Search

Your search keyword '"M. Nakaoka"' showing total 6 results
Start Over Author "M. Nakaoka" Publisher wiley
6 results on '"M. Nakaoka"'

3. AC constant voltage regulator by improved partial voltage phase-control technique

Author

M. Nakaoka, Tadashi Ito, and Toru Maruhashi

Subjects
Low-dropout regulator, Materials science, Dropout voltage, Control theory, Voltage divider, Energy Engineering and Power Technology, Voltage multiplier, Voltage droop, Voltage source, Voltage regulator, Electrical and Electronic Engineering, Peak inverse voltage
Published
1975

5. Series self-commutated dc/dc converter circuits

Author

Masataro Nishimura, M. Nakaoka, and T. Hamaguchi

Subjects
Physics, Forward converter, Series (mathematics), Flyback converter, business.industry, Ćuk converter, Electrical engineering, Energy Engineering and Power Technology, Boost converter, Charge pump, Electrical and Electronic Engineering, business, Dc dc converter, Electronic circuit
Published
1973

6. Validation study of assay method for DX-8951 and its metabolite in human plasma and urine by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.

Author

Oguma T, Konno T, Inaba A, and Nakaoka M

Subjects
Antineoplastic Agents blood, Antineoplastic Agents urine, Atmospheric Pressure, Calibration, Camptothecin analogs & derivatives, Camptothecin blood, Camptothecin urine, Humans, Sensitivity and Specificity, Antineoplastic Agents pharmacokinetics, Camptothecin pharmacokinetics, Chromatography, High Pressure Liquid methods, Mass Spectrometry methods
Abstract

A new liquid chromatographic/mass spectrometric assay has been developed for the determination of DX-8951, a new anti-tumor drug, and its 4-hydroxymethyl metabolite (UM-1) in human plasma and urine. Solid-phase extractions were used for sample preparation. A gradient reverse-phase HPLC separation was developed with mobile phases consisting of trifluoroacetic acid and methanol. The detection was conducted using atmospheric pressure chemical ionization tandem mass spectrometry in the selected reaction monitoring mode. A structural analog, camptothecin (CPT), was used as the internal standard. The assay was validated for the determination of DX-8951 and UM-1 in human plasma and urine. The lower limits of quantitation of DX-8951 and UM-1 were 0.1 ng/mL in plasma and 1 ng/mL in urine. The method showed a satisfactory sensitivity, precision, accuracy, recovery and selectivity., (Copyright 2001 John Wiley & Sons, Ltd.)

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results