15 results on '"Ling You"'
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2. Multiple micromeningiomas coexist with primary lung adenocarcinoma: A case report
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Jindong Chen, Ling You, and Jingsi Dong
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coexistence ,lung cancer ,pulmonary meningioma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Cases of multiple ectopic meningiomas in the lung coexisting with pulmonary malignancies are extremely rare in the clinic. On imaging, it is difficult to distinguish multiple ectopic meningiomas from lung cancer, which puts forward higher requirements for treatment. A 65‐year‐old female patient was admitted to our department for multiple nodules in both lungs. The patient underwent thoracoscopic wedge resection and segmental resection. Postoperative pathological examination found lung meningioma, atypical adenomatoid hyperplasia (AAH), carcinoma in situ (AIS), invasive adenocarcinoma, and other pathological types. In this case, pulmonary meningioma, AAH, AIS, and invasive adenocarcinoma of various pulmonary nodules were observed. This case, which has not been reported before, is unique in that it has multiple pathologic types in one organ. This puts forward higher requirements for clinical diagnosis and treatment.
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- 2023
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3. Impact of Left Atrial Appendage Closure Combined with Catheter Ablation on Endocrine and Mechanical Cardiac Function in Patients with Atrial Fibrillation
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Jing Yang, Ling You, Mingqing Liu, Guangming Zhang, Liang Feng, Yue Liu, Xue Geng, Jinglan Wu, and Ruiqin Xie
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background. The combined procedure of left atrial appendage closure (LAAC) and catheter ablation (CA) is a safe and feasible therapy to treat patients with atrial fibrillation (AF). However, the effect of the combined procedure on cardiac function remains unclear. This study aimed to investigate the changes in endocrine and mechanical function of the heart following the combined procedure. Methods. This retrospective study included 62 consecutive patients who underwent the combined procedure of AF ablation and WATCHMAN LAAC and 62 sex and age-matched patients who only received AF ablation. During follow-up, patients were examined for brain natriuretic peptide (BNP) levels to represent endocrine cardiac function. Mechanical cardiac function was assessed during echocardiographic examination by means of the LA ejection fraction, LA strain (Ƹ), and LA strain rate (SR). Results. (1) The BNP levels decreased acutely after the procedure, rose at day 3 postoperation, but trended downwards at 3 months postoperation in both groups. No significant difference was observed between the two groups. (2) LA ejection fraction, LA Ƹ, and SR exhibited a continuous upward trend over a 3-month follow-up in both groups. There was no significant difference in LA ejection fractions, SRe (the parameter of LA conduit function), and SRa (the parameter of LA booster pump function) between the two groups. However, the Ƹ and SRs (the parameters of LA reservoir function) improved in patients treated with CA alone. Conclusions. The combined procedure of LAAC and CA significantly improved the endocrine and mechanical function of the heart. Compared to simple CA, based on CA with LAAC intervention, it does not significantly change LA endocrine function but may lead to a decline in the LA reservoir function.
