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13 results on '"Guan, Huashi"'

2. Potential of Eigen Value Method to the Study on Structure-antioxidant Activity Relationship

Author

Kong De-Xin, Guan Huashi, and Jiang Tao

Subjects
Quantitative structure–activity relationship, Chemistry, Stereochemistry, otorhinolaryngologic diseases, Structure (category theory), General Chemistry, Biochemical engineering, Eigenvalues and eigenvectors
Abstract

Antioxidants are of great interest because of their involvement in many important biological and industrial processes. It is meaningful to study their structure-antioxidant activity relationship (SAAR) and design novel, efficient and low-toxicity antioxidant. In this paper, Eigen Value Analysis (EVA), a 3-dimensional quantitative structure activity relationship (3-D QSAR) method, was employed to study antioxidant SAAR. Significant relational models were obtained with all the PLS cross-validate values being larger than 0.5, meaning that the models have sound predictive power. Compared with other QSAR methods, EVA possesses several advantages, especially that it does not need alignment. It should be believed that EVA will be an efficient approach to SAAR.

Published
2005
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3. 12?,13-Dihydroxyolean-3-oxo-28-oic acid, a New Triterpene, and the Known Oleanonic Acid as a New Cell Cycle Inhibitor fromSchefflera venulosa

Author

Wang Lei, Gu Qianqun, Liu Rui, Cai Bing, Cui Chengbin, Liu Hongbing, and Guan Huashi

Subjects
chemistry.chemical_classification, Triterpene, chemistry, Stereochemistry, General Chemistry, Fractionation, Cell cycle, Schefflera venulosa, IC50, Oleanonic acid
Abstract

12±,13-Dihydroxyolean-3-oxo-28-oic acid (1), a new pentacyclic triterpene, was isolated from Schefflera venulosa (Wight et Arn.) Harms through a bioassay-guided fractionation procedure, together with the known oleanonic acid (2) as a new cell cycle inhibitor. Structures were established by spectroscopy. Compound 2 inhibited the proliferation of K562 cells with the IC50 value of 0.13 µmol/mL by the SRB method and inhibited the cell cycle of tsFT210 cells at the G0/G1 phase at the concentration higher than 10 µg/mL.

Published
2005
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