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25 results on '"Liang, Zi"'

1. Historical trends of breast cancer burden attributable to metabolic factors among Chinese women, 1990–2019: A population‐based epidemiological study

Author

Liang‐Zi Zhang, Qi‐Cheng Sun, Hang‐Hang Luan, Qian‐Qian Yuan, Tong Deng, Li‐Sha Luo, and Xiao‐Lin Tan

Subjects
breast cancer, high body mass index, high fasting plasma glucose, metabolic factors, trend, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background This study aims to analyze breast cancer burden attributable to high body mass index (BMI) and high fasting plasma glucose (FPG) in China from 1990 to 2019. Methods Data were obtained from the Global Burden of Disease (GBD) study 2019. Deaths and disability‐adjusted life years (DALYs) were used for attributable burden, and age‐period‐cohort (APC) model was used to evaluate the independent effects of age, period and birth cohort. Results In 2019, the age‐standardized mortality and DALY rates of breast cancer attributable to high BMI were 1.107 (95% UI: 0.311, 2.327) and 29.990 (8.384, 60.713) per 100 000, and mortality and DALY rates attributable to high FPG were 0.519 (0.095, 1.226) and 13.662 (2.482, 32.425) per 100 000. From 1990 to 2019, the age‐standardized mortality and DALY rates of breast cancer attributable to high BMI increased by 1.192% and 1.180%, and the trends of high FPG were not statistically significant. The APC results showed that the age effects of high BMI and high FPG‐mortality and DALY rates increased, with the highest rates in the age group over 80 years. The birth cohort effects of high BMI showed “inverted V” shapes, while high FPG showed downward trends. Conclusions Age was the main reason for the increase of attributable burden, and postmenopausal women were the high‐risk groups. Therefore, targeted prevention measures should be developed to improve postmenopausal women's awareness and effectively reduce the prevalence of obesity and diabetes, thereby reducing the breast cancer burden caused by metabolic factors in China.

Published
2024
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9. Emergence of a young case infected with avian influenza A (H5N6) in Anhui Province, East China during the COVID‐19 pandemic

Author

Jiabing Wu, Sai Hou, Qingqing Chen, Lan He, Weiwei Li, Zhen-Tao Ding, Xin-Er Huang, Meng Wang, Ge Bu, Lei Gong, Yong Sun, Liang-Zi Guo, Hai-Feng Pan, Zhao-Qian Meng, Ya-Ting Feng, Jun He, Xue Zhou, Zhiwei Xu, and Jun-Ling Yu

Subjects
China, viruses, Reassortment, Hemagglutinin (influenza), Genome, Viral, medicine.disease_cause, Poultry, Virus, Viral Proteins, COVID‐19, Virology, Influenza, Human, Pandemic, medicine, Influenza A virus, Animals, Humans, Phylogeny, Research Articles, Coronavirus, biology, SARS-CoV-2, COVID-19, H5N6, Influenza A virus subtype H5N1, Infectious Diseases, Child, Preschool, Influenza in Birds, Mutation, biology.protein, Female, epidemiology, genetic, Neuraminidase, Reassortant Viruses, Research Article
Abstract

In the context of the coronavirus disease 2019 pandemic, we investigated the epidemiological and clinical characteristics of a young patient infected by avian influenza A (H5N6) virus in Anhui Province, East China, and analyzed genomic features of the pathogen in 2020. Through the cross‐sectional investigation of external environment monitoring (December 29–31, 2020), 1909 samples were collected from Fuyang City. It was found that the positive rate of H5N6 was higher than other areas obviously in Tianma poultry market, where the case appeared. In addition, dual coinfections were detected with a 0.057% polymerase chain reaction positive rate the surveillance years. The virus was the clade 2.3.4.4, which was most likely formed by genetic reassortment between H5N6 and H9N2 viruses. This study found that the evolution rates of the hemagglutinin and neuraminidase genes of the virus were higher than those of common seasonal influenza viruses. The virus was still highly pathogenic to poultry and had a preference for avian receptor binding., Highlights Various avian influenza virus (AIV) subtypes naturally have caused zoonotic infections, but the subtypes H5N1 and H7N9 have caused a prominent impact.At present, the outbreak of novel coronavirus pneumonia (coronavirus disease 2019 [COVID‐19]) has caused a worldwide pandemic.To our knowledge, this is the youngest child infected with H5N6 subtype avian influenza in Anhui Province.Herein, we analyzed the epidemiology of the case and the characteristics of the pathogen genome, to find out the possible evolution of the virus.

Published
2021

12. Emergence of a young case infected with avian influenza A (H5N6) in Anhui Province, East China during the COVID‐19 pandemic

Author

Yu, Jun‐Ling, primary, Hou, Sai, additional, Feng, Ya‐Ting, additional, Bu, Ge, additional, Chen, Qing‐Qing, additional, Meng, Zhao‐Qian, additional, Ding, Zhen‐Tao, additional, Guo, Liang‐Zi, additional, Zhou, Xue, additional, Wang, Meng, additional, Huang, Xin‐Er, additional, Li, Wei‐Wei, additional, He, Lan, additional, Gong, Lei, additional, Sun, Yong, additional, Xu, Zhiwei, additional, Pan, Hai‐Feng, additional, He, Jun, additional, and Wu, Jia‐Bing, additional

Published
2021
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15. Postoperative intensity‐modulated radiation therapy reduces local recurrence and improves overall survival in III‐N2 non‐small‐cell lung cancer: A single‐center, retrospective study

