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Evaluation of the diet of the pig (Sus scrofa) in natural settings may provide new views on diet optimization for growth and development of commercially raised piglets under farm conditions. A field study was conducted to gain insight in the diet and stomach characteristics of feral piglets. Forty animals (body weight: 4.6 ± 1.37 kg) were collected from the Bahía Samborombón (Buenos Aires, Argentina). Stomachs were weighed after storage in formalin and the particle size distribution of their contents was determined by wet sieving. Diet items present in their stomachs were classified and their proportional weight and relative abundance was calculated. Based on their dentition, 5, 16 and 19 piglets were approximately 1, 3-6 and 6-16 weeks of age respectively. Vegetable matter (mainly 'leaves and stems') was predominantly present in 39 animals. It represented on average 83 ± 36.4% of total stomach contents by weight. The stomachs of 12 piglets contained curd and represented on average 16 ± 35.1% by weight. Other diet items were less abundant or absent. The proportion of stomach particles retained were 24%, 13%, 22%, 13% and 28% for sieves with mesh sizes of 2000, 1000, 420, 210 and210 µm respectively. For comparison, we used data of farmed piglets of similar age and fed a nutrient-dense, finely ground diet. Feral piglets' relative empty stomach weights increased with age (p 0.050), whereas this was not the case for farmed piglets. Relative stomach contents weight increased significantly with age only for farmed piglets (p 0.050). We infer from our data that feral suckling piglets consumed a variety of non-milk items, mainly consisting of vegetable material with a coarse particle size from their first week in life onwards. Their diet is associated with an enhanced stomach development compared to those of farmed piglets.

Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and antithrombotic agents is associated with increased risks of both bleeding and thromboembolism. In this prospective intervention study, community pharmacists screened for NSAID-antithrombotic interactions and contacted the prescribing physician to discuss interaction management. We included 782 interactions; these were found in an older, polymedicated patient population (mean age: 68 y, median of 5 other drugs). Ibuprofen (in 43.0% of cases) and low-dose aspirin (78.8%) were the most frequently involved NSAID and antithrombotic, respectively. Anticoagulants were involved in 16.1% of interaction cases. For 61% of cases, the interacting drugs were prescribed by the same physician. The pharmacist-physician discussion about how to manage the interaction mostly resulted in no change of pharmacotherapy (60.7%); the most frequent reason given by physicians was that the NSAID was for short-term use only. In 39.3% of cases the discussion resulted in a pharmacotherapy change; replacing the NSAID by paracetamol was the most common change.

Contains fulltext : 290514.pdf (Publisher’s version ) (Open Access) Aims: The aim of this study was to develop insights into how and why Dutch government policies on deployment and training of nurse practitioners and physician assistants have effect and under what circumstances. Design A realist analysis using qualitative interviews. Methods: Data analysis of 50 semi-structured interviews conducted in 2019 with healthcare providers, sectoral and professional associations, and training coordinators. Stratified purposive and snowball sampling were used. Results: Policies stimulated employment and training of nurse practitioners and physician assistants by: (1) contributing to the familiarity of participants in the decision-making process in healthcare providers with and medical doctors' trust in these professions; (2) contributing to participants' motivation in employment and training; and (3) eliminating barriers perceived by medical doctors, managers and directors. The extent to which policies affected employment and training was largely determined by sectoral and organizational circumstances, such as healthcare demand and complexity, and decision-makers in healthcare providers (medical doctors or managers/directors). Conclusion: Effectuating familiarity and trust among participants in the decision-making process is a crucial first step. Next, policymakers can motivate participants and lower their perceived barriers by extending the scope of practice, creating reimbursement opportunities and contributing to training costs. Theoretical insights into nurse practitioner and physician assistant employment and training have been refined. Impact The findings highlight how governments, health insurers, sectoral and professional associations, departments, councils, healthcare providers and professionals can facilitate and support nurse practitioner and physician assistant employment and training by contributing to familiarity, trust and motivation, and by clearing perceived barriers. 15 p.

Physical activity (PA) is a complex human behavior, which implies that multiple dimensions need to be taken into account in order to reveal a complete picture of the PA behavior profile of an individual. This scoping review aimed to map advanced analytical methods and their summary variables, hereinafter referred to as wearable-specific indicators of PA behavior (WIPAB), used to assess PA behavior. The strengths and limitations of those indicators as well as potential associations with certain health-related factors were also investigated. Three databases (MEDLINE, Embase, and Web of Science) were screened for articles published in English between January 2010 and April 2020. Articles, which assessed the PA behavior, gathered objective measures of PA using tri-axial accelerometers, and investigated WIPAB, were selected. All studies reporting WIPAB in the context of PA monitoring were synthesized and presented in four summary tables: study characteristics, details of the WIPAB, strengths, and limitations, and measures of association between those indicators and health-related factors. In total, 7247 records were identified, of which 24 articles were included after assessing titles, abstracts, and full texts. Thirteen WIPAB were identified, which can be classified into three different categories specifically focusing on (1) the activity intensity distribution, (2) activity accumulation, and (3) the temporal correlation and regularity of the acceleration signal. Only five of the thirteen WIPAB identified in this review have been used in the literature so far to investigate the relationship between PA behavior and health, while they may provide useful additional information to the conventional PA variables.