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- 2022
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4. LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling
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Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, and Ruiqin Xie
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Pathology ,RB1-214 - Abstract
Objective. Long non-coding RNAs (lncRNAs) play many important roles in gene regulation and disease pathogenesis. Here, we sought to determine that mitochondrial dynamic related lncRNA (MDRL) modulates NLRP3 inflammasome activation and apoptosis of vascular smooth muscle cells (VSMCs) and protects arteries against atherosclerosis. Methods. In vivo experiments, we applied LDLR knockout (LDLR-/-) mice fed the high-fat diet to investigate the effects of MDRL on atherosclerosis. In vitro experiments, we applied mouse aortic smooth muscle cells to determine the mechanism of MDRL in abrogating NLRP3 inflammasome and inhibiting cell apoptosis through miR-361/sequentosome 1 (SQSTM1) by TUNEL staining, quantitative RT-PCR, western blot, microribonucleoprotein immunoprecipitation, and luciferase reporter assay. Results. Downregulated MDRL and increased NLRP3 were observed in mouse atherosclerotic plaques, accompanied with the increase of miR-361. The results showed that MDRL overexpression significantly attenuated the burden of atherosclerotic plaque and facilitated plaque stability through inhibiting NLRP3 inflammasome activation and cell apoptosis, and vice versa. Mechanically, MDRL suppressed NLRP3 inflammasome activation and VSMC apoptosis via suppressing miR-361. Furthermore, miR-361 directly bound to the 3’UTR of SQSTM1 and inhibited its translation, subsequently activating NLRP3 inflammasome. Systematic delivery of miR-361 partly counteracted the beneficial effects of MDRL overexpression on atherosclerotic development in LDLR-/- mice. Conclusions. In summary, MDRL alleviates NLRP3 inflammasome activation and apoptosis in VSMCs through miR-361/SQSTM1/NLRP3 pathway during atherogenesis. These data indicate that MDRL and inhibition of miR-361 represent potential therapeutic targets in atherosclerosis-related diseases.
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- 2022
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5. Uniform attribute-content model
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Yingzhuo Xiang, Jikun Yan, Ling You, and Pu An
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feature extraction ,information retrieval ,text analysis ,monte carlo methods ,uniform attribute-content model ,text processing ,text modelling methods ,content feature extraction process ,content information ,attribute information ,monte carlo method ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
There have been growing needs for text processing, such as classifying, retrieving and clustering. The foundation of such a process is to extract features, which can best describe the text. Great progress has been made in text modelling. However, most of the text modelling methods are based only on the content, nor only on the attributes. Although there have been some combined models proposed in recent years, the lack of universality limits such models. In this study, the authors propose a uniform attribute-content model, which uses the attributes to influence the content feature extraction process. They design the attributes as a special filter to each feature extracted from the content. Thus the mixed features contain both content information and attribute information, which can describe the text more precise. They also propose a Monte Carlo method to solve this model. Experimental results on the Enron email dataset demonstrate the effectiveness of the authors’ proposed models.
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- 2019
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6. Optimization of ETL‐free Cs 2 TiBr 6 /MASnBr 3 laminated structure perovskite solar cells by SCAPS‐1D simulation
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Ling You, Xin Zhang, Qian Ma, Wu Zhu, and Jiang Wu
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Materials Chemistry ,Surfaces and Interfaces ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
7. The immediate trends in atrial electrical remodeling for paroxysmal atrial fibrillation across different modes of catheter ablation
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Qian Hou, Liang Feng, Jing Yang, Qian Liu, Ling You, Yue Liu, Yuliang Zhao, Ruiqin Xie, Lianxia Wang, and Yan Zhang
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medicine.medical_specialty ,Radiofrequency ablation ,Paroxysmal atrial fibrillation ,medicine.medical_treatment ,Clinical Investigations ,Catheter ablation ,immediate trends ,030204 cardiovascular system & hematology ,law.invention ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,law ,Internal medicine ,catheter ablation ,Atrial Fibrillation ,medicine ,Humans ,Electrical Remodeling ,Heart Atria ,030212 general & internal medicine ,paroxysmal atrial fibrillation ,Coronary sinus ,medicine.diagnostic_test ,business.industry ,Cryoablation ,Atrial Remodeling ,General Medicine ,Ablation ,Treatment Outcome ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,atrial electrical remodeling - Abstract
Background Catheter ablation has emerged as a major strategy for paroxysmal atrial fibrillation (PAF). Atrial electrical remodeling (AER) plays a critical role in the recurrence of PAF after ablation. Hypothesis To characterize the immediate trends of AER during ablations in patients with PAF, and assess the relationship between immediate trends and recurrence. Methods We performed this prospective observational study of 135 patients to investigate AER following three ablation modes: radiofrequency ablation (RFA), cryoablation (CA) and 3D mapping‐guided cryoablation (3D‐CA). The atrial effective refractory period (AERP) and atrial conduction time (ACT) were measured via electrophysiology before and immediately after ablation, and P‐wave indices were measured via electrocardiography before and within 24 h after ablation. Follow‐up visits were conducted for at least 1 year or until relapse. Results Different approaches of ablation caused a fairly significant increase in the shortest P‐wave duration and AERP in both the proximal coronary sinus (PCS) and distal coronary sinus (DCS) but caused a shortened P‐wave dispersion. No different effect was found at the AERP among the three modes. Compared to patients who received CA, among patients who received RFA, a significant reduction in total ACT and right ACT was seen. Statistically, there was a weakly positive association between changes in total ACT and early recurrence. Conclusions Injury during ablation for PAF was associated with an increase in the AERP but not in the ACT. Total ACT and right ACT were shorter after RFA than after CA. The increase in total ACT were slightly predictive of early recurrence.
