1. Effect of the combined intervention of low‐FODMAPs diet and probiotics on IBS symptoms in Western China: A randomized controlled trial
- Author
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Yingying Liu, Di Jin, Tian He, Xinyi Liao, Limei Shao, Lei Shi, and Ling Liu
- Subjects
irritable bowel syndrome ,low‐FODMAPs diet ,probiotics ,Western China ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract The effect of low‐FODMAPs diet on irritable bowel syndrome (IBS) in Western China has not been reported. We aimed to investigate the effect of low‐FODMAPs diet on IBS patients in the area and whether low‐FODMAPs diet‐induced alterations of microbiota could be improved through probiotics. IBS patients were randomized to the control group, low‐FODMAPs diet group, probiotics group, or combined group. IBS Symptom Severity Score questionnaire (IBS‐SSS) and IBS Quality of Life Score questionnaire (IBS‐QOL) were completed at baseline, 2 and 4 weeks to evaluate the severity of symptoms. Fresh feces were collected for analyses of gut microbiota and short‐chain fatty acids at baseline and 4 weeks after intervention. Seventy‐three patients were included in the per protocol analysis. After intervention, there was significant improvement in IBS‐SSS in the low‐FODMAPs group (37.5%, 44.2%), probiotics group (51.4%, 62.0%), and combined group (34.1%, 40.4%) at both 2 weeks and 4 weeks, compared with the baseline (p
- Published
- 2024
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