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Your search keyword '"HSIEH, M-Y."' showing total 18 results
Start Over Author "HSIEH, M-Y." Publisher wiley
18 results on '"HSIEH, M-Y."'

1. Acute disseminated encephalomyelitis that meets modified McDonald criteria for dissemination in space is associated with a high probability of conversion to multiple sclerosis in Taiwanese patients

Author

Liao, M. F., primary, Huang, C. C., additional, Lyu, R. K., additional, Chen, C. M., additional, Chang, H. S., additional, Chu, C.‐C., additional, Hsu, W. C., additional, Wu, Y. R., additional, Kuo, H. C., additional, Cheng, M. Y., additional, Hung, P. C., additional, Chou, M. L., additional, Lin, K. L., additional, Hsieh, M. Y., additional, and Ro, L. S., additional

Published
2011
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17. Stochastic simulations of ErbB homo and heterodimerisation: potential impacts of receptor conformational state and spatial segregation.

Author

Hsieh MY, Yang S, Raymond-Stinz MA, Steinberg S, Vlachos DG, Shu W, Wilson B, and Edwards JS

Subjects
Cell Membrane ultrastructure, Computer Simulation, Dimerization, Protein Conformation, Stochastic Processes, Structure-Activity Relationship, Cell Membrane chemistry, Cell Membrane metabolism, Models, Biological, Models, Chemical, Models, Molecular, Receptor, ErbB-2 chemistry, Receptor, ErbB-2 metabolism, Receptor, ErbB-2 ultrastructure
Abstract

ErbB overexpression is linked to carcinogenesis. It is hypothesised that this is due to increased receptor density and receptor clustering, leading to increased receptor dimerisation and activation. Herein, spatial stochastic simulations have been performed to shed light receptor dimerisation processes. First, ligand-independent homodimerisation, is considered, based upon constitutive oligomerisation estimates (14%) in A431 cells that overexpress epidermal growth factor receptor (EGFR). When autocrine stimulation is blocked, ligand-independent EGFR activation is demonstrated by persistent, low levels of phosphorylation. The possibility that ligand-independent signalling is due to the fluctuation of EGFR conformation is considered. The agent-based model predicts the frequency (expressed as a probability) that uniformly distributed receptors would need to flux to the open conformation to reach 14% EGFR dimers at high receptor density. Simulations suggest that ligand-independent EGFR homodimerisation is highly density dependent, since collisions between 'open', dimerisation-competent receptors are a rare event at low receptor levels. Simulations that incorporate receptor clustering lower the threshold for homodimerisation of unoccupied receptors as well as the estimate of the probability for fluxing to the dimer-competent conformation. The impact of ErbB receptor clustering patterns on hetero and homodimerisation rates is also considered, using immunoelectron microscopy data derived from SKBR3 breast cancer cells that express ErbB2>>EGFR>ErbB3. Partial spatial segregation of ErbB receptors has a profound effect on simulated heterodimerisation rates. Despite the general assumption that ErbB2 is a preferred heterodimerising partner for other ErbBs, it is predicted that most ErbB2 will form homodimers. Overall, it is proposed that both receptor density and membrane spatial organisation contribute to the carcinogenesis process.

Published
2008
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18. The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case-control study.

Author

Chuang WL, Chang WY, Lu SN, Su WP, Lin ZY, Chen SC, Hsieh MY, Wang LY, You SL, and Chen CJ

Subjects
Adult, Aged, Case-Control Studies, Female, Hepacivirus immunology, Hepatitis Antibodies analysis, Hepatitis B Surface Antigens analysis, Humans, Male, Middle Aged, Taiwan, Carcinoma, Hepatocellular microbiology, Hepatitis B complications, Hepatitis C complications, Liver Neoplasms microbiology
Abstract

To investigate the role of hepatitis B (HBV) and C viruses (HCV) in hepatocellular carcinoma (HCC) in an HBV endemic area and elucidate the interaction of these two viruses, a case-control study of 128 patients with HCC and 384 age-matched and sex-matched control subjects was done. The positive rates of hepatitis B surface antigen (HBsAg, 77.3%, 99 of 128) and anti-HCV (19.5%, 25 of 128) in patients with HCC were significantly higher than in control subjects (P less than 0.001). Both HBsAg and anti-HCV were important risk factors for HCC (relative risks, 13.96 and 27.12, respectively), and the risk for HCC was elevated significantly to 40.05 (95% confidence interval, 12.57 to 127.6) when HBsAg and anti-HCV were considered simultaneously. These results suggested that HBV and HCV were associated highly with HCC in an HBV endemic area and that these two viruses might contribute independent but synergistic effects to the pathogenesis of HCC.

Published
1992
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