5 results on '"Joseph Sweeny"'
Search Results
2. Cardiovascular outcomes after percutaneous coronary intervention on bifurcation lesions with moderate to severe coronary calcium: A <scp>single‐center</scp> registry study
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Vishal Kapur, Prakash Krishnan, Yuliya Vengrenyuk, Pooja Vijay, Joseph Sweeny, Roxana Mehran, Naotaka Okamoto, Samin K. Sharma, Vaishvi Jhaveri, Melissa Aquino, George Dangas, Usman Baber, Nileshkumar J. Patel, Jonathan Luke Murphy, Annapoorna Kini, Nitin Barman, and Choudhury Hasan
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Percutaneous coronary intervention ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Angiography ,Conventional PCI ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Mace ,Calcification - Abstract
Background Both target vessel calcification and target vessel bifurcation are associated with worse outcomes following percutaneous coronary intervention (PCI). Whether these entities in combination interact to influence outcomes after PCI of complex coronary disease is not known. Objectives This study evaluated the association of target vessel bifurcation and target vessel calcification, alone and in combination, with adverse events following PCI. Methods Registry data from 21,165 patients who underwent PCI with drug-eluting stents (DES) between January 2009 and December 2017 were analyzed. Patients were divided into four groups according to the presence or absence of target vessel bifurcation and presence of none/mild or moderate/severe target vessel calcification on angiography. Associations between lesion groups and 1 year major adverse cardiac events (MACE) were examined using Cox regression analysis. Results At 1 year, unadjusted rates of MACE, death, myocardial infarction (MI), as well as stent thrombosis were highest in the group with both bifurcation lesion and moderate/severe calcification. After adjusting for confounders such as age, renal disease, and smoking, hazard ratios for MACE were 1.14 (95%CI 0.99-1.33) for bifurcation with none/mild calcification, 1.21 (95%CI 1.06-1.38) for no bifurcation and moderate/severe calcification, and 1.37 (95%CI 1.14-1.64) for bifurcation and moderate severe calcification, compared to patients with no bifurcation and none/mild calcification. Conclusions The presence of a bifurcating target vessel with moderate/severe calcification is associated with a higher risk of adverse outcomes than either attribute alone. New approaches are needed to improve outcomes in this subset of patients with complex coronary artery disease.
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- 2020
3. Impact of sex on long‐term cardiovascular outcomes of patients undergoing percutaneous coronary intervention for acute coronary syndromes
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Roxana Mehran, Bimmer E. Claessen, Joseph Sweeny, Prakash Krishnan, Davide Cao, Johny Nicolas, Rebecca Torguson, Samin K. Sharma, Anastasios Roumeliotis, Samantha Sartori, Mauro Chiarito, Annapoorna Kini, George Dangas, Hanbo Qiu, Rishi Chandiramani, Nitin Barman, Anton Camaj, and Ridhima Goel
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Male ,Bare-metal stent ,Acute coronary syndrome ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Population ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Acute Coronary Syndrome ,education ,education.field_of_study ,business.industry ,Unstable angina ,Percutaneous coronary intervention ,Drug-Eluting Stents ,General Medicine ,medicine.disease ,Treatment Outcome ,Conventional PCI ,Cardiology ,ST Elevation Myocardial Infarction ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Women with acute coronary syndrome (ACS) generally present with more comorbidities and experience worse clinical outcomes compared with males. However, it is unclear whether this represents genuine sex-related difference or stems from clinical, procedural and socioeconomic factors. METHODS We analyzed consecutive patients undergoing percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), non-STEMI or unstable angina at a single tertiary-care center. Exclusion criteria were unknown sex, age
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- 2021
4. Prevalence and prognostic impact of hsCRP elevation are age‐dependent in women but not in men undergoing percutaneous coronary intervention
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George Dangas, Nitin Barman, Samin K. Sharma, Usman Baber, Sebastian Kelle, Jason C. Kovacic, Prakash Krishnan, Anastasios Roumeliotis, Samantha Sartori, Rishi Chandiramani, Roxana Mehran, Moritz Blum, Davide Cao, Niklas Beyhoff, Joseph Sweeny, Ridhima Goel, and Annapoorna Kini
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Prevalence ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,education ,education.field_of_study ,Proportional hazards model ,business.industry ,nutritional and metabolic diseases ,Percutaneous coronary intervention ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,C-Reactive Protein ,Treatment Outcome ,Quartile ,Conventional PCI ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Mace - Abstract
BACKGROUND High-sensitivity C-reactive protein (hsCRP) predicts outcomes after percutaneous coronary intervention (PCI). OBJECTIVE We studied the prevalence and prognostic impact of hsCRP elevation according to age in men and women undergoing PCI. METHODS We included patients undergoing PCI at our center from 2010 until 2017, excluding those with myocardial infarction (MI) on presentation, neoplastic disease and hsCRP >10 mg/L at baseline. Elevated hsCRP was defined as >3 mg/L. The outcome of interest was major adverse cardiac events (MACE) consisting of all-cause death, MI and target vessel revascularization. The association between hsCRP elevation and outcomes was assessed using adjusted Cox models. RESULTS 10,432 men and 4,345 women were included. Elevation of hsCRP was present in 25.7% of men and 37.0% of women (p
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- 2020
5. Mid-term outcomes of consecutive 998 cases of coronary atherectomy in contemporary clinical practice
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Samin K. Sharma, Nitin Barman, Sonny Sayseng, Usman Baber, Nishtha Sareen, Joseph Sweeny, Vishal Kapur, Melissa Aquino, and Annapoorna Kini
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Atherectomy, Coronary ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Perforation (oil well) ,Myocardial Infarction ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary artery disease ,Atherectomy ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Postoperative Complications ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Myocardial infarction ,Vascular Calcification ,Adverse effect ,Prospective cohort study ,Aged ,Retrospective Studies ,business.industry ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,Conventional PCI ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives To compare clinical and safety endpoints with use of rotational (RA) and orbital (OA) atherectomy in a large patient population with moderate to severely calcified lesions undergoing percutaneous coronary intervention (PCI). Background Coronary artery calcification (CAC) has been recognized as a risk factor for adverse outcomes with coronary artery disease (CAD). Though atheroablative techniques, RA and OA have been used extensively, comparison of their clinical and safety endpoints is lacking. Comparison of these two modalities formed the basis of our study. Methods and Results Of 12 001 patients who underwent PCI at our institution between January 2013-December 2015, we studied 998 consecutive patients with severe calcification treated with atheroablation. We assessed clinical outcomes including death, myocardial infarction (MI) and target lesion revascularization (TLR) at 30 days and 6 months in addition to post-procedural complications. Device perforation occurred more frequently with use of OA at high burr speed versus RA (1.9%, n = 3 vs. 0.2%, n = 2, P = 0.03). Rates of composite adverse events were similar between groups at 6 months (18.55 vs. 11.46%; P = 0.11) Conclusion In this retrospective, single center study, we observed no significant differences in 6-month rates of adverse events associated with use of OA vs. RA in patients with moderate to severe calcification undergoing PCI. Larger, prospective studies are needed to confirm our findings.
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- 2017
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