105 results on '"Fen Zhang"'
Search Results
2. The 90‐Day Survival Threshold: A Pivotal Determinant of Long‐Term Prognosis in HBV‐ACLF Patients – Insights from a Prospective Longitudinal Cohort Study
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Lanlan Xiao, Jiajia Chen, Shuai Zhao, Wenxin Zhoudi, Keting He, Xiaohan Qian, Fen Zhang, Qiuhong Liu, Tan Li, Danhua Zhu, Xiaoxin Wu, Zhangya Pu, Jianrong Huang, Zhongyang Xie, and Xiaowei Xu
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acute‐on‐chronic liver failure ,HBeAg seroconversion ,hepatitis B virus ,liver fibrosis ,long term prognosis ,virological responses ,Science - Abstract
Abstract This work aims to explore the long‐term prognosis of hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF). In this prospective study, eligible inpatients with HBV‐ACLF are enrolled and followed up from December 2012 to February 2023, for clinical events, laboratory tests at least every 6 months. Overall, the survival rates at 28 days, 90 days, 1 year, 5 years, and 8 years are 64.7%, 48.8%, 46.1%, 43.8%, and 42.2%, respectively. Among the 8‐year mortality and liver transplant cases, ACLF survivors (who survived over 90 days) accounted for 7.8% (9/115). Among 101 patients who survived for more than 90 days, 97.9% of patients achieve virologic response at 1 year. For HBeAg‐positive patients, the HBeAg seroconversion are 25.5%, 63.6%, and 76.9% at 1, 5, and 8 years, respectively. Alanine aminotransferase, aspartate aminotransferase, total bilirubin, INR, white blood cell count, and albumin levels gradually improve within the first year. Fibrosis biomarkers APRI, FIB‐4 and Chitinase‐3‐like protein 1 (CHI3L1) levels decreases within the first 5 years. The Cox proportional hazards regression reveal that high total bilirubin (HR = 1.008, p = 0.021) is the independent risk factor for 8‐year survival of ALCF survivors. The 90‐day period following of HBV‐ACLF represented a critical juncture for long‐term prognosis, revealing favorable outcomes beyond this timeframe.
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- 2024
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3. Expression of SALL4 in the synovial tissue of refractory rheumatoid arthritis patients
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Ru Fan, Zeqiong Liang, Yujie Bu, Fen Zhang, Xing Cen, Yuqing Liu, Fenping Lian, Fengwu Chen, Shengxiao Zhang, and Junwei Chen
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Immunologic diseases. Allergy ,RC581-607 ,Diseases of the musculoskeletal system ,RC925-935 - Published
- 2024
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4. Clinical efficacy of plasma exchange in systemic lupus erythematosus during pregnancy
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Fen Zhang, Bing‐Ying Zhang, Ru Fan, Ting Cheng, Xiao‐Rong Hu, Yu‐Qing Liu, Xing Cen, Yu‐Jie Bu, Jian‐Ping Cao, Feng‐Wu Chen, and Jun‐Wei Chen
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efficacy ,plasmapheresis ,pregnancy ,systemic lupus erythematosus ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Objective To investigate the clinical efficacy of plasma exchange (PE) with or without prednisone and hydroxychloroquine (HCQ) for the treatment of systemic lupus erythematosus (SLE) during pregnancy. Methods The clinical characteristics of 14 pregnant women with SLE admitted to our hospital were retrospectively analyzed, including 7 only treated with prednisone and HCQ (non‐PE group) as well as 7 combined PE (PE group). The delivery situations of 14 patients were recorded. Data like erythrocyte sedimentation rate (ESR), urine protein, platelet count, and SLEDAI scores were compared between two groups before treatment and 3, 6, and 12 months after delivery. Results Three patients in the non‐PE group ended in miscarriage while all patients in the PE group were delivered successfully. Eleven successfully delivered fetuses in the two groups were healthy, and the Apgar scores were over 8. The ESR of the PE group was significantly lower than that of the non‐PE group at 6 and 12 months after delivery, while there was no statistical difference in ESR between the two groups before treatment and 3 months after delivery. The ESR and urine protein were significantly higher in the non‐PE group at months 3, 6, and 12 postpartum. There was a significant decrease in disease activity postpartum in the PE group compared to predelivery disease activity. The change in platelet counts between the two groups significantly increased over time in the PE group, while SLEDAI scores decreased. Conclusions The combination of PE and oral prednisone and HCQ is possibly a more effective treatment than oral prednisone and HCQ alone for patients with active SLE during pregnancy. This treatment option reduces pregnancy loss and promotes the patients' postpartum condition to a certain extent.
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- 2023
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5. Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study
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Dan Li, Zhihao Huo, Danyang Liu, Nirong Gong, Fen Zhang, Yaozhong Kong, Yunfang Zhang, Xiaoyan Su, Qingdong Xu, Jiexia Feng, Fuzhang Luo, Cheng Wang, Xianrui Dou, Guohui Sun, Difei Zhang, Xianhui Qin, Guangqing Zhang, Fuhua Lu, and Jun Ai
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apparent treatment‐resistant hypertension ,dialysis adequacy ,home blood pressure monitoring ,peritoneal dialysis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Apparent treatment‐resistant hypertension (aTRH) is the most commonly used term to report resistant hypertension (RH) and is considered as a common problem in dialysis population. However, few reports have focused on peritoneal dialysis (PD) hypertensive patients. The authors conducted a multi‐center cross‐sectional study involving 1789 PD patients from nine centers in Guangdong, China. The prevalence of aTRH was estimated by home blood pressure (BP) monitoring. Evaluating drug adherence through Eight‐item Morisky Medication Adherence Scale (MMAS‐8) and pill counting was performed to assess RH in one PD center. Related factors of aTRH were analyzed using logistic regression analysis. The prevalence of aTRH in PD patients was estimated at 42.2% (755 out of 1789 hypertensive patients) based on home BP. Of those, 91.4% patients were classified as uncontrolled RH, 2.0% as controlled RH, and 6.6% as refractory hypertension. The prevalence of RH was 40.6% and 41.9% among those with medium/high adherence based on the MMAS‐8 scores and the pill counting rate, respectively. PD patients who were younger, with higher body mass index, with lower serum albumin and poorer dialysis adequacy were significantly associated with higher aTRH incident. In conclusion, the present study demonstrates a high prevalence of aTRH in PD population, which occurs in about two in five treated hypertensive patients. Nutritional status and dialysis adequacy might tightly associate with aTRH.
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- 2022
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6. Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study
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Zhiwen Xiao, Jianwei Tian, Fen Zhang, Xiaohong Zhong, Tingting Zhang, Zhixiu Yi, Yanhong Lin, Cong Yang, Dan Tang, Nirong Gong, and Jun Ai
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Pathology ,RB1-214 - Abstract
Background. Matrix metalloproteinase-7 (MMP7) is markedly expressed in patients with chronic kidney disease; its expression in dialysate and role in patients undergoing peritoneal dialysis (PD) have not been well established. Methods. Participants undergoing PD from June 1st, 2015, to June 30th, 2020, were involved and were followed up every 3 months for the first year and every 6 months thereafter until death, PD withdrawal, or the end of the study. Data at each follow-up point were collected and analyzed for the association with congestive heart failure (CHF), PD withdrawal, and combined endpoint. Results. A total of 283 participants were included in this study. During a median follow-up of 21 months, 20 (7%) participants died, 93 (33%) withdrew from PD, and 105 (37%) developed CHF. A significantly increased level of serum and dialysate MMP7 was observed at baseline. Dialysate MMP7 presented a good linearity with serum MMP7. Baseline serum and dialysate MMP7 levels were associated with CHF in multivariable Cox proportional hazards regression models. After categorization, participants with high baseline MMP7 levels had a higher incidence of CHF (42%), and the hazard ratios (95% confidence intervals) were 1.595 (1.023-2.488). Interestingly, participants with higher serum MMP7 levels were trended to use dialysate with higher glucose concentration. However, the ultrafiltration volumes were not significantly increased. Higher MMP7 levels were also positively associated with PD withdrawal and combined endpoint. Conclusions. The expression of MMP7 in serum and dialysate was markedly increased and was tightly associated with the risk of CHF in PD patients. This finding suggests that the measurement of MMP7 may inform strategies for managing CHF at an earlier stage.
