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101 results on '"Ito, Yoshinori"'

3. Quantitative assessment of viral load in the blood and urine of patients with congenital cytomegalovirus infection using droplet digital PCR

Author

Yamaguchi, Makoto, Kawada, Jun‐ichi, Torii, Yuka, Haruta, Kazunori, Suzuki, Takako, Horiba, Kazuhiro, Takahashi, Yoshiyuki, Ito, Yoshinori, Yamaguchi, Makoto, Kawada, Jun‐ichi, Torii, Yuka, Haruta, Kazunori, Suzuki, Takako, Horiba, Kazuhiro, Takahashi, Yoshiyuki, and Ito, Yoshinori

Abstract

Congenital cytomegalovirus infection (cCMV) is a common cause of congenital infections, leading to neurodevelopmental sequelae. Real-time quantitative polymerase chain reaction (qPCR) has been widely used for the diagnosis and assessment of cCMV; however, the correlation between CMV DNA load and the severity of cCMV symptoms has been inconclusive. Droplet digital PCR (ddPCR) offers an improvement over the current qPCR methods through the absolute quantification of viral loads. We compared ddPCR and qPCR results for the quantification of CMV DNA in blood and urine specimens from 39 neonates with cCMV (21 symptomatic and 18 asymptomatic). There was no significant difference in blood CMV DNA loads measured by ddPCR and qPCR, with or without any clinical findings. However, developmental delays at 36 months were significantly more frequently observed in patients with high CMV DNA loads (≥2950 copies/ml), as measured by ddPCR at diagnosis, than in those with lower CMV DNA loads. The association of urine CMV DNA load with symptoms and developmental delay was not observed. CMV DNA loads in the blood might be used as a predictor of developmental outcomes in cCMV patients, and absolute quantitation of viral loads by ddPCR assay could contribute to the standardization of CMV load measurement.

Published
2023

5. Multicenter retrospective study of stereotactic body radiotherapy for patients with previously untreated initial small hepatocellular carcinoma

Author

Doi, Yoshiko, primary, Nagata, Yasushi, additional, Matsumoto, Yasuo, additional, Numata, Kazushi, additional, Sasaki, Ryu, additional, Yamada, Takashi, additional, Igaki, Hiroshi, additional, Imagumbai, Toshiyuki, additional, Katoh, Norio, additional, Yoshitake, Tadamasa, additional, Shimizuguchi, Takuya, additional, Fujioka, Den, additional, Inoue, Minoru, additional, Koide, Yutaro, additional, Kimura, Tomoki, additional, and Ito, Yoshinori, additional

Published
2023
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6. Enhancement of the Lowering Effect on Energy Levels of LUMO by the Formation of B-N Dative Bond for Near-infrared Light Absorption Properties Based on 1,3,4,6,8,9 b-Hexaazaphenalene

Author

Watanabe, Hiroyuki, Ito, Yoshinori, Tanaka, Kazuo, and Chujo, Yoshiki

Subjects
azaphenalene, near infrared, low-lying LUMO, Boron
Abstract

We illustrate the development of 1, 3, 4, 6, 8, 9b-hexaazaphenalene (6AP) derivatives which exhibit excellent near-infrared (NIR) light absorption properties and deep LUMO levels. The electron-withdrawing character of the 8-nitrogen atom in the 6AP scaffold was enhanced by the introduction of a B−N dative bond. This formation of a boron-nitrogen Lewis acid-base pair succeeded in strengthening the electron-withdrawing ability of the 8-nitrogen atom, which induced the low-lying LUMO levels of the resultant boron complexes. The data from UV−vis−NIR absorption spectroscopy and cyclic voltammetry suggested that these deep LUMO levels were the origins of the narrow HOMO−LUMO gap caused by selectively lowering the LUMO energy level. Furthermore, the enhancement of the molar absorption coefficients was observed in the boron complex compared to other azaphenalene derivatives in the previous reports. From theoretical calculations, the electron-withdrawing character of the 8-nitrogen atom induced the weak but substantial delocalization of the LUMO into the 7, 9-positions, where the LUMOs of other azaphenalene derivatives hardly exist. This electronic effect could influence the intrinsic symmetry forbidden character of electronic transition between the HOMO and the LUMO, resulting in the larger molar absorption coefficients by partially transforming to the allow character compared to those of other azaphenalene derivatives. In summary, the introduction of the boron-nitrogen Lewis acid-base pair into the π-conjugated system of azaphenalene afforded the NIR light absorption properties with the ϵ reaching ∼10⁴ M⁻¹cm⁻¹ and the deep LUMO levels around −4.0 eV (estimated by cyclic voltammetry).