Cone calorimeter and controlled atmosphere cone calorimeter experiments were conducted on various samples. The intent of the tests was to examine the behavior of uniform and composite samples in a range of thicknesses, irradiances, and oxygen concentrations. Single, uniform layers of acrylonitrile butadiene styrene (ABS) were compared to a composite mix, comprising of ABS with a surface layer of cardboard and a secondary layer of polyethylene bubble wrap (intended to represent a potential storage arrangement). The horizontal samples have been tested at irradiances of 25 and 50 kW/m2 and oxygen concentrations of 20.95%, 17%, and 15% to examine a range of significant variables. Results for the uniform arrangement indicated various correlations, previously observed in the works of others, such as the relationships typically described between applied heat flux, ignitability, heat release rate and the effect of the introduction of hypoxic conditions. However, results were shown to change significantly when samples were arranged to feature composite layers. A hypothesized cause of the behavioral change, namely the soot and char residual introduced from the incomplete combustion of the cardboard layer, highlights further important variables that require consideration in material testing under hypoxic conditions. Such variables, namely specific material behaviors and sample orientation, must be sufficiently captured in the design methodologies of systems reliant upon the introduction of hypoxic conditions. It is concluded that sufficiently capturing a wider range of variables in burning materials under hypoxic conditions will introduce further design resilience and help optimize fire protection/prevention methods. (Less)

This study experimentally investigates the radiation heat flux distribution received on the floor due to fire plume impinging upon an inclined ceiling, which has not been quantified previously. The radiation heat fluxes were measured on the floor for 160 experimental conditions, involving various fire source heat release rates, source-ceiling heights, angles of ceiling inclination and dimensions (aspect ratios) of the rectangular sources. The main findings include that the declining rate of the radiation heat flux along with distance received by the downstream floor decreases, while that received by the upstream floor increases, with the increasing of ceiling inclination angle. The radiation heat flux received by the floor is higher as the ceiling inclination angle is smaller for the downstream side, while it is lower as the ceiling inclination angle is smaller for the upstream side. Both of these variations can be explained by change of the flow distribution as well as flame length due to combustion and heat released in the two directions beneath the inclined ceiling. Further, a model with various fire source heat release rates, source-ceiling height, and ceiling inclination angles is proposed, to globally describe the radiation heat flux received by both the upstream and downstream floors.

This study presents the results from a set of 11 large-scale open fire tests performed on flexible polyurethane foam slabs/mattresses. The purpose of the study was to investigate the influence of the ignition location on the fire behaviour of the foam slabs and to generate data on a highly characterised material that could be used for modelling work in the future. A method for obtaining spatially resolved flame spread data for this type of material was presented using a gridded array of 5 × 10 thermocouples placed on the underside the foam slab and from this, flame spread was examined using three different approaches. The heat release rate (HRR) results showed clear shapes forming that were dependent on the ignition location, with two distinct behaviours being observed between the various different ignition locations, this was also observed in the calculated flame spread rate (FSR) data. Results within an individual test, showed the calculated range of FSRs over the geometry of the slab varied between approximately 1 and 8 mm/s depending on the ignition location. The average FSR values between tests varied between 3 and 7 mm/s and the maximum and minimum values were calculated to be approximately 11 and 2 mm/s respectively.

CERN operates one of the most complex particle accelerator facilities in the world. Several different hazards, including fires, are present and need to be investigated and reduced to a tolerable level. Toward this goal, CERN aims at developing a catalog containing detailed fire dynamics descriptions of combustible items present in its facilities. This paper contributes to this catalog in two ways. First, through the development of a design fire calculator for electrical cabinets that allows the determination of potential design fire curves for any number of electrical cabinets/racks. The second contribution was to experimentally characterize the smoke production rates and smoke particle properties of the most common cables and insulating oils used at CERN by coupling a fast particle mobility analyzer to a cone calorimeter. The two particle size modes (accumulation and nucleation mode) could be linked to the fire properties and heat release rate. Accumulation mode particles (~200 nm) were associated with high heat release rates and high soot emissions from the flame. This study identifies a necessity to consider ultrafine particle emissions with low mass emissions but high number emissions in relation to risk assessments pertaining to nuclear facilities and dispersion of radioactive aerosols to the surrounding environment. (Less)

