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Your search keyword '"Gallego R. A."' showing total 42 results
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42 results on '"Gallego R. A."'

2. From seed dispersal service to reproductive collapse: density-dependent outcome of a palm–mammal interaction

Author

Muñoz-Gallego, R., Wiegand, Thorsten, Traveset, A., Fedriani, J.M., Muñoz-Gallego, R., Wiegand, Thorsten, Traveset, A., and Fedriani, J.M.

Abstract

Interspecific ecological interactions are inherently context-dependent. They may vary in both magnitude and sign depending on the biotic and abiotic conditions, depicting a mutualism–antagonism continuum. However, how population abundances and the activity of interacting species modulate these interactions remains underexplored. Here, we chose the interaction between the Mediterranean palm Chamaerops humilis and the feral goat Capra hircus in Mallorca (Balearic Islands, Spain). We selected three study plots with low, intermediate and high intensities of goat activity where we characterized palm distribution, seed rain, seed predation and early palm recruitment during two consecutive years. Since goats can cause both costs (e.g. florivory) and benefits (e.g. seed dispersal) to C. humilis performance, we investigated the following three questions: 1) does the spatial distribution of adult palms vary depending on the intensity of goat activity? 2) Does the intensity of goat activity influence seed rain and its potential spatial association with adult palms? 3) To what extent does the intensity of goat activity determine post-dispersal events such as seed predation and seedling emergence? We found that adult palms showed a more clumped and complex distribution (double-cluster process) in plots with low and intermediate goat activity compared to that with high goat activity (simple-cluster process). In the low goat activity plot, dispersed seeds were spatially aggregated around adult palms, showing twice as much insect-seed predation and nearly three times lower seed germination success than those in the intermediate goat activity plot. Palm seed dispersal and recruitment were almost nil in the high goat activity plot due to heavy consumption of palm inflorescences and developing fruits by goats. Our findings demonstrate how the net outcome of plant–animal interactions can change from mutualism to antagonism, from reproductive service to reproductive collapse, depending

Published
2023

3. Use of tocilizumab in kidney transplant recipients with COVID-19

Author

Perez-Saez M, Blasco M, Redondo-Pachon D, Ventura-Aguiar P, Bada-Bosch T, Perez-Flores I, Melilli E, Sanchez-Camara L, Lopez-Oliva M, Canal C, Shabaka A, Garra-Moncau N, Martin-Moreno P, Lopez V, Hernandez-Gallego R, Siverio O, Galeano C, Espi-Reig J, Cabezas C, Rodrigo M, Llinas-Mallol L, Fernandez-Reyes M, Cruzado-Vega L, Perez-Tamajon L, Santana-Estupinan R, Ruiz-Fuentes M, Tabernero G, Zarraga S, Ruiz J, Gutierrez-Dalmau A, Mazuecos A, Sanchez-Alvarez E, Crespo M, Pascual J, and Spanish Soc Nephrology COVID-19 Gr

Subjects
Graft Rejection, Male, kidney transplantation/nephrology, Comorbidity, Gastroenterology, law.invention, chemistry.chemical_compound, infection and infectious agents ‐ viral, Randomized controlled trial, law, Immunology and Allergy, Pharmacology (medical), education.field_of_study, Mortality rate, Incidence, Hazard ratio, Middle Aged, practice, clinical research/practice, infection and infectious agents - viral, kidney transplantation/nephrology, patient survival, Treatment Outcome, Female, Cohort study, Adult, medicine.medical_specialty, infection and infectious agents - viral, Population, nephrology, kidney transplantation, Brief Communication, clinical research/practice, Antibodies, Monoclonal, Humanized, Young Adult, Tocilizumab, patient survival, Internal medicine, medicine, Humans, education, Pandemics, Retrospective Studies, Transplantation, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Kidney Transplantation, Confidence interval, chemistry, clinical research, Spain, business, Cytokine storm, Follow-Up Studies
Abstract

Acute respiratory distress syndrome associated with coronavirus infection is related to a cytokine storm with large interleukin-6 (IL-6) release. The IL-6-receptor blocker tocilizumab may control the aberrant host immune response in patients with coronavirus disease 2019 (COVID-19) . In this pandemic, kidney transplant (KT) recipients are a high-risk population for severe infection and showed poor outcomes. We present a multicenter cohort study of 80 KT patients with severe COVID-19 treated with tocilizumab during hospital admission. High mortality rate was identified (32.5%), related with older age (hazard ratio [HR] 3.12 for those older than 60 years, P = .039). IL-6 and other inflammatory markers, including lactic acid dehydrogenase, ferritin, and D-dimer increased early after tocilizumab administration and their values were higher in nonsurvivors. Instead, C-reactive protein (CRP) levels decreased after tocilizumab, and this decrease positively correlated with survival (mean 12.3 mg/L in survivors vs. 33 mg/L in nonsurvivors). Each mg/L of CRP soon after tocilizumab increased the risk of death by 1% (HR 1.01 [confidence interval 1.004-1.024], P = .003). Although patients who died presented with worse respiratory situation at admission, this was not significantly different at tocilizumab administration and did not have an impact on outcome in the multivariate analysis. Tocilizumab may be effective in controlling cytokine storm in COVID-19 but randomized trials are needed.

