13 results on '"M Lanning"'
Search Results
2. A comprehensive comparative analysis of treatment modalities for sinonasal malignancies
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Tyler P. Robin, Diana Abbott, Oren M. Gordon, Andy Phan, Bernard L. Jones, David Raben, Ryan M. Lanning, Jessica D. McDermott, Julie A. Goddard, and Sana D. Karam
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Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Head and neck cancer ,Cancer ,medicine.disease ,Nose neoplasm ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,030223 otorhinolaryngology ,business ,Survival rate ,Chemoradiotherapy ,Neoadjuvant therapy - Abstract
BACKGROUND Sinonasal malignancies are a rare and heterogeneous group of tumors for which there is a paucity of robust data with which to guide management decisions. The authors used the National Cancer Data Base to better understand the presenting characteristics of these tumors and to compare outcomes by treatment modality. METHODS The National Cancer Data Base was queried for sinonasal malignancies diagnosed between 2004 and 2012. Overall survival was assessed using multivariate analyses and propensity score matching. RESULTS A total of 11,160 patients were identified for the initial analysis. The majority were male, aged 40 to 69 years, with tumors of the nasal cavity or maxillary sinus. Squamous cell histology was most common. The majority of patients presented with advanced tumor stage but without locoregional lymph node or distant metastases. Treatment modalities were compared for squamous cell carcinomas. In multivariate analysis, compared with surgery alone, patients who received adjuvant radiotherapy (hazard ratio [HR], 0.658 [P more...
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- 2017
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3. Bacterial chemotaxis transverse to axial flow in a microfluidic channel
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Roseanne M. Ford, Larry M. Lanning, and Tao Long
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Aspartic Acid ,Chemotactic Factors ,Chemistry ,Ecology ,Chemotaxis ,Microfluidics ,Flow (psychology) ,Bioengineering ,Laminar flow ,Fluid mechanics ,Microfluidic Analytical Techniques ,Applied Microbiology and Biotechnology ,Transverse plane ,Axial compressor ,Flow velocity ,Escherichia coli ,Biophysics ,Biotechnology - Abstract
Swimming bacteria sense and respond to chemical signals in their environment. Chemotaxis is the directed migration of a bacterial population toward increasing concentrations of a chemical that they perceive to be beneficial to their survival. Bacteria that are indigenous to groundwater environments exhibit chemotaxis toward chemical contaminants such as hydrocarbons, which they are also able to degrade. This phenomenon may facilitate bioremediation processes by bringing bacteria into closer proximity to these contaminants. A microfluidic device was assembled to study chemotaxis transverse to advective flow. Using a T-shaped channel design (T-sensor), two fluid streams were brought into contact by impinging flow. They then flowed adjacent to each other along a transparent channel. An advantage to this design is that it allows real-time visualization of bacterial distributions within the channel. Under laminar flow conditions a chemotactic driving force was created perpendicular to the direction of flow by diffusion of the chemical attractant from one input stream to the other. A comparison of the chemotactic band behavior in the absence and presence of flow showed that fluid velocity did not significantly impede chemotactic migration in the transverse direction. more...
