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Your search keyword '"Kurt Schibler"' showing total 9 results
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9 results on '"Kurt Schibler"'

1. Individualized Human Milk Fortification to Improve the Growth of Hospitalized Preterm Infants

Author

Jingran Ma, Lijuan Gou, Chen Wang, Dan-Hua Wang, Lejia Zhang, Zheng-Hong Li, Zhixing Sun, Kurt Schibler, and Meiying Quan

Subjects
Male, Pediatrics, medicine.medical_specialty, 030309 nutrition & dietetics, Fortification, Medicine (miscellaneous), Gestational Age, Weight Gain, Body weight, Enteral administration, 03 medical and health sciences, Enteral Nutrition, 0302 clinical medicine, medicine, Humans, Infant, Very Low Birth Weight, Prospective Studies, Blood urea nitrogen, 0303 health sciences, Nutrition and Dietetics, Milk, Human, business.industry, Infant, Newborn, Gestational age, Hospitalization, Very preterm, Regimen, Treatment Outcome, Dietary Supplements, Food, Fortified, Female, 030211 gastroenterology & hepatology, Dietary Proteins, medicine.symptom, business, Weight gain, Infant, Premature
Abstract

BACKGROUND Human milk (HM) is the first choice for preterm infants, but exclusive HM feeding is inadequate for the growth of very preterm infants. The hypothesis of this trial is that infants fed according to an individualized fortification regimen will have higher protein intake and improved weight gain velocity (WGV). METHODS A prospective, randomized, controlled study was conducted. Infants

Published
2019

2. Grade and laterality of intraventricular haemorrhage to predict 18-22 month neurodevelopmental outcomes in extremely low birthweight infants

Author

Stephanie L. Merhar, Kurt Schibler, Meredith E. Tabangin, and Jareen Meinzen-Derr

Subjects
medicine.medical_specialty, Pediatrics, Multivariate analysis, business.industry, Obstetrics, MEDLINE, General Medicine, medicine.disease, Sepsis, Low birth weight, Text mining, Intraventricular hemorrhage, Pediatrics, Perinatology and Child Health, Laterality, Severity of illness, medicine, medicine.symptom, business
Abstract

Aims To determine whether extremely low birth weight (ELBW) infants with bilateral compared to unilateral intraventricular hemorrhage (IVH) have worse neurodevelopmental outcomes at 18–22 months.

Published
2012

3. Genetic mutations and aminoglycoside‐induced ototoxicity in neonates

Author

Kurt Schibler, John H. Greinwald, Aliza P. Cohen, Romaine F. Johnson, and Yingshi Guo

Subjects
Male, Pediatrics, medicine.medical_specialty, Hearing loss, Birth weight, Population, Infant, Premature, Diseases, Ototoxicity, Risk Factors, Intensive care, medicine, Humans, Prospective Studies, Hearing Loss, education, education.field_of_study, business.industry, Aminoglycoside, Infant, Newborn, medicine.disease, Low birth weight, Aminoglycosides, Otorhinolaryngology, Mutation, Population study, Female, Surgery, Gentamicins, medicine.symptom, business, Infant, Premature
Abstract

Mutations in the 12S rRNA gene have been associated with aminoglycoside-induced ototoxicity. Our objective was to study the relationship of these mutations in neonates, duration of aminoglycoside exposure, and other known risk factors to the presence of hearing loss.Prospective case-cohort study.Three neonatal intensive care units (NICUs) in Cincinnati, OH.We studied a population of premature, low-birth-weight (2500 g) infants admitted to one of three ICUs. Demographic, genetic, clinical, and audiometric data were collected, and the prevalence of 12S rRNA mutations was calculated.Of the 436 patients enrolled in the study, 378 were exposed to gentamicin during their ICU stay. Mutations in the 12S rRNA gene were identified in four patients (0.9%), all of whom received gentamicin. Of the cohort, 256 patients (60%) received a complete audiometric assessment; 39 failed their initial hearing assessment. Only one of these patients had a 12S rRNA mutation. Of these 39 patients, the mean birth weight (1645 g vs 1306 g) was significantly less than the birth weight of those infants who passed their initial hearing screening. Definitive hearing assessment for those who failed showed no significant differences, however.The prevalence of 12S rRNA mutations related to aminoglycoside ototoxicity in our study population was approximately one percent. Most patients with this mutation and aminoglycoside exposure showed no evidence of hearing loss. Low birth weight was one risk factor related to the presence of failing a hearing assessment.

Published
2010

4. Preterm Infant Gut Microbiome and Weight at 36 Weeks Corrected Gestational Age

Author

Ardythe L. Morrow, Namasivayam Ambalavanan, Barbara S. Davidson, Diana H. Taft, Zhuoteng Yu, D Ward, Nicholas J. Ollberding, David S. Newburg, and Kurt Schibler

Subjects
biology, business.industry, Physiology, Gut flora, biology.organism_classification, medicine.disease, digestive system, Biochemistry, Obesity, Gut microbiome, stomatognathic diseases, fluids and secretions, Corrected Gestational Age, Genetics, medicine, business, Molecular Biology, Biotechnology
Abstract

The gut microbiota is thought to influence obesity, but the impact of the microbiota on preterm infant growth has not been studied. We hypothesized that growth of preterm infants could be associate...

Published
2015

5. Intestinal microbiota of preterm infants differ between sites and over time: a comparison of two large neonatal intensive care units (637.8)

Author

Ardythe L. Morrow, Doyle V. Ward, Namasivayam Ambalavanan, Zhuoteng Yu, David S. Newburg, Diana Taft, and Kurt Schibler

Subjects
medicine.medical_specialty, business.industry, health care facilities, manpower, and services, medicine.disease, digestive system, Biochemistry, digestive system diseases, Sepsis, stomatognathic diseases, fluids and secretions, Intensive care, Necrotizing enterocolitis, Genetics, medicine, business, Intensive care medicine, Molecular Biology, Biotechnology
Abstract

Neonatal intensive care units (NICUs) differ in their rates of necrotizing enterocolitis (NEC) and sepsis. Intestinal microbiota are implicated in these diseases, but the microbiota of different NI...

Published
2014

7. A pilot study of TLR4 polymorphism in relation to intestinal dysbiosis and risk of necrotizing enterocolitis in preterm infants

Author

Dirk Gevers, David S. Newburg, Ardythe L. Morrow, Leah C. Kottyan, Zhuoteng Yu, Diana H. Taft, Anne J. Lagomarcino, Curtis Huttenhower, Doyle V. Ward, and Kurt Schibler

Subjects
medicine.medical_specialty, business.industry, TLR4 POLYMORPHISM, Intestinal dysbiosis, medicine.disease, Biochemistry, Gastroenterology, Internal medicine, Necrotizing enterocolitis, Genetics, medicine, business, Molecular Biology, Biotechnology
Published
2013

8. Early intestinal colonization phenotypes predict necrotizing enterocolitis in preterm infants

Author

Michael A. Kennedy, Anne J. Lagomarcino, Dirk Gevers, Ardythe L. Morrow, Doyle V. Ward, Diana H. Taft, Kurt Schibler, David S. Newburg, Curtis Huttenhower, Bo Wang, and Zhuoteng Yu

Subjects
business.industry, Necrotizing enterocolitis, Immunology, Genetics, Medicine, business, Intestinal colonization, medicine.disease, Molecular Biology, Biochemistry, Phenotype, Biotechnology
Published
2013

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