Author

Wei, Wei, primary, Zhou, Jiao, additional, Zhang, Qun, additional, Liao, De‐Hua, additional, Liu, Qiao‐Dan, additional, Zhong, Bei‐Long, additional, Liang, Zi‐Bin, additional, Zhang, Yong‐Chang, additional, Jiang, Rong, additional, Liu, Gui‐Yun, additional, Xu, Chen‐Yang, additional, Li Zhou, Huai‐, additional, Zhu, Su‐Yu, additional, Yang, Nong, additional, Jiang, Wen, additional, and Liu, Zhi‐Gang, additional

Published
2020
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18. Legendre-Gauss-Lobatto spectral collocation method for nonlinear delay differential equations

Author

Liang Zi-qiang, Wang Zhong-qing, and Yi Li-jun

Subjects
Nonlinear system, Spectral collocation, General Mathematics, Collocation method, Mathematical analysis, Convergence (routing), Gauss, General Engineering, Orthogonal collocation, Delay differential equation, Legendre polynomials, Mathematics
Abstract

A Legendre–Gauss–Lobatto spectral collocation method is introduced for the numerical solutions of a class of nonlinear delay differential equations. An efficient algorithm is designed for the single-step scheme and applied to the multiple-domain case. As a theoretical result, we obtain a general convergence theorem for the single-step case. Numerical results show that the suggested algorithm enjoys high-order accuracy both in time and in the delayed argument and can be implemented in a robust and efficient manner. Copyright © 2013 John Wiley & Sons, Ltd.

Published
2013

19. Overexpression of Arabidopsis thaliana PTEN caused accumulation of autophagic bodies in pollen tubes by disrupting phosphatidylinositol 3-phosphate dynamics

Author

Sheila McCormick, James Pao, Chao Zhou, Yan Zhang, Sha Li, Emily Fox, Wei Sun, and Liang-Zi Zhou

Subjects
biology, Phosphatidylinositol 3-phosphate, Phosphatase, Autophagy, Cell Biology, Plant Science, Cell biology, chemistry.chemical_compound, chemistry, Biochemistry, Lipid phosphatase activity, Genetics, biology.protein, Tensin, PTEN, Phosphatidylinositol, PI3K/AKT/mTOR pathway
Abstract

Summary Autophagy is a pathway in eukaryotes by which nutrient remobilization occurs through bulk protein and organelle turnover. Autophagy not only aides cells in coping with harsh environments but also plays a key role in many physiological processes that include pollen germination and tube growth. Most autophagic components are conserved among eukaryotes, but phylum-specific molecular components also exist. We show here that Arabidopsis thaliana PTEN, a protein and lipid dual phosphatase homologous to animal PTENs (phosphatase and tensin homologs deleted on chromosome 10), regulates autophagy in pollen tubes by disrupting the dynamics of phosphatidylinositol 3-phosphate (PI3P). The pollen-specific PTEN bound PI3P in vitro and was localized at PI3P-positive vesicles. Overexpression of PTEN caused accumulation of autophagic bodies and resulted in gametophytic male sterility. Such an overexpression effect was dependent upon its lipid phosphatase activity and was inhibited by exogenous PI3P or by expression of a class III phosphatidylinositol 3-kinase (PI3K) that produced PI3P. Overexpression of PTEN disrupted the dynamics of autophagosomes and a subpopulation of endosomes, as shown by altered localization patterns of respective fluorescent markers. Treatment with wortmannin, an inhibitor of class III PI3K, mimicked the effects by PTEN overexpression, which implied a critical role for PI3P dynamics in these processes. Despite sharing evolutionarily conserved catalytic domains, plant PTENs contain regulatory sequences that are distinct from those of animal PTENs, which might underlie their differing membrane association and thereby function. Our results show that PTEN regulates autophagy through phylum-specific molecular mechanisms.

Published
2011

25. Effect of milking time on yield, composition, and antimicrobial components of milk in lactating goats.

Author

Liang ZL, Nii T, Suzuki N, Tsugami Y, Sugino T, and Isobe N

Subjects
Animals, Female, Time Factors, Dairying methods, Sodium blood, Sodium analysis, Anti-Infective Agents analysis, Goats physiology, Lactation, Milk chemistry, Prolactin blood, beta-Defensins analysis
Abstract

Various studies have attempted to improve the milk yield and composition in dairy animals. However, no study has examined the effects of milking at different times on milk yield and composition. Therefore, this study aimed to compare the yield, composition, and antimicrobial components of milk obtained from milking at different times in lactating goats. Eight goats were milked once daily at different times for three consecutive weeks (first week: 06:00 h; second week: 09:00 h; and third week: 12:00 h). The light ranged from 06:30 to 19:00 h. Milk and blood samples were collected once a day during milking time. Milking at 09:00 h resulted in a significantly higher milk yield than that obtained after milking at 06:00 and 12:00 h. Prolactin levels in plasma and the fat, Na + , β-defensin, and S100A7 (antimicrobial component) levels in milk were the lowest in the 09:00 h milking. These results indicate that milk yield, composition, and antimicrobial components can be affected by milking time, which may be related to the altered concentration of prolactin in the blood. These findings provide a rational basis for achieving maximal milk production with strong immunity by changing to a more effective milking time., (© 2024 The Author(s). Animal Science Journal published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Animal Science.)

Published
2024
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