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46 results on '"Losic, Dusan"'

6. Converging 2D Nanomaterials and 3D Bioprinting Technology: State‐of‐the‐Art, Challenges, and Potential Outlook in Biomedical Applications (Adv. Healthcare Mater. 22/2021)

Author

Rastin, Hadi, primary, Mansouri, Negar, additional, Tung, Tran Thanh, additional, Hassan, Kamrul, additional, Mazinani, Arash, additional, Ramezanpour, Mahnaz, additional, Yap, Pei Lay, additional, Yu, Le, additional, Vreugde, Sarah, additional, and Losic, Dusan, additional

Published
2021
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44. Diatomaceous Lessons in Nanotechnology and Advanced Materials

Author

James G. Mitchell, Dusan Losic, Nicolas H. Voelcker, Losic, Dusan, Mitchell, James, and Voelcker, Nicolas

Subjects
Materials science, Frustule, biology, Mechanical Engineering, Nanotechnology, self-assembly, Advanced materials, biology.organism_classification, diatom annotecnology, diatoms, Mechanics of Materials, nanofabrication, General Materials Science, porous silica, Biomimetics
Abstract

Diatoms occupy sunlit aquatic environments. From a materialsscientist’s point of view, these unicellular algae are microscopicsilica nanofabrication factories that use two overlapping valvessealed together by girdle bands to encase themselves in a silicafrustule. The frustule is created with 3D precision of tens ofnanometers, in a hierarchical manner, and with multifunctionalproperties (Fig. 1).

Published
2009

45. Porous Alumina with Shaped Pore Geometries and Complex Pore Architectures Fabricated by Cyclic Anodization

Author

Dusan Losic, Mickael Lillo, Losic, Dusan, Lillo,Michael, and Losic, Jnr. Dusan

Subjects
Fabrication, Materials science, Anodizing, Nanotechnology, General Chemistry, Molding (process), Scanning beam, Biomaterials, Nanolithography, Cyclization, Aluminum Oxide, Microscopy, Electron, Scanning, General Materials Science, Porosity, Electrodes, Embossing, Lithography, Biotechnology
Abstract

The fabrication of three-dimensional (3D) architectures withnanoscale dimensions is still an evolving research area ofnanotechnology. Various methodologies including conven-tional and unconventional fabrications, such as photolitho-graphy, scanning beam lithography, molding, embossing, andimprinting, have been developed in the past decade.

Published
2009

46. Beta-amyloid fibril formation is promoted by step edges of highly oriented pyrolytic graphite.

Author

Losic D, Martin LL, Aguilar MI, and Small DH

Subjects
Humans, Microscopy, Atomic Force, Protein Conformation, Surface Properties, Amyloid chemistry, Amyloid ultrastructure, Amyloid beta-Peptides chemistry, Amyloid beta-Peptides ultrastructure, Graphite chemistry, Peptide Fragments chemistry, Peptide Fragments ultrastructure
Abstract

The aggregation of the amyloid-beta-protein (Abeta) is an important step in the pathogenesis of Alzheimer's disease. As Abeta fibrils are not found in all brain regions, endogenous factors may influence Abeta fibril formation. In this study, atomic force microscopy was used to investigate the role of surface phenomena in directing amyloid aggregation. Abeta1-40 was applied to a surface of highly oriented pyrolytic graphite at a concentration of 0.5 microM. Steps formed by edge-plane surface defects on the graphite were found to act as a template to promote the assembly of Abeta into fibrils. Initially, after being deposited on the graphite surface, Abeta had a uniform beaded morphology. However, after incubating (aging) the Abeta on the surface for several hours, the Abeta assembled along step edges to form linear aggregates. After more prolonged incubation, the linear Abeta aggregates fused to form mature fibrils with a distinctive helical morphology. The results demonstrate that surface interactions can promote the aggregation of Abeta into amyloid fibrils and they suggest that similar interactions could promote amyloid aggregation in vivo., ((c) 2006 Wiley Periodicals, Inc.)

Published
2006
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