Simulation of Hot Stamping Forming of AZ Series Magnesium Alloys and Optimization of Die Process

Author

Fang Qian

Subjects
Chemistry, QD1-999
Abstract

In order to deal with the bottleneck of poor plasticity and low formability of magnesium alloys at room temperature, a numerical simulation and a die process optimization method based on hot stamping of AZ series magnesium alloys were proposed. Firstly, based on the PAM-STAMP finite element analysis platform, the thermomechanical coupling numerical simulation is carried out for the cross cup-shaped deep drawing, and the changes in the stress and temperature field during the forming process are analyzed. Aiming at the influence of various process parameters on the plastic formability of magnesium alloys, the effects of sheet metal shape, die fillet size, friction factor, and blank holder force on the forming quality were analyzed through experiments. The experimental results show that under the same conditions such as temperature and blank holder force, the numerical simulation method and the mold process optimized in this paper can be used to form parts that are 25% deeper than the traditional process, and the sheet material can be thinned to the maximum at this time. The amount is 0.152 mm, which verifies the correctness and superiority of the method and process in this paper.

Published
2022
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25. Pyruvate alleviates high glucose‐induced endoplasmic reticulum stress and apoptosis in HK‐2 cells

Author

Xiao Meng Zhang, Yi Zhen Wang, Jin Dong Tong, Xu Chao Ning, Fang Qiang Zhou, Xiu Hong Yang, and Hui Min Jin

Subjects
apoptosis, diabetes, diabetic nephropathy, endoplasmic reticulum stress, HK‐2 cells, pyruvate, Biology (General), QH301-705.5
Abstract

Endoplasmic reticulum (ER) stress plays a critical role in the development of diabetic nephropathy (DN). We previously demonstrated that pyruvate (Pyr)‐enriched oral rehydration solution improved glucometabolic disorders and ameliorated DN outcome in db/db mice. Here, we investigated the effects of Pyr on high glucose‐induced ER stress and apoptosis in HK‐2 cells. Our results suggest that high glucose can induce reactive oxygen species production, apoptosis and ER stress in HK‐2 cells, and that Pyr treatment can ameliorate these effects and restore the expression of key proteins involved in ER stress. Thus, Pyr may have potential for the development of novel strategies for the prevention and treatment of clinical DN.

Published
2020
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26. In vitro study of the antioxidative and antiproliferative capabilities of Lactobacillus casei 16‐fermented soymilk

Author

Fang Qian, Jiang Zhang, Kairong Hou, Yuqing Zhang, Zifei Wang, Pengjie Luo, and Yanfeng Tuo

Subjects
antioxidation, antiproliferation, fermentation, soymilk, Nutrition. Foods and food supply, TX341-641
Abstract

Abstract In this study, soymilk was fermented with Lactobacillus casei 16. The contents of aglycone isoflavones, saponins, total phenolic, and free amino acid in the fermented soymilk, and the protection for the HepG2 cells against 2,2'‐azobis(2‐amidinopropane) dihydrochloride (ABAP) damage and the antiproliferative effects of the fermented soymilk on the HT‐29 cells and Caco‐2 cells were studied. The results showed that the levels of total phenolic, aglycone isoflavones, and free amino acids in the L. casei 16‐fermented soymilk were enhanced. The ethanol extract and the water extract of the L. casei 16‐fermented soymilk showed protection for HepG2 cells against ABAP damage and inhibited the proliferation of the HT‐29 cells and Caco‐2 cells, which may be attributed to the enhanced level of total phenolic, aglycone isoflavones, and free amino acids in the L. casei 16‐fermented soymilk.