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- 2023
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7. Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China
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Ping Chen, Fen Zhang, Yiqun Shen, Yubo Cai, Chaolei Jin, Yan Li, Mingmin Tu, Weizhen Zhang, Yu Wang, Shi-Feng Zhang, Jiangyun Wang, and Lanjuan Li
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Health-related quality of life (HRQoL) is an important aspect in the management of patients with hepatitis B (HB), which remains a serious health problem in China. There have been relatively few HRQoL studies involving Chinese patients with HB. The aim of this study was to analyze HRQoL in patients diagnosed with HB living in Zhejiang Province, China. A cross-sectional sample of 98 patients with chronic HB (CHB), 56 patients with advanced HB that have developed cirrhosis, and 48 healthy controls (HCs), all from Zhejiang Province, was used in this study. HRQoL was assessed using Short-Form 36 (SF-36) version 2, European quality of life questionnaire-5 dimensions (EQ-5D), and chronic liver disease questionnaire (CLDQ). Intergroup score differences were detected with U tests. Factors with a significant effect on HRQoL were identified with Spearman correlational analyses. Patients with HB (both groups) had lower SF-36 scores than HCs (p
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- 2021
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8. Clinical Features of Combined Central Retinal Artery and Vein Occlusion
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Hao Wang, Yongye Chang, Fen Zhang, Rong Yang, Suxia Yan, Jieying Dong, Minglian Zhang, and Shaomin Peng
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Ophthalmology ,RE1-994 - Abstract
Purpose. To describe the clinical features of combined central retinal artery and vein occlusion (CCRAVO). Methods. This retrospective study included 33 admitted patients (33 eyes) who had CCRAVO. Clinical data, such as age, gender, best-corrected visual acuity (BCVA), intraocular pressure (IOP), findings on fundus color photography and fundus fluorescein angiography (FFA), and information about follow-up, were collected and analyzed. Results. The age of the patients with CCRAVO ranged from 22 to 78 years, with a mean of 48.8 ± 14.1 years. At presentation, BCVA of the involved eyes ranged from no light perception (NLP) to 20/20. In addition, 45.5% (15/33) of the eyes had BCVA of finger counting (FC) or below, whereas 12.1% (4/33) had BCVA of 20/60 or above. The IOP was lower in the involved eyes than in the fellow eyes (15.0 ± 3.0 mmHg vs. 16.4 ± 2.3 mmHg, p=0.03). Ophthalmoscopic examination showed changes in both central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO), including retinal hemorrhage, retinal ischemic whitening, optic disc hyperemia and/or edema, venous dilation and tortuosity, cotton wool spot (CWS), and Roth’s spot. FFA showed prolonged arm-to-retina time (ART) and retinal arteriovenous passage time (RAP) (17.1 ± 4.9 s and 12.1 ± 8.8 s, respectively). Capillary nonperfusion (CNP) was seen in 21 eyes (63.6%), and in 14 (42.2%) of these, CNP was larger than 10 disc areas. At 2 to 3 weeks after presentation, BCVA improved in 23 eyes (71.9%) and further deteriorated in 5 eyes (15.6%). Retinal ischemic whitening improved in more than half of the eyes, whereas retinal hemorrhage increased in nearly half of the eyes. Follow-up ranged from 6 to 56 months. Seven patients were lost to follow-up. At final follow-up, six eyes had a visual acuity of 20/60 or greater, but 6 eyes had FC or worse. Four eyes developed neovascularization on follow-up. Conclusion. CCRAVO is a sight-threatening entity. Manifestations of CRAO and CRVO can be seen simultaneously in the early stage of disease, and CRVO may play a more important role in the development of CCRAVO.
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- 2019
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9. The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
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Dong Weng, Xian-Qiu Chen, Hui Qiu, Yuan Zhang, Qiu-Hong Li, Meng-Meng Zhao, Qin Wu, Tao Chen, Yang Hu, Liu-Sheng Wang, Ya-Ru Wei, Yu-Kui Du, Shan-Shan Chen, Ying Zhou, Fen Zhang, Li Shen, Yi-Liang Su, Martin Kolb, and Hui-Ping Li
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Pathology ,RB1-214 - Abstract
Background. Acute exacerbation of IPF (AE-IPF) is associated with high mortality. We studied changes in pathogen involvement during AE-IPF and explored a possible role of infection in AE-IPF. Objectives. Our purpose is to investigate the role of infection in AE-IPF. Methods. Overall, we recruited 170 IPF patients (48 AE-IPF, 122 stable) and 70 controls at Shanghai Pulmonary Hospital. Specific IgM against microbial pathogens and pathogens in sputum were assessed. RNA sequences of pathogens in nasopharyngeal swab of IPF patients were detected by PathChip. A panel of serum parameters reflecting immune function were assessed. Results. Antiviral/bacterial IgM was higher in IPF vs. controls and in AE-IPF vs. stable IPF. Thirty-eight different bacterial strains were detected in IPF patient sputum. Bacteria-positive results were found in 9/48 (18.8%) of AE-IPF and in 26/122 (21.3%) stable IPF. Fifty-seven different viruses were detected in nasopharyngeal swabs of IPF patients. Virus-positive nasopharyngeal swabs were found in 18/30 (60%) of tested AE-IPF and in 13/30 (43.3%) of stable IPF. AE-IPF showed increased inflammatory cytokines (IL-6, IFN-γ, MIG, IL-17, and IL-9) vs. stable IPF and controls. Mortality of AE-IPF in one year (39.5%) was higher compared to stable IPF (28.7%).Conclusions. IPF patients had different colonization with pathogens in sputum and nasopharyngeal swabs; they also displayed abnormally activated immune response, which was exacerbated during AE-IPF.
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- 2019
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10. A genomic‐augmented multivariate prognostic model for the survival of natural‐killer/T‐cell lymphoma patients from an international cohort
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Jing Quan Lim, Dachuan Huang, Jason Yongsheng Chan, Yurike Laurensia, Esther Kam Yin Wong, Daryl Ming Zhe Cheah, Burton Kuan Hui Chia, Wen‐Yu Chuang, Ming‐Chung Kuo, Yi‐Jiun Su, Qing‐qing Cai, Yanfen Feng, Huilan Rao, Li‐Na Feng, Pan‐Pan Wei, Jie‐Rong Chen, Bo‐Wei Han, Guo‐Wang Lin, Jun Cai, Yu Fang, Jing Tan, Huangming Hong, Yanhui Liu, Fen Zhang, Wenyu Li, Michelle L. M. Poon, Siok‐Bian Ng, Anand Jeyasekharan, Jeslin Chian Hung Ha, Lay Poh Khoo, Suk Teng Chin, Wan Lu Pang, Rebecca Kee, Chee Leong Cheng, Nicholas Francis Grigoropoulos, Tiffany Tang, Miriam Tao, Mohamad Farid, Kia Joo Puan, Jie Xiong, Wei‐Li Zhao, Chiea Chuen Khor, William Hwang, Won Seog Kim, Elias Campo, Patrick Tan, Bin Tean Teh, Wee‐Joo Chng, Olaf Rötzschke, Thomas Tousseyn, Hui‐Qiang Huang, Steve Rozen, Soon Thye Lim, Lee‐Yung Shih, Jin‐Xin Bei, and Choon Kiat Ong
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EXPRESSION ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Science & Technology ,MUTATIONS ,BLOCKADE ,Genomics ,GENETIC RISK ,Hematology ,Prognosis ,Disease-Free Survival ,VARIABLES ,Lymphoma, Extranodal NK-T-Cell ,PERIPHERAL T-CELL ,Humans ,BARR-VIRUS-DNA ,NASAL ,SMILE ,Life Sciences & Biomedicine ,Retrospective Studies - Abstract
With lowering costs of sequencing and genetic profiling techniques, genetic drivers can now be detected readily in tumors but current prognostic models for Natural-killer/T cell lymphoma (NKTCL) have yet to fully leverage on them for prognosticating patients. Here, we used next-generation sequencing to sequence 260 NKTCL tumors, and trained a genomic prognostic model (GPM) with the genomic mutations and survival data from this retrospective cohort of patients using LASSO Cox regression. The GPM is defined by the mutational status of 13 prognostic genes and is weakly correlated with the risk-features in International Prognostic Index (IPI), Prognostic Index for Natural-Killer cell lymphoma (PINK), and PINK-Epstein-Barr virus (PINK-E). Cox-proportional hazard multivariate regression also showed that the new GPM is independent and significant for both progression-free survival (PFS, HR: 3.73, 95% CI 2.07-6.73; p
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- 2022
11. The relationship between ethical leadership and nurse well‐being: The mediating role of workplace mindfulness
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Xiaona Si, Huiyuan Xue, Xiaoren Song, Xiaoli Liu, and Fen Zhang
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General Nursing - Published
- 2023
12. Vaccination status for mild and asymptomatic infections with SARS‐CoV‐2 Omicron BA.2 variant in Shanghai
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Yong Yin, Jilei Lin, Shuhua Yuan, Shilu Tong, Yi He, Bin Dong, Fen Zhang, Erzhen Chen, Junhua Zheng, and Wei Wang
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Infectious Diseases ,Virology - Published
- 2023
13. Preparation and Evaluation of Polyacrylate Microgels and Their Adjuvant Activities Using Ovalbumin as a Model Antigen
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Chengyu Li, Yutong Bi, Mengmeng Zhou, Lu Bai, Xiaoqi Chen, Jijun Xiao, Fen Zhang, Haijun Zhou, and Yantao Li
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General Chemistry - Published
- 2023
14. Response to the letter to the editor 'Electrical flash burns due to switchboard explosion'
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Chao Lian, Xuan‐Fen Zhang, Xue‐Lei Li, and Xiao‐Jun Liu
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Surgery ,Dermatology - Published
- 2022
15. Transcriptome‐wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma
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Yong‐Qiao He, Wen‐Qiong Xue, Dan‐Hua Li, Tong‐Min Wang, Zhi‐Ming Mai, Da‐Wei Yang, Chang‐Mi Deng, Ying Liao, Wen‐Li Zhang, Ruo‐Wen Xiao, Luting Luo, Hua Diao, Xiating Tong, Yanxia Wu, Jiang‐Bo Zhang, Ting Zhou, Xi‐Zhao Li, Pei‐Fen Zhang, Xiao‐Hui Zheng, Shao‐Dan Zhang, Ye‐Zhu Hu, Minzhong Tang, Yuming Zheng, Yonglin Cai, Ellen T. Chang, Zhe Zhang, Guangwu Huang, Su‐Mei Cao, Qing Liu, Lin Feng, Ying Sun, Maria Li Lung, Hans‐Olov Adami, Weimin Ye, Tai‐Hing Lam, and Wei‐Hua Jia
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Cancer Research ,Nasopharyngeal Carcinoma ,Oncology ,Gene Expression Profiling ,Humans ,Genetic Predisposition to Disease ,Nasopharyngeal Neoplasms ,Transcriptome - Published
- 2022
16. WRKY33‐mediated indolic glucosinolate metabolic pathway confers resistance against Alternaria brassicicola in Arabidopsis and Brassica crops
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Han Tao, Huiying Miao, Lili Chen, Mengyu Wang, Chuchu Xia, Wei Zeng, Bo Sun, Fen Zhang, Shuqun Zhang, Chuanyou Li, and Qiaomei Wang
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Indoles ,Arabidopsis Proteins ,Gene Expression Regulation, Plant ,Glucosinolates ,Arabidopsis ,Alternaria ,Brassica ,Plant Science ,Biochemistry ,Metabolic Networks and Pathways ,General Biochemistry, Genetics and Molecular Biology ,Plant Diseases ,Transcription Factors - Abstract
The tryptophan (Trp)-derived plant secondary metabolites, including camalexin, 4-hydroxy-indole-3-carbonylnitrile, and indolic glucosinolate (IGS), show broad-spectrum antifungal activity. However, the distinct regulations of these metabolic pathways among different plant species in response to fungus infection are rarely studied. In this study, our results revealed that WRKY33 directly regulates IGS biosynthesis, notably the production of 4-methoxyindole-3-ylmethyl glucosinolate (4MI3G), conferring resistance to Alternaria brassicicola, an important pathogen which causes black spot in Brassica crops. WRKY33 directly activates the expression of CYP81F2, IGMT1, and IGMT2 to drive side-chain modification of indole-3-ylmethyl glucosinolate (I3G) to 4MI3G, in both Arabidopsis and Chinese kale (Brassica oleracea var. alboglabra Bailey). However, Chinese kale showed a more severe symptom than Arabidopsis when infected by Alternaria brassicicola. Comparative analyses of the origin and evolution of Trp metabolism indicate that the loss of camalexin biosynthesis in Brassica crops during evolution might attenuate the resistance of crops to Alternaria brassicicola. As a result, the IGS metabolic pathway mediated by WRKY33 becomes essential for Chinese kale to deter Alternaria brassicicola. Our results highlight the differential regulation of Trp-derived camalexin and IGS biosynthetic pathways in plant immunity between Arabidopsis and Brassica crops.
