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1. Seventy‐Year Trends in Ship‐Reported Oceanic Precipitation Frequency

Author

Grant W. Petty and Harrison K. Tran

Subjects
ocean precipitation frequency, climate change, ship weather reports, Geophysics. Cosmic physics, QC801-809
Abstract

Abstract Ship present‐weather reports from 1950 to 2019 are used to assess trends in the reporting of precipitation occurrence over the global oceans. Annual reported precipitation frequency shows statistically significant positive trends of up to ∼15% per decade throughout most ocean areas equatorward of 45°. However, latitudes poleward of 45° are dominated by negative trends, some areas of which meet the 95% confidence threshold. Nine smaller regions were subjectively selected for further investigation, revealing that the observed trends, both positive and negative, are often but not always nearly linear, with the amplitude of interannual fluctuations usually being much larger than that expected from random sampling error alone. The annual time series reveal that four comparatively dry areas are associated with the largest overall positive trends, ranging from 8.3% to 12.8% (relative) per decade. Trends were also computed separately for each season, revealing remarkable overall consistency in trends across seasons.

Published
2023
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9. Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer

Author

Asrani, Kaushal, primary, Torres, Alba FC, additional, Woo, Juhyung, additional, Vidotto, Thiago, additional, Tsai, Harrison K, additional, Luo, Jun, additional, Corey, Eva, additional, Hanratty, Brian, additional, Coleman, Ilsa, additional, Yegnasubramanian, Srinivasan, additional, De Marzo, Angelo M, additional, Nelson, Peter S, additional, Haffner, Michael C, additional, and Lotan, Tamara L, additional

Published
2021
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10. Phenotypic characterization of two novel cell line models of castration‐resistant prostate cancer

Author

Haffner, Michael C., primary, Bhamidipati, Akshay, additional, Tsai, Harrison K., additional, Esopi, David M., additional, Vaghasia, Ajay M., additional, Low, Jin‐Yih, additional, Patel, Radhika A., additional, Guner, Gunes, additional, Pham, Minh‐Tam, additional, Castagna, Nicole, additional, Hicks, Jessica, additional, Wyhs, Nicolas, additional, Aebersold, Ruedi, additional, De Marzo, Angelo M., additional, Nelson, William G., additional, Guo, Tiannan, additional, and Yegnasubramanian, Srinivasan, additional

Published
2021
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12. Deforming to Best Practice: Key considerations for deformable image registration in radiotherapy

Author

Barber, J, Yuen, J, Jameson, M, Schmidt, L, Sykes, J, Gray, A, Hardcastle, N, Choong, C, Poder, J, Walker, A, Yeo, A, Archibald-Heeren, B, Harrison, K, Haworth, A, Thwaites, D, Barber, J, Yuen, J, Jameson, M, Schmidt, L, Sykes, J, Gray, A, Hardcastle, N, Choong, C, Poder, J, Walker, A, Yeo, A, Archibald-Heeren, B, Harrison, K, Haworth, A, and Thwaites, D

Abstract

Image registration is a process that underlies many new techniques in radiation oncology - from multimodal imaging and contour propagation in treatment planning to dose accumulation throughout treatment. Deformable image registration (DIR) is a subset of image registration subject to high levels of complexity in process and validation. A need for local guidance to assist in high-quality utilisation and best practice was identified within the Australian community, leading to collaborative activity and workshops. This report communicates the current limitations and best practice advice from early adopters to help guide those implementing DIR in the clinic at this early stage. They are based on the state of image registration applications in radiotherapy in Australia and New Zealand (ANZ), and consensus discussions made at the 'Deforming to Best Practice' workshops in 2018. The current status of clinical application use cases is presented, including multimodal imaging, automatic segmentation, adaptive radiotherapy, retreatment, dose accumulation and response assessment, along with uptake, accuracy and limitations. Key areas of concern and preliminary suggestions for commissioning, quality assurance, education and training, and the use of automation are also reported. Many questions remain, and the radiotherapy community will benefit from continued research in this area. However, DIR is available to clinics and this report is intended to aid departments using or about to use DIR tools now.