Background: Stopping nucleos(t)ide analogues (NA) after hepatitis B e antigen (HBeAg) seroconversion is associated with high relapse rates in Asian patients, but data in Caucasian cohorts are scarce. Clinical course, outcomes and immunological aspects of chronic hepatitis B infections differ substantially between distinct ethnicities. Aim: The aim of this study was to determine relapse rates, factors predicting relapse and clinical outcomes after nucleos(t)ide analogue cessation in a large, predominantly Caucasian cohort of chronic hepatitis B patients with nucleos(t)ide analogue-induced HBeAg seroconversion. Methods: This is a nationwide observational cohort study including HBeAg positive, mono-infected chronic hepatitis B patients with nucleos(t)ide analogue-induced HBeAg seroconversion from 18 centres in Belgium. Results: A total of 98 patients with nucleo(s)tide analogue-induced HBeAg seroconversion were included in the study. Of the 62 patients who stopped treatment after a median consolidation treatment of 8 months, 30 relapsed. Higher gamma-glutamyl transferase levels at both treatment initiation (HR 1.004; P = 0.001 per unit increment) and HBeAg seroconversion (HR 1.006; P = 0.013 per unit increment) were associated with an increased risk of clinically significant relapse in a multivariate Cox regression model. Treatment cessation led to liver-related death in 2 patients, of whom one showed a severe flare. Of the patients who continued treatment after HBeAg seroconversion, none relapsed or developed severe hepatic outcomes. Conclusion: Treatment withdrawal in Caucasian chronic hepatitis B patients after nucleos(t)ide analogue-induced HBeAg seroconversion results in viral relapses in more than half of patients with potential fatal outcomes. These real-world data further lend support to preferentially continue NA treatment after HBeAg seroconversion until HBsAg loss. Foundation Against Cancer Belgium, Grant/Award Number: 2014-087

This work aims to explore possible ways of improving the precision of ignition measurements in the cone calorimeter. Both inherent repeatability of parts of the testing equipment and operator-dependent variations are considered. Inherent repeatability is indicated to be slightly improved if the test samples used are circular rather than square. Operator-dependent variation is discussed in terms of the method used for determining ignition. Four procedures are compared, namely, visual observation, usage of a light sensor, and looking at the peak of the second and first derivatives of the mass loss and heat release curves, respectively. Results indicate that the preferable operator-independent method depends on the test conditions; the derivative of the heat release rate is an alternative to the mass loss rate derivative when the scale is of standardised quality. A light sensor for ignition time observation is a good option when the surrounding light is not changed during the test.

Modelling fire performance of building fire barriers would allow optimising the design solutions before performing costly fire resistance tests and promote performance-based fire safety engineering. Numerical heat conduction analysis is widely used for predicting the insulation capability of fire barriers. Heat conduction analysis uses material properties and boundary condition parameters as the input. The uncertainties in these input parameters result in a wide range of possible model outcomes. In this study, the output sensitivity of a heat conduction model to the uncertainties in the input parameters was investigated. The methodology was applied to stone wool core sandwich panels subjected to the ISO 834 standard fire resistance temperature/time curve. Realistic input parameter value distributions were applied based on material property measurements at site and data available in literature. A Monte Carlo approach and a functional analysis were used to analyse the results. Overall, the model is more sensitive to the boundary conditions than to the material thermal properties. Nevertheless, thermal conductivity can be identified as the most important individual input parameter.

Summary Flooded (paddy) rice (Oryza sativa) can take up ions from the irrigation water by foliar uptake via the exposed stem base. We hypothesised that the stem base uptake of radiocaesium (RCs) is a pathway for rice grown in RCs-contaminated environments. We developed a bi-compartmental device which discriminates the stem base from root RCs uptake from solutions, thereby using RCs isotopes (137Cs and 134Cs) with

Fires in enclosures equipped with mechanical ventilation remain one of the key issues for fire safety assessment in multifamily homes and industries. Therefore, a wide variation of methods for preventing smoke spread through the ventilation system exist and are applied, in performance-based designs. Through the use of the heating, ventilation and air conditioning (HVAC) model in the fire dynamics simulator, several different common and less common methods for preventing smoke spread in the ventilation system were tested. The effects on smoke spread with changing building leakage and fire growth rates were also investigated. The results were evaluated by determining the total soot spread from the fire room to other compartments connected to the ventilation system, as well as soot/thermal load on the fans and system in general. The maximum and average heat release rate was also of interest and hence compared between systems. It was found that, while many methods perform similar, a few proven methods, such as fire and smoke dampers, performed very well with very little smoke spread to the rest of the system. The study should be considered as an introduction to implementing a similar methodology in specific cases because different ventilations systems will present very different challenges and weaknesses. (Less)

This study aims to give an overview over different reaction-to-fire prediction models developed over the last decades by finding similarities and differences between models, as well as identifying their robustness in scaling. The models have been divided into four categories - empirical, thermal, polynomial and comprehensive - depending on how pyrolysis is modelled. Empirical models extrapolate bench-scale test results to larger scales. These models are pertinent to applications that they have been validated for, but surfacic parameters used may not be scalable. In thermal models, pyrolysis is represented by heat transfer rates. The models are feasible for materials with high activation energies and where little pyrolysis occur before ignition. Polynomial models are empirical models that also take the environment into account. The validity of scaling is yet to be established. The comprehensive methodology includes chemical kinetics in the condensed phase. It has the potential to be used for any application; however, many parameters are needed. This increases the degrees of freedom versus data available for the description of the problem. Consequently, possible errors are introduced, and uncertainty is increased. A comprehensive multi-scale methodology is a way forward, where many steps of validation are possible. (Less)