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- 2022
17. Boundedly Rational Decisions on Exploration Versus Exploitation in Alliance Portfolios: Problemistic and Slack Searches Under CEO Overconfidence
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Fen Zhang, Xiaotian Yang, Changhong Yuan, and Weiguo Fan
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Management of Technology and Innovation ,Strategy and Management ,General Business, Management and Accounting - Published
- 2023
18. Angiopoietin‐like protein 4 treated bone marrow‐derived mesenchymal stem cells alleviate myocardial injury of patients with myocardial infarction
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Fen Zhang, Jie Wu, Xingxing Li, Xuan Ying, Wenbing Fang, and Yang Dong
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Vascular Endothelial Growth Factor A ,Bone Marrow ,Myocardial Infarction ,Angiopoietin-Like Protein 4 ,Animals ,Humans ,Mesenchymal Stem Cells ,General Medicine ,Mesenchymal Stem Cell Transplantation ,General Nursing ,Rats - Abstract
Bone marrow-derived mesenchymal stem cells (BMSCs) and their exosomes are of great significance for the recovery of cardiac function in patients with myocardial infarction (MI). However, the underlying mechanisms of BMSCs applied to MI treatment remain unclear. Fluorescence-activated cell sorting (FACs) are performed to assess the apoptosis, reactive oxygen species levels and glucose uptake capacity of BMSCs. Reverse transcription polymerase chain reaction is conducted to detect the levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), insulin-like growth factor (IGF), transforming growth factor-beta 1, connective tissue growth factor, and platelet-derived growth factor. The levels of apoptosis-related proteins were detected by Western blot. The levels of VEGF, bFGF, HGF, and IGF were assessed by enzyme-linked immunosorbent assay. The biochemical kits are applied to detect the levels of malondialdehyde, superoxide dismutase, and adenosine triphosphate/adenosine diphosphate. 2,3,5-triphenyltetrazolium and Masson staining and immunofluorescence are performed to assess myocardial function of rats. Angiopoietin-like protein 4 (ANGPTL4) alleviates apoptosis and oxidative stress of BMSCs induced by serum deprivation and hypoxia; ANGPTL4 activates paracrine and accelerate metabolic energy of BMSCs; and ANGPTL4 treated-BMSCs alleviate myocardial injury of rats with MI. ANGPTL4 treated-BMSCs alleviate myocardial injury in rats with MI, indicating the combination therapy of ANGPTL4 and BMSCs may alleviate myocardial injury in rats with MI.
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- 2022
19. Regulation of autophagy protects against liver injury in liver surgery‐induced ischaemia/reperfusion
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Chenxia Hu, Lingfei Zhao, Fen Zhang, and Lanjuan Li
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autophagy ,Programmed cell death ,Necrosis ,medicine.medical_treatment ,Ischemia ,Reviews ,Apoptosis ,Mitochondria, Liver ,Review ,Liver transplantation ,Protective Agents ,medicine ,Animals ,Hepatectomy ,Humans ,Ischemic Preconditioning ,Liver injury ,liver transplantation ,business.industry ,Liver Diseases ,Autophagy ,Mitophagy ,Disease Management ,ischaemia/reperfusion ,Cell Biology ,medicine.disease ,cell death ,Gene Expression Regulation ,Reperfusion Injury ,liver resection ,Cancer research ,Molecular Medicine ,Disease Susceptibility ,Liver function ,medicine.symptom ,business ,Biomarkers ,Homeostasis ,Signal Transduction - Abstract
Transient ischaemia and reperfusion in liver tissue induce hepatic ischaemia/reperfusion (I/R) tissue injury and a profound inflammatory response in vivo. Hepatic I/R can be classified into warm I/R and cold I/R and is characterized by three main types of cell death, apoptosis, necrosis and autophagy, in rodents or patients following I/R. Warm I/R is observed in patients or animal models undergoing liver resection, haemorrhagic shock, trauma, cardiac arrest or hepatic sinusoidal obstruction syndrome when vascular occlusion inhibits normal blood perfusion in liver tissue. Cold I/R is a condition that affects only patients who have undergone liver transplantation (LT) and is caused by donated liver graft preservation in a hypothermic environment prior to entering a warm reperfusion phase. Under stress conditions, autophagy plays a critical role in promoting cell survival and maintaining liver homeostasis by generating new adenosine triphosphate (ATP) and organelle components after the degradation of macromolecules and organelles in liver tissue. This role of autophagy may contribute to the protection of hepatic I/R‐induced liver injury; however, a considerable amount of evidence has shown that autophagy inhibition also protects against hepatic I/R injury by inhibiting autophagic cell death under specific circumstances. In this review, we comprehensively discuss current strategies and underlying mechanisms of autophagy regulation that alleviates I/R injury after liver resection and LT. Directed autophagy regulation can maintain liver homeostasis and improve liver function in individuals undergoing warm or cold I/R. In this way, autophagy regulation can contribute to improving the prognosis of patients undergoing liver resection or LT.
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- 2021
20. The novel HLA‐B*13:01:21 allele identified by <scp>Sanger</scp> dideoxy nucleotide sequencing in a <scp>Chinese</scp> individual
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Yan‐fen Zhang, Zhong‐zheng Zheng, Ke‐ming Du, Lin An, and Da Gao
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Immunology ,Genetics ,Immunology and Allergy - Abstract
HLA-B*13:01:21 differs from HLA-B*13:01:01:01 by one nucleotide in exon 2. This article is protected by copyright. All rights reserved.
