1. An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium
- Author
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Worm, Margitta M., Alexiou, Aikaterina, Höfer, Veronika, Birkner, Till, Jeanrenaud, Alexander C.S.N., Fauchère, Florent, Pažur, Kristijan, Steinert, Carolin, Arnau-Soler, Aleix, Banerjee, Priyanka, Diefenbach, Andreas, Dobbertin-Welsch, Josefine, Dölle-Bierke, Sabine, Francuzik, W., Ghauri, Ahla, Heller, Stephanie, Kalb, Birgit, Löber, Ulrike, Marenholz, Ingo, Markó, Lajos, Scheffel, Jörg, Potapenko, Olena, Roll, Stephanie, Lau, Susanne, Lee, Young-ae, Braun, Julian, Thiel, Andreas, Babina, Magda, Altrichter, Sabine, Forslund, Sofia Kirke, Beyer, Kirsten, and Publica
- Subjects
food allergy ,epigenetics ,Cardiovascular and Metabolic Diseases ,biomarker ,microbiome ,peanut allergy - Abstract
Background: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. Methods: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.
- Published
- 2022