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262 results on '"Henry, A. L."'

1. Association Between Glycemic Control and Complications With Concentration of Urinary Exfoliated Proximal Tubule Kidney Cells in People With Diabetes Mellitus

Author

Henry H. L. Wu, Venkatesha Bhagavath, Long The Nguyen, Rajkumar Chinnadurai, Ewa M. Goldys, Carol A. Pollock, and Sonia Saad

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Conclusions: Our results indicate increased shedding of PTCs into the urinary tract in patients with poorer glycemic control, particularly those with diabetic retinopathy and in females.

Published
2025
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7. Combining working memory and speech data in a digital app for early detection of cognitive impairment in primary care

Author

Hilsabeck, Robin C., primary, Keller, Jeffrey N., additional, Henry, Maya L., additional, Li, J. Jessy, additional, Pugalenthi, Lokesh, additional, Rathouz, Paul, additional, Toprac, Paul, additional, Chang, Patrick, additional, Chang, Joshua, additional, Schmitz, Suzanne, additional, Largent, Avery, additional, Foil, Heather, additional, Brouillette, Robert, additional, and Lester‐Smith, Rosemary A, additional

Published
2023
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9. Peritoneal dialysis‐associated peritonitis presenting with <scp> Ralstonia pickettii </scp> infection: A novel series of three cases during the COVID‐19 pandemic

Author

Henry H. L. Wu, Joanne Collier, Laurie Crosby, David Holder, Elizabeth Trautt, David Lewis, Dimitrios Poulikakos, and Rajkumar Chinnadurai

Subjects
Nephrology
Abstract

Peritoneal dialysis (PD)-associated peritonitis secondary to Ralstonia infection is very rare. Ralstonia pickettii is an organism which can grow in contaminated saline, water, chlorhexidine and other medical products used in laboratories and the clinical setting. Infective endocarditis, prosthetic joint and severe chest infections are previously reported with Ralstonia pickettii infection. We report a novel series of three cases diagnosed with PD-associated peritonitis presenting with Ralstonia pickettii, where the cases appeared consecutively to our unit during a span of four weeks. During the COVID-19 pandemic, there were increased uses of non-sterile gloves by clinical staff as a form of personal protective equipment throughout patient interaction and PD exchange, as recommended by local hospital policy for all staff attending to patient care. A multidisciplinary team root cause analysis of our cases suggested non-sterile gloves being the likely source of environmental contamination, leading to PD-associated peritonitis presenting with Ralstonia pickettii in this scenario.

Published
2022
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13. Network anatomy in logopenic variant of primary progressive aphasia

Author

Mandelli, Maria Luisa, primary, Lorca‐Puls, Diego L., additional, Lukic, Sladjana, additional, Montembeault, Maxime, additional, Gajardo‐Vidal, Andrea, additional, Licata, Abigail, additional, Scheffler, Aaron, additional, Battistella, Giovanni, additional, Grasso, Stephanie M., additional, Bogley, Rian, additional, Ratnasiri, Buddhika M., additional, La Joie, Renaud, additional, Mundada, Nidhi S., additional, Europa, Eduardo, additional, Rabinovici, Gil, additional, Miller, Bruce L., additional, De Leon, Jessica, additional, Henry, Maya L., additional, Miller, Zachary, additional, and Gorno‐Tempini, Maria Luisa, additional

Published
2023
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17. Multidisciplinary collaboration to develop a digital health solution for early detection of cognitive decline in primary care

Author

Hilsabeck, Robin C., primary, Keller, Jeffrey N., additional, Henry, Maya L, additional, Toprac, Paul, additional, Rathouz, Paul, additional, Sreekanth, Varshinee, additional, Largent, Avery, additional, Chang, Joshua, additional, Li, Jessy, additional, Pugalenthi, Lokesh, additional, Parsons, Thomas, additional, Cuevas, Heather E, additional, and Schmitz, Suzanne, additional

Published
2022
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22. The effect of simultaneous dual‐focus integration on the global flash multifocal electroretinogram in the human eye

Author

Henry H. L. Chan, Mavis M Y Fung, and Kai Yip Choi

Subjects
Adult, Male, medicine.medical_specialty, genetic structures, Contact Lenses, Retina, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Flash (photography), 0302 clinical medicine, Ophthalmology, Electroretinography, medicine, Humans, Dual focus, Cross-Over Studies, Chemistry, Repeated measures design, Retinal, eye diseases, Sensory Systems, Electrophysiology, medicine.anatomical_structure, Direct component, 030221 ophthalmology & optometry, Female, Human eye, sense organs, Photic Stimulation, 030217 neurology & neurosurgery, Optometry
Abstract