Published
2020

13. An international survey on the clinical use of rigid and deformable image registration in radiotherapy

Author

Yuen, J, Barber, J, Ralston, A, Gray, A, Walker, A, Hardcastle, N, Schmidt, L, Harrison, K, Poder, J, Sykes, JR, Jameson, MG, Yuen, J, Barber, J, Ralston, A, Gray, A, Walker, A, Hardcastle, N, Schmidt, L, Harrison, K, Poder, J, Sykes, JR, and Jameson, MG

Abstract

OBJECTIVES: Rigid image registration (RIR) and deformable image registration (DIR) are widely used in radiotherapy. This project aims to capture current international approaches to image registration. METHODS: A survey was designed to identify variations in use, resources, implementation, and decision-making criteria for clinical image registration. This was distributed to radiotherapy centers internationally in 2018. RESULTS: There were 57 responses internationally, from the Americas (46%), Australia/New Zealand (32%), Europe (12%), and Asia (10%). Rigid image registration and DIR were used clinically for computed tomography (CT)-CT registration (96% and 51%, respectively), followed by CT-PET (81% and 47%), CT-CBCT (84% and 19%), CT-MR (93% and 19%), MR-MR (49% and 5%), and CT-US (9% and 0%). Respondent centers performed DIR using dedicated software (75%) and treatment planning systems (29%), with 84% having some form of DIR software. Centers have clinically implemented DIR for atlas-based segmentation (47%), multi-modality treatment planning (65%), and dose deformation (63%). The clinical use of DIR for multi-modality treatment planning and accounting for retreatments was considered to have the highest benefit-to-risk ratio (69% and 67%, respectively). CONCLUSIONS: This survey data provides useful insights on where, when, and how image registration has been implemented in radiotherapy centers around the world. DIR is mainly in clinical use for CT-CT (51%) and CT-PET (47%) for the head and neck (43-57% over all use cases) region. The highest benefit-risk ratio for clinical use of DIR was for multi-modality treatment planning and accounting for retreatments, which also had higher clinical use than for adaptive radiotherapy and atlas-based segmentation.

Published
2020

15. Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma

Author

Alshalalfa, Mohammed, primary, Liu, Yang, additional, Wyatt, Alexander W., additional, Gibb, Ewan A., additional, Tsai, Harrison K., additional, Erho, Nicholas, additional, Lehrer, Jonathan, additional, Takhar, Mandeep, additional, Ramnarine, Varune R., additional, Collins, Colin C., additional, Den, Robert B., additional, Schaeffer, Edward M., additional, Davicioni, Elai, additional, Lotan, Tamara L., additional, and Bismar, Tarek A., additional

Published
2019
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16. Twist and Degrade—Impact of Molecular Structure on the Photostability of Nonfullerene Acceptors and Their Photovoltaic Blends

Author

Luke, Joel, primary, Speller, Emily M., additional, Wadsworth, Andrew, additional, Wyatt, Mark F., additional, Dimitrov, Stoichko, additional, Lee, Harrison K. H., additional, Li, Zhe, additional, Tsoi, Wing C., additional, McCulloch, Iain, additional, Bagnis, Diego, additional, Durrant, James R., additional, and Kim, Ji‐Seon, additional

Published
2019
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18. Interface Modification by Ionic Liquid: A Promising Candidate for Indoor Light Harvesting and Stability Improvement of Planar Perovskite Solar Cells

Author

Li, Meng, primary, Zhao, Chao, additional, Wang, Zhao‐Kui, additional, Zhang, Cong‐Cong, additional, Lee, Harrison K. H., additional, Pockett, Adam, additional, Barbé, Jérémy, additional, Tsoi, Wing Chung, additional, Yang, Ying‐Guo, additional, Carnie, Matthew J., additional, Gao, Xing‐Yu, additional, Yang, Wen‐Xing, additional, Durrant, James R., additional, Liao, Liang‐Sheng, additional, and Jain, Sagar M., additional

Published
2018
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19. Effect of four rounds of annual school-wide mass praziquantel treatment forschistosoma mansonicontrol on schistosome-specific immune responses

Author

Diana K. Riner, Horace Ochanda, Harrison K. Korir, Jennifer M. Carter, Daniel G. Colley, William Evan Secor, Lee Ym, Nupur Kittur, Bernard O. Abudho, Diana M. S. Karanja, and Eric M. Ndombi

Subjects
Male, 0301 basic medicine, Adolescent, 030231 tropical medicine, Immunology, Mebendazole, Antibodies, Helminth, Enzyme-Linked Immunosorbent Assay, Schistosomiasis, Immunoglobulin E, Praziquantel, Immune System Phenomena, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, medicine, Animals, Humans, Child, skin and connective tissue diseases, Anthelmintics, biology, Schistosoma mansoni, biology.organism_classification, medicine.disease, Kenya, Schistosomiasis mansoni, Cross-Sectional Studies, 030104 developmental biology, Immunoglobulin G, biology.protein, Cytokines, Female, Parasitology, Antibody, medicine.drug
Abstract