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- 2008
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4. Glass micromodel study of bacterial dispersion in spatially periodic porous networks
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Roseanne M. Ford and Larry M. Lanning
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Materials science ,Light ,Bioengineering ,Porous glass ,Models, Biological ,Sensitivity and Specificity ,Applied Microbiology and Biotechnology ,Light scattering ,Motion ,Cell Movement ,Dispersion relation ,Dispersion (optics) ,Escherichia coli ,Scattering, Radiation ,Computer Simulation ,Turbidity ,Porosity ,Chemotaxis ,Equipment Design ,Mechanics ,Micromodel ,Volumetric flow rate ,Oxygen ,Biofilms ,Glass ,Rheology ,Biotechnology - Abstract
Successful implementation of bioremediation clean-up strategies depends on accurate predictions of the transport of bacteria within the subsurface. In this study, etched flat-plate glass micromodels were used to examine bacterial transport in a homogenous network. These networks were created by acid-etching interconnected channels into a glass plate and then fusing it to an unetched plate forming semi-cylindrical pores. The transparent nature of the micromodel allows for both qualitative observations of the bacteria within the pores and quantitative measurements of their concentration. The micromodels are designed to allow establishment of a well-characterized step change in bacterial concentration (Escherichia coli NR50) within the network. During the experiments, bacteria are dispersed through the network by flow. Light scattering is used to detect the change in turbidity within the pores as the bacteria travel through the network. The change in turbidity is used to construct breakthrough curves and spatial concentration profiles of bacteria within the network. The breakthrough curves are fit to the one-dimensional advection/dispersion equation to determine dispersion coefficients at different interstitial fluid velocities. From the breakthrough curves, dispersion coefficients were reproducible for replicate experiments over a range of velocities in the advection-dominated regime. The dispersivity values for two network designs resembling an interconnecting capillary network and a spatially periodic network of cylinders were 0.28 and 0.33 cm respectively, which are slightly greater than the literature values found for other pore networks. Experiments were also conducted within the diffusion-dominated regime to examine the effects of bacterial motility on dispersion. The accumulation of bacteria on the pore walls became significant at the low flow rates and extended experimental times thereby rendering the use of light scattering to determine concentrations ineffective. Bacterial chemotaxis, created by a self-imposed oxygen gradient, was also observed in the micromodel under stagnant fluid conditions. more...
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- 2002
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5. Osteonecrosis in children treated for acute lymphoblastic leukemia
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B M Lanning, Eija Pääkkö, F P Lanning, and A E Ojala
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Cancer Research ,Chemotherapy ,medicine.medical_specialty ,medicine.diagnostic_test ,Bone disease ,business.industry ,medicine.drug_class ,medicine.medical_treatment ,Magnetic resonance imaging ,medicine.disease ,Gastroenterology ,Asymptomatic ,Surgery ,medicine.anatomical_structure ,Oncology ,Acute lymphocytic leukemia ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Corticosteroid ,Bone marrow ,medicine.symptom ,business ,Dexamethasone ,medicine.drug - Abstract
The purpose of the study was to find out the prevalence of osteonecrosis in children with acute lymphoblastic leukemia (ALL) in complete bone marrow remission at the end of the treatment. Twenty-eight children with ALL underwent MRI of the upper and/or lower extremities. Bone marrow signal intensity was analyzed on T1-weighted images, where circumscribed lesions with a rim of low signal intensity were considered typical of osteonecrosis. Osteonecrosis was found in 9 of the 28 children (32%, 95% CI 16% to 52%). Five of them were asymptomatic. They had been treated with high risk and intermediate risk protocols, both of which include a delayed intensification phase with dexamethasone. None of the patients with standard risk ALL were found to have developed osteonecrosis. Osteonecroses occurred unexpectedly in symptomless patients and in patients with mild transient symptoms treated with high risk and intermediate risk protocols. Our study suggests that the intensification phase of the treatment protocols with intensive dexamethasone medication might be responsible for the development of osteonecrosis. more...