Published
2023

7. The impact of chronic Epstein–Barr virus infection on the liver graft of pediatric liver transplant recipients: A retrospective observational study

Author

Shizuku, Masato, Kamei, Hideya, Yoshizawa, Atsushi, Ito, Yoshinori, Ogura, Yasuhiro, Yoshikawa, Junichi, Kurata, Nobuhiko, Jobara, Kanta, Kodera, Yasuhiro, Shizuku, Masato, Kamei, Hideya, Yoshizawa, Atsushi, Ito, Yoshinori, Ogura, Yasuhiro, Yoshikawa, Junichi, Kurata, Nobuhiko, Jobara, Kanta, and Kodera, Yasuhiro

Abstract

Background: Chronic high Epstein–Barr virus loads (CHEBV) are commonly observed in pediatric liver transplant patients. However, it is unclear how CHEBV impacts the liver graft. The aim of this study was to clarify the clinical and pathological impacts of CHEBV on the liver graft. Methods: From 2012 to 2020, we retrospectively investigated 46 pediatric liver transplant patients (under 16 years) who survived ≥6 months. The patients were divided into two groups: CHEBV group (EBV DNA >10 000 IU/ml of whole blood for ≥6 months) and nonchronic high EBV (NCHEBV) group (patients who did not meet CHEBV criteria). Tacrolimus was reduced to <3.0 ng/ml in patients with EBV DNA >5000 IU/ml. Blood biochemistry data and pathological findings, obtained at the time of protocol and episodic biopsies, were compared between the two groups. Results: Out of 46 patients, 28 CHEBV and 18 NCHEBV patients were enrolled. The blood biochemical examination did not show a significant difference between the two groups. In addition, no significant differences between the two groups were found in the pathological findings, including frequency of late acute rejection and the progression of fibrosis at the time of both protocol and episodic biopsies. Appropriate adjustment of immunosuppression for CHEBV management may have contributed to the prevention of the progression of fibrosis. Conclusion: CHEBV had little adverse effect on the liver graft. Graft fibrosis might have been avoided through optimal dose modification of tacrolimus. Further long-term monitoring is necessary because CHEBV may affect the pediatric liver graft in the long term.

Published
2022

10. Serial circulating tumor DNA monitoring of CDK4/6 inhibitors response in metastatic breast cancer

Author

Chin, Yoon Ming, primary, Shibayama, Tomoko, additional, Chan, Hiu Ting, additional, Otaki, Masumi, additional, Hara, Fumikata, additional, Kobayashi, Takayuki, additional, Kobayashi, Kokoro, additional, Hosonaga, Mari, additional, Fukada, Ippei, additional, Inagaki, Lina, additional, Ono, Makiko, additional, Ito, Yoshinori, additional, Takahashi, Shunji, additional, Ohno, Shinji, additional, Ueno, Takayuki, additional, Nakamura, Yusuke, additional, and Low, Siew‐Kee, additional

Published
2022
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11. Clinical practice guidelines for the management of children with mother‐to‐child transmitted hepatitis C virus infection

Author

Tajiri, Hitoshi, primary, Bessho, Kazuhiko, additional, Nakayama, Yoshiko, additional, Abukawa, Daiki, additional, Iitsuka, Yoshinori, additional, Ito, Yoshinori, additional, Inui, Ayano, additional, Etani, Yuri, additional, Suzuki, Mitsuyoshi, additional, Takano, Tomoko, additional, Tanaka, Atsushi, additional, Mizuochi, Tatsuki, additional, Miyoshi, Yoko, additional, and Murakami, Jun, additional

Published
2022
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12. A prognostic biomarker study in patients with clinical stage I esophageal squamous cell carcinoma: JCOG0502‐A1