This study evaluated potential changes in antischistosome immune responses in children from schools that received 4 rounds of annual mass drug administration (MDA) of praziquantel (PZQ). In a repeated cross-sectional study design, 210 schistosome egg-positive children were recruited at baseline from schools in western Kenya (baseline group). Another 251 children of the same age range were recruited from the same schools and diagnosed with schistosome infection by microscopy (post-MDA group). In-vitro schistosome-specific cytokines and plasma antibody levels were measured by ELISA and compared between the 2 groups of children. Schistosome soluble egg antigen (SEA) and soluble worm antigen preparation (SWAP) stimulated higher IL-5 production by egg-negative children in the post-MDA group compared to the baseline group. Similarly, anti-SEA IgE levels were higher in egg-negative children in the post-MDA group compared to the baseline group. Anti-SEA and anti-SWAP IgG4 levels were lower in egg-negative children in the post-MDA group compared to baseline. This resulted in higher anti-SEA IgE/IgG4 ratios for children in the post-MDA group compared to baseline. These post-MDA immunological changes are compatible with the current paradigm that treatment shifts immune responses to higher antischistosome IgE:IgG4 ratios in parallel with a potential increase in resistance to reinfection.

Published
2018
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21. Direct coupling of polymer-based microchip electrophoresis to online MALDI-MS using a rotating ball inlet

Author

Damien A. Narcisse, Harrison K. Musyimi, Kermit K. Murray, Jason Guy, and Steve Allan Soper

Subjects
Materials science, Clinical Biochemistry, Microfluidics, Analytical chemistry, Substance P, Bradykinin, Mass spectrometry, Biochemistry, Analytical Chemistry, law.invention, Electrophoresis, Microchip, law, Miniaturization, Polymethyl Methacrylate, Trypsin, chemistry.chemical_classification, Cytochromes c, Injector, Polymer, Peptide Fragments, Cathode, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Electrode, Bombesin, Direct coupling
Abstract

We report on the coupling of a polymer-based microfluidic chip to a MALDI-TOF MS using a rotating ball interface. The microfluidic chips were fabricated by micromilling a mold insert into a brass plate, which was then used for replicating polymer microparts via hot embossing. Assembly of the chip was accomplished by thermally annealing a cover slip to the embossed substrate to enclose the channels. The linear separation channel was 50 microm wide, 100 microm deep, and possessed an 8 cm effective length separation channel with a double-T injector (V(inj) = 10 nL). The exit of the separation channel was machined to allow direct contact deposition of effluent onto a specially constructed rotating ball inlet to the mass spectrometer. Matrix addition was accomplished in-line on the surface of the ball. The coupling utilized the ball as the cathode transfer electrode to transport sample into the vacuum for desorption with a 355 nm Nd:YAG laser and analyzed on a TOF mass spectrometer. The ball was cleaned online after every rotation. The ability to couple poly(methylmethacrylate) microchip electrophoresis devices for the separation of peptides and peptide fragments produced from a protein digest with subsequent online MALDI MS detection was demonstrated.

Published
2005
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22. Radical nerve-sparing laparoscopic prostatectomy

Author

Ingolf A. Tuerk and Harrison K. Rhee

Subjects
Male, Prostatectomy, Prostatic Diseases, medicine.medical_specialty, Nerve sparing, business.industry, Urology, medicine.medical_treatment, Suture Techniques, Endoscopic surgery, Surgery, Medical Illustration, Laparoscopic Prostatectomy, medicine, Humans, Laparoscopy, Prostate disease, business
Published
2004
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24. Down‐conversion materials for organic solar cells: Progress, challenges, and perspectives

Author

Ram Datt, Swati Bishnoi, Harrison Ka Hin Lee, Sandeep Arya, Sonal Gupta, Vinay Gupta, and Wing Chung Tsoi

Subjects
down‐conversion, down‐shifting, lanthanides, organic solar cells, photostability, Chemistry, QD1-999, Biology (General), QH301-705.5
Abstract

Abstract Organic solar cells (OSCs) in terms of power conversion efficiency (PCE) and operational lifetime have made remarkable progress during the last decade by improving the active layer materials and introducing new interlayers. The newly developed wide bandgap organic donor and low bandgap acceptor molecules covered the absorption from the visible to the near‐infrared region. Whereas the incident high energy region (UV) is not in favor of OSCs. Its absorption causes thermalization losses and photoinduced degradation, which hinders the PCE and lifetime of OSCs. Recently, lanthanide and non‐lanthanide‐based down‐conversion (DC) materials have been introduced, which can effectively convert the high‐energy photons (UV) to low‐energy photons (visible) and resolve the spectral mismatch losses that limit the absorption of OSCs in high energy incident spectrum. Furthermore, the DC materials also protect the OSCs from UV‐induced degradation. The DC materials were also proposed to cross the Shockley‐Queisser efficiency limit of the solar cell. In this review, the need for DC materials and their processing method for OSCs have been thoroughly discussed. However, the main emphasis has been given to developing lanthanides and non‐lanthanides‐based DC materials for OSCs, their applications, and their impact on photovoltaic device performance, stability, and future perspectives.

Published
2022
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