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- 1997
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6. Is there a role for interleukin-3 in Diamond-Blackfan anaemia? Results of a European multicentre study
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N. A. Bekassy, Göran Elinder, Y. Bastion, L. Wranne, W. A. Kamps, Pierre Bordigoni, Marianne Debré, M. Lanning, A. Makipernaa, Sarah E. Ball, Thierry Leblanc, and Gil Tchernia
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Adult ,Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Microgram ,Spontaneous remission ,Gastroenterology ,Subcutaneous injection ,In vivo ,Internal medicine ,medicine ,Humans ,Eosinophilia ,Platelet ,Treatment Failure ,Child ,business.industry ,Hematology ,Middle Aged ,Recombinant Proteins ,Clinical trial ,Fanconi Anemia ,Treatment Outcome ,Child, Preschool ,Erythropoiesis ,Female ,Interleukin-3 ,medicine.symptom ,business - Abstract
Forty patients (nine adults aged 20-54; 31 children aged 1-17) with Diamond-Blackfan anaemia (DBA) were treated with recombinant human interleukin-3 (IL-3) in a European multicentre compassionate-need study. IL-3 was given as a daily subcutaneous injection at a starting dose of 2.5 micrograms/kg, escalating at day 21 to 5 micrograms/kg, and then to 10 micrograms/kg if there was no response, for a total duration of 12 weeks. Three children achieved a significant response, achieving sustained remissions off all therapy. At the time of entry, one was steroid-responsive and transfusion-independent, and two were transfusion-dependent. Two adults had a transient reduction in transfusion requirements, but could not tolerate the complete course of therapy. Eosinophilia was common; neutrophil and platelet counts were unaffected except in three patients in whom previously noted mild thrombocytopenia was transiently exacerbated. Clinical response to IL-3 did not correlate with in vitro culture results. A comparison of individual patient characteristics of our study with previously reported series confirms earlier impressions that patients who have never achieved significant in vivo erythropoiesis in response to steroids or during a spontaneous remission are highly unlikely to respond to IL-3. In contrast, there may be a 50% chance of a sustained remission, off steroids, in children who are steroid-dependent and transfusion-independent at the time of IL-3 therapy, suggesting a possible role for a short course of IL-3 earlier in the treatment of children with steroid-responsive DBA. more...
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- 1995
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7. Second Malignant Neoplasms in Patients Treated for Childhood Leukemia: A Population-based Cohort Study from the Nordic Countries
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P. J. Moe, Stanislaw Garwicz, T. Haldorsen, R. Nygaard, M. Lanning, G. Jonmundsson, and H Hertz
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Oncology ,medicine.medical_specialty ,Childhood leukemia ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,General Medicine ,medicine.disease ,Malignancy ,Rate ratio ,Surgery ,Radiation therapy ,Leukemia ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Cohort ,medicine ,Rhabdomyosarcoma ,business - Abstract
Among a cohort of 981 children who were followed up 4.3-26.5 years after cessation of antileukemic therapy, eight patients in remission of acute lymphoblastic leukemia (ALL) developed a distinctively new malignant disease. The second malignant neoplasms (SMN) included brain tumors, basal cell carcinomas, thyroid cancer, leiomyosarcoma and finally rhabdomyosarcoma in a patient who also had suffered from Hodgkin's disease while still on antileukemic treatment. Cranial radiation had been given to 58.4% of the patients in the study group, which consisted of 895 ALL patients who had completed various chemotherapy protocols. With one exception, the SMN appeared after 7.5-16.5 years at a location previously exposed to radiotherapy (RT). The estimated cumulative risk of SMN appearing within 20 years after diagnosis was 2.9%, and the corresponding risk for cases with RT was 8.1% compared to 0.3% for those without (p = 0.05). In a Cox regression analysis, the incidence rate ratio of SMN between patients with and without RT was 6.7 (95% CI = 0.8, 57.7). Based on age-, year- and sex-specific cancer incidence figures for Norway, the overall standardized incidence rate ratio (SIR) of SMN after treatment for ALL was 5.9 (95% CI = 2.2, 12.9). The number of brain tumors among patients who had received cranial radiation was nearly 27 times greater than expected, whereas no such tumors were seen after chemotherapy. Individuals treated for childhood ALL are at increased risk of a new malignancy, and this seems mainly to be associated with previous irradiation. more...
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- 1991
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8. MR imaging of patients with implanted drug infusion pumps
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Rosellen M. Lanning, Frederick A. Eames, and Reinhard Von Roemeling
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Drug infusion ,Magnetic resonance imaging ,Infusion Pumps, Implantable ,Area of interest ,Magnetic Resonance Imaging ,Mr imaging ,Signal ,Surgery ,Image Artifact ,Humans ,Medicine ,Equipment Failure ,Radiology, Nuclear Medicine and imaging ,Drug infusion pumps ,In patient ,Artifacts ,business ,Biomedical engineering - Abstract
The influence of magnetic resonance (MR) imaging on the integrity and function of an implantable, programmable drug infusion pump and the distortion of the image by this device were tested. Six identical pumps were tested in magnetic fields of 1.5 T. Pump memory was not affected by the procedure. The pump rotor stalled (no infusion) as long as the device was within the magnetic field. Drug delivery resumed as programmed after the pump was removed from the field. No structural damage to the electrical or mechanical pump components was detected. The pump caused a circular image artifact (a signal dropout) within 8-10 cm of the device. The authors conclude that MR imaging is accurate if the area of interest is at least 10 cm from the pump, and that with awareness of temporary infusion cessation, it is safe to perform MR imaging in patients with this implanted pump. more...
