1. Fabrication, characterization, andin vitroevaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing
- Author
-
Donald C. Aduba, Seon Sook An, W. Andrew Yeudall, Gretchen S. Selders, Juan Wang, Todd Kitten, Hu Yang, and Gary L. Bowlin
- Subjects
Materials science ,Fabrication ,Biomedical Engineering ,02 engineering and technology ,Bacterial growth ,010402 general chemistry ,01 natural sciences ,Biomaterials ,chemistry.chemical_compound ,Freeze-drying ,Arabinoxylan ,medicine ,cardiovascular diseases ,Composite material ,Hydrogen peroxide ,Porosity ,Metals and Alloys ,021001 nanoscience & nanotechnology ,Antimicrobial ,0104 chemical sciences ,chemistry ,Ceramics and Composites ,lipids (amino acids, peptides, and proteins) ,Swelling ,medicine.symptom ,0210 nano-technology - Abstract
Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2456-2465, 2016.
- Published
- 2016
- Full Text
- View/download PDF