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Your search keyword '"Louahed, Jamila"' showing total 9 results
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9 results on '"Louahed, Jamila"'

3. Gene expression of MAGE-A3 and PRAME tumor antigens and EGFR mutational status in Taiwanese non-small cell lung cancer patients

Author

Pan, Szu-Hua, primary, Su, Kang-Yi, additional, Spiessens, Bart, additional, Kusuma, Nicole, additional, Delahaye, Nicolas F, additional, Gruselle, Olivier, additional, Myo, Aung, additional, de Creus, An, additional, Louahed, Jamila, additional, Chang, Gee-Cheng, additional, Yu, Sung-Liang, additional, and Yang, Pan-Chyr, additional

Published
2016
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8. IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice

Author

Dong, Qu, primary, Louahed, Jamila, additional, Vink, Anne, additional, Sullivan, Christine D., additional, Messler, Carol J., additional, Zhou, Yuhong, additional, Haczku, Angela, additional, Huaux, Francois, additional, Arras, Mohamed, additional, Holroyd, Kenneth J., additional, Renauld, Jean-Christophe, additional, Levitt, Roy C., additional, and Nicolaides, Nicholas C., additional

Published
1999
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9. A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction.

Author

Zhou Y, Shapiro M, Dong Q, Louahed J, Weiss C, Wan S, Chen Q, Dragwa C, Savio D, Huang M, Fuller C, Tomer Y, Nicolaides NC, McLane M, and Levitt RC

Subjects
Amino Acid Sequence, Animals, Bronchoalveolar Lavage Fluid chemistry, Cells, Cultured drug effects, Cells, Cultured metabolism, Chloride Channels physiology, Crosses, Genetic, Gels, Goblet Cells metabolism, Goblet Cells pathology, Humans, Immunologic Techniques, Inflammation, Lung drug effects, Lung pathology, Metaplasia, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Transgenic, Molecular Sequence Data, Mucins biosynthesis, Mucins chemistry, Mucoproteins physiology, Patch-Clamp Techniques, Reverse Transcriptase Polymerase Chain Reaction, Solubility, Chloride Channels drug effects, Goblet Cells drug effects, Lung metabolism, Mucoproteins drug effects, Niflumic Acid pharmacology
Abstract

We have previously shown that expression of a Ca2+-activated Cl- channel (mCLCA3 in mice and bCLCA1 in humans) is up-regulated along with goblet cell metaplasia and mucus overproduction in the lungs of interleukin 9 (IL9) transgenic mice, and in human primary lung cultures by IL4, IL13 and IL9. We show here that hCLCA1 expression in NCI-H292 cells specifically induces soluble gel-forming mucin production. Moreover, niflumic acid (NFA), a blocker of hCLCA1-dependent Cl- efflux, inhibits MUC5A/C production in these cells. NFA treatment during natural antigen-exposure, where mCLCA3 is greatly up-regulated in the lung, significantly reduces airway inflammation, goblet cell metaplasia and mucus overproduction in vivo. These data suggest that this Ca2+-activated Cl- channel plays an important role in epithelial-regulated inflammatory responses, including goblet cell metaplasia, and represents a potential novel therapeutic target for the control of mucus overproduction in chronic pulmonary disorders.

Published
2002

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