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- 1991
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9. Chediak-Higashi syndrome: four cases from Northern Finland
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P, Baumann, primary, UM, Saarinen-Pihkala, additional, M, Möttönen, additional, and M, Lanning, additional
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- 2003
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10. Lymphocyte Blast Transformation Responses in Measles Infection
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Jorma Ilonen, M Lanning, E. Herva, and Aimo Salmi
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Male ,Time Factors ,Immunology ,Mumps virus ,Lymphocyte Activation ,medicine.disease_cause ,Measles ,Rubella ,Measles virus ,Leukocyte Count ,Antigen ,medicine ,Humans ,Lymphocytes ,Child ,Antigens, Viral ,biology ,Pokeweed mitogen ,Infant ,Rubella virus ,DNA ,General Medicine ,medicine.disease ,biology.organism_classification ,Rash ,Virology ,Child, Preschool ,Female ,Mitogens ,medicine.symptom - Abstract
Lymphocyte blast transformation responses were studied in eight patients with natural measles infection. A specific response to purified measles virus antigen and a weaker response to crude measles virus antigen were found after infection. The response to purified measles antigen appeared 1-3 weeks after the beginning of the rash, when the great number of proliferating mononuclear cells found in the peripheral blood during the rash was declining. In the first weeks after onset of the rash also leucocyte and lymphocyte numbers were decreased, and specific responses to purified tuberculin (PPD) and to rubella and mumps virus antigens were suppressed. In mitogen stimulation tests there was no significant suppression of phytohaemagglutinin and concanavalin responses in this small series, but the response to pokeweed mitogen was decreased. The responses to antigens other than measles virus antigens recovered in parallel with the increase of the measles-specific response. more...
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- 1980
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11. Military service of male survivors of childhood malignancies.
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Lähteenmäki PM, Salmi HA, Salmi TT, Helenius H, Mäkipernaa A, Lanning M, Perkkiö M, and Siimes MA
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- Adolescent, Adult, Body Height, Body Weight, Child, Child, Preschool, Educational Status, Finland epidemiology, Health Services Needs and Demand statistics & numerical data, Humans, Infant, Male, Neoplasms complications, Neoplasms physiopathology, Physical Fitness, Military Personnel statistics & numerical data, Neoplasms epidemiology, Survivors statistics & numerical data
- Abstract
Background: The objective of this study was to assess the eligibility for and the course of compulsory military service of childhood cancer survivors., Methods: The medical, military recruitment, conscription, and military service data of male Finnish childhood cancer survivors were collected from manually filed records. Inclusion criteria were: survivors born 1977 or earlier, treated for a malignancy between birth and age 15 years, and followed by a pediatrician until at least age 18 years. The documents of 207 survivors from the Pediatric Clinics of Finnish University Hospitals were examined, and 130 of these survivors were considered eligible for military service. Demographic factors, the predictors of fitness for military service, factors associated with service interruption, the attained level of military training, and the health status of conscripts during service were evaluated. Comparisons were made with the Finnish male population of the same age and with conscripts serving at the corresponding time., Results: Approximately 60% of studied survivors were enlisted. Positive predictors of fitness for service were year of birth of 1973 or later (odds ratio [OR], 3.2), height at call-up age of 170-174.9 cm (OR, 3.6), and the man's own positive opinion of his fitness for service (OR, 62.3). Negative predictors were age at diagnosis > or = 11 years (OR, 0.5), central nervous system radiotherapy (OR, 0.3), limb defects (OR, 0.02), and the group of sequelae concerning neurologic, cardiopulmonary, and gastrointestinal systems, or secondary malignancies (OR, 0.3). Survivors interrupted their service more often (20%) (P < 0.001). Leukemia survivors were less likely to interrupt their service (7%) compared with other survivors (P = 0.04). Factors associated with service interruption were: diagnosis (P = 0.04), the man's own opinion of his fitness for service (P = 0.013), surgery (P = 0.003), and height (P = 0.049), weight (P = 0.019), and body mass index (P = 0.035) at the beginning of military service. The attained level of military training was equal to that of controls. The survivors visited the garrison physician less frequently in total (mean, 5.9 times) (P < 0.001), visited because of infections as much as controls, and were off duty more (mean, 11.9 days) (P = 0.012) than controls., Conclusions: The current study found that childhood cancer survivors were less likely to meet the requirements set for military service in Finland. The causes of rejection usually were obvious, but approximately 30% were rejected merely on the basis of a former cancer diagnosis. However, enlisted survivors coped well with military service if their treatment sequelae were taken into consideration carefully at the time of enlistment. Vocational opportunities within the armed forces might be an appropriate career option even for survivors of childhood malignancies. more...