PURPOSE To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG). METHODS Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0-8°), para-macular (8-18°) and peri-macular (18-30°) regions, and then compared across the three conditions using two-way, repeated measures ANOVA. RESULTS Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p

Published
2020
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23. Prognostic implications of traditional and non‐traditional cardiovascular risk factor profiles in patients with non‐valvular atrial fibrillation

Author

Aditya Bhat, Gary C. H. Gan, Henry H. L. Chen, Sumreen Nawaz, Shaun Khanna, Timothy Dobbins, and Timothy C. Tan

Subjects
Male, Stroke, Cardiovascular Diseases, Heart Disease Risk Factors, Risk Factors, Atrial Fibrillation, Clinical Biochemistry, Humans, Female, General Medicine, Prognosis, Risk Assessment, Biochemistry
Abstract

Atrial fibrillation (AF) is a prevalent disease with associated mortality risk, mediated in large part through its associated cardiovascular risk factors. Standard modifiable cardiovascular risk factors (SMuRFs; hypercholesterolaemia, hypertension, diabetes and smoking) are established drivers of cardiovascular disease; however, the importance of non-traditional mediators of cardiovascular risk (NTRFs) such as chronic renal impairment, obstructive sleep apnoea and obesity is emerging. The differential impact of these risk factors on outcomes in patients with AF is not well studied.Consecutive patients admitted to our service between January 2013 and January 2018 with a primary diagnosis of non-valvular AF were assessed. Assessment of demographic, anthropometric, risk factor profile and pharmacotherapeutics was performed. The clinical course of these patients was followed for up to five years for the composite outcome of all-cause death and major adverse cardiovascular events.Of the 1010 patients (62.29 ± 16.81 years, 51% men) included, 154 (15%) had no risk factors, 478 (47%) had only SMuRFs, 59 (6%) had only NTRFs and 319 (32%) had both SMuRFs and NTRFs. Over a mean follow-up period of 33.18 ± 21.27 months, a total of 288 patients met the composite outcome. On Cox regression, the coexistence of SMuRFs and NTRFs was an independent predictor of the composite outcome (HR 1.40; 95%CI 1.09-1.82, p = .01). Other independent predictors included age, heart failure, CHAThe presence of both SMuRFs and NTRFs has prognostic implications in patients with non-valvular AF.

Published
2022
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25. Insomnia disorder: State of the science and challenges for the future

Author

Riemann, Dieter, primary, Benz, Fee, additional, Dressle, Raphael J., additional, Espie, Colin A., additional, Johann, Anna F., additional, Blanken, Tessa F., additional, Leerssen, Jeanne, additional, Wassing, Rick, additional, Henry, Alasdair L., additional, Kyle, Simon D., additional, Spiegelhalder, Kai, additional, and Van Someren, Eus J. W., additional

Published
2022
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36. Use of contemporary live tele‐video conferencing for continuing surgical training at the time of COVID ‐19 pandemic

Author

Ismail Sagap, Henry C L Tan, and Jih Huei Tan

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Malaysia, MEDLINE, COVID-19, General Medicine, medicine.disease, computer.software_genre, Surgical training, Education, Distance, Videoconferencing, General Surgery, Pandemic, Medicine, Education, Medical, Continuing, Surgery, Medical emergency, Letters to the Editor, business, Letter to the Editor, computer
Published
2020
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37. Evaluation of the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented lesions in Asians

Author

Henry H-L. Chan, Samantha Y N Shek, Chi K Yeung, and Ka-yee Kung

Subjects
medicine.medical_specialty, Side effect, Visual analogue scale, business.industry, Melasma, Standard treatment, Tattoo removal, Dermatology, medicine.disease, 01 natural sciences, Hyperpigmentation, 010309 optics, Lesion, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Patient satisfaction, 0103 physical sciences, Medicine, Surgery, medicine.symptom, business
Abstract

Background and objectives Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with skin of color. Recently, the novel picosecond laser with pulse durations operating at sub-nanosecond domains has been shown to be effective in tattoo removal and in the treatment of acne scars. The objective of this study is to examine the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented skin lesions in Asian patients. Methods Twelve subjects with benign pigmentary disorders and Fitzpatrick skin types III to IV were recruited in a prospective clinical study to examine the safety and efficacy of the dual wavelength picosecond laser. Patients were treated at approximately 2-6 week intervals depending of the type of lesion. The primary efficacy endpoint is the global percent of clearance which was evaluated by blinded observers using post treatment photographs compared to baseline photographs. Safety was evaluated before and after each laser treatment and patients were asked to rate the level of pain according to the Visual Analog Scale after each treatment session. Patient satisfaction was assessed at the completion of treatment with questionnaires. All patients were followed up at 4, 8, and 12 weeks after the last treatment session. Results The pigmentary conditions treated included melasma, freckles, lentiginies, cafe au lait macules, and Hori's macules. Three months after treatment, 53.8% of all pigments achieved excellent response (75-94% lightening,) 30.8% of pigments achieved good response (50-74% lightening,) and 7.7% of pigments achieved both fair (25-49% lightening) and poor responses (0-24% lightening), respectively. The average number of treatment sessions required to reach at least 50% clearance was 4.5 for melasma, 1 for freckles, 1.5 for lentigines and 1 for cafe au lait. The patient with Hori's macules did not reach 50% clearance after a total of six treatments. Sixty three percent of patients reported satisfaction in the subjective assessment, while 27.3% were neutral and 9.1% were very dissatisfied. The post inflammatory hyperpigmentation rate was 4.8% and 6.5% of subjects developed blistering as a side effect of treatment. Conclusion The dual wavelength picosecond laser is a safe and effective treatment of benign pigmentary conditions in patients with skin of color. In particular, superior clinical efficacy is demonstrated for treatment of freckles and lentigines with a low risk of PIH. Lasers Surg. Med. 51:14-22, 2019. © 2018 Wiley Periodicals, Inc.

Published
2018
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43. Insomnia as a mediating therapeutic target for depressive symptoms: A sub‐analysis of participant data from two large randomized controlled trials of a digital sleep intervention

Author

Henry, Alasdair L., primary, Miller, Christopher B., additional, Emsley, Richard, additional, Sheaves, Bryony, additional, Freeman, Daniel, additional, Luik, Annemarie I., additional, Littlewood, Donna L., additional, Saunders, Kate E. A., additional, Kanady, Jennifer C., additional, Carl, Jenna R., additional, Davis, Michelle L., additional, Kyle, Simon D., additional, and Espie, Colin A., additional

Published
2020
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46. Role of AIG1 and ADTRP in Endogenous FAHFA Regulation

Author

Ertunc, Meric Erikci, primary, Kok, Bernard P., additional, Parsons, William H., additional, Wang, Justin G., additional, Tan, Dan, additional, Donaldson, Cynthia J., additional, Pinto, Antonio M., additional, Vaughan, Joan M., additional, Ngo, Nhi, additional, Lum, Kenneth M., additional, Henry, Cassandra L., additional, Coppola, Aundrea R., additional, Niphakis, Micah J., additional, Cravatt, Benjamin F., additional, Saez, Enrique, additional, and Saghatelian, Alan, additional

Published
2020
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48. Childhood exposure to constricted living space: a possible environmental threat for myopia development

Author

Henry H. L. Chan, Zhe Chuang Li, Yamunadevi Lakshmanan, Kai Yip Choi, Wing Yan Yu, Man Pan Chin, Christie Hang I Lam, Paul H. Lee, Francisca Siu Yin Wong, and Chi Wai Do

Subjects
Male, Refractive error, medicine.medical_specialty, Living space, Demographics, Living environment, Refraction, Ocular, Population density, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, Myopia, Prevalence, medicine, Humans, Child, Retrospective Studies, business.industry, Confounding, Environmental Exposure, Axial length, medicine.disease, Sensory Systems, Axial Length, Eye, Ophthalmology, 030221 ophthalmology & optometry, Hong Kong, Optometry, Female, business, 030217 neurology & neurosurgery, Follow-Up Studies, Demography
Abstract

Purpose People in Hong Kong generally live in a densely populated area and their homes are smaller compared with most other cities worldwide. Interestingly, East Asian cities with high population densities seem to have higher myopia prevalence, but the association between them has not been established. This study investigated whether the crowded habitat in Hong Kong is associated with refractive error among children. Methods In total, 1075 subjects [Mean age (S.D.): 9.95 years (0.97), 586 boys] were recruited. Information such as demographics, living environment, parental education and ocular status were collected using parental questionnaires. The ocular axial length and refractive status of all subjects were measured by qualified personnel. Results Ocular axial length was found to be significantly longer among those living in districts with a higher population density (F2,1072 = 6.15, p = 0.002) and those living in a smaller home (F2,1072 = 3.16, p = 0.04). Axial lengths were the same among different types of housing (F3,1071 = 1.24, p = 0.29). Non-cycloplegic autorefraction suggested a more negative refractive error in those living in districts with a higher population density (F2,1072 = 7.88, p

Published
2017
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