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- 2023
21. Which phase of Ta 2 O 5 being of the largest dielectric constant
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Tsu-Chien Weng, Hui-Fen Zhang, Bo-Yuan Ning, and Xi-Jing Ning
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Materials science ,Condensed matter physics ,Phase (matter) ,Materials Chemistry ,Ceramics and Composites ,Density functional theory ,Dielectric - Published
- 2021
22. MMP‐7 affects peritoneal ultrafiltration associated with elevated aquaporin‐1 expression via MAPK/ERK pathway in peritoneal mesothelial cells
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Jun Ai, Gong Nirong, Daming Zuo, Fen Zhang, Zhuojun Zheng, Zhiwen Xiao, Qiaomu Yang, Yue Yin, and Jia Zhou
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Adult ,Male ,0301 basic medicine ,MAPK/ERK pathway ,MAP Kinase Signaling System ,Cell osmotic pressure ,Cellular homeostasis ,Matrix metalloproteinase ,Epithelium ,Cell Line ,03 medical and health sciences ,Peritoneal cavity ,0302 clinical medicine ,Osmotic Pressure ,medicine ,Extracellular ,Humans ,matrix metalloproteinases‐7 ,peritoneal membrane dysfunction ,Peritoneal Cavity ,Cells, Cultured ,Mitogen-Activated Protein Kinase 1 ,Mitogen-Activated Protein Kinase 3 ,Aquaporin 1 ,Chemistry ,Epithelial Cells ,Original Articles ,Cell Biology ,Middle Aged ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,aquaporin‐1 ,Matrix Metalloproteinase 7 ,030220 oncology & carcinogenesis ,Peritoneal Absorption ,ultrafiltration failure ,Molecular Medicine ,Original Article ,Female ,extracellular signal‐regulated kinase ,Peritoneal Dialysis ,Mesothelial Cell ,Homeostasis - Abstract
Peritoneal membrane dysfunction and the resulting ultrafiltration failure are the major disadvantages of long‐term peritoneal dialysis (PD). It becomes increasingly clear that mesothelial cells play a vital role in the pathophysiological changes of the peritoneal membrane. Matrix metalloproteinases (MMPs) function in the extracellular environment of cells and mediate extracellular matrix turnover during peritoneal membrane homeostasis. We showed here that dialysate MMP‐7 levels markedly increased in the patients with PD, and the elevated MMP‐7 level was negatively associated with peritoneal ultrafiltration volume. Interestingly, MMP‐7 could regulate the cell osmotic pressure and volume of human peritoneal mesothelial cells. Moreover, we provided the evidence that MMP‐7 activated mitogen‐activated protein kinases (MAPKs)‐extracellular signal‐regulated kinase 1/2 (ERK) pathway and subsequently promoted the expression of aquaporin‐1 (AQP‐1) resulting in the change of cell osmotic pressure. Using a specific inhibitor of ERK pathway abrogated the MMP‐7‐mediating AQP‐1 up‐regulation and cellular homeostasis. In summary, all the findings indicate that MMP‐7 could modulate the activity of peritoneal cavity during PD, and dialysate MMP‐7 might be a non‐invasive biomarker and an alternative therapeutic target for PD patients with ultrafiltration failure.
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- 2021
23. Associations between optic disc characteristics and macular choroidal microvasculature in young patients with high myopia
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Wenfeng Wu, Qian Wang, Zhu Xie, Miaoran Zheng, Xinjie Mao, Yanli Wang, Fan Lu, Fen Zhang, and Xinting Liu
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medicine.medical_specialty ,genetic structures ,Optic Disk ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ophthalmology ,Myopia ,medicine ,Humans ,medicine.diagnostic_test ,Choroid ,Flow area ,business.industry ,Parapapillary atrophy ,High myopia ,Retinal ,eye diseases ,Scanning laser ophthalmoscopy ,Optic Atrophy ,Cross-Sectional Studies ,medicine.anatomical_structure ,chemistry ,Microvessels ,Angiography ,030221 ophthalmology & optometry ,Optic nerve ,sense organs ,business ,Tomography, Optical Coherence ,030217 neurology & neurosurgery ,Optic disc - Abstract
BACKGROUND This study aimed to examine changes to optic disc characteristics and macular choroidal microvasculature, and their relationships in young patients with high myopia (HM). METHODS A total of 90 patients were enrolled in this cross-sectional study. Based on their refractive power, the patients were divided into three groups: 27 in the control group, 34 in the HM group and 29 in the extremely high myopia group. Images of each patient's macula and optic disc were taken by ocular coherence tomography angiography. The macular choroidal and retinal thickness, capillary vessel density and capillary flow area were measured using Matlab software. Parapapillary atrophy (PPA) and the ovality index (OI) obtained from the scanning laser ophthalmoscopy images and the degree of optic disc tilt obtained from the optic nerve head ocular coherence tomography B-scans were analysed by Image J and Matlab software. RESULTS The PPA area, OI and degree of optic disc tilt were significantly different among the three groups (all p ≤ 0.001). The macular choroidal thickness and microvasculature were significantly different among the three groups (all p
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- 2021
24. Establishment and validation of a prediction model for the probability of malignancy in solid solitary pulmonary nodules in northwest China
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Xi-Zhi Liu, Ling Chen, Chun-Hui Dong, Li-Fen Zhang, Xinhan Zhao, Yihui Liu, Xiao-Li Wang, Wen-Wen Zhang, and Xue-Qin Duan
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Adult ,Male ,China ,medicine.medical_specialty ,Lung Neoplasms ,Adolescent ,Logistic regression ,Malignancy ,Young Adult ,03 medical and health sciences ,Hosmer–Lemeshow test ,0302 clinical medicine ,Carcinoembryonic antigen ,Risk Factors ,Total serum protein ,Biomarkers, Tumor ,medicine ,Humans ,Aged ,Aged, 80 and over ,Solitary pulmonary nodule ,Models, Statistical ,Receiver operating characteristic ,biology ,business.industry ,Incidence ,Solitary Pulmonary Nodule ,General Medicine ,Middle Aged ,Nomogram ,Prognosis ,medicine.disease ,Nomograms ,ROC Curve ,Oncology ,Area Under Curve ,030220 oncology & carcinogenesis ,biology.protein ,Female ,030211 gastroenterology & hepatology ,Surgery ,Radiology ,business ,Follow-Up Studies - Abstract
To construct a prediction model of solitary pulmonary nodules (SPNs), to predict the possibility of malignant SPNs in patients aged 15-85 years in northwest China for clinical diagnostic and therapeutic decision-making.The features of SPNs were assessed by multivariate logistic regression, followed by visualization using a nomogram. Hosmer lemeshow was applied to evaluate the fitting degree of the model. The area under the receiver operating characteristic (ROC) curve was identified to determine the discriminative ability of the model.Lobulation, spiculation, pleural-tag, carcinoembryonic antigen, neuron-specific enolase, and total serum protein were independent predictors of malignant pulmonary nodules (p .05). Lobulation (100 points) scored the highest in the nomogram, and the Hosmer-Lemeshow goodness-of-fit statistic was 0.805 (p .05). The area under curve (AUC) of the modeling and validation groups using logistic regression were 0.859 (95% CI, 0.805-0.903) and 0.823 (95% CI, 0.738-0.890), respectively. Moreover, the AUC of our model was higher than that of the Mayo model, VA model, and Peking University (AUC 0.823 vs. 0.655 vs. 0.603 vs. 0.521).Our prediction model is more suitable for predicting the possibility of malignant SPNs in northwest China, and can be calculated using a nomogram to determine further treatments.
- Published
- 2021
25. Follicle stimulating hormone, its association with glucose and lipid metabolism during the menopausal transition
- Author
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Xuejing Jin, Zhi-Fen Zhang, Xue Wang, Yijie Chen, Yini Du, and Hongyan Zhang
- Subjects
endocrine system ,medicine.medical_specialty ,Homocysteine ,Blood viscosity ,03 medical and health sciences ,chemistry.chemical_compound ,Follicle-stimulating hormone ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,030219 obstetrics & reproductive medicine ,Estradiol ,business.industry ,Obstetrics and Gynecology ,Lipid metabolism ,Lipid Metabolism ,Cross-Sectional Studies ,Glucose ,Blood pressure ,Endocrinology ,chemistry ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,Female ,Follicle Stimulating Hormone ,Menopause ,business ,Body mass index ,hormones, hormone substitutes, and hormone antagonists ,Lipoprotein - Abstract
AIM Accumulative evidence shows that follicle stimulating hormone (FSH) is associated with metabolic disorders. We aimed to ascertain the relationship between FSH, blood glucose and lipid metabolism in general perimenopausal women. METHODS This cross-sectional study analyzed 2121 perimenopausal women aged 40-54 years in Zhejiang Province from January 2016 to December 2018. Regression analysis was performed to assess the relationship between FSH and metabolic parameters. RESULTS Serum FSH had a significant inverse association with fasting plasma glucose (P
- Published
- 2020
26. Coexpression of parental homeologs of leaf dissection related genes are associated with intermediate leaf forms of two allotetraploid yarrows ( Achillea , Asteraceae)
- Author
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Chu-Ze Shen, Jin‐Xiu Ke, Yu‐Fen Zhang, Duo Chen, and Yan-Ping Guo
- Subjects
Morphometrics ,Genetics ,Achillea ,Gene expression ,medicine ,Plant Science ,Dissection (medical) ,Biology ,Asteraceae ,medicine.disease ,biology.organism_classification ,Gene ,Ecology, Evolution, Behavior and Systematics - Published
- 2020
27. Origin of sulphate in the unsaturated zone and groundwater of a loess aquifer
- Author
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Zhonghe Pang, Fen Zhang, Tianming Huang, Baoqiang Ma, Yin Long, Zhenbin Li, and Yiman Li
- Subjects
Hydrology ,geography ,geography.geographical_feature_category ,Loess ,Vadose zone ,Environmental science ,Aquifer ,Groundwater recharge ,Groundwater ,Water Science and Technology - Published
- 2021
28. Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China
- Author
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Xiaoli Huang, Hui-Fen Zhang, Xing-Dong Wu, Ji-Ming Li, and Jiyong Zhang
- Subjects
Male ,Quality Control ,medicine.medical_specialty ,Clinical Biochemistry ,Veins ,Age groups ,Reference Values ,White blood cell ,Internal medicine ,Humans ,Medicine ,Child ,medicine.diagnostic_test ,business.industry ,Biochemistry (medical) ,Infant ,Reproducibility of Results ,Complete blood count ,Absolute lymphocyte count ,Hematology ,General Medicine ,Venous blood ,Blood Cell Count ,Reference intervals ,Red blood cell ,medicine.anatomical_structure ,Child, Preschool ,Absolute neutrophil count ,Female ,business - Abstract
Objectives To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs). Methods Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool-age children and school-age children. Venous blood was analysed for 17 parameters. Outlier data for each parameter were eliminated and RIs were established based on the Clinical and Laboratory Standards Institute C28-A3c guideline. Results The RIs for certain parameters differed among the different age groups. The white blood cell (WBC) count differed among the four age groups. The variation trends for absolute neutrophil count in all age groups were opposite to those for WBC and absolute lymphocyte count. The mean absolute eosinophil count values were significantly higher in the infant group than in the other groups. The RIs for red blood cell were identical across all age groups except in infants. The mean Hb level for infants was significantly lower than that for the other age groups. The mean and RI for platelet count were significantly higher in the infant group than in the other groups. Conclusions There are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential.