Published
2020

4. Clinical Characteristics and Outcome of Drug‐Induced Liver Injury in the Older Patients: From the Young‐Old to the Oldest‐Old

Author

Weersink, Rianne A., primary, Alvarez‐Alvarez, Ismael, additional, Medina‐Cáliz, Inmaculada, additional, Sanabria‐Cabrera, Judith, additional, Robles‐Díaz, Mercedes, additional, Ortega‐Alonso, Aida, additional, García‐Cortés, Miren, additional, Bonilla, Elvira, additional, Niu, Hao, additional, Soriano, German, additional, Jimenez‐Perez, Miguel, additional, Hallal, Hacibe, additional, Blanco, Sonia, additional, Kaplowitz, Neil, additional, Lucena, M. Isabel, additional, Andrade, Raúl J., additional, Andrade, R.J., additional, Lucena, M.I., additional, Stephens, C., additional, García Cortés, M., additional, Robles Díaz, M., additional, Ortega Alonso, A., additional, Pinazo, J., additional, García Muñoz, B., additional, Alcántara, R., additional, Hernández, A., additional, García‐Escaño, M.D., additional, Medina‐Cáliz, I., additional, Sanabria‐Cabrera, J., additional, Alvarez‐Alvarez, I., additional, Bonilla, E., additional, Niu, H., additional, Di‐Zeo, D., additional, Del Campo, E., additional, Jiménez Pérez, M., additional, González Grande, R., additional, López Ortega, S., additional, Santaella, I., additional, Ocaña, A., additional, Palomino, P., additional, Fernández, M.C., additional, Porcel, A., additional, Casado, M., additional, González Sánchez, M., additional, Romero‐Gómez, M., additional, Millán‐Domínguez, R., additional, Fombuena, B., additional, Gallego, R., additional, Ampuero, J., additional, del Campo, J.A., additional, Calle‐Sanz, R., additional, Rojas, L., additional, Rojas, A., additional, Gil Gómez, A., additional, Vilar, E., additional, Soriano, G., additional, Guarner, C., additional, Román, E.M., additional, Quijada Manuitt, M.A., additional, Antonijoan Arbos, R.M., additional, Farré, M., additional, Montané, E., additional, Arellano, A.L., additional, Barriocanal, A.M., additional, Sanz, Y., additional, Morillas, R.M., additional, Sala, M., additional, Masnou Ridaura, H., additional, Sánchez Delgado, J., additional, Vergara Gómez, M., additional, Hallal, H., additional, García Oltra, E., additional, Titos Arcos, J.C., additional, Pérez Martínez, A., additional, Sánchez Cobarro, C., additional, Egea Caparrós, J.M., additional, Castiella, A., additional, Arenas, J., additional, Gomez Osua, M.I., additional, Gómez García, A., additional, Esandi, F.J., additional, Blanco, S., additional, Martínez Odriozola, P., additional, Crespo, J., additional, Iruzubieta, P., additional, Cabezas, J., additional, Giráldez Gallego, A., additional, Rodríguez Seguel, E. del P., additional, Cuaresma, M., additional, Prieto, M., additional, Conde Amiel, I., additional, Berenguer, M., additional, García‐Eliz, M., additional, Moreno, J.M., additional, Martínez‐Rodenas, P., additional, Garrido, M., additional, Oliva, C., additional, Gómez Domínguez, E., additional, Cabrera, L., additional, Cuevas, L., additional, Bruguera, M., additional, Gines, P., additional, Lens, S., additional, García, J.C., additional, Mariño, Z., additional, Hernández Guerra, M., additional, Moreno San Fiel, M., additional, Boada Fernández del Campo, C., additional, Fuentes Olmo, J., additional, Fernández Bonilla, E.M., additional, Jorquera, F., additional, and González Gallego, J., additional

Published
2020
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5. Role of mTOR inhibitors for the control of viral infection in solid organ transplant recipients

Author

Pascual, J, Royuela, A, Fernandez, AM, Herrero, I, Delgado, JF, Sole, A, Guirado, L, Serrano, T, de la Torre-Cisneros, J, Moreno, A, Cordero, E, Gallego, R, Lumbreras, C, and Aguado, JM

Subjects
mTOR inhibitors, sirolimus, virus diseases, everolimus, cytomegalovirus
Abstract

Appropriate post-transplant immunosuppressive regimens that avoid acute rejection, while reducing risk of viral reactivation, have been sought, but remain a chimera. Recent evidence suggesting potential regulatory and antiviral effects of mammalian target of rapamycin inhibitors (mTORi) is of great interest. Although the concept of an immunosuppressive drug with antiviral properties is not new, little effort has been made to put the evidence together to assess the management of immunosuppressive therapy in the presence of a viral infection. This review was developed to gather the evidence on antiviral activity of the mTORi against the viruses that most commonly reactivate in adult solid organ recipients: cytomegalovirus (CMV), polyomavirus, Epstein-Barr virus (EBV), human herpesvirus 8 (HHV8), and hepatitis C virus (HCV). A rapid review methodology and evaluation of quality and consistency of evidence based on the GRADE system was used. The existing literature was variable in nature, although indicating a potential advantage of mTORi in CMV, polyomavirus, and HHV8 infection, and a most doubtful relation with EBV and HCV infection. Several recommendations about the management of these infections are presented that can change certain current patterns of immunosuppression and help to improve the prognosis of the direct and indirect effects of viral infection in solid organ recipients.

Published
2016

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