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Your search keyword '"Kyung, M."' showing total 22 results
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22 results on '"Kyung, M."'

1. Elucidating the cellular uptake mechanisms of heptamethine cyanine dye analogues for their use as an anticancer drug‐carrier molecule for the treatment of glioblastoma

Author

Cooper, Elizabeth, primary, Choi, Peter J., additional, Hwang, Kihwan, additional, Nam, Kyung M., additional, Kim, Chae‐Yong, additional, Shaban, Tina, additional, Schweder, Patrick, additional, Mee, Edward, additional, Correia, Jason, additional, Turner, Clinton, additional, Faull, Richard L. M., additional, Denny, William A., additional, Noguchi, Katsuya, additional, Dragunow, Mike, additional, Jose, Jiney, additional, and Park, Thomas I.‐H., additional

Published
2022
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2. Bone augmentation using small molecules with biodegradable calcium sulfate particles in a vertical onlay graft model in the rabbit calvarium

Author

Ui Won Jung, Jae Kook Cha, Doo Hyung Kim, Kyung M. Woo, and Young Woo Song

Subjects
Male, 0301 basic medicine, Bone Regeneration, Materials science, Biomedical Engineering, chemistry.chemical_element, Calcium, Calcium Sulfate, Bone augmentation, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Absorbable Implants, Animals, Animal study, Small particles, Bone regeneration, Skull, Significant difference, Sodium butyrate, 030206 dentistry, Bone area, Amino Acids, Dicarboxylic, 030104 developmental biology, chemistry, Bone Substitutes, Butyric Acid, Rabbits, Biomedical engineering
Abstract

Small molecules including sodium butyrate (SB) and dimethyloxalylglycine (DMOG) can promote bone regeneration via inhibitive effects eliciting cellular responses through signaling cascades. The purpose of this study was to determine the synergistic effects of SB and DMOG loaded on calcium sulfate (CaS) on bone regeneration in the challenging vertical augmentation model in the rabbit calvarium. Four plastic cylinders screwed on the calvarium of each of 10 rabbits were randomly grafted with CaS, CaS/SB, CaS/DMOG, or CaS/DMOG/SB. All specimens were assessed by radiographic, histologic, and histomorphometric analyses. In the radiographic analysis, three different layers (new bone, degraded CaS, and pristine CaS layers) could be distinguished within the cylinder in all groups at 2 weeks. Newly formed bone grew up from basal bone, and CaS in contact with newly formed bone was degraded into small particles to form a different layer. At 8 weeks, most of the pristine CaS had been absorbed and hardly seen within the cylinder. In the histomorphometric analysis, all groups showed comparable new bone areas and heights at 2 and 8 weeks. The DMOG group showed a significant increase in new bone area at 8 weeks compared with 2 weeks, but there was no significant difference among the groups at 8 weeks. The DMOG group showed significantly lower values for the residual material area than the control group at 2 weeks. Within the limitations of this study, SB and DMOG seem to exert smaller synergistic effects on bone regeneration compared to CaS alone in vertical bone augmentation.

Published
2020

3. Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3‐Driven Inflammation and Gouty Arthritis

Author

Yang, Gabsik, primary, Lee, Hye E., additional, Moon, Su‐Jin, additional, Ko, Kyung M., additional, Koh, Jung H., additional, Seok, Jin K., additional, Min, Jun‐Ki, additional, Heo, Tae‐Hwe, additional, Kang, Han C., additional, Cho, Yong‐Yeon, additional, Lee, Hye S., additional, Fitzgerald, Katherine A., additional, and Lee, Joo Y., additional

Published
2020
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5. Influence of Nitrogen, Plant Growth Regulators, and Iron Sulfate on Annual Bluegrass Populations on a Golf Green

Author

Kyung M. Han, Timothy T. Lulis, and John E. Kaminski

Subjects
0106 biological sciences, Plant growth, chemistry.chemical_element, 04 agricultural and veterinary sciences, General Medicine, 01 natural sciences, Nitrogen, Iron sulfate, chemistry.chemical_compound, chemistry, Agronomy, Botany, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Environmental science, 010606 plant biology & botany
Published
2017

6. Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice

Author

David A. Sinclair, Jaime M. Ross, Lars Olson, Rui M. M. Branca, Giuseppe Coppotelli, Kyung M. Kim, and Janne Lehtiö

Subjects
Male, Proteomics, 0301 basic medicine, Premature aging, Aging, medicine.medical_specialty, Mitochondrial DNA, Protein subunit, Oxidative phosphorylation, Biology, Mitochondrion, DNA, Mitochondrial, Mice, 03 medical and health sciences, 0302 clinical medicine, Physical Conditioning, Animal, Internal medicine, medicine, Animals, Muscle, Skeletal, exercise, mtDNA, Brain, Original Articles, Cell Biology, Phenotype, Mice, Mutant Strains, mitochondria, Citric acid cycle, 030104 developmental biology, Endocrinology, Mutation, Female, Original Article, PolG, 030217 neurology & neurosurgery
Abstract

The accumulation of mitochondrial DNA (mtDNA) mutations is a suspected driver of aging and age‐related diseases, but forestalling these changes has been a major challenge. One of the best‐studied models is the prematurely aging mtDNA mutator mouse, which carries a homozygous knock‐in of a proofreading deficient version of the catalytic subunit of mtDNA polymerase‐γ (PolgA). We investigated how voluntary exercise affects the progression of aging phenotypes in this mouse, focusing on mitochondrial and protein homeostasis in both brain and peripheral tissues. Voluntary exercise significantly ameliorated several aspects of the premature aging phenotype, including decreased locomotor activity, alopecia, and kyphosis, but did not have major effects on the decreased lifespan of mtDNA mutator mice. Exercise also decreased the mtDNA mutation load. In‐depth tissue proteomics revealed that exercise normalized the levels of about half the proteins, with the majority involved in mitochondrial function and nuclear–mitochondrial crosstalk. There was also a specific increase in the nuclear‐encoded proteins needed for the tricarboxylic acid cycle and complex II, but not in mitochondrial‐encoded oxidative phosphorylation proteins, as well as normalization of enzymes involved in coenzyme Q biosynthesis. Furthermore, we found tissue‐specific alterations, with brain coping better as compared to muscle and with motor cortex being better protected than striatum, in response to mitochondrial dysfunction. We conclude that voluntary exercise counteracts aging in mtDNA mutator mice by counteracting protein dysregulation in muscle and brain, decreasing the mtDNA mutation burden in muscle, and delaying overt aging phenotypes.

Published
2019

15. Propranolol Treatment of Infantile Hemangiomas: Anticipatory Guidance for Parents and Caretakers

Author

Martin, Kari, primary, Bleib, Francine, additional, Chamlin, Sarah L., additional, Chiu, Yvonne E., additional, Frieden, Ilona J., additional, Frommelt, Peter C., additional, Garzon, Maria C., additional, Kwon, Eun-Kyung M., additional, MacLellan-Tobert, Susan, additional, Mancini, Anthony J., additional, Seefeldt, Marcia, additional, Sidbury, Robert, additional, Siegel, Dawn H., additional, Drolet, Beth A., additional, and Boucek, Robert J., additional

Published
2013
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22. A review of next-generation genetic testing for the dermatologist.

Author

Kwon EK, Basel D, Siegel D, and Martin KL

Subjects
Child, Humans, Dermatology, Genetic Testing methods, Genetic Testing trends, Pediatrics, Skin Diseases diagnosis, Skin Diseases genetics
Abstract

Dermatologists have been placed in a prime position to make new genetic discoveries. Tissue is easily obtained from the skin or mucosa for the study of germline and somatic mosaic disorders. This, along with the recent development of next-generation sequencing, makes dermatology an exciting field with essentially endless possibilities for discovering genes responsible for disease, better understanding complex molecular pathways, and eventually developing targeted therapies. To take advantage of this great opportunity, a basic understanding of the advances in genetic testing is vital. Herein we give an overview of next-generation sequencing, including some of the applications it may be used for. We also review various study designs for genetic discovery, each of their benefits and downfalls, and how they may be applied to the study of dermatologic disease., (© 2012 Wiley Periodicals, Inc.)

Published
2013
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