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34 results on '"Le Yuan"'

1. Recent progress on smart hydrogels for biomedicine and bioelectronics

Author

Fa Zou, Jiefang Xu, Le Yuan, Qinyong Zhang, and Lili Jiang

Subjects
bioelectronics, biomedicine, electrical response, magnetic response, smart hydrogel, thermo‐responsive, Biotechnology, TP248.13-248.65, Biochemistry, QD415-436
Abstract

Abstract The increasing development of biomedicine and bioelectronics has highlighted the requirement for smart materials that can respond to changes in physical and chemical properties under external environments, such as magnetic fields, electric fields, and temperature. Accordingly, hydrogels have been widely evaluated as promising candidates for smart materials owing to their intriguing structures comprising a cross‐linked network of polymer chains with interstitial spaces filled with solvent water. This feature endows hydrogels with soft and wet characteristics, which not only induce high tissue affinity but also allow the introduction of environmentally responsive nanoparticles to release specific smart properties. Herein, we reviewed novel smart hydrogels that can be applied in biomedicine and bioelectronics, and highlighted and discussed existing challenges in current technologies and research.

Published
2022
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10. Epigenetic modification of H3K4 and oxidative stress are involved in MC‐LR‐induced apoptosis in testicular cells of SD rats

Author

Pavankumar Petlulu, Huizhen Zhang, Ya Ma, Le Yuan, Xingde Du, Xuemin Cheng, Xinghai Chen, Yueqin Wang, Rui Wang, Donggang Zhuang, Haohao Liu, Xiaofeng Zhang, Hongxiang Guo, Xiaohui Liu, and Jinxia Wu

Subjects
Male, medicine.medical_specialty, Microcystins, Arginine, Health, Toxicology and Mutagenesis, Apoptosis, 010501 environmental sciences, Management, Monitoring, Policy and Law, Mitochondrion, Toxicology, medicine.disease_cause, 01 natural sciences, Epigenesis, Genetic, Histones, Rats, Sprague-Dawley, 03 medical and health sciences, Histone H3, 0302 clinical medicine, Internal medicine, Testis, medicine, Animals, Humans, 0105 earth and related environmental sciences, Membrane Potential, Mitochondrial, chemistry.chemical_classification, Reactive oxygen species, Sertoli Cells, General Medicine, Rats, Oxidative Stress, Endocrinology, chemistry, 030220 oncology & carcinogenesis, H3K4me3, Marine Toxins, Reactive Oxygen Species, Reproductive toxicity, Oxidative stress
Abstract

Microcystin-leucine arginine (MC-LR) is a cyclic heptapeptide, produced by aquatic cyanobacteria such as microcystis, with strong reproductive toxicity which poses greater threat to the reproductive abilities of humans and animals. By exploring the role of trimethylation of histone H3 at lysine 4 (H3K4me3) and the role of oxidative stress in MC-LR-induced apoptosis in testicular Sertoli cells in Sprague-Dawley (SD) rats, this study indicated that MC-LR increased the expression levels of apoptosis-related genes by raising the levels of H3K4me3. 5'-Deoxy-5'-methylthioadenosine (MTA), the inhibitor of H3K4me3, reduced apoptosis, indicating for the first time that epigenetic modification is closely related to the testicular reproductive toxicity induced by MC-LR. MC-LR also induced oxidative stress by stimulating the generation of reactive oxygen species (ROS), and subsequently triggering mitochondria-mediated apoptotic pathway by decreasing mitochondrial membrane potential and increasing the levels of Bax, Bcl-2, Caspase-3, and so on. MC-LR-induced apoptosis of testicular cells could be decreased after pretreatment with oxidative stress inhibitor N-acetyl-cysteine (NAC). Furthermore, the pathological damage to mitochondria and testes were observed in SD rats. These results show that MC-LR can induce apoptosis by raising the levels of H3K4me3, and pretreatment with MTA can ameliorate the MC-LR-induced apoptosis of cocultured cells by lowering the levels of H3K4me3. Furthermore, NAC has a protective effect on MC-LR-induced apoptosis of testicular cells in SD rats by inhibiting the oxidative stress.

Published
2019
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16. Characterization and Luminescence Properties of YAG:Ce3+ Phosphors by Molten Salt Synthesis

Author

Huarui Xu, Huijuan Yang, Guisheng Zhu, Aibing Yu, Fengsheng Li, Le Yuan, and Chi Zhang

Subjects
Materials science, Analytical chemistry, Phosphor, Emission intensity, law.invention, law, Phase (matter), Materials Chemistry, Ceramics and Composites, Calcination, Particle size, Molten salt, Luminescence, Eutectic system
Abstract

The Y2.9Ce0.1Al5O12 (YAG:Ce3+) phosphors were successfully prepared via molten salt synthesis (MSS) method using the eutectic mixtures of NaNO2–KNO2 or NaCl–KCl as the flux. Using NaCl–KCl as the flux, Y3Al5O12 phase is formed above 1000°C, and the as-prepared YAG:Ce3+ phosphor with 2 μm average particle size has good emission and excitation spectra. Using NaNO2–KNO2 as the flux, Y3Al5O12 phase can be formed at a temperature as low as 400°C, but the as-prepared YAG:Ce3+ phosphor with 200 nm average particle size do not have obvious emission and excitation spectra, and after being annealed at 1100°C, the powder also has 200 nm average particle size but has stronger emission and excitation spectra. Compared with the commercial YAG:Ce3+ phosphor, the emission intensity of the phosphor prepared by MSS using NaNO2–KNO2 as the flux followed by calcination is a little low, but the latter has a smaller particle size, which will reduce the amount of phosphors utilized in white light-emitting diodes.