Author

Oshima, Kotoe, primary, Kato, Ken, additional, Ito, Yoshinori, additional, Daiko, Hiroyuki, additional, Nozaki, Isao, additional, Nakagawa, Satoru, additional, Shibuya, Yuichi, additional, Kojima, Takashi, additional, Toh, Yasushi, additional, Okada, Morihito, additional, Hironaka, Shuichi, additional, Akiyama, Yuji, additional, Komatsu, Yoshito, additional, Maejima, Kazuhiro, additional, Nakagawa, Hidewaki, additional, Onuki, Ritsuko, additional, Nagai, Momoko, additional, Kato, Mamoru, additional, Kanato, Keisuke, additional, Kuchiba, Aya, additional, Nakamura, Kenichi, additional, and Kitagawa, Yuko, additional

Published
2021
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16. Prognostic Value of Epithelial Cell Adhesion Molecules in T1‐2N0M0 Glottic Cancer

Author

Murakami, Naoya, primary, Mori, Taisuke, additional, Machida, Ryunosuke, additional, Kodaira, Takeshi, additional, Ito, Yoshinori, additional, Shikama, Naoto, additional, Konishi, Koji, additional, Matsumoto, Yasuo, additional, Murakami, Yuji, additional, Nakamura, Naoki, additional, Yamashita, Hideomi, additional, Yorozu, Atsunori, additional, Yoshimura, Michio, additional, Inoue, Koichi, additional, Nozaki, Miwako, additional, Ishikura, Satoshi, additional, Itami, Jun, additional, Nishimura, Yasumasa, additional, and Kagami, Yoshikazu, additional

Published
2020
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18. Clinical outcomes of definitive whole pelvic radiotherapy for clinical lymph node metastatic prostate cancer

Author

Tsuchida, Keisuke, primary, Inaba, Koji, additional, Kashihara, Tairo, additional, Murakami, Naoya, additional, Okuma, Kae, additional, Takahashi, Kana, additional, Igaki, Hiroshi, additional, Nakayama, Yuko, additional, Maejima, Aiko, additional, Shinoda, Yasuo, additional, Matsui, Yoshiyuki, additional, Komiyama, Motokiyo, additional, Fujimoto, Hiroyuki, additional, Ito, Yoshinori, additional, Sumi, Minako, additional, Nakano, Takashi, additional, and Itami, Jun, additional

Published
2020
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19. Ribociclib, a CDK 4/6 inhibitor, plus endocrine therapy in Asian women with advanced breast cancer

Author

Yap, Yoon‐Sim, primary, Chiu, Joanne, additional, Ito, Yoshinori, additional, Ishikawa, Takashi, additional, Aruga, Tomoyuki, additional, Kim, Seung Jin, additional, Toyama, Tatsuya, additional, Saeki, Toshiaki, additional, Saito, Mitsue, additional, Gounaris, Ioannis, additional, Su, Fei, additional, Ji, Yan, additional, Han, Yu, additional, Gazdoiu, Mihaela, additional, and Masuda, Norikazu, additional

Published
2020
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21. Clinical outcomes of locally advanced esophageal neuroendocrine carcinoma treated with chemoradiotherapy

Author

Honma, Yoshitaka, primary, Nagashima, Kengo, additional, Hirano, Hidekazu, additional, Shoji, Hirokazu, additional, Iwasa, Satoru, additional, Takashima, Atsuo, additional, Okita, Natsuko, additional, Kato, Ken, additional, Boku, Narikazu, additional, Murakami, Naoya, additional, Inaba, Kouji, additional, Ito, Yoshinori, additional, Itami, Jun, additional, Kanamori, Jun, additional, Oguma, Junya, additional, and Daiko, Hiroyuki, additional

Published
2019
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24. Phase I study of taselisib in Japanese patients with advanced solid tumors or hormone receptor‐positive advanced breast cancer

Author

Tamura, Kenji, primary, Kodaira, Makoto, additional, Shimizu, Chikako, additional, Yonemori, Kan, additional, Yunokawa, Mayu, additional, Shimomura, Akihiko, additional, Kobayashi, Takayuki, additional, Nakano, Kenji, additional, Tomomatsu, Junichi, additional, Ito, Yoshinori, additional, Tanaka, Jun, additional, Kuriki, Hiroshi, additional, Gu, Zhaodi, additional, and Takahashi, Shunji, additional

Published
2018
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25. Importance of the site of positive surgical margin in salvage external beam radiation therapy for biochemical recurrence of prostate cancer after radical prostatectomy

