1. Discovery and in vitro Evaluation of Potent TrkA Kinase Inhibitors: Oxindole and Aza-Oxindoles
- Author
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Lee F. Kuyper, Kimberly G. Petrov, Karen Lackey, Robert N. Hunter, Edgar R. Wood, and Philip A. Harris
- Subjects
Models, Molecular ,Indoles ,Stereochemistry ,Clinical Biochemistry ,Drug Evaluation, Preclinical ,Pharmaceutical Science ,Tropomyosin receptor kinase A ,Biochemistry ,Chemical synthesis ,Substrate Specificity ,Structure-Activity Relationship ,chemistry.chemical_compound ,Drug Discovery ,CDC2-CDC28 Kinases ,Structure–activity relationship ,Oxindole ,Enzyme Inhibitors ,Receptor, trkA ,Methylene ,Molecular Biology ,Molecular Structure ,biology ,Kinase ,Cyclin-Dependent Kinase 2 ,Organic Chemistry ,Cyclin-dependent kinase 2 ,General Medicine ,In vitro ,Proto-Oncogene Proteins c-raf ,chemistry ,Enzyme inhibitor ,biology.protein ,Molecular Medicine - Abstract
The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.
- Published
- 2004
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