1. Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial
- Author
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Corine M. Koopmans, Hubertina C.J. Scheepers, M. Porath, M.G. van Pampus, Kitty W.M. Bloemenkamp, K. de Boer, J. A. M. van der Post, C. J. M. de Groot, A.J. van Loon, K. van der Tuuk, G. A. van Unnik, Anjoke J.M. Huisjes, R.J. Rijnders, Patrick M. Bossuyt, B.W. Mol, R.H. Stigter, D. N. M. Papatsonis, Hendricus Groen, P. P. van der Berg, E. van Beek, Anneke Kwee, Parvin Tajik, A. H. Zwinderman, Amsterdam Public Health, Amsterdam Reproduction & Development (AR&D), Epidemiology and Data Science, Obstetrics and Gynaecology, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), Obstetrie & Gynaecologie, RS: GROW - School for Oncology and Reproduction, Science in Healthy Ageing & healthcaRE (SHARE), Reproductive Origins of Adult Health and Disease (ROAHD), Methods in Medicines evaluation & Outcomes research (M2O), Obstetrics and gynaecology, and ICaR - Ischemia and repair
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Gestational hypertension ,Pregnancy, High-Risk ,medicine.medical_treatment ,law.invention ,Randomized controlled trial ,law ,reproductive and urinary physiology ,expectant management ,RISK ,education.field_of_study ,Obstetrics ,CESAREAN DELIVERY ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,Bishop score ,female genital diseases and pregnancy complications ,medicine.anatomical_structure ,PREGNANCY ,Female ,Adult ,medicine.medical_specialty ,induction of labour ,pre-eclampsia ,Decision Making ,Population ,Maternal Medicine ,Gestational Age ,medicine ,MANAGEMENT ,gestational hypertension ,Humans ,Caesarean section ,Labor, Induced ,education ,Cervix ,Gynecology ,Pregnancy ,Cesarean Section ,business.industry ,NULLIPAROUS WOMEN ,Hypertension, Pregnancy-Induced ,Delivery, Obstetric ,medicine.disease ,cervical length ,ELECTIVE INDUCTION ,Quality of hospital and integrated care [NCEBP 4] ,business ,Cervical Ripening - Abstract
Please cite this paper as: Tajik P, van der Tuuk K, Koopmans C, Groen H, van Pampus M, van der Berg P, van der Post J, van Loon A, de Groot C, Kwee A, Huisjes A, van Beek E, Papatsonis D, Bloemenkamp K, van Unnik G, Porath M, Rijnders R, Stigter R, de Boer K, Scheepers H, Zwinderman A, Bossuyt P, Mol B. Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial. BJOG 2012;119:11231130. Objective To examine whether cervical favourability (measured by cervical length and the Bishop score) should inform obstetricians decision regarding labour induction for women with gestational hypertension or mild pre-eclampsia at term. Design A post hoc analysis of the Hypertension and Pre-eclampsia Intervention Trial At Term (HYPITAT). Setting Obstetric departments of six university and 32 teaching and district hospitals in the Netherlands. Population A total of 756 women diagnosed with gestational hypertension or pre-eclampsia between 36 + 0 and 41 + 0 weeks of gestation randomly allocated to induction of labour or expectant management. Methods Data were analysed using logistic regression modelling. Main outcome measures The occurrence of a high-risk maternal situation defined as either maternal complications or progression to severe disease. Secondary outcomes were caesarean delivery and adverse neonatal outcomes. Results The superiority of labour induction in preventing high-risk situations in women with gestational hypertension or mild pre-eclampsia at term varied significantly according to cervical favourability. In women who were managed expectantly, the longer the cervix the higher the risk of developing maternal high-risk situations, whereas in women in whom labour was induced, cervical length was not associated with a higher probability of maternal high-risk situations (test of interaction P = 0.03). Similarly, the beneficial effect of labour induction on reducing the caesarean section rate was stronger in women with an unfavourable cervix. Conclusion Against widely held opinion, our exploratory analysis showed that women with gestational hypertension or mild pre-eclampsia at term who have an unfavourable cervix benefited more from labour induction than other women. Trial registration The trial has been registered in the clinical trial register as ISRCTN08132825.
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- 2012