- Published
- 2019
29. Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma
- Author
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Shu Ting Huang, Xi Zhao Li, Rong Xin Liang, Sen wei Jiang, Lan Zhang, Yu Chuan Jiang, Min Zheng, Jian Hua Wang, Pei Fen Zhang, Xing Juan Yu, Zhe Sheng Wen, Zi Gang Liu, and Yi Nan Jiang
- Subjects
Adult ,Male ,0301 basic medicine ,Cancer Research ,Gene Expression ,CD47 Antigen ,Positive correlation ,Esophageal squamous cell carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Cancer stem cell ,Biomarkers, Tumor ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,CD133 ,AC133 Antigen ,CD47 ,neoplasms ,Survival analysis ,Original Research ,Aged ,Neoplasm Staging ,Proportional hazards model ,business.industry ,ESCC ,Middle Aged ,Prognosis ,Immunohistochemistry ,Survival Analysis ,therapeutic ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Neoplastic Stem Cells ,Cancer research ,CSCs ,Female ,Esophageal Squamous Cell Carcinoma ,Neoplasm Grading ,business ,Cancer Prevention - Abstract
Background Treatments based on the inhibition of pivotal signals of cancer stem cells (CSCs) are on a promising track. Recent studies have shown that targeting CSCs with broader immune‐based therapeutic methods, for example, the anti‐CD47 treatment, may serve as a more potent strategy for eliminating these intractable cells. We aimed to explore the prognostic effects of CD47/CD133 and the potential therapeutic significance of CD47 in esophageal squamous cell carcinoma (ESCC). Methods Immunohistochemistry was employed to identify the characteristics of CD47 and CD133 in 26 pairs of tumor tissues and adjacent non‐tumor tissues and 136 ESCC tissues. Kaplan‐Meier analysis and Cox proportional hazards models were built for estimating the prognostic values of CD47 and CD133 expression and their combined stemness index. Sphere formation assays were undertaken to explore the effects of CD47 inhibition on primary human ESCC CSCs. Results Results conclude that CD47 and CD133 expression is increased in tumor tissues as compared to adjacent non‐tumor tissues. A positive correlation between CD47/CD133 expression and differentiation was found in 136 ESCC patients. Survival analysis indicated that patients with high CD47 or CD133 expression exhibited poor overall survival and progression‐free survival (PFS). The combination of high CD47 and CD133 expression was a reliable independent prognostic factor for both OS (HR = 1.940, 95% CI = 1.399‐2.690, P
- Published
- 2019
30. Effects of dipeptidyl peptidase-4 inhibitors on transforming growth factor-β1 signal transduction pathways in the ovarian fibrosis of polycystic ovary syndrome rats
- Author
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Shuang-Shuang Wei, Yi-Ran He, Hong-Yan Wu, Zhi-Fen Zhang, and Fang Wang
- Subjects
medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,biology ,business.industry ,Obstetrics and Gynecology ,Dehydroepiandrosterone ,medicine.disease ,Polycystic ovary ,CTGF ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Sex hormone-binding globulin ,Fibrosis ,030220 oncology & carcinogenesis ,Internal medicine ,Sitagliptin ,medicine ,biology.protein ,business ,Dipeptidyl peptidase-4 ,Testosterone ,medicine.drug - Abstract
AIM Examine the effects of dipeptidyl peptidase-4 (DPP4) inhibitor Sitagliptin on the transforming growth factor-β1 (TGF-β1) signal transduction pathway in polycystic ovary syndrome (PCOS) rats with ovarian fibrosis. METHODS Thirty rats were divided randomly into the PCOS model group, Sitagliptin treatment group and blank control group. Dehydroepiandrosterone was administered to the model group and treatment group to establish the models. Then, the phenotype of rats was recorded, and the serum sex hormone levels were measured. The pathological structures of the rat ovaries were observed. The protein and mRNA expression levels of DPP4, connective tissue growth factor (CTGF), TGF-β1 and Smad2/3 in the ovaries were analyzed. RESULTS There was no statistically difference in fasting body weight and blood glucose among the three groups before Sitagliptin treatment (P > 0.05). The fasting blood glucose level was significantly decreased after the administration of Sitagliptin (P < 0.05). The level of testosterone in the model group was reduced remarkably after Sitagliptin treatment (P < 0.001). The protein expression levels of DPP4, CTGF and TGF-β1 in the ovarian stroma were lower in the treatment group than in the model group (P < 0.01, P < 0.001, P < 0.05). The mRNA levels of DPP4, CTGF and TGF-β1 in the model group also greatly declined after Sitagliptin treatment (P < 0.05, P < 0.001, P < 0.01). CONCLUSION The DPP4 inhibitor Sitagliptin lowers fasting blood glucose, relieves the high androgen state of PCOS rats and delays the process of ovarian fibrosis, which may be related to reducing the levels of factors related to the TGF-β1/Smad2/3 signaling pathway.
- Published
- 2018
31. Melatonin and its protective role in attenuating warm or cold hepatic ischaemia/reperfusion injury
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Lingfei Zhao, Chenxia Hu, Fen Zhang, and Lanjuan Li
- Subjects
Graft Rejection ,0301 basic medicine ,Cirrhosis ,injury ,medicine.medical_treatment ,Ischemia ,Reviews ,melatonin ,Apoptosis ,Inflammation ,Review ,Liver transplantation ,Pharmacology ,liver ,Protective Agents ,medicine.disease_cause ,Antioxidants ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,medicine ,Humans ,cardiovascular diseases ,business.industry ,ischaemia/reperfusion ,Cell Biology ,General Medicine ,medicine.disease ,Free radical scavenger ,Mitochondria ,030104 developmental biology ,inflammation ,Reperfusion Injury ,030220 oncology & carcinogenesis ,medicine.symptom ,business ,Reperfusion injury ,Oxidative stress ,Signal Transduction - Abstract
Although the liver is the only organ with regenerative capacity, various injury factors induce irreversible liver dysfunction and end‐stage liver disease. Liver resection and liver transplantation (LT) are effective treatments for individuals with liver failure, liver cirrhosis and liver cancers. The remnant or transplanted liver tissues will undergo hepatic ischaemia/reperfusion (IR), which leads to oxidative stress, inflammation, immune injury and liver damage. Moreover, systemic ischaemia induced by trauma, stroke, myocardial ischaemia, haemorrhagic shock and other injury factors also induces liver ischaemia/reperfusion injury (IRI) in individuals. Hepatic IRI can be divided into warm IRI, which is induced by liver surgery and systemic ischaemia, and cold IRI, which is induced by LT. Multiple studies have shown that melatonin (MT) acts as an endogenous free radical scavenger with antioxidant capacity and is also able to attenuate hepatic IRI via its anti‐inflammatory and antiapoptotic capacities. In this review, we discuss the potential mechanisms and current strategies of MT administration in liver surgery for protecting against warm or cold hepatic IRI. We highlight strategies to improve the efficacy and safety of MT for attenuating hepatic IRI in different conditions. After the potential mechanisms underlying the interactions between MT and other important cellular processes during hepatic IR are clarified, more opportunities will be available to use MT to treat liver diseases in the future., Melatonin serves as an endogenous free radical scavenger with antioxidation capacity, and it is also able to attenuate hepatic ischaemia/reperfusion injury via its anti‐inflammation, and antiapoptotic capacities.