Published
2020
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48. Dual Passivation of Perovskite and SnO2 for High‐Efficiency MAPbI3 Perovskite Solar Cells

Author

Yali Chen, Xuejiao Zuo, Yiyang He, Fang Qian, Shengnan Zuo, Yalan Zhang, Lei Liang, Zuqin Chen, Kui Zhao, Zhike Liu, Jing Gou, and Shengzhong (Frank) Liu

Subjects
europium, perovskite, photovoltaics, solar cells, Science
Abstract

Abstract So far, most techniques for modifying perovskite solar cells (PSCs) focus on either the perovskite or electron transport layer (ETL). For the sake of comprehensively improving device performance, a dual‐functional method of simultaneously passivating trap defects in both the perovskite and ETL films is proposed that utilizes guidable transfer of Eu3+ in SnO2 to perovskite. Europium ions are distributed throughout the SnO2 film during the formation process of SnO2, and they can diffuse directionally through the SnO2/perovskite interface into the perovskite, while most of the europium ions remain at the interface. Under the synergistic effect of distributed Eu3+ in the SnO2 and aggregated Eu3+ at the interface, the electron mobilities of ETLs are evidently improved. Meanwhile, diffused Eu3+ ions passivate the perovskite to reduce trap densities at the grain boundaries, which can dramatically elevate the open‐circuit voltage (Voc) of PSCs. Finally, the mainly PSCs coated on SnO2:Eu3+ ETL achieve a power conversion efficiency of 20.14%. Moreover, an unsealed device degrades by only 13% after exposure to ambient atmosphere for 84 days.

Published
2021
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49. Comparison of Sudden Sensorineural Hearing Loss with Tinnitus and Short-Term Tinnitus

Author

Fang Qi, Liang Chaoqun, Yan Lin, and Yang Jianming

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Objective. As one of the common symptoms of sudden sensorineural hearing loss (SSH), tinnitus seriously affects the life and work of SSH patients. The present study is aimed at exploring whether SSH can receive acoustic therapy and the factors that affect the efficacy of SSH acoustic therapy. Methods. A total of 162 patients were outpatients and inpatients, 86 were SSH, and 76 were short-term tinnitus (STT). Both groups received pure tone audiometry, tinnitus matching, and residual inhibition test (RI). The Tinnitus Handicap Inventory (THI), visual analog scale with respect to tinnitus loudness (VAS), and RI in each group were evaluated. The effects of age, degree of hearing loss, and tinnitus course on the efficacy of SSH acoustic therapy were also evaluated. Results. In the comparison of RI, THI, and VAS, there was no difference between SSH and STT (P>0.05). SSH patients with mild hearing loss showed better acoustic therapy efficacy compared with SSH patients with severe hearing loss (P0.05). Conclusion. The present study showed that SSH may improve tinnitus symptom through receiving acoustic therapy and SSH patients with mild hearing loss can get better acoustic therapy effects.

Published
2021
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50. Variations on Reservoir Parameters of Oil Shale Deposits under Periodic Freeze-Thaw Cycles: Laboratory Tests

Author

Rui-heng Li, Zhong-guang Sun, Jiang-fu He, Zhi-wei Liao, Lei Li, and Fang Qian

Subjects
Geology, QE1-996.5
Abstract

As one of the most important unconventional hydrocarbon resources, the oil shale has been extracted with a frozen wall to successfully increase the shale oil production and reduce environmental pollution, which results from the harmful liquids in the in situ conversion processing of oil shale. Thereby, the strength and permeability of the frozen wall are extremely critical to reduce the harmful chemicals leaching into the groundwater. However, the permeability and strength of the frozen wall can be influenced by periodic freeze-thaw cycles. In order to investigate the damage and deterioration characteristics of oil shale samples after various periodic freeze-thaw cycles, the oil shale samples were periodically frozen and thawed as many as 48 times, after which the sample mass, stress-strain, freeze-thaw coefficient, uniaxial compressive strength, elastic modulus, and longitudinal wave velocity of the oil shale samples were separately measured. According to the measured results, the number of freeze-thaw cycles greatly influenced the physical and mechanical properties of oil shale samples. The uniaxial compressive strength and elastic modulus of the oil shale samples were changed with maximum variation rates of 64% and 65%, respectively. Meanwhile, the freeze-thaw coefficient of measured oil shale samples exponentially decreased with the increased number of freeze-thaw cycles, whereas the longitudinal wave velocity of tested samples ranged from 1602 m/s to 2464 m/s as a result of the new micropores inside the oil shale sample. Research results have enormous significance to the efficient and safe in situ exploitation of oil shale deposits.

Published
2021
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