Published
2011
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17. Expression of TLR2/4 on Epididymal Spermatozoa of the Chinese Soft‐Shelled Turtle Pelodiscus sinensis During the Hibernation Season

Author

Hu, Lisi, primary, Li, Quanfu, additional, Yang, Ping, additional, Gandahi, Jameel A., additional, Arain, Tamseel S., additional, Le, Yuan, additional, Zhang, Qian, additional, Liu, Tengfei, additional, Y. Waqas, Muhammad, additional, Ahmad, Nisar, additional, Liu, Yi, additional, and Chen, Qiusheng, additional

Published
2016
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29. Simultaneous myocardial strain and dark-blood perfusion imaging using a displacement-encoded MRI pulse sequence

Author

Le, Yuan, primary, Stein, Ashley, additional, Berry, Colin, additional, Kellman, Peter, additional, Bennett, Eric E., additional, Taylor, Joni, additional, Lucas, Katherine, additional, Kopace, Rael, additional, Chefd'Hotel, Christophe, additional, Lorenz, Christine H., additional, Croisille, Pierre, additional, and Wen, Han, additional

Published
2010
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33. Wavelet MRE: Imaging propagating broadband acoustic waves with wavelet-based motion-encoding gradients.

Author

Le Y, Chen J, Rossman PJ, Bolster B Jr, Kannengiesser S, Manduca A, Glaser KJ, Sui Y, Huston J 3rd, Yin Z, and Ehman RL

Subjects
Humans, Algorithms, Brain diagnostic imaging, Phantoms, Imaging, Sound, Magnetic Resonance Imaging methods, Elasticity Imaging Techniques methods
Abstract

Purpose: To demonstrate a novel MR elastography (MRE) technique, termed here wavelet MRE. With this technique, broadband motion sensitivity is achievable. Moreover, the true tissue displacement can be reconstructed with a simple inverse transform., Methods: A wavelet MRE sequence was developed with motion-encoding gradients based on Haar wavelets. From the phase images' displacement was estimated using an inverse transform. Simulations were performed using a frequency sweep and a transient as ground-truth motions. A PVC phantom was scanned using wavelet MRE and standard MRE with both transient (one and 10 cycles of 90-Hz motion) and steady-state dual-frequency motion (30 and 60 Hz) for comparison. The technique was tested in a human brain, and motion trajectories were estimated for each voxel., Results: In simulation, the displacement information estimated from wavelet MRE closely matched the true motion. In the phantom test, the MRE phase data generated from the displacement information derived from wavelet MRE agreed well with standard MRE data. Testing of wavelet MRE to assess transient motion waveforms in the brain was successful, and the tissue motion observed was consistent with a previous study., Conclusion: The uniform and broadband frequency response of wavelet MRE makes it a promising method for imaging transient, multifrequency motion, or motion with unknown frequency content. One potential application is measuring the response of brain tissue undergoing low-amplitude, transient vibrations as a model for the study of traumatic brain injury., (© 2023 International Society for Magnetic Resonance in Medicine.)

Published
2024
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34. Improved T1, contrast concentration, and pharmacokinetic parameter quantification in the presence of fat with two-point Dixon for dynamic contrast-enhanced magnetic resonance imaging.

Author

Le Y, Dale B, Akisik F, Koons K, and Lin C

Subjects
Adipose Tissue physiology, Adolescent, Adult, Aged, Female, Humans, Linear Models, Liver diagnostic imaging, Liver physiology, Male, Middle Aged, Phantoms, Imaging, Young Adult, Adipose Tissue diagnostic imaging, Contrast Media pharmacokinetics, Image Processing, Computer-Assisted methods, Magnetic Resonance Imaging methods, Signal Processing, Computer-Assisted
Abstract

Purpose: To evaluate the impact of fat and fat-suppression on the quantification of T1, gadolinium concentration, and pharmacokinetic parameters in DCE-MRI., Methods: T1 values were measured in fat-free phantoms using variable flip angle with no fat suppression, quick or interleaved fat saturation (QFS), or two-point Dixon and were compared with reference values measured with inversion recovery-prepared turbo spin echo. Relaxivity of gadolinium-benzyloxypropionictetraacetate (Gd-BOPTA) was measured in emulsions of Gd-BOPTA solution and fat using Dixon in-phase and water-only images. Liver T1 and pharmacokinetic parameters of 15 patients were calculated from Dixon in-phase and water-only images and were correlated with liver fat signal fraction., Results: T1 values measured using Dixon water-only and non-fat-suppressed images matched the reference values; while T1 values measured using QFS showed large deviations. Relaxivities and Gd measured in the Dixon water-only images were less affected by the fat than those measured in the in-phase images. The correlation between liver fat fraction and the differences in measured pharmacokinetic parameters using Dixon in-phase and water-only images were significant (P < 0.05) for T1, K(trans), and incremental area under the curve, but not Ve (P = 0.1)., Conclusion: Dixon water-only images provided more reliable estimation of T1, Gd, and pharmacokinetic parameters when fat was present., (© 2015 Wiley Periodicals, Inc.)

Published
2016
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