- Published
- 2021
32. Nasopharyngeal brushing: a convenient and feasible sampling method for nucleic acid-based nasopharyngeal carcinoma research
- Author
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Shao Dan Zhang, Xi Zhao Li, Ye Zhu Hu, Tian Tian, Wei Hua Jia, Pei Fen Zhang, and Xiao Hui Zheng
- Subjects
0301 basic medicine ,Viral nucleic acid ,medicine.medical_specialty ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Cancer research ,Tissue samples ,Gastroenterology ,lcsh:RC254-282 ,Virus ,Specimen Handling ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Nasopharynx ,otorhinolaryngologic diseases ,medicine ,Nasopharyngeal carcinoma ,Humans ,business.industry ,Endoscopic biopsy ,Nasopharyngitis ,Reproducibility of Results ,Endoscopy ,Nasopharyngeal Neoplasms ,DNA, Neoplasm ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,MicroRNAs ,stomatognathic diseases ,030104 developmental biology ,Real-time polymerase chain reaction ,Oncology ,Nucleic acid ,030220 oncology & carcinogenesis ,Healthy individuals ,DNA, Viral ,Feasibility Studies ,RNA, Viral ,business ,Nasopharyngeal brushing - Abstract
Background Tissue specimens for nasopharyngeal carcinoma (NPC) research are scarce because of sampling difficulties. Previous studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC diagnosis. The present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for research. Methods Nasopharyngeal brushing samples were acquired from 24 healthy individuals and 48 NPC patients. Tissues from 48 NPC and 18 nasopharyngitis patients were collected by endoscopic biopsy. The expression levels of tumor suppressor genes (TSGs) and Epstein–Barr virus (EBV)-encoded microRNAs as well as EBV DNA copy number were measured by quantitative polymerase chain reaction in both types of samples. Results Among six TSGs examined, the expression levels of two genes were significantly decreased in nasopharyngeal brushing and tissue samples from NPC patients as compared with those from healthy/nasopharyngitis individuals. Four EBV-encoded microRNAs, mir-bart1-5p, mir-bart5, mir-bart6-5p, and mir-bart17-5p, were significantly up-regulated in both NPC brushing and tissue samples compared with those from healthy/nasopharyngitis controls (P
- Published
- 2018
33. Notch signaling pathway regulates cell cycle in proliferating hepatocytes involved in liver regeneration
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Shuqiang Yue, Xiao Li, Bowei Li, Kaishan Tao, Jinglong Zhang, and Fen Zhang
- Subjects
0301 basic medicine ,chemistry.chemical_classification ,Hepatology ,business.industry ,Gastroenterology ,Notch signaling pathway ,Cell cycle ,Ligand (biochemistry) ,Liver regeneration ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Enzyme ,chemistry ,030220 oncology & carcinogenesis ,Hepatocyte ,medicine ,business ,Protein kinase B ,Cyclin - Abstract
Background and aim It has been well documented that Notch signaling is involved in liver regeneration. However, the exact molecular mechanism mediating this process is not fully elucidated. The current study aimed to investigate the role of Notch signaling regulating cell cycle in proliferating hepatocytes in liver regeneration after partial hepatectomy (PHx, 67% resection) and the related molecular mechanism. Methods Partial hepatectomy was performed in Sprague Dawley rats, and remnant livers were harvested 0, 1, 3, 5, and 7 days after operation, and primary hepatocytes were isolated to investigate the molecular mechanism. Results Notch signaling activation and hepatocyte proliferation were significantly increased after PHx, while treatment with FLI-06, the inhibitor of γ-secreting enzyme, blocked these trends. Besides, inhibition of Notch signaling led to dysregulation of cell cycle and cell-cycle components. Furthermore, Akti-1/2 (a selective Akt inhibitor) and PX-478 (a selective Hif-1α inhibitor) inhibited hepatocyte proliferation and liver regeneration after PHx, and the effect of downstream molecules activation by Jagged-1 (Notch-1 ligand) in hepatocytes was abolished by FLI-06, Akti-1/2, and PX-478. Conclusion The current study demonstrated for the first time that Notch signaling regulated cell cycle in proliferating hepatocytes involved in liver regeneration through NICD/Akt Akt/Hif-1α pathway.
- Published
- 2018
34. Thermal Decomposition Kinetics of Nitroguanidine Propellant under Different Pressures
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Zhitao Liu, Fen Zhang, and Ping Du
- Subjects
Propellant ,Materials science ,010304 chemical physics ,General Chemical Engineering ,Kinetics ,Thermal decomposition ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Nitroguanidine ,chemistry ,Chemical engineering ,0103 physical sciences - Published
- 2018
35. Diffuse large B cell lymphoma associated with chronic inflammation arising within atrial myxoma: aggressive histological features but indolent clinical behaviour
- Author
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Su Yao, Jinhai Yan, Jiao He, Dong-lan Luo, Jie Xu, Lingyi Fu, Fangping Xu, Yu Chen, Xin-lan Luo, Fen Zhang, and Yan-hui Liu
- Subjects
Male ,Epstein-Barr Virus Infections ,Pathology ,medicine.medical_specialty ,Histology ,Proliferative index ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Immunophenotyping ,Pathology and Forensic Medicine ,Heart Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,medicine ,Humans ,Heart Atria ,Epstein–Barr virus infection ,Inflammation ,Chemotherapy ,business.industry ,Myxoma ,General Medicine ,Middle Aged ,medicine.disease ,Lymphoma ,Radiation therapy ,030220 oncology & carcinogenesis ,Chronic Disease ,Female ,Lymphoma, Large B-Cell, Diffuse ,business ,Diffuse large B-cell lymphoma - Abstract
Aims Primary cardiac lymphoma (PCL) is a rare neoplasm. PCL is fatal, unless it is diagnosed and treated early. Recently, a small number of cases of diffuse large B cell lymphoma (DLBCL) arising within atrial myxoma have been reported in immunocompetent patients and showed aggressive histologic features but an indolent clinical behaviour. Methods And Results We presented four unusual cases of Epstein-Barr virus (EBV)-positive DLBCL arising within atrial myxoma with detailed clinical, histologic, immunophenotypic and genotypic features in immunocompetent patients, and reviewed the literature for 11 similar cases. All the patients appeared to have morphologic features of DLBCL, B-lineage immunophenotype, high proliferative index and latency type III of EBV infection. They achieved complete tumour resection without chemotherapy or radiotherapy after surgery and were healthy at 10-year, 7-year, 7-month and 3-month follow-ups, respectively. Conclusions We suggest that this lymphoma should be noted as a unique DLBCL associated with chronic inflammation (DLBCL-CI) because of an indolent clinical behaviour to avoid excessive or unnecessary treatments. In addition, early accurate diagnosis and complete resection of this tumour are crucial for the patients’ medical prognosis. This article is protected by copyright. All rights reserved.
- Published
- 2017
36. Risk factors of lymph node metastasis in 1620 early gastric carcinoma radical resections in Jiangsu Province in China: A multicenter clinicopathological study
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Ling Chen, Yao Hui Wang, Yu Qing Cheng, Ming Zhan Du, Jiong Shi, Xiang Shan Fan, Xiao Li Zhou, Yi Fen Zhang, Ling Chuan Guo, Gui Fang Xu, Ya Min He, Dan Zhou, Xiao Ping Zou, Qin Huang, and The Jiangsu Province Early Gastric Team
- Subjects
Oncology ,medicine.medical_specialty ,Univariate analysis ,business.industry ,Lymphovascular invasion ,Gastroenterology ,Perineural invasion ,Cancer ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Poorly cohesive carcinoma ,030220 oncology & carcinogenesis ,Signet ring cell carcinoma ,Internal medicine ,medicine ,Carcinoma ,Adenocarcinoma ,030211 gastroenterology & hepatology ,business - Abstract
OBJECTIVE To investigate risk factors (RF) of lymph node metastasis (LNM) in early gastric carcinoma (EGC) in 4 tertiary medical centers in Jiangsu Province. METHODS Among 10097 consecutive combined gastric cancer radical resections, 1903 EGCs were identified and reviewed, 283 excluded, and 1620 included for the study. All pathologic and some endoscopic reports were studied for demographic, tumor location, gross feature, the number of lymph nodes retrieved and involved. Two pathologists independently investigated pathologic features of tumor type, differentiation, invasion depth, lymphovascular invasion (LVI), and perineural invasion. The data were statistically analyzed to determine RF of LNM. RESULTS The average number of lymph nodes retrieved was 17.5 per case. LNM was diagnosed in 15.5%. By univariate analysis, significant RFs for LNM included age > 41 years, female gender, flat and depressed patterns, size over 1 cm, submucosal invasion, poor differentiation, poorly cohesive carcinoma, micropapillary adenocarcinoma, adenocarcinoma mixed with signet-ring cell carcinoma, LVI, perineural invasion, and distal gastric location. By multivariate analysis, independent RFs for LNM were size > 3 cm (OR: 1.9), poor differentiation (OR: 2.5), adenocarcinoma mixed with signet-ring cell carcinoma (OR: 1.7), LVI (OR: 5.8), and submucosal invasion (OR: 2.9). In contrast, size < 3 cm and ulcer were not significant RFs. Early cardiac carcinoma (OR: 0.4) had significantly lower risk. CONCLUSION Independent RFs for LNM in EGC in Chinese patients included tumor size > 3 cm, poor differentiation, submucosal invasion, adenocarcinoma mixed with signet-ring cell carcinoma, and LVI. Early cardiac carcinoma had significantly lower risk for LNM.
- Published
- 2017
37. The small ubiquitin-like modifier E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under low-temperature conditions in apple
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Li-Jie Zhou, Yuan-Yuan Li, Xing-Bin Xie, Chun-Ling Zhang, Cheng Zhao, Yu-Jin Hao, and Rui-Fen Zhang
- Subjects
0106 biological sciences ,0301 basic medicine ,biology ,Physiology ,fungi ,SUMO protein ,food and beverages ,Plant Science ,01 natural sciences ,Ubiquitin ligase ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,chemistry ,Biochemistry ,Ubiquitin ,Transcription (biology) ,Anthocyanin ,biology.protein ,MYB ,Post-translational regulation ,Transcription factor ,010606 plant biology & botany - Abstract
MdMYB1 acts as a crucial component of the MYB-bHLH-WD40 (MBW) complex to regulate anthocyanin biosynthesis in red-skinned apples (Malus domestica), but little is known about its posttranslational regulation. Here, a SUMO E3 ligase MdSIZ1 was screened out as an MdMYB1-interacting protein with a yeast two-hybridization approach. The interaction between MdSIZ1 and MdMYB1 was further verified with pull-down and CoIP assays. Furthermore, it was found that MdSIZ1 directly sumoylated MdMYB1 proteins in vivo and in vitro, especially under moderately low temperature (17 °C) conditions, and that this sumoylation was required for MdMYB1 protein stability. Moreover, the transcription level of MdSIZ1 gene was remarkably induced by low temperature and phosphorus deficiency, and MdSIZ1 overexpression exerted a large positive influence on anthocyanin accumulation and red fruit coloration, suggesting its important role in the regulation of anthocyanin biosynthesis under stress conditions. Our findings reveal an important role for a SUMO modification of MYB transcription factors in regulation of anthocyanin biosynthesis in plants.
