1. Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis
- Author
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Carlos Vilar, Jose E Martínez-Rodríguez, Angela Vincent, Joan Santamaria, Francesc Graus, Linda Clover, Alex Iranzo, Jaume Morera, and Jordi Bruna
- Subjects
Male ,Polysomnography ,Rapid eye movement sleep ,REM Sleep Behavior Disorder ,Electroencephalography ,behavioral disciplines and activities ,Antibodies ,Central nervous system disease ,Limbic system ,Limbic Encephalitis ,mental disorders ,medicine ,Humans ,Aged ,medicine.diagnostic_test ,Electromyography ,business.industry ,Limbic encephalitis ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Potassium channel ,medicine.anatomical_structure ,nervous system ,Neurology ,Potassium Channels, Voltage-Gated ,Neurology (clinical) ,business ,Neuroscience ,psychological phenomena and processes ,Encephalitis - Abstract
Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage-gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage-gated potassium channel antibody-associated limbic encephalitis onset. In three patients, immunosuppression resulted in resolution of RBD in parallel with remission of the limbic syndrome. RBD persisted in two patients with partial resolution of the limbic syndrome. Our findings suggest that RBD is frequent in the setting of voltage-gated potassium channel antibody-associated limbic encephalitis and can be related to autoimmune-mediated mechanisms. In addition, these observations suggest that impairment of the limbic system may play a role in the pathogenesis of RBD.
- Published
- 2005