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Your search keyword '"Lee, Yu Ri"' showing total 16 results
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16 results on '"Lee, Yu Ri"'

1. Extremely Thin Bilayer Electrolyte for Solid Oxide Fuel Cells (SOFCs) Fabricated by Chemical Solution Deposition (CSD)

Author

Jong-Ho Lee, Lee Yu Ri, Hae-Weon Lee, Sun-Young Park, Eun-Ok Oh, Chin-Myung Whang, Kyung Joong Yoon, Ji-Won Son, and Dasari Hari Prasad

Subjects
Materials science, Open-circuit voltage, Mechanical Engineering, Bilayer, Inorganic chemistry, Temperature, Oxide, Metal Nanoparticles, Oxides, Substrate (electronics), Electrolyte, Solutions, Electrolytes, chemistry.chemical_compound, Electric Power Supplies, chemistry, Chemical engineering, Mechanics of Materials, Yttrium, General Materials Science, Solid oxide fuel cell, Zirconium, Thin film, Electrodes, Yttria-stabilized zirconia
Abstract

An extremely thin bilayer electrolyte consisting of yttria-stabilized zirconia (YSZ) and gadolinia-doped ceria (GDC) is successfully fabricated on a sintered NiO-YSZ substrate. Major processing flaws are effectively eliminated by applying local constraints to YSZ nanoparticles, and excellent open circuit voltage and cell performance are demonstrated in a solid oxide fuel cell (SOFC) at intermediate operating temperatures.

Published
2012

16. High glucose-induced changes in hyaloid-retinal vessels during early ocular development of zebrafish: a short-term animal model of diabetic retinopathy.

Author

Jung SH, Kim YS, Lee YR, and Kim JS

Subjects
Animals, Animals, Genetically Modified, Diabetic Retinopathy chemically induced, Larva drug effects, Larva metabolism, NG-Nitroarginine Methyl Ester pharmacology, Nitric Oxide biosynthesis, Ranibizumab pharmacology, Receptors, Vascular Endothelial Growth Factor metabolism, Retinal Vessels metabolism, Retinal Vessels pathology, Tight Junction Proteins metabolism, Vascular Endothelial Growth Factor A biosynthesis, Zebrafish growth & development, Zebrafish Proteins biosynthesis, Diabetic Retinopathy metabolism, Disease Models, Animal, Glucose adverse effects, Retinal Vessels drug effects, Zebrafish metabolism
Abstract

Background and Purpose: Although a variety of animal models have been used to test drug candidates and examine the pathogenesis of diabetic retinopathy, time-saving and inexpensive models are still needed to evaluate the increasing number of therapeutic approaches., Experimental Approach: We developed a model for diabetic retinopathy using the early stage of transgenic zebrafish (flk:EGFP) by treating embryos with 130 mM glucose, from 3-6 days post fertilisation (high-glucose model). On day 6, lenses from zebrafish larvae were isolated and treated with 3% trypsin, and changes in hyaloid-retinal vessels were analysed using fluorescent stereomicroscopy. In addition, expression of tight junction proteins (such as zonula occludens-1), effects of hyperosmolar solutions and of hypoxia, and Vegf expression were assessed by RT -PCR. NO production was assessed with a fluorescent substrate. Effects of inhibitors of the VEGF receptor, NO synthesis and a VEGF antibody (ranibizumab) were also measured., Key Results: In this high-glucose model, dilation of hyaloid-retinal vessels, on day 6, was accompanied by morphological lesions with disruption of tight junction proteins, overproduction of Vegf mRNA and increased NO production. Treatment of this high-glucose model with an inhibitor of VEGF receptor tyrosine kinase or an inhibitor of NO synthase or ranibizumab decreased dilation of hyaloid-retinal vessels., Conclusions and Implications: These findings suggest that short-term exposure of zebrafish larvae to high-glucose conditions could be used for screening and drug discovery for diabetic retinopathy and particularly for disorders of retinal vessels related to disruption of tight junction proteins and excessive VEGF and NO production., (© 2015 The British Pharmacological Society.)

Published
2016
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