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Your search keyword '"Iwanari, Hiroko"' showing total 17 results
Start Over Author "Iwanari, Hiroko" Publisher wiley
17 results on '"Iwanari, Hiroko"'

1. High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG

Author

Miyazaki-Komine, Kaori, primary, Takai, Yoshiki, additional, Huang, Ping, additional, Kusano-Arai, Osamu, additional, Iwanari, Hiroko, additional, Misu, Tatsuro, additional, Koda, Katsushi, additional, Mitomo, Katsuyuki, additional, Sakihama, Toshiko, additional, Toyama, Yoshiaki, additional, Fujihara, Kazuo, additional, Hamakubo, Takao, additional, Yasui, Masato, additional, and Abe, Yoichiro, additional

Published
2015
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2. Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses

Author

Nakayama, Taisuke, primary, Mizohata, Eiichi, additional, Yamashita, Takefumi, additional, Nagatoishi, Satoru, additional, Nakakido, Makoto, additional, Iwanari, Hiroko, additional, Mochizuki, Yasuhiro, additional, Kado, Yuji, additional, Yokota, Yuki, additional, Satoh, Reiko, additional, Tsumoto, Kouhei, additional, Fujitani, Hideaki, additional, Kodama, Tatsuhiko, additional, Hamakubo, Takao, additional, and Inoue, Tsuyoshi, additional

Published
2015
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4. Epigenetically coordinated GATA2 binding is necessary for endothelium-specificendomucinexpression

Author

Kanki, Yasuharu, primary, Kohro, Takahide, additional, Jiang, Shuying, additional, Tsutsumi, Shuichi, additional, Mimura, Imari, additional, Suehiro, Jun-ichi, additional, Wada, Youichiro, additional, Ohta, Yoshihiro, additional, Ihara, Sigeo, additional, Iwanari, Hiroko, additional, Naito, Makoto, additional, Hamakubo, Takao, additional, Aburatani, Hiroyuki, additional, Kodama, Tatsuhiko, additional, and Minami, Takashi, additional

Published
2011
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5. Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4α may complement mucin phenotype of differentiated-type early gastric carcinoma

Author

Takano, Kabuto, primary, Hasegawa, Go, additional, Jiang, Shuying, additional, Kurosaki, Isao, additional, Hatakeyama, Katsuyoshi, additional, Iwanari, Hiroko, additional, Tanaka, Toshiya, additional, Hamakubo, Takao, additional, Kodama, Tatsuhiko, additional, and Naito, Makoto, additional

Published
2009
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7. Expression of liver X receptor α and lipid metabolism in granulocyte–macrophage colony‐stimulating factor‐induced human monocyte‐derived macrophage

Author

Kazawa, Toshihiro, primary, Kawasaki, Takashi, additional, Sakamoto, Azusa, additional, Imamura, Masaru, additional, Ohashi, Riuko, additional, Jiang, Shuying, additional, Tanaka, Toshiya, additional, Iwanari, Hiroko, additional, Hamakubo, Takao, additional, Sakai, Juro, additional, Kodama, Tatsuhiko, additional, and Naito, Makoto, additional

Published
2009
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11. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by β-catenin/TCF

Author

Torisu, Yuichi, primary, Watanabe, Akira, additional, Nonaka, Aya, additional, Midorikawa, Yutaka, additional, Makuuchi, Masatoshi, additional, Shimamura, Takahiro, additional, Sugimura, Haruhiko, additional, Niida, Atsushi, additional, Akiyama, Tetsu, additional, Iwanari, Hiroko, additional, Kodama, Tatsuhiko, additional, Zeniya, Mikio, additional, and Aburatani, Hiroyuki, additional

Published
2008
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12. Downregulated P1 promoter-driven hepatocyte nuclear factor-4? expression in human colorectal carcinoma is a new prognostic factor against liver metastasis

Author

Oshima, Tomoko, primary, Kawasaki, Takashi, additional, Ohashi, Riuko, additional, Hasegawa, Go, additional, Jiang, Shuying, additional, Umezu, Hajime, additional, Aoyagi, Yutaka, additional, Iwanari, Hiroko, additional, Tanaka, Toshiya, additional, Hamakubo, Takao, additional, Kodama, Tatsuhiko, additional, and Naito, Makoto, additional

Published
2007
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14. Overexpression of MUC13 is associated with intestinal‐type gastric cancer

Author

Shimamura, Takahiro, primary, Ito, Hirotaka, additional, Shibahara, Junji, additional, Watanabe, Akira, additional, Hippo, Yoshitaka, additional, Taniguchi, Hirokazu, additional, Chen, Yongxin, additional, Kashima, Takeshi, additional, Ohtomo, Toshihiko, additional, Tanioka, Fumihiko, additional, Iwanari, Hiroko, additional, Kodama, Tatsuhiko, additional, Kazui, Teruhisa, additional, Sugimura, Haruhiko, additional, Fukayama, Masashi, additional, and Aburatani, Hiroyuki, additional

Published
2005
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17. High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG.

Author

Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M, and Abe Y

Subjects
Animals, Astrocytes immunology, CHO Cells, Cell Line, Cricetinae, Cricetulus, Endocytosis immunology, Humans, Immunoglobulin G immunology, Protein Binding, Protein Structure, Tertiary, Antibodies, Monoclonal immunology, Antibody Affinity, Aquaporin 4 chemistry, Aquaporin 4 immunology, Autoantibodies immunology, Neuromyelitis Optica immunology
Abstract

Background and Purpose: Most of the cases of neuromyelitis optica (NMO) are characterized by the presence of an autoantibody, NMO-IgG, which recognizes the extracellular domains of the water channel, aquaporin-4. Binding of NMO-IgG to aquaporin-4 expressed in end-feet of astrocytes leads to complement-dependent disruption of astrocytes followed by demyelination. One therapeutic option for NMO is to prevent the binding of NMO-IgG to aquaporin-4, using high-avidity, non-pathogenic-chimeric, monoclonal antibodies to this water channel. We describe here the development of such antibodies., Experimental Approach: cDNAs encoding variable regions of heavy and light chains of monoclonal antibodies against the extracellular domains of human aquaporin-4 were cloned from hybridoma total RNA and fused to those encoding constant regions of human IgG1 and Igκ respectively. Then mammalian expression vectors were constructed to establish stable cell lines secreting mature chimeric antibodies., Key Results: Original monoclonal antibodies showed high avidity binding to human aquaporin-4, as determined by ELISA. Live imaging using Alexa-Fluor-555-labelled antibodies revealed that the antibody D15107 more rapidly bound to cells expressing human aquaporin-4 than others and strongly enhanced endocytosis of this water channel, while D12092 also bound rapidly to human aquaporin-4 but enhanced endocytosis to a lesser degree. Chimeric D15107 prevented complement-dependent cytotoxicity induced by NMO-IgG from patient sera in vitro., Conclusions and Implications: We have established non-pathogenic, high-avidity, chimeric antibodies against the extracellular domains of human aquaporin-4, which provide a novel therapeutic option for preventing the progress and recurrence of NMO/NMO spectrum disorders., (© 2015 The British Pharmacological Society.)

Published
2016
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