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Your search keyword '"Fu, Qiong"' showing total 24 results
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24 results on '"Fu, Qiong"'

1. Single‐Cell Profiling of Bone Marrow B Cells and Early B Cell Developmental Disorders Associated With Systemic Lupus Erythematosus

Author

Dong, Chen, primary, Guo, Yicheng, additional, Chen, Zechuan, additional, Li, Teng, additional, Ji, Juan, additional, Sun, Chi, additional, Li, Jing, additional, Cao, Haixia, additional, Xia, Yunfei, additional, Xue, Zhonghui, additional, Gu, Xixi, additional, Liang, Qian, additional, Zhao, Rui, additional, Fu, Ting, additional, Ma, Jiaqiang, additional, Jiang, Shan, additional, Wu, Chunmei, additional, Fu, Qiong, additional, Guo, Genkai, additional, Bao, Yanfeng, additional, Guo, Hua, additional, Yang, Junling, additional, Xu, Min, additional, Zhang, Xiaoming, additional, Sheng, Zizhang, additional, and Gu, Zhifeng, additional

Published
2024
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3. CAR modulates plasma membrane nano‐organization and immune signaling downstream of RALF1‐FERONIA signaling pathway

Author

Chen, Weijun, primary, Zhou, Huina, additional, Xu, Fan, additional, Yu, Meng, additional, Coego, Alberto, additional, Rodriguez, Lesia, additional, Lu, Yuqing, additional, Xie, Qijun, additional, Fu, Qiong, additional, Chen, Jia, additional, Xu, Guoyun, additional, Wu, Dousheng, additional, Li, Xiushan, additional, Li, Xiaojuan, additional, Jaillais, Yvon, additional, Rodriguez, Pedro L., additional, Zhu, Sirui, additional, and Yu, Feng, additional

Published
2023
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4. Two Distinct Immune Cell Signatures Predict the Clinical Outcomes in Patients With Amyopathic Dermatomyositis With Interstitial Lung Disease

Author

Ye, Yan, primary, Zhang, Xueliang, additional, Li, Teng, additional, Ma, Jiaqiang, additional, Wang, Ran, additional, Wu, Chunmei, additional, Wang, Runci, additional, Bao, Chunde, additional, Ye, Shuang, additional, Shen, Nan, additional, Guo, Qiang, additional, Fu, Qiong, additional, and Zhang, Xiaoming, additional

Published
2022
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10. Urine Metabolic Fingerprints Encode Subtypes of Kidney Diseases

Author

Yang, Jing, primary, Wang, Ran, additional, Huang, Lin, additional, Zhang, Mengji, additional, Niu, Jingyang, additional, Bao, Chunde, additional, Shen, Nan, additional, Dai, Min, additional, Guo, Qiang, additional, Wang, Qian, additional, Wang, Qin, additional, Fu, Qiong, additional, and Qian, Kun, additional

Published
2019
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12. Early intervention with glucagon‐like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice

Author

Weijie Xu, Yan Yang, Fu-Qiong Chen, Delin Ma, Wen-Zhu Yue, and Gang Yuan

Subjects
Blood Glucose, Male, medicine.medical_specialty, medicine.medical_treatment, Tau protein, Hyperphosphorylation, tau Proteins, Type 2 diabetes, Biology, Weight Gain, Hippocampus, Biochemistry, Diabetes Mellitus, Experimental, Glycogen Synthase Kinase 3, Mice, Cellular and Molecular Neuroscience, Diabetic Neuropathies, Internal medicine, medicine, Animals, Hypoglycemic Agents, Insulin, Phosphorylation, Glycogen synthase, Protein kinase B, Brain Chemistry, Liraglutide, medicine.disease, Glucagon-like peptide-1, Oncogene Protein v-akt, Endocrinology, biology.protein, Insulin Resistance, medicine.drug
Abstract

Increasing evidence has shown that type 2 diabetes (T2D) is a risk factor for Alzheimer's disease. Neurofibrillary tangles, which consist of hyperphosphorylated tau and misfolded microtubules, is one of the neuropathological hallmarks of Alzheimer's disease. Db/db mice, a rodent model of T2D, also exhibited age-dependent tau hyperphosphorylation. Glucagon-like peptide-1 (GLP-1) mimetics, a type of drug used in T2D, has been found to have neuroprotective effects. The aim of this study was to explore the potential effects of liraglutide (a GLP-1 analog), or insulin, on tau phosphorylation in T2D animals. Male db/db mice (3-3.5 weeks) were daily injected subcutaneously with liraglutide (n = 27), insulin (n = 27), or saline (n = 26), and five to seven mice were killed every 2 weeks for analysis of plasma and cerebrospinal (CSF) insulin levels by ELISA, and protein levels in the hippocampal formation by western blot. We found that db/db mice treated with saline exhibited an age-dependent decrease in CSF insulin and an increase in hippocampal tau phosphorylation. Liraglutide injection reversed the CSF insulin to ~1 mIU/L by the end of 8 weeks treatment, and prevented the hyperphosphorylation of tau protein in the hippocampal formation. By contrast, insulin injection had no effects on CSF insulin or phosphorylation of tau protein. In summary, this study indicates that early GLP-1 analog intervention prevented the age-dependent tau hyperphosphorylation in T2D mice brain, probably by facilitating sequential activation in an insulin signaling pathway reflected in increased basal activation of Akt and basal suppression of glycogen synthase kinase-3 beta.

Published
2015

19. Reply

Author

Fu, Qiong, primary, Zhao, Jian, additional, Hahn, Bevra H., additional, Harley, John B., additional, Mok, Mo Yin, additional, Bae, Sang-Cheol, additional, Arnett, Frank C., additional, and Tsao, Betty P., additional

Published
2011
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24. Antinuclear antibodies and interleukin responses in patients with Schistosoma japonicum infection.

Author

Wang X, Fu Q, Song R, Duan B, Bergquist R, Xu J, Li S, Zhou D, and Qin Z

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Animals, Antibodies, Antinuclear immunology, Antibodies, Protozoan immunology, Autoimmunity immunology, Child, Female, Humans, Male, Middle Aged, Schistosomiasis japonica blood, Young Adult, Antibodies, Antinuclear blood, Antibodies, Protozoan blood, Antigens, Helminth immunology, Helminth Proteins immunology, Interleukin-10 blood, Interleukin-12 blood, Interleukin-17 blood, Schistosoma japonicum immunology, Schistosomiasis japonica immunology
Abstract

Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late-stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflected by dysfunctional, auto-reactive antibodies. Antinuclear antibodies (ANA) have been reported in schistosomiasis due to S. mansoni and S. haematobium. We demonstrate ANA in schistosomiasis japonica and explore the relationship between this infection and autoimmune disease by measuring ANA and interleukin (IL)-10, IL-12 and IL-17 responses in the sera of 125 Chinese patients with different stages of schistosomiasis japonica. The incidence rates of ANA in the patients with acute, chronic and late stages of schistosomiasis infection were 6.7%, 23.3% and 70.0%, respectively, with statistically significant differences between each stage (P = 0.000). IL-17 concentrations were high at the acute stage of schistosomiasis compared to the other stages of the disease (P = 0.000). This pattern was also seen for IL-10 and IL-12 concentrations (P = 0.01). IL concentrations in patients in the chronic and late stages of the disease were low and showed no difference compared to the healthy adults., (© 2018 John Wiley & Sons Ltd.)

Published
2018
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