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- 1999
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12. Prospective controlled survey of viral infections in children with acute lymphoblastic leukemia during chemotherapy.
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Möttönen M, Uhari M, Lanning M, and Tuokko H
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- Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Prospective Studies, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Virus Diseases etiology
- Abstract
Background: Infections cause significant morbidity in children with acute lymphoblastic leukemia (ALL). The incidence of viral infections commonly occurring in children with ALL receiving chemotherapy was compared with viral infections in control children and the spread of infections in families was traced., Methods: Fifteen families of children with ALL receiving chemotherapy (62 members) and 26 matched control families (106 members) were monitored for a total of 36,197 and 36,583 days, respectively, from November/ 1987 to December/1989 for the occurrence of infections., Results: The children with ALL had more infections than their control counterparts (P < 0.01) with respiratory infections the most common in both groups. Viral etiology was verified for 47 episodes [5.2/1000 days at risk, 95% confidence interval (CI) 3.9-7.0] in the children with ALL and 22 (2.4/1000 days at risk, 95% CI 1.5-3.7) in the control subjects (P < 0.01 for the difference). Parainfluenza viruses, enteroviruses, and adenoviruses were the most common agents in both groups. The infections of the other members of the patients' families were similar to those of their controls. The children most commonly fell ill first, and although children with ALL had more infections, they did not appear to spread the infections to their family members., Conclusions: The children with ALL had more infections than their controls, but they managed to recover well from viral infections caused by common respiratory viruses. The children with ALL did not change the spread of infections among family members. more...
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- 1995
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13. White matter changes in children treated for acute lymphoblastic leukemia.
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Pääkkö E, Vainionpää L, Lanning M, Laitinen J, and Pyhtinen J
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- Adolescent, Adult, Brain radiation effects, Brain Neoplasms prevention & control, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Injections, Spinal, Magnetic Resonance Imaging, Male, Methotrexate administration & dosage, Methotrexate adverse effects, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma radiotherapy, Radiotherapy adverse effects, Brain pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
- Abstract
Background and Methods: Twenty-seven children with acute lymphoblastic leukemia (ALL) were studied by magnetic resonance (MR) imaging after central nervous system (CNS) treatment. The children were followed by clinical evaluations and computed tomographic (CT) brain scans. Two CNS treatment techniques were used. Eleven patients received intravenous and intrathecal methotrexate; 16 patients received 18-30 Gy of cranial radiation therapy in addition to systemic chemotherapy. The time interval between the CNS treatment and MR scans varied from 9 months to 4 years 8 months., Results: Four of the 27 children (15%) showed white matter changes on the MR scans attributable to therapy, but only one had hypodensity on CT. Three of the 16 children (19%) receiving radiation therapy in addition to chemotherapy had white matter changes. One of the 11 patients (9%) from the group receiving only chemotherapy did so. The difference between the two treatment groups was not significant., Conclusions: Radiation therapy or chemotherapy (alone or in combination) may have been responsible for the white matter changes. MR imaging is a sensitive detector of white matter changes in children with ALL, but its value and significance during follow-up should be assessed in well-designed longitudinal research studies. more...
- Published
- 1992
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