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- 2017
38. Interdecadal moisture patterns and teleconnections in Monsoonal Asia over the past seven centuries
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Fen Zhang, Feifei Zhou, Yingjun Li, and Keyan Fang
- Subjects
Wet season ,Atmospheric Science ,geography ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,Ocean current ,Zonal and meridional ,010502 geochemistry & geophysics ,Spatial distribution ,Monsoon ,01 natural sciences ,Peninsula ,Climatology ,Antarctic oscillation ,Geology ,0105 earth and related environmental sciences ,Teleconnection - Abstract
Interdecadal (10- to 100-year oscillation) moisture variations over the Monsoonal Asia (MA) is highly variable across regions and time, which are relatively less understood due to the shortness of the instrumental data of a few decades. In this study, comprehensive investigations on the spatiotemporal distributions of the interdecadal moisture variations over MA as well as their evolution from prior to the industrial era were conducted utilizing the tree-ring based drought reconstructions, i.e. the Monsoonal Asia Drought Atlas. Nine interdecadal moisture patterns in MA are identified using the self-organizing map based on the ensemble empirical mode decomposition. To further investigate these interdecadal moisture patterns, we aggregated the selected nine nodes into four patterns using a hierarchical clustering approach. Among them, Pattern 1 stands for a teleconnection between the Northeast MA and the Indian Peninsula, and Pattern 2 represents a dipole pattern between the Southern and Northern MA. We find that Pattern 1 may be linked with the dynamics of the Antarctic Oscillation that can modulate the strength of the Asian summer monsoon through meridional teleconnections. Pattern 2 is mainly driven by the elevated El Nino-Southern Oscillation variance and the zonal 'Silk Road Pattern' to bridge this interdecadal modulation.
- Published
- 2016
39. Enantioselective Construction of Aryl-Substituted All-Carbon Quaternary Stereocenters by Using Tertiary Amine-Thiourea-Catalyzed Michael Additions
- Author
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Peng Chen, Guo-Jie Liu, Xu Bao, Le-Fen Zhang, and Yi-Jun Jiang
- Subjects
Tertiary amine ,010405 organic chemistry ,Aryl ,Organic Chemistry ,Enantioselective synthesis ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Stereocenter ,chemistry.chemical_compound ,Enantiopure drug ,chemistry ,Organocatalysis ,Michael reaction ,Organic chemistry ,Physical and Theoretical Chemistry - Abstract
A catalytic enantioselective synthetic strategy for the aryl-substituted all-carbon quaternary stereocenters of bioactive hydrodibenzofuran alkaloids was achieved by the Michael addition reaction of α-cyano ketones and acrylates using a chiral tertiary amine–thiourea catalyst. This method can tolerate steric bulkiness and multiple functional groups, and 32 Michael adducts were prepared in good to excellent yields with moderate to good enantioselectivities. The enantiopurity of the products could also be enriched up to 99 % ee after one recrystallization. This enantioselective Michael addition features a low cost, metal-free, and easily operable procedure that can provide multifunctionalized enantiopure Michael adducts on a four-gram scale and supply sufficient amounts of potential precursors for a number of hydrodibenzofuran natural products.
- Published
- 2016
40. Tree-ring recorded drought variability in the northern Min Mountains of northwestern China
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Xiaohua Gou, Yang Deng, Fen Zhang, Xiangyu Xu, Meixue Yang, and Linlin Gao
- Subjects
Atmospheric Science ,010504 meteorology & atmospheric sciences ,Range (biology) ,Asian summer monsoon ,010502 geochemistry & geophysics ,01 natural sciences ,Geography ,Climatology ,Evapotranspiration ,Pinus tabulaeformis ,Dendrochronology ,Precipitation ,China ,0105 earth and related environmental sciences - Abstract
Drought is a recurrent natural disaster in northwestern China and it can have a substantial impact on the affected region; therefore, knowledge of drought variability is very important for drought adaptation and mitigation. However, the observed climate data are generally limited in length, which may hamper our understanding the full range of drought variability. Using tree-ring width measurements of 155 series from 81 Pinus tabulaeformis trees at three sites in the northern Min Mountains of northwestern China, the standardized precipitation evapotranspiration index (SPEI) for May-August from 1804 to 2011 were reconstructed, which account for 64.8% of the variance in the instrumental record over 1954-2011. The new reconstruction is generally consistent with other moisture reconstructions nearby. Two notable features of the SPEI reconstruction is the severe drought starting in the late 1990s and the gradual drying trend since 1954. These features are also apparent in areas located in the north boundaries of Eastern Asian Summer Monsoon (EASM), which indicates that the study area may be affected by the EASM.
- Published
- 2015
41. Peroxymonosulfate Improves the Activity and Stability of Manganese Oxide for Oxidation of Arsenite to Arsenate
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Jingtao Hou, Yong Liu, Fen Zhang, and William Hartley
- Subjects
Quenching (fluorescence) ,Sulfate radicals ,Arsenate ,02 engineering and technology ,010501 environmental sciences ,Manganese oxide ,Phosphate ,01 natural sciences ,Pollution ,Redox ,Catalysis ,chemistry.chemical_compound ,020401 chemical engineering ,chemistry ,Environmental Chemistry ,0204 chemical engineering ,0105 earth and related environmental sciences ,Water Science and Technology ,Nuclear chemistry ,Arsenite - Abstract
Manganese oxide has been widely investigated for oxidation of arsenite (As(III)) to arsenate (As(V)) due to its high redox potential, however it becomes extremely unstable after reuse. Here, As(III) oxidation activity and stability of manganese oxide in the presence of peroxymonosulfate (PMS) was investigated. Batch experimental results revealed that manganese oxide/PMS exhibits high catalytic activity for As(III) oxidation compared to manganese oxide or PMS alone. Addition of PMS to manganese oxide not only revealed long‐term stability for As(III) oxidation, but also showed high As(III) oxidation activity in the presence of coexisting ions such as As(V) and phosphate. Quenching tests revealed that As(III) oxidation in the manganese oxide/PMS system was attributed to activation of PMS by manganese oxide at different oxidation states (Mn(III) and Mn(IV)), and the generation of sulfate radicals that were responsible for As(III) oxidation.
- Published
- 2020
42. Analysis of upper and middle segment esophageal setup errors and planning of target margins based on cone beam computed tomography for esophageal radiation with immobilized thermoplastic film
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Yong, Shi, primary, Ying, Chen, additional, Fen, Zhang, additional, Ling, Li, additional, Yanli, Liu, additional, Qinying, Yan, additional, Min, Zhang, additional, Chengjian, Li, additional, and Dong, Li, additional
- Published
- 2019
- Full Text
- View/download PDF
43. Effect of codoping Ce 3+ on the luminescence properties of Sr 9 Mg 1.5 (PO 4 ) 7 :Eu 2+ orange–yellow phosphor
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Wanjun, Tang, primary and Fen, Zhang, additional
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- 2019
- Full Text
- View/download PDF
44. Two New Iridoid Esters from the Root and Rhizome ofValeriana jatamansi<scp>Jones</scp>
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Yao-Kang Xiong, Hua-Jun Zhao, Man-cang Gu, Jian-fen Zhang, Hui-zhu Song, and Bo Yang
- Subjects
Iridoid ,Chemistry ,Stereochemistry ,medicine.drug_class ,Valeriana jatamansi ,Chemical structure ,Plant composition ,Organic Chemistry ,Biochemistry ,Catalysis ,Jatamanvaltrate P ,Rhizome ,Inorganic Chemistry ,Drug Discovery ,Botany ,medicine ,Physical and Theoretical Chemistry ,Chemical composition - Abstract
Two new iridoid esters, named valerjatadoids A and B (1 and 2, resp.), together with three known iridoid esters, jatamanin O (3), jatamanvaltrate P (4), and jatamanvaltrate Q (5), have been isolated from the root and rhizome of Valeriana jatamansi Jones. The structures of the two new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques.
