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International audience; Objectives: High rates of clinical acute rejection after kidney transplantation have been reported in people living with HIV (PLHIV), probably as a consequence of drug interactions. We therefore investigated the incidence of acute rejection within 6 months of transplantation in HIV-infected recipients treated with a protease-inhibitor-free raltegravir-based regimen.Methods: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE (NCT01453192) study was a prospective multicentre single-arm trial in adult PLHIV awaiting kidney transplantation, with viral load < 50 HIV-1 RNA copies/mL, CD4 T-cell count > 200 cells/μL, and HIV-1 strains sensitive to raltegravir, aiming to demonstrate 6-month clinical acute rejection rates < 30%. Time to transplantation was compared with that for uninfected subjects matched for age, sex and registration date.Results: In total, 61 participants were enrolled in the study, and 26 underwent kidney transplantation. Two participants experienced clinical acute rejection, corresponding to an estimated clinical acute rejection rate of 8% [95% confidence interval (CI) 2-24%] at 6 and 12 months post-transplantation. HIV infection remained under control in all but one participant, who temporarily stopped antiretroviral treatment. Median time to transplantation was longer in PLHIV than in controls (4.3 versus 2.8 years, respectively; P = 0.002) and was not influenced by blood group.Conclusions: Acute rejection rates were low after kidney transplantation in PLHIV treated with a raltegravir-based regimen. However, PLHIV have poorer access to transplantation than HIV-uninfected individuals after registration on the waiting list.

Poly(para-phenylene)s (PPPs) are an interesting class of rigid-rod polymers that have excellent thermal and mechanical properties. Because of their high degree of crystallinity and lower permeability to methanol, PPPs are insoluble and infusible. A number of methods have been developed to synthesize substituted sulfonated PPPs bearing lateral chains to improve their solubility. In this work, a comparison of the physicochemical properties of three PPP-based polymers is made with respect to Nafion membranes. One of these polymers was prepared with the postsulfonation method, and the other two were made with a new method of grafting developed in the Commissariat a l'Energie Atomique laboratory (a grafted sulfonated PPP polymer and a grafted perfluorinated sulfonated polymer). The sulfonated PPP polymers were examined for their mechanical properties, small-angle X-ray scattering, water absorption, proton conductivity, and methanol permeability. Relations between structures and properties were also investigated. Performances in fuel-cell tests were also investigated. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 944–952, 2006