Author

Kashihara, Tairo, primary, Nakamura, Satoshi, additional, Wakita, Akihisa, additional, Okamoto, Hiroyuki, additional, Inaba, Koji, additional, Umezawa, Rei, additional, Shima, Satoshi, additional, Tsuchida, Keisuke, additional, Kobayashi, Kazuma, additional, Takahashi, Kana, additional, Murakami, Naoya, additional, Ito, Yoshinori, additional, Igaki, Hiroshi, additional, Fujimoto, Hiroyuki, additional, Uno, Takashi, additional, and Itami, Jun, additional

Published
2018
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28. Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

Author

Furukawa, Chisa, primary, Fujii, Naoko, additional, Manabe, Aya, additional, Matsunaga, Toshiyuki, additional, Endo, Satoshi, additional, Hasegawa, Hajime, additional, Ito, Yoshinori, additional, Yamaguchi, Masahiko, additional, Yamazaki, Yasuhiro, additional, and Ikari, Akira, additional

Published
2017
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33. Correlation of rabbit antithymocyte globulin serum levels and clinical outcomes in children who received hematopoietic stem cell transplantation from an alternative donor

Author

Elmahdi, Shaimaa, primary, Muramatsu, Hideki, additional, Narita, Atsushi, additional, Torii, Yuka, additional, Ismael, Olfat, additional, Kawashima, Nozomu, additional, Okuno, Yusuke, additional, Sekiya, Yuko, additional, Xu, Yinyan, additional, Wang, Xinan, additional, Hama, Asahito, additional, Ito, Yoshinori, additional, Takahashi, Yoshiyuki, additional, and Kojima, Seiji, additional

Published
2015
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34. Effectiveness of a psycho‐oncology training program for oncology nurses: a randomized controlled trial

Author

Kubota, Yosuke, primary, Okuyama, Toru, additional, Uchida, Megumi, additional, Umezawa, Shino, additional, Nakaguchi, Tomohiro, additional, Sugano, Koji, additional, Ito, Yoshinori, additional, Katsuki, Fujika, additional, Nakano, Yumi, additional, Nishiyama, Takeshi, additional, Katayama, Yoshiko, additional, and Akechi, Tatsuo, additional

Published
2015
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36. Four types of Ipsilateral Breast Tumor Recurrence (IBTR) after breast-conserving surgery: Classification of IBTR based on precise pathological examination

Author

Sakai, Takehiko, primary, Nishimura, Seiichiro, additional, Ogiya, Akiko, additional, Tanabe, Masahiko, additional, Kimura, Kiyomi, additional, Morizono, Hidetomo, additional, Iijima, Kotaro, additional, Miyagi, Yumi, additional, Makita, Masujiro, additional, Ito, Yoshinori, additional, Oguchi, Masahiko, additional, Horii, Rie, additional, Akiyama, Futoshi, additional, and Iwase, Takuji, additional

Published
2015
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37. Expression of EpCAM and prognosis in early‐stage glottic cancer treated by radiotherapy

Author

Murakami, Naoya, primary, Mori, Taisuke, additional, Yoshimoto, Seiichi, additional, Ito, Yoshinori, additional, Kobayashi, Kazuma, additional, Ken, Harada, additional, Kitaguchi, Mayuka, additional, Sekii, Shuhei, additional, Takahashi, Kana, additional, Yoshio, Kotaro, additional, Inaba, Koji, additional, Morota, Madoka, additional, Sumi, Minako, additional, and Itami, Jun, additional

Published
2014
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39. Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy

Author

Makuuchi, Yosuke, primary, Honda, Kazufumi, additional, Osaka, Yoshiaki, additional, Kato, Ken, additional, Kojima, Takashi, additional, Daiko, Hiroyuki, additional, Igaki, Hiroyasu, additional, Ito, Yoshinori, additional, Hoshino, Sumito, additional, Tachibana, Shingo, additional, Watanabe, Takafumi, additional, Furuta, Koh, additional, Sekine, Shigeki, additional, Umaki, Tomoko, additional, Watabe, Yukio, additional, Miura, Nami, additional, Ono, Masaya, additional, Tsuchida, Akihiko, additional, and Yamada, Tesshi, additional

Published
2013
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