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2. Cytotoxicity of Mixed Human Monoclonal Antibodies Reacting to Tumor Antigens

Author

Yasuyuki Aotsuka and Hideaki Hagiwara

Subjects
Cytotoxicity, Immunologic, medicine.drug_class, Cell, Monoclonal antibody, Antigen, Antigens, Neoplasm, Glioma, Tumor Cells, Cultured, medicine, Humans, Cytotoxicity, Hybridomas, biology, business.industry, Antibodies, Monoclonal, Complement System Proteins, medicine.disease, Primary and secondary antibodies, Molecular biology, Complement-dependent cytotoxicity, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, biology.protein, Antibody, business
Abstract

Two kinds of human monoclonal antibodies, CLN-IgG and SLN-IgG, were obtained from human x human hybridomas, termed CLNH11 and SLNF10, respectively. These antibodies recognized different molecules which were expressed simultaneously on the cell surface of tumor cells. When both antibodies were added into culture medium in the presence of complement, a remarkable synergistic cytotoxic-effect against glioblastoma cells was observed.

Published
1987

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