Search

Your search keyword '"Kieda, Claudine"' showing total 19 results
Start Over Author "Kieda, Claudine" Publisher wiley
19 results on '"Kieda, Claudine"'

5. ROS implication in a new antitumor strategy based on non‐thermal plasma

Author

Vandamme, Marc, primary, Robert, Eric, additional, Lerondel, Stéphanie, additional, Sarron, Vanessa, additional, Ries, Delphine, additional, Dozias, Sébastien, additional, Sobilo, Julien, additional, Gosset, David, additional, Kieda, Claudine, additional, Legrain, Brigitte, additional, Pouvesle, Jean‐Michel, additional, and Pape, Alain Le, additional

Published
2011
Full Text
View/download PDF

19. Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.

Author

Oknińska M, Paterek A, Grzanka M, Zajda K, Surzykiewicz M, Rolski F, Zambrowska Z, Torbicki A, Kurzyna M, Kieda C, Piekiełko-Witkowska A, and Mączewski M

Subjects
Animals, Male, Rats, Ventricular Dysfunction, Right drug therapy, Ventricular Dysfunction, Right prevention & control, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Heart Failure drug therapy, Heart Failure chemically induced, Heart Failure prevention & control, Heart Failure metabolism, Monocrotaline, Hypertension, Pulmonary chemically induced, Hypertension, Pulmonary drug therapy, Hypertension, Pulmonary metabolism, Hypertension, Pulmonary prevention & control, Inositol Phosphates metabolism, Rats, Sprague-Dawley
Abstract

Background and Purpose: Pulmonary hypertension (PH) results from pulmonary vasculopathy, initially leading to a compensatory right ventricular (RV) hypertrophy, and eventually to RV failure. Hypoxia can trigger both pulmonary vasculopathy and RV failure. Therefore, we tested if myo-inositol trispyrophosphate (ITPP), which facilitates oxygen dissociation from haemoglobin, can relieve pulmonary vasculopathy and RV hypoxia, and eventually prevent RV failure and mortality in the rat model of monocrotaline-induced PH., Experimental Approach: Rats were injected with monocrotaline (PH) or saline (control) and received ITPP or placebo for 5 weeks. Serial echocardiograms were obtained to monitor the disease, pressure-volume loops were recorded and evaluated, myocardial pO 2 was measured using a fluorescent probe, and histological and molecular analyses were conducted at the conclusion of the experiment., Key Results and Conclusions: ITPP reduced PH-related mortality. It had no effect on progressive increase in pulmonary vascular resistance, yet significantly relieved intramyocardial RV hypoxia, which was associated with improvement of RV function and reduction of RV wall stress. ITPP also tended to prevent increased hypoxia inducible factor-1α expression in RV cardiac myocytes but did not affect RV capillary density., Implications: Our study suggests that strategies aimed at increasing oxygen delivery to hypoxic RV in PH could potentially be used as adjuncts to other therapies that target pulmonary vessels, thus increasing the ability of the RV to withstand increased afterload and reducing mortality. ITPP may be one such potential therapy., (© 2024 British Pharmacological Society.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results