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5 results on '"Hanoglu L"'

2. Surgical Outcome of Epilepsy Patients Evaluated with a Noninvasive Protocol

Author

Aysin Dervent, Lutfu Hanoglu, Filiz Onat, Cengiz Kuday, Cigdem Ozkara, Emin Ozyurt, Mine Ozmen, Esat Eşkazan, Naci Kocer, Buge Oz, Ozkara, C, Ozyurt, E, Hanoglu, L, Eskazan, E, Dervent, A, Kocer, N, Ozmen, M, Onat, F, Oz, B, and Kuday, C

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Turkey, SURGERY, LOBECTOMY, Neuropsychological Tests, Hippocampus, AMYGDALOHIPPOCAMPECTOMY, Functional Laterality, Temporal lobe, Epilepsy, amygdalo-hippocampectomy, TUMOR, TEMPORAL-LOBE EPILEPSY, medicine, Humans, Ictal, Epilepsy surgery, EEG, Child, Electrocorticography, Cerebral Cortex, Hippocampal sclerosis, ELECTROCORTICOGRAPHY, LESIONS, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Perioperative, Amygdala, medicine.disease, Magnetic Resonance Imaging, Surgery, Treatment Outcome, Neurology, hippocampal sclerosis, epilepsy surgery, Female, Neurology (clinical), SEIZURE ONSET, business, MRI
Abstract

Surgery is now an accepted treatment for some medically intractable epilepsies. Presurgical evaluation is particularly important for the localization of the epileptogenic zone, which may necessitate sophisticated imaging techniques and intracranial electroencephalogram (EEG) recordings. If patients are carefully selected, however, successful results can be achieved with noninvasive evaluation methods. Seventy-seven patients were operated on for intractable seizures. All patients underwent EEG, neuropsychological, psychiatric, and magnetic resonance imaging investigations. Ictal EEG-video recording was performed in all nonlesional and in some lesional cases that had discordant data. Selective amygdalo-hippocampectomy was performed on patients with mesial temporal lobe epilepsy (MTLE), an extended or a limited lesionectomy was performed on patients with structural lesions, and a lesionectomy with deafferentation was performed on two patients with West syndrome. Electrocorticography was not used. Temporal lobe directed surgery was performed in 63.6% of the cases. The pathological examinations of all cases showed hippocampal sclerosis (HS) in 43%, tumor or tumor-like lesions in 36%, and cortical dysplasia in 5% of patients. After a mean follow-up of 17 months (range, 2-53), 75% of the patients were seizure-free with or without aura and 15% had a marked improvement, whereas 10% did not benefit from surgery. Neuropsychological outcome of patients with MTLE and I-IS also showed worthwhile results. Our patients, who were evaluated without pre- and perioperative intracranial recordings and other sophisticated techniques, had an outcome comparable to those in other series from more experienced centers. Our experience indicates that successful results, especially for patients with MTLE-HS and lesion-related epilepsies, can be obtained at centers with limited resources if the diagnoses and evaluation procedures are performed carefully.

Published
2000
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3. Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease.

Author

Ayyildiz S, Velioglu HA, Ayyildiz B, Sutcubasi B, Hanoglu L, Bayraktaroglu Z, Yildirim S, Atasever A, and Yulug B

Subjects
Humans, Aged, Gray Matter diagnostic imaging, Magnetic Resonance Imaging methods, Alzheimer Disease, Parkinson Disease, Claustrum, Healthy Aging
Abstract

The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical areas as well as subcortical structures. Although the claustrum has been involved in several neurodegenerative diseases, specific changes in connections of the claustrum remain unclear in Alzheimer's disease (AD), and Parkinson's disease (PD). Resting-state fMRI and T1-weighted structural 3D images from healthy elderly (n = 15), AD (n = 16), and PD (n = 12) subjects were analyzed. Seed-based FC analysis was performed using CONN FC toolbox and T1-weighted images were analyzed with the Computational Anatomy Toolbox for voxel-based morphometry analysis. While we observed a decreased FC between the left claustrum and sensorimotor cortex, auditory association cortex, and cortical regions associated with social cognition in PD compared with the healthy control group (HC), no significant difference was found in alterations in the FC of both claustrum comparing the HC and AD groups. In the AD group, high FC of claustrum with regions of sensorimotor cortex and cortical regions related to cognitive control, including cingulate gyrus, supramarginal gyrus, and insular cortex were demonstrated. In addition, the structural results show significantly decreased volume in bilateral claustrum in AD and PD compared with HC. There were no significant differences in the claustrum volumes between PD and AD groups so the FC may offer more precise findings in distinguishing changes for claustrum in AD and PD., (© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)

Published
2023
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4. Spitting as an ictal event.

Author

Ozkara C, Hanoglu L, Eskazan E, and Ozyurt E

Subjects
Humans, Male, Automatism complications, Epilepsy complications, Epilepsy diagnosis, Saliva, Stereotypic Movement Disorder complications
Published
2001

5. Ictal spitting during a left emporal lobe-originated complex partial seizure: a case report.

Author

Ozkara C, Hanoglu L, Eşkazan E, Kulaksizogvlu IB, and Ozyurt E

Subjects
Adult, Atrophy, Automatism genetics, Automatism physiopathology, Epilepsy, Complex Partial genetics, Epilepsy, Complex Partial physiopathology, Epilepsy, Temporal Lobe genetics, Epilepsy, Temporal Lobe physiopathology, Hippocampus pathology, Hippocampus physiopathology, Humans, Magnetic Resonance Imaging, Male, Sclerosis, Temporal Lobe pathology, Automatism diagnosis, Dominance, Cerebral physiology, Electroencephalography, Epilepsy, Complex Partial diagnosis, Epilepsy, Temporal Lobe diagnosis, Temporal Lobe physiopathology
Abstract

We present a 35-year-old male patient with intractable temporal lobe epilepsy in whom spitting automatism was documented by ictal recordings during seizures. Spitting is an uncommon automatism and occurs mainly with right-sided, nondominant, temporal focus. However, our patient had left mesial temporal sclerosis with nonverbal memory impairment, but intracarotid amobarbital test demonstrated language and memory dominance on the right hemisphere. The authors feel that this case supports the hypothesis of a nondominant, temporal lobe origin for the spitting automatism.

Published
2000

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