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Background The incidence of immune thrombocytopenia (ITP) is not well known in Asians. The aims of this study were to survey incidences and clinical features of ITP in Taiwan. Study design and methods This study identified 4855 incident ITP cases from the population-based National Health Insurance Research Database from mid-2006 to mid-2013, and compared incidences, patient characteristics, and clinical manifestations of ITP by age. Results Respective ITP incidence rates among those aged 15 years. Conclusion Incidence estimates of ITP in Taiwan were close to those of Western countries, with age-specific variations in sex ratio, comorbidity, splenectomy, secondary causes, and incidence trends. The results suggest no racial variations in ITP incidences, but a geographical difference in causes of secondary ITP.

Summary Evidence from our previous study suggested that the incidence of germ cell neoplasms in children and adolescents is increasing. The objectives of this analysis were to quantify this trend in patients aged 0–9 and 10–19 years (pre-pubertal and adolescent groups, respectively) and compare rates in Taiwan according to geographic distribution. Germ cell neoplasm frequencies among 1267 patients aged 0–19 years spanning 1995–2009 were obtained from the population-based Taiwan Cancer Registry. The incidence patterns according to sex, age, disease subgroup, and geographic distribution were analyzed. The incidence rates in the pre-pubertal and adolescent groups were 10.58 and 16.06 per million person-years, respectively. The overall rates increased significantly by 3.2% annually in the adolescent group during the 15-year study period, and increased only among the males. In contrast, no change in trend was observed in the pre-pubertal group. Subgroup analysis showed significant upward trends in the incidence rates of intracranial/intraspinal and testicular germ cell tumors (GCTs) in the adolescent males and extracranial/extragonadal GCTs in the pre-pubertal boys. The most striking differences between the study population and white Americans were that the rates of testicular GCTs were 5-fold higher and 4-fold lower in the Taiwanese pre-pubertal and adolescent groups, respectively. Significantly higher rates were found in Hualien and Chiayi Counties compared with the other areas of Taiwan. The upward trend of testicular GCTs in the adolescent males is consistent with findings from Western countries. The underlying causes that led to the high rate of testicular GCTs in the pre-pubertal boys and significantly higher rates in specific counties warrant further investigation.

BACKGROUND Currently, little information is available on childhood cancer incidence rates in Eastern Asia. The objective of this study was to report the first population-based cancer surveillance of children and adolescents in Taiwan. METHODS Data from the Taiwan Cancer Registry were examined for cancer frequencies and incidence rates among individuals ages birth to 19 years from 1995 to 2009. Types of cancers were grouped according to the International Classification of Childhood Cancer. Rates were compared by sex and age. For further comparisons with other countries, rates were age standardized to the 2000 world standard population in 5-year age groups. Trends in incidence rates also were evaluated. RESULTS In total, 12,315 individuals were diagnosed with childhood cancers, for an age-standardized incidence rate (ASR) of 132.1 per million person-years from 1995 to 2009. The male-to-female incidence rate ratio was 1.19. Overall, leukemias were the most common cancer (ASR, 39.1 per million person-years), followed by central nervous system neoplasms (15.8 per million person-years), and lymphomas (15.3 per million person-years). During the 15-year study period, the incidence rates increased by 1% annually. Compared with other countries, the rate of hepatic tumors was 2 times greater in Taiwan. The rate of germ cell neoplasms in Taiwan was similar to that in the United States and was 1.3 to 1.9 times greater compared with Canada, Brazil, Israel, and Japan. CONCLUSIONS Based on the current data, the observed increase in overall incidence rates was attributable only marginally to improvements in case ascertainment and diagnostic procedures. The high rates of malignant hepatic tumors and germ cell neoplasms in Taiwan suggest variations in the background risk factors. Cancer 2014;120:3545–3553. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. The authors examine cancer incidence patterns in children and adolescents based on a national, population-based cancer registry of 12,315 individuals in Taiwan from 1995 to 2009. The high rates of malignant hepatic tumors and germ cell neoplasms in Taiwan suggest variations in background risk factors.

The sensory hair cells in mammalian inner ear are responsible for sound transduction.Sound waves deflect hair bundles and open the mechanotransducer (MET) channels, which initiated mechanotransduct...

The perception of equilibrium and sound in fish depends on the deflection of hair bundles of hair cell by the otolith. However, the accreting nature of teleostean otoliths poses a problem for maintenance of proper contact between the hair bundle and the otolith surface. Immunocytochemical staining localizes abundant proton-secreting H-ATPase in the apical membrane of the hair cells. The H-ATPase-mediated proton secretion into the endolymph causes an approximately 0.4-unit pH decrease, which was quantified by an H-selective microelectrode. Thus, the hair cells maintain the proper distance from the otolith by neutralizing the alkaline endolymph to retard CaCO3 deposition on the otolith opposite the sensory macula. Carbonic anhydrase, which hydrolyses CO2 and produces HCO3 – and H, was also localized in the hair cells. Ionocytes showed prominent immunostaining of carbonic anhydrase and Na-K-ATPase, indicating its role in transepithelial transport of HCO3 – across the membranous labyrinth into the endolymph. Ionocytes form a ring closely surrounding the sensory macula. HCO3 – secreted from the ionocytes may serve as a barrier to neutralize H diffused from the sensory macula while keeping the endolymph alkaline outside the sensory macula. The ingenious arrangement of ionocytes and hair cells results in a unique sculptured groove, which is a common feature on the proximal surface of all teleostean otoliths. J. Comp. Neurol. 488:331–341, 2005. © 2005 Wiley-Liss, Inc.

To investigate whether Na+ uptake by zebrafish is dependent on NH4+ excretion, a scanning ion-selective electrode technique was applied to measure Na+ and NH4+ gradients at the yolk-sac surface of ...