1. Diabetes duration and glycaemic control as predictors of cardiovascular disease and mortality
- Author
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Hai-Lian Yang, Fu-Rong Li, Guo-Chong Chen, Rui Zhou, Xian-Bo Wu, Jiazhen Zheng, Meng-Chen Zou, and Xiao-Xiang Wu
- Subjects
Diabetes duration ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Glycemic Control ,Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,Humans ,Medicine ,Glycated Hemoglobin ,business.industry ,Proportional hazards model ,Hazard ratio ,Anthropometry ,medicine.disease ,Confidence interval ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,business ,Cohort study - Abstract
AIMS To assess the associations of diabetes duration and glycaemic control (defined by plasma glycated haemoglobin [HbA1c] level) with the risks of cardiovascular disease (CVD) and all-cause mortality and to determine whether the addition of either or both to the established CVD risk factors can improve predictions. MATERIALS AND METHODS A total of 435 679 participants from the UK Biobank without CVD at baseline were included. Cox models adjusting for classic risk factors (sociodemographic and anthropometric characteristics, lipid profiles and medication use) were used, and predictive utility was determined by the C-index and net reclassification improvement (NRI). RESULTS Compared with participants without diabetes, participants with longer diabetes durations and poorer glycaemic control had a higher risk of fatal/nonfatal CVD. Among participants with diabetes, the fully-adjusted hazard ratios (HRs) for diabetes durations of 5 to
- Published
- 2021
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