- Published
- 2015
45. Serum Krebs von den Lungen-6 level as a diagnostic biomarker for interstitial lung disease in Chinese patients
- Author
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Li Shen, Fen Zhang, Shan-Shan Du, Hua-Ping Dai, Ying Zhou, Hui-Ping Li, Xian He, Liu-Sheng Wang, Xiao-Li Sun, Dong Weng, Yiliang Su, Yue-Ping Jin, Jinghong Dai, Yang Hu, Yu-Kui Du, Wen-Hui Zhang, Jing-Jing Ding, Hou-Rong Cai, and Qiuhong Li
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pathology ,behavioral disciplines and activities ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Immunology and Allergy ,Medicine ,Diagnostic biomarker ,Genetics (clinical) ,030203 arthritis & rheumatology ,Kappa value ,Receiver operating characteristic ,business.industry ,Interstitial lung disease ,Diagnostic marker ,respiratory system ,medicine.disease ,Confidence interval ,respiratory tract diseases ,body regions ,030228 respiratory system ,Healthy individuals ,Biomarker (medicine) ,business - Abstract
Objectives The purpose of this study was to determine the diagnostic and prognostic values of serum KL-6 levels in Chinese patients with interstitial lung disease (ILDs). Methods A total of 1084 subjects including 373 cases of ILDs, 584 cases of non-ILD pulmonary diseases, and 127 healthy individuals were recruited from three clinical centers in China between January 2011 and December 2013. A total of 106 patients undergoing treatments for ILDs in Shanghai Pulmonary Hospital between January 2011 and December 2013 were enrolled. Baseline and posttreatment serum KL-6 levels were determined. Results Serum KL-6 levels in patients with ILDs were significantly higher than those in patients with non-ILD pulmonary diseases or in healthy individuals (1492.09 ± 2230.08 U/mL vs 258.67 ± 268.73 U/mL or 178.73 ± 71.17 U/mL, all P
- Published
- 2015
46. Neonatal thyroid function born to mothers living with long-term excessive iodine intake from drinking water
- Author
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Wen Chen, Shu-fen Zhang, Feng Dong, Guiqin Zhang, Wei Wei, Long Tan, Wanqi Zhang, Jun Shen, Na Zhao, Zhaixiao Yao, Zanjun Chu, and Zhongna Sang
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Thyroid Gland ,Thyrotropin ,chemistry.chemical_element ,Excessive iodine intake ,Urine ,Thyroid Function Tests ,Iodine ,Thyroid function tests ,Young Adult ,Endocrinology ,Pregnancy ,Internal medicine ,medicine ,Humans ,Geography ,medicine.diagnostic_test ,business.industry ,Drinking Water ,Thyroid ,Infant, Newborn ,Fetal Blood ,medicine.disease ,Thyroxine ,Cross-Sectional Studies ,medicine.anatomical_structure ,chemistry ,Prenatal Exposure Delayed Effects ,Cord blood ,Triiodothyronine ,Female ,Thyroid function ,business - Abstract
SummaryObjective The effects of long-term excessive maternal iodine intake on neonatal thyroid function are less known. This study aimed to assess the effects of maternal excessive iodine intake from drinking water on thyroid functions of both mothers and their neonates. Design and Methods This observational study was performed in high iodine (HI) areas and adequate iodine (AI) intake areas, including 384 healthy pregnant women in late gestation (mean week 39·3 ± 1·6 weeks) and their newborns. Blood and urine samples were obtained from pregnant women, while cord blood samples were obtained from neonates. Urinary iodine concentration (UIC) and thyroid function were evaluated. Results The median maternal UIC was 1241 and 217 μg/l in HI and AI areas, respectively (P
- Published
- 2014
47. Uterine perforation in an adolescent using an intrauterine device with memory function: A case report and review of the published work
- Author
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Zhi-Fen Zhang, Jin-Yi Tong, Mei Jin, Wen-Chao Sun, Juan Li, and Xiu-Zhen Shen
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Abdominal pain ,medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Obstetrics ,Uterine perforation ,Population ,Obstetrics and Gynecology ,medicine.disease ,Intrauterine device ,Endoscopy ,Surgery ,Vomiting ,Medicine ,medicine.symptom ,business ,Complication ,Laparoscopy ,education - Abstract
Intrauterine devices (IUD) are the most common method of reversible birth control used worldwide. Adolescents infrequently have uterine perforation caused by IUD, hampering both the diagnosis and treatment. Herein, we report a case of uterine perforation in an 18-year-old primipara after insertion of an IUD that possessed memory function (AiMu MCu). The patient presented with vomiting and abdominal pain after insertion of an AiMu MCu IUD, was treated via laparoscopy and had a full recovery. The present case indicated that uterine perforation caused by an AiMu MCu IUD may occur as a rare complication and that uterine perforation can occur in an adolescent. Clinicians might consider a diagnosis of uterine perforation in an adolescent reporting vomiting and abdominal pain after IUD insertion. Laparoscopy could be a reasonable treatment option for such patients.
- Published
- 2014
48. Changing trends in the proportions of small (≤2 cm) proximal and non-proximal gastric carcinomas treated at a high-volume tertiary medical center in China
- Author
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Bi Yun Xu, Qin Huang, Hiroshi Mashimo, Xiao Ping Zou, Lily Huang, Qi Sun, Jiong Shi, Cheng Gong Yu, Hui Ping Yu, Yi Fen Zhang, and Jason S. Gold
- Subjects
medicine.medical_specialty ,business.industry ,Male patient ,Internal medicine ,Female patient ,Gastroenterology ,medicine ,Gastric carcinoma ,business ,Gastroesophageal Junction ,Gastric corpus ,Surgery - Abstract
Objective Guided by the recently established histological criteria of the gastroesophageal junction (GEJ), we aimed to investigate and compare trends in the proportions of small (≤2 cm) proximal gastric carcinoma (PGC) vs non-PGC (NPGC) in Chinese patients over an 8-year period. Methods The study was conducted with consecutive surgical resected specimens of small PGC that was located within 3 cm below the GEJ and NPGC (located at all other gastric regions) treated at a single medical center in China. Differences in proportions between the two groups were compared. Results Among all 313 cases, 111 (35.5%) were classified as PGC and the remaining 202 (64.5%) as NPGC. Patients with PGC were significantly elder than those with NPGC, and none aged younger than 40 years. The proportions of PGC significantly and progressively increased from 16% in 2004 to 45% in 2011, in contrast to a steady decreasing trend for NPGC from 84% to 55% over the same period. The difference in trends between the two groups approached, but was not at a statistically significant level (P = 0.08). Proportions of small cancers in the gastric corpus and in female patients remained low and stable, in contrast to a significantly higher proportion in male patients (P
- Published
- 2014
49. Optical properties and energy transfer of Eu2+/Ce3+co-activated Na3Ca6(PO4)5phosphor
- Author
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Wanjun Tang and Fen Zhang
- Subjects
Crystal ,Chemistry (miscellaneous) ,Chemistry ,Phase (matter) ,Doping ,Biophysics ,Analytical chemistry ,Phosphor ,Luminescence ,Emission intensity ,Powder diffraction ,Ion - Abstract
Ce(3+) /Eu(2+) co-doped Na3 Ca6 (PO4 )5 phosphors were prepared using a combustion-assisted synthesis method. X-Ray powder diffraction (XRD) analysis confirmed the formation of a Na3 Ca6 (PO4 )5 crystal phase. Na3 Ca6 (PO4 )5 :Eu(2+) phosphors have an efficient bluish-green emission band that peaks at 489 nm, whereas Ce(3+) -doped Na3 Ca6 (PO4 )5 showed a bright emission band at 391 nm. Analysis of the experimental results suggests that enhancement of the Eu(2+) emission intensity in co-doped Na3 Ca6 (PO4 )5 :Eu(2+) ,Ce(3+) phosphors is due to a resonance-type energy transfer from Ce(3+) to Eu(2+) ions, which is predominantly governed by an exchange interaction mechanism. These results indicate that Ce(3+) /Eu(2+) co-doped Na3 Ca6 (PO4 )5 is potentially useful as a highly efficient, bluish-green emitting, UV-convertible phosphor for white-light-emitting diodes.
- Published
- 2014
50. Asymmetric consequences of host plant occupation on the competition between the whiteflies Bemisia tabaci cryptic species MEAM1 and Trialeurodes vaporariorum (Hemiptera: Aleyrodidae)
- Author
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Fang-Hao Wan, Man Hu, Gábor L. Lövei, and Gui-fen Zhang
- Subjects
Species complex ,biology ,Ecology ,media_common.quotation_subject ,Trialeurodes ,General Medicine ,Whitefly ,Interspecific competition ,biology.organism_classification ,Hemiptera ,Competition (biology) ,Colonisation ,Insect Science ,Nymph ,Agronomy and Crop Science ,media_common - Abstract
BACKGROUND The two common whitefly species, Bemisia tabaci (Gennadius) MEAM1 and Trialeurodes vaporariorum (Westwood), often co-occur on their host plants. The effect of host plant occupation by one species on later-arriving conspecific individuals or on the other competing species was examined. RESULTS Resource preoccupied by T. vaporariorum had mostly negative effects on the life history parameters of later-arriving conspecifics. Red-eyed nymph and immature survival of T. vaporariorum decreased when resource was preoccupied by conspecifics, irrespective of the previous occupation scenario. However, resource preoccupied by T. vaporariorum had only minor detrimental effects on the performance of later-arriving B. tabaci MEAM1. In the opposite colonisation sequence, previous occupation by B. tabaci MEAM1 had no significant effects on the life history parameters of later-arriving conspecifics, but severe detrimental effects were observed on the performance of later-arriving T. vaporariorum. Total immature survival of T. vaporariorum decreased in both weak and strong previous occupation situations by B. tabaci MEAM1. CONCLUSION The interspecific interactions between B. tabaci MEAM1 and T. vaporariorum were asymmetric, with B. tabaci MEAM1 being the superior competitor. This superiority could partially explain the rapid spread of B. tabaci MEAM1 in China. © 2013 Society of Chemical Industry
- Published
- 2014
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