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1. The prognostic value of metabolic dysfunction‐associated steatotic liver disease in acute myocardial infarction: A propensity score‐matched analysis

Author

Kong, Gwyneth, primary, Cao, Grace, additional, Koh, Jaycie, additional, Chan, Siew Pang, additional, Zhang, Audrey, additional, Wong, Esther, additional, Chong, Bryan, additional, Jauhari, Silingga Metta, additional, Wang, Jiong‐Wei, additional, Mehta, Anurag, additional, Figtree, Gemma A., additional, Mamas, Mamas A., additional, Ng, Gavin, additional, Chan, Koo Hui, additional, Chai, Ping, additional, Low, Adrian F., additional, Lee, Chi Hang, additional, Yeo, Tiong Cheng, additional, Yip, James, additional, Foo, Roger, additional, Tan, Huay Cheem, additional, Huang, Daniel Q., additional, Muthiah, Mark, additional, Chan, Mark Yan‐Yee, additional, Loh, Poay‐Huan, additional, and Chew, Nicholas W. S., additional

Published
2024
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2. Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

Author

Chin, YipHan, primary, Lim, Jieyu, additional, Kong, Gwyneth, additional, Ng, Cheng Han, additional, Goh, Rachel, additional, Muthiah, Mark, additional, Mehta, Anurag, additional, Chong, Bryan, additional, Lin, Chaoxing, additional, Chan, Kai En, additional, Kong, William, additional, Poh, Kian Keong, additional, Foo, Roger, additional, Chai, Ping, additional, Yeo, Tiong‐Cheng, additional, Low, Adrian F., additional, Lee, Chi Hang, additional, Tan, Huay Cheem, additional, Chan, Mark Yan‐Yee, additional, Richards, A Mark, additional, Loh, Poay‐Huan, additional, and Chew, Nicholas W. S., additional

Published
2023
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3. Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population

Author

Chang, Xuling, primary, Dorajoo, Rajkumar, additional, Han, Yi, additional, Wang, Ling, additional, Liu, Jianjun, additional, Khor, Chiea‐Chuen, additional, Low, Adrian F., additional, Chan, Mark Yan‐Yee, additional, Yuan, Jian‐Min, additional, Koh, Woon‐Puay, additional, Friedlander, Yechiel, additional, and Heng, Chew‐Kiat, additional

Published
2020
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4. Incidence and predictors of target lesion failure in a multiethnic Asian population receiving the SYNERGY coronary stent: A prospective all-comers registry

Author

Ananthakrishna, Rajiv, primary, Kristanto, William, additional, Liu, Li, additional, Chan, Siew-Pang, additional, Loh, Poay Huan, additional, Tay, Edgar L., additional, Chan, Koo Hui, additional, Chan, Mark Y., additional, Lee, Chi-Hang, additional, Low, Adrian F., additional, Tan, Huay Cheem, additional, and Loh, Joshua P., additional

Published
2018
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5. Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction

Author

Chan, Michelle M.Y., primary, Santhanakrishnan, Rajalakshmi, additional, Chong, Jenny P.C., additional, Chen, Zhaojin, additional, Tai, Bee Choo, additional, Liew, Oi Wah, additional, Ng, Tze Pin, additional, Ling, Lieng H., additional, Sim, David, additional, Leong, Kui Toh G., additional, Yeo, Poh Shuan Daniel, additional, Ong, Hean-Yee, additional, Jaufeerally, Fazlur, additional, Wong, Raymond Ching-Chiew, additional, Chai, Ping, additional, Low, Adrian F., additional, Richards, Arthur M., additional, and Lam, Carolyn S.P., additional

Published
2015
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6. Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction

Author

Wong, Lee Lee, primary, Armugam, Arunmozhiarasi, additional, Sepramaniam, Sugunavathi, additional, Karolina, Dwi Setyowati, additional, Lim, Kai Ying, additional, Lim, Jia Yuen, additional, Chong, Jenny P. C., additional, Ng, Jessica Y. X., additional, Chen, Yei-Tsung, additional, Chan, Michelle M. Y., additional, Chen, Zhaojin, additional, Yeo, Poh Shuan D., additional, Ng, Tze P., additional, Ling, Lieng H., additional, Sim, David, additional, Leong, Kui Toh G., additional, Ong, Hean Y., additional, Jaufeerally, Fazlur, additional, Wong, Raymond, additional, Chai, Ping, additional, Low, Adrian F., additional, Lam, Carolyn S. P., additional, Jeyaseelan, Kandiah, additional, and Richards, Arthur Mark, additional

Published
2015
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7. Iron deficiency in a multi-ethnic Asian population with and without heart failure: prevalence, clinical correlates, functional significance and prognosis

Author

Yeo, Tee Joo, primary, Yeo, Poh Shuan Daniel, additional, Ching-Chiew Wong, Raymond, additional, Ong, Hean Yee, additional, Leong, Kui Toh Gerard, additional, Jaufeerally, Fazlur, additional, Sim, David, additional, Santhanakrishnan, Rajalakshmi, additional, Lim, Shir Lynn, additional, M.Y. Chan, Michelle, additional, Chai, Ping, additional, Low, Adrian F., additional, Ling, Lieng H., additional, Ng, Tze Pin, additional, Richards, A. Mark, additional, and Lam, Carolyn S.P., additional

Published
2014
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9. Growth differentiation factor 15, ST2, high‐sensitivity troponin T, and N‐terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction

Author

Santhanakrishnan, Rajalakshmi, primary, Chong, Jenny P.C., additional, Ng, Tze P., additional, Ling, Lieng H., additional, Sim, David, additional, Toh G. Leong, Kui, additional, Shuan D. Yeo, Poh, additional, Ong, Hean Y., additional, Jaufeerally, Fazlur, additional, Wong, Raymond, additional, Chai, Ping, additional, Low, Adrian F., additional, Richards, Arthur Mark, additional, and Lam, Carolyn S.P., additional

Published
2012
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13. Two‐Year Clinical Registry Follow‐up of Endothelial Progenitor Cell Capture Stent Versus Sirolimus‐Eluting Bioabsorbable Polymer‐Coated Stent Versus Bare Metal Stents in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction

Author

CHONG, ERIC, primary, POH, KIAN KEONG, additional, LIANG, SHEN, additional, LEE, RONALD CHI‐HANG, additional, LOW, ADRIAN, additional, TEO, SWEE‐GUAN, additional, and TAN, HUAY CHEEM, additional

Published
2010
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15. An Intravascular Ultrasound Study of Cypher, Taxus, and Endeavor Stents on Relation between Neointimal Proliferation and Residual Plaque Burden

Author

LEE, CHI-HANG, primary, ZHANG, JUNJIE, additional, KAILASAM, ANAND, additional, TAI, BEE-CHOO, additional, YE, FEI, additional, LOW, ADRIAN F., additional, HOU, XUMIN, additional, HAY, EDOURDO TIN, additional, TEO, SWEE-GUAN, additional, LIM, YEAN-TENG, additional, CHEN, SHAOLIANG, additional, and TAN, HUAY-CHEEM, additional

Published
2008
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16. Shortening of Median Door‐to‐Balloon Time in Primary Percutaneous Coronary Intervention in Singapore by Simple and Inexpensive Operational Measures: Clinical Practice Improvement Program

Author

LEE, CHI‐HANG, primary, OOI, SHIRLEY B.S., additional, TAY, EDGAR L., additional, LOW, ADRIAN F., additional, TEO, SWEE‐GUAN, additional, LAU, CINDY, additional, TAI, BEE‐CHOO, additional, LIM, IRENE, additional, LAM, SUSAN, additional, LIM, ING‐HAAN, additional, CHAI, PING, additional, and TAN, HUAY‐CHEEM, additional

Published
2008
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20. Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction.

Author

Chan MM, Santhanakrishnan R, Chong JP, Chen Z, Tai BC, Liew OW, Ng TP, Ling LH, Sim D, Leong KT, Yeo PS, Ong HY, Jaufeerally F, Wong RC, Chai P, Low AF, Richards AM, and Lam CS

Subjects
Aged, Biomarkers blood, Female, Humans, Inflammation blood, Male, Middle Aged, Natriuretic Peptide, Brain blood, Patient Readmission statistics & numerical data, Peptide Fragments blood, Prognosis, Proportional Hazards Models, ROC Curve, Singapore epidemiology, Survival Analysis, Growth Differentiation Factor 15 blood, Heart Failure blood, Heart Failure diagnosis, Heart Failure epidemiology, Heart Failure physiopathology, Stroke Volume
Abstract

Aim: Growth differentiation factor 15 (GDF15) is a cytokine highly expressed in states of inflammatory stress. We aimed to study the clinical correlates and prognostic significance of plasma GDF15 in heart failure with preserved ejection fraction (HFpEF) vs. reduced ejection fraction(HFrEF), compared with N-terminal pro-brain natriuretic peptide (NT-proBNP), an indicator of haemodynamic wall stress., Methods: Plasma GDF15 and NT-proBNP were prospectively measured in 916 consecutive patients with HFrEF (EF <50%; n = 730) and HFpEF (EF ≥50%; n = 186), and measured again at 6 months in 488 patients. Patients were followed up for a composite outcome of death or first HF rehospitalization., Results: Median GDF15baseline values were similarly elevated in HFpEF [2862 (1812 represent the 25th percentile and 4176 represent the 75th percentile) ng/L] and HFrEF [2517 (1555, 4030) ng/L] (P = 0.184), whereas NT-proBNP was significantly lower in HFpEF than HFrEF (1119 ng/L vs. 2335 ng/L, P < 0.001). Independent correlates of GDF15baseline were age, systolic blood pressure, New York Heart Association (NYHA) class, diabetes, atrial fibrillation, sodium, haemoglobin, creatinine, diuretic therapy, high sensitivity troponin T (hsTnT) and NT-proBNP (all P < 0.05). During a median follow-up of 23 months, there were 379 events (307 HFrEF, 72 HFpEF). GDF15 remained a significant independent predictor for composite outcome even after adjusting for important clinical predictors including hsTnT and NT-proBNP (adjusted hazard ratio 1.76 per 1 Ln U, 95% confidence interval 1.39-2.21; P < 0.001), regardless of HF group (Pinteraction  = 0.275). GDF15baseline provided incremental prognostic value when added to clinical predictors, hsTnT and NT-proBNP (area under receiver operating characteristic curve increased from 0.720 to 0.740, P < 0.019), with a net reclassification improvement of 0.183 (P = 0.004). Patients with ≥20% GDF156months increase had higher risk for composite outcome (adjusted hazard ratio 1.68, 95% confidence interval 1.15-2.45; P = 0.007) compared with those with GDF156months within ± 20% of baseline., Conclusions: The similarly elevated levels and independent prognostic utility of GDF15 in HFrEF and HFpEF suggest that beyond haemodynamic stress (NT-proBNP), inflammatory injury (GDF15) may play an important role in both HF syndromes., (© 2015 The Authors European Journal of Heart Failure © 2015 European Society of Cardiology.)

Published
2016
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