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Objectives: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by premature platelet destruction induced by autoantibodies directed against platelet glycoproteins (GPs). Despite being a clinically important disorder, ITP lacks a feasible diagnostic assay for routine clinical use. This study was meant to evaluate a newly developed flow cytometric immunobead assay for determination of platelet-bound GP-specific autoantibodies in comparison with indirect monoclonal antibody-specific immobilization of platelet antigen (MAIPA) in the diagnosis of ITP. Methods: Platelet-bound and plasma GPIIb/IIIa and GPIb/IX autoantibodies were determined by flow cytometric immunobead assay and indirect modified MAIPA, respectively. The average fluorescence level for platelet-bound, GP-specific autoantibodies was given as a ratio to three normal controls tested simultaneously. Results: The median value of platelet-bound GPIIb/IIIa and GPIb/IX autoantibodies in ITP group were 3.09 (range 0.78, 30.2) and 3.09 (range 0.72, 19.2), respectively, which were significantly higher than non-ITP group [1.01 (0.67, 5.59) and 1.01 (0.79, 5.56), respectively, P

Mesoporous (MSU) Ce0.5Zr0.5O2 mixed oxide with a high specific surface area has been synthesized under weak acidic condition in the presence of an anionic surfactant, sodium dodecylbenzenesulfonate. The effect of the pH value on the formation of mesostructure and the thermal stability of the material has been evaluated. The products were characterized by transmission electron microscopy, powder X-ray diffraction and nitrogen adsorption-desorption measurements. The results showed that the as-prepared Ce0.5Zr0.5O2 mixed oxide possessed a specific surface area of 163.3 m2·g−1, which had a cubic fluorite-type structure and possessed specific surface areas of 148.4 and 62.4 m2·g−1 after calcination at 500 and 800 °C for 2 h, respectively. The material showed excellent thermal stability.