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- 2021
8. Clinical diagnosis of pandemic <scp>A</scp> ( <scp>H</scp> 1 <scp>N</scp> 1) 2009 influenza in children with negative rapid influenza diagnostic test by lymphopenia and lower <scp>C</scp> ‐reactive protein levels
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Huey-Ling You, Ing-Kit Lee, Hock-Liew Eng, Kuo-Shu Tang, Lin Wang, Ling-Sai Chang, Kuender D. Yang, and Chung-Chen Li
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Receiver operating characteristic ,biology ,medicine.diagnostic_test ,Epidemiology ,business.industry ,Lymphocyte ,C-reactive protein ,Public Health, Environmental and Occupational Health ,virus diseases ,Complete blood count ,Gastroenterology ,respiratory tract diseases ,Infectious Diseases ,medicine.anatomical_structure ,Throat ,Internal medicine ,Cohort ,Immunology ,medicine ,biology.protein ,business ,Viral load ,Cohort study - Abstract
Background The sensitivity of rapid influenza diagnostic test (RIDT) of children with influenza-like illness (ILI) remains low. Objective We compare the parameters between pandemic A(H1N1) 2009 influenza with negative RIDT and ILI not H1N1 for improving the low sensitivity of RIDT for children with ILI. Methods In a cohort of consecutive laboratory-confirmed H1N1 influenza, we identified 150 H1N1 children with positive RIDT, 152 H1N1 children with negative RIDT, and 75 children with ILI not H1N1. Viral load in throat, complete blood count (CBC), and C-reactive protein (CRP) levels between H1N1 children with negative RIDT and children with ILI not H1N1 were assessed. Results The diagnostic sensitivity of the RIDT was 45·5%. An analysis of CBC and CRP levels indicated that H1N1 children with negative RIDT had lower total leukocyte, neutrophil, lymphocyte, and basophil counts, and serum CRP levels (P
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- 2013
9. Direct and indirect costs among patients with binge‐eating disorder in the United States
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Ling, You‐Li, primary, Rascati, Karen L., additional, and Pawaskar, Manjiri, additional
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- 2016
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10. Sustained release of melatonin from poly (lactic‐co‐glycolic acid) (PLGA) microspheres to induce osteogenesis of human mesenchymal stem cells in vitro
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Zhang, Liangming, primary, Zhang, Jinling, additional, Ling, You, additional, Chen, Changhua, additional, Liang, Anjing, additional, Peng, Yan, additional, Chang, Hong, additional, Su, Peiqiang, additional, and Huang, Dongsheng, additional
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- 2012
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11. Anti‐influenza A (H1N1) virus effect of gallic acid through inhibition of virulent protein production and association with autophagy
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Cheng‐Chieh Chang, Huey‐Ling You, Huey‐Jen Su, I‐Ling Hung, Chao‐Wei Kao, and Sheng‐Teng Huang
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autophagy ,gallic acid ,influenza virus ,LC3B ,virulent protein ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract Influenza remains one of the most serious infectious diseases. Gallic acid is one of the most common and representative phenolic acids found in various plants. This is an interesting subject to explore how gallic acid could inhibit H1N1 influenza virus infection by reducing the production of virulent proteins and interrupting autophagy machinery for influenza virus replication on the host cell. Cellular viability was assessed by XTT assay. The inhibitory effects on the H1N1 influenza virus were assessed by hemagglutination assay, plaque assay, and qRT‐PCR. Western blot analysis was used for detecting protein levels of M1, M2, NP, LC3B, and beclin‐1. Autophagy activity was demonstrated by acridine orange staining assay. The result demonstrated that there was no cytotoxic effect of gallic acid on A549 cells, and gallic acid could restore the cellular viability of H1N1 influenza virus‐infected A549 cells within the experimental concentration treatment. Moreover, gallic acid could effectively restrain viral activity of the H1N1 influenza virus. After the treatment of gallic acid, the production of virulent H1N1 influenza virus proteins, that is, M1, M2, and NP protein were reduced. As for autophagic mechanism, both of the LC3B II conversion and the level ratio of LC3B II to LC3B I were notably decreased. The acridine orange staining assay also revealed decreased accumulation of autophagosomes in H1N1 influenza virus‐infected cells. In conclusion, gallic acid suppresses H1N1 influenza viral infectivity through restoration of autophagy pathway and inhibition of virulent M1, M2, and NP protein production.
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- 2024
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12. EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis
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Wen-Chan Chiu, Ching-Mei Chen, Tien-Tsai Cheng, Huey-Ling You, Shan-Fu Yu, Lin-Hsiu Weng, Hsuan-Ying Huang, Chao-Cheng Huang, and Chung-Jen Chen
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EBER1 ,Inflammation ,Rheumatoid arthritis ,Medicine (General) ,R5-920 - Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by perpetuated inflammation in multiple joints. To date, there is no cure for RA, and the causal factor for non-resolving inflammation in RA remains unclear. In this study, we initially observed expression of Epstein–Barr virus-encoded small RNA1 (EBER1) in the synovial tissue of all five patients who showed nonresolving RA inflammation. By contrast, EBER1 was detected in the synovial tissue of only one out of seven patients with advanced osteoarthritis (OA; p
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- 2013
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13. Arsenic Modulates Posttranslational S-Nitrosylation and Translational Proteome in Keratinocytes
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Bin Huang, Kuo-Hao Chiang, Hsin-Su Yu, Ying-Lun Chen, Huey-Ling You, and Wei-Ting Liao
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Technology ,Medicine ,Science - Abstract
Arsenic is a class I human carcinogen (such as inducing skin cancer) by its prominent chemical interaction with protein thio (-SH) group. Therefore, arsenic may compromise protein S-nitrosylation by competing the -SH binding activity. In the present study, we aimed to understand the influence of arsenic on protein S-nitrosylation and the following proteomic changes. By using primary human skin keratinocyte, we found that arsenic treatment decreased the level of protein S-nitrosylation. This was coincident to the decent expressions of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS). By using LC-MS/MS, around twenty S-nitrosoproteins were detected in the biotin-switched eluent. With the interest that arsenic not only regulates posttranslational S-nitrosylation but also separately affects protein’s translation expression, we performed two-dimensional gel electrophoresis and found that 8 proteins were significantly decreased during arsenic treatment. Whether these decreased proteins are the consequence of protein S-nitrosylation will be further investigated. Taken together, these results provide a finding that arsenic can deplete the binding activity of NO and therefore reduce protein S-nitrosylation.
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- 2014
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14. Direct and indirect costs among patients with binge-eating disorder in the United States.
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Ling YL, Rascati KL, and Pawaskar M
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- Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, United States, Binge-Eating Disorder economics, Cost of Illness, Health Care Costs statistics & numerical data, Health Surveys methods
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Objective: To quantify the economic burden of binge-eating disorder (BED) in terms of work productivity loss, healthcare resource utilization, and healthcare costs., Methods: Respondents of the US National Health and Wellness Survey 2013 were invited to participate in a follow-up internet survey to identify adults with BED using DSM-5 criteria. Work productivity loss, healthcare resource utilization, and direct and indirect costs were assessed for BED respondents and matched non-BED respondents using generalized linear models or two-part models as appropriate., Results: A total of 1,720 people were included in our analysis (N = 344 with BED; N= 1,376 without BED). BED respondents had higher levels of activity impairment than non-BED respondents (41.29% vs. 23.18%, p < .001). Employed BED respondents (N = 178) had a greater level of work impairment than employed non-BED respondents (N = 686) (36.83% vs. 14.41%, p = .009). Higher healthcare resource utilization in the past 6 months among BED respondents was reported than matched non-BED respondents: numbers of surgeries (0.23 vs. 0.13, p = .021), ER visits (0.26 vs. 0.15, p = .016), and physician visits (6.09 vs. 4.56, p = .002). BED respondents reported higher total direct costs than matched non-BED respondents ($20,194 vs. $14,465, p = .005). The indirect costs among employed BED respondents were also higher than those without BED ($19,327 vs. $9,032, p < .001)., Discussion: Individuals with BED reported significantly greater economic burden with respect to work productivity loss, level of healthcare resource utilization, and costs compared to non-BED respondents. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:523-532)., (© 2016 Wiley Periodicals, Inc.)
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- 2017
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15. Sustained release of melatonin from poly (lactic-co-glycolic acid) (PLGA) microspheres to induce osteogenesis of human mesenchymal stem cells in vitro.
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Zhang L, Zhang J, Ling Y, Chen C, Liang A, Peng Y, Chang H, Su P, and Huang D
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- Alkaline Phosphatase biosynthesis, Cell Differentiation drug effects, Cell Proliferation drug effects, Cells, Cultured, Delayed-Action Preparations administration & dosage, Humans, Lactic Acid administration & dosage, Mesenchymal Stem Cells physiology, Microspheres, Polyglycolic Acid administration & dosage, Polylactic Acid-Polyglycolic Acid Copolymer, Young Adult, Melatonin administration & dosage, Mesenchymal Stem Cells drug effects, Osteogenesis drug effects
- Abstract
Melatonin promotes bone formation and prevents bone degradation via receptor-dependent or receptor-independent actions. The aim of this study is to encapsulate melatonin into poly (lactic-co-glycolic acid) (PLGA) microspheres (PLGA-MEL-MS) and create a melatonin sustained release system, then to evaluate its effect on the osteogenesis of human mesenchymal stem cells (hMSCs) in vitro. PLGA-MEL-MS were prepared by single emulsion solvent evaporation technique. Scanning electron microscopy demonstrated the incorporation of melatonin did not disturb the conventional generation of PLGA microspheres in size and morphology. In vitro drug release assay showed that PLGA-MEL-MS exhibited a biphasic drug release pattern: a low initial burst release effect with approximately 40% drug release at the first 3 days and a relatively retarded and continuous release with about 85% drug release over the 25 days. Cell proliferation assay demonstrated that PLGA-MEL-MS had no apparent effect on proliferation of human MSCs. In an osteogenesis assay, PLGA-MEL-MS obviously enhanced alkaline phosphatase (ALP) mRNA expression and increased ALP activity compared to that in the control group. Meanwhile, several markers of osteoblast differentiation were also significantly upregulated, including runx2, osteopontin, and osteocalcin. Furthermore, quantificational alizarin red-based assay demonstrated that PLGA-MEL-MS significantly enhanced calcium deposit of hMSCs compared to the controls. Therefore, this simple melatonin sustained release system can control released melatonin to generate a microenvironment with a relatively stable concentration of melatonin for a period of time to support osteogenic differentiation of hMSCs in vitro. This suggests that this system may be used as bone growth stimulator in bone healing in vivo., (© 2012 John Wiley & Sons